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Biosynthesis and functions of two phytotoxins in Septoria nodorum blotch. This project aims to investigate how a fungal plant pathogen makes and uses small bioactive molecules to facilitate infection. It will characterise the function of the genes and enzymes involved in the biosynthesis of a light-activated phytotoxic molecule and a potential anti-plant defence molecule found in the pathogenic wheat fungus Parastagonospora nodorum, and investigate their contribution to disease development. Expe ....Biosynthesis and functions of two phytotoxins in Septoria nodorum blotch. This project aims to investigate how a fungal plant pathogen makes and uses small bioactive molecules to facilitate infection. It will characterise the function of the genes and enzymes involved in the biosynthesis of a light-activated phytotoxic molecule and a potential anti-plant defence molecule found in the pathogenic wheat fungus Parastagonospora nodorum, and investigate their contribution to disease development. Expected outcomes include better understanding of plant-microbe interactions, disease management strategies, technologies for identifying biosynthetic pathways in other fungi, and enzyme technology for synthesising molecules. This could lead to new herbicides, biopesticides and drugs.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100024
Funder
Australian Research Council
Funding Amount
$520,000.00
Summary
Melbourne and Monash integrated proteomics facility. This project will provide two Victorian proteomic core facilities with cutting edge technology that will address a major gap in our mass spectrometry and protein interaction capabilitiy. These core facilities support a vast array of basic/applied research that depends on the characterisation of proteins and small molecules at a molecular level.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100092
Funder
Australian Research Council
Funding Amount
$240,000.00
Summary
A high-throughput protein production and structure facility. Making proteins and studying their structures and properties is a key activity in biotechnology, drug design, food security and bio-nanotechnology. The Protein Production and Structure Facility will provide Western Australian researchers and their international partners with world-class resources to pursue this research for the benefit of all Australians.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100096
Funder
Australian Research Council
Funding Amount
$180,000.00
Summary
Biomolecular Interaction Facility. Biomolecular interaction facility: A biomolecular interaction facility located in Perth is essential to support the research performed by a growing community of key protein researchers. The infrastructure provided by this integrated facility will act as a hub for analysis of samples produced by high-throughput protein production methods and will provide high-level training with cutting-edge equipment for researchers at all levels. It will underpin faster and be ....Biomolecular Interaction Facility. Biomolecular interaction facility: A biomolecular interaction facility located in Perth is essential to support the research performed by a growing community of key protein researchers. The infrastructure provided by this integrated facility will act as a hub for analysis of samples produced by high-throughput protein production methods and will provide high-level training with cutting-edge equipment for researchers at all levels. It will underpin faster and better fundamental and translational research in the areas of structural biology, biotechnology, biomedical science, plant science and nanotechnology, supporting the activities of researchers and their collaborators in Australia and worldwide.Read moreRead less
Fungal Ribosomally Synthesised and Post-translationally Modified Peptides. Fungi produce an array of molecules called secondary metabolites (SMs) that impact on everyday life (e.g. penicillin). This project aims to investigate a new class of fungal peptide SMs called RiPPs which are structurally unique from existing molecules and offer the exciting prospect of harbouring new and novel biological activities. This project expects to discover the mechanisms of RiPP synthesis and their biological ro ....Fungal Ribosomally Synthesised and Post-translationally Modified Peptides. Fungi produce an array of molecules called secondary metabolites (SMs) that impact on everyday life (e.g. penicillin). This project aims to investigate a new class of fungal peptide SMs called RiPPs which are structurally unique from existing molecules and offer the exciting prospect of harbouring new and novel biological activities. This project expects to discover the mechanisms of RiPP synthesis and their biological roles in plant pathogenic fungi, and uncover and engineer novel RiPPs with desired bioactivities. The expected outcome from this project will be a seminal advance in fungal SM biology which should provide significant benefits through the generation of exciting new lead molecules for the agricultural and medical industries.Read moreRead less