Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100181
Funder
Australian Research Council
Funding Amount
$650,000.00
Summary
Strengthening merit-based access and support at the new National Computing Infrastructure petascale supercomputing facility. World-leading high-performance computing is fundamental to Australia's international research success. This facility will provide access to the new National Computational Infrastructure facility by world-leading researchers from six research universities, and sustain ground-breaking work in an increasingly competitive environment.
Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technologica ....Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technological potential as commercially relevant research tools.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100043
Funder
Australian Research Council
Funding Amount
$435,279.00
Summary
High-throughput portable and wearable device fabrication facility. This project aims to establish a fabrication and characterisation facility for high-throughput production of portable, wearable and stretchable biomedical devices to accelerate the design–fabrication–evaluation process and save ‘trial-and-error’ costs during optimisation turnaround. It will apply computer-aided design for the programmable synthesis of hybrid materials for high-throughput screening of disease biomarkers, and super ....High-throughput portable and wearable device fabrication facility. This project aims to establish a fabrication and characterisation facility for high-throughput production of portable, wearable and stretchable biomedical devices to accelerate the design–fabrication–evaluation process and save ‘trial-and-error’ costs during optimisation turnaround. It will apply computer-aided design for the programmable synthesis of hybrid materials for high-throughput screening of disease biomarkers, and super-solution imaging of single molecules in live cells. This facility will provide capability for researchers pursuing industry transformation and other initiatives in the development of advanced materials, biomolecular sciences, nanotechnology, photonics and device engineering.Read moreRead less
Closing the data gap: High throughput screening of nanoparticle toxicity. The nanotechnology sector is experiencing an exponential growth period with over 100 products containing manufactured nanoparticles entering the market every year. Ensuring growth of the sector needs to be balanced against the imperative of protecting both human and environmental safety. This project aims to develop new methodological and conceptual avenues to close the gap between innovation in nanotechnology and risk ass ....Closing the data gap: High throughput screening of nanoparticle toxicity. The nanotechnology sector is experiencing an exponential growth period with over 100 products containing manufactured nanoparticles entering the market every year. Ensuring growth of the sector needs to be balanced against the imperative of protecting both human and environmental safety. This project aims to develop new methodological and conceptual avenues to close the gap between innovation in nanotechnology and risk assessment. This is intended to be achieved by developing and validating high-throughput in vitro toxicity screening platforms for manufactured nanoparticles. The approach is based on advanced lab-on-a-chip microfluidic technologies. The predictive power of the platform will be refined and optimised via ex-vivo and in-vivo models.Read moreRead less
Molecular insights into bacterial metal ion homeostasis and toxicity. This project aims to measure bacterial cellular metal concentrations, elucidate mechanisms cells use to adapt to changing extracellular metal concentrations, and reveal the molecular targets of metal toxicity. Metal ions are essential to all forms of life, and half of all proteins use metal ions for cellular chemical processes. However, how cells precisely balance sufficient metal ions for essential cellular chemistry without ....Molecular insights into bacterial metal ion homeostasis and toxicity. This project aims to measure bacterial cellular metal concentrations, elucidate mechanisms cells use to adapt to changing extracellular metal concentrations, and reveal the molecular targets of metal toxicity. Metal ions are essential to all forms of life, and half of all proteins use metal ions for cellular chemical processes. However, how cells precisely balance sufficient metal ions for essential cellular chemistry without accumulating a toxic excess (metal homeostasis) is poorly understood. Discovering the roles of metal ions in bacterial cells will be key to defining the chemical biology of living systems and will provide information essential to understanding how microbes adapt to changing environments.Read moreRead less
Nanoparticle-enabled photorefractive digital holography: toward the next generation ultrafast and multi-colour three dimensional display technology. The cutting-edge knowledge in nanoparticle-enabled photorefractive polymers will provide an innovative material for green-photonics industry. The new generation ultrafast and multi-colour digital holographic three dimensional display technology will be potentially beneficial to entertainment sectors, remote education and medical diagnosis and photov ....Nanoparticle-enabled photorefractive digital holography: toward the next generation ultrafast and multi-colour three dimensional display technology. The cutting-edge knowledge in nanoparticle-enabled photorefractive polymers will provide an innovative material for green-photonics industry. The new generation ultrafast and multi-colour digital holographic three dimensional display technology will be potentially beneficial to entertainment sectors, remote education and medical diagnosis and photovoltaics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100019
Funder
Australian Research Council
Funding Amount
$408,000.00
Summary
A Scalable and Adaptive-Resilient Blockchain. This project aims to address the security and scalability challenges that limit blockchain adoption. Existing blockchains do not scale and are vulnerable to attacks (e.g. with a total loss of over US$1 billion in 2019). This project expects to improve security by adaptively enforcing the currently broken security assumptions, and to improve scalability by designing blockchains with high concurrency via relaxed criteria on the ordering of transactions ....A Scalable and Adaptive-Resilient Blockchain. This project aims to address the security and scalability challenges that limit blockchain adoption. Existing blockchains do not scale and are vulnerable to attacks (e.g. with a total loss of over US$1 billion in 2019). This project expects to improve security by adaptively enforcing the currently broken security assumptions, and to improve scalability by designing blockchains with high concurrency via relaxed criteria on the ordering of transactions. The expected outcomes include foundations and practical solutions for self-adaptive, secure and scalable blockchains. The benefits of this would be improved confidence in and capacity for building blockchain applications, which have a predicted value of over US$3.1 trillion by 2030.Read moreRead less
Understanding the composite structures and properties of wild silk cocoons. This project will reveal the secret of wild silk cocoon structures, which are very thin and light in weight, yet they can protect wild silkworms in very harsh environments. This new knowledge will lead to the development of nature inspired materials and structures for personal protection.
Local Aboriginal community archives: the use of information technology and the National Broadband Network in disaster preparedness and recovery. This project will redefine the way significant and at-risk audiovisual archival material in Aboriginal communities is preserved, protected and made accessible for future generations via new initiatives such as cloud technology and the National Broadband Network, ensuring intergenerational transmission of vital cultural heritage.
Superconducting silicon nanodevices. This project will investigate superconductivity in silicon nanowire devices exhibiting both p-type and n-type conductivity. It builds on the recent demonstration at the University of Melbourne of superconductivity in nanowire devices at length-scales suitable for realisation of a broad range of superconducting device structures and utilises standard semiconductor-industry processes. This project will create a new platform for superconducting device developmen ....Superconducting silicon nanodevices. This project will investigate superconductivity in silicon nanowire devices exhibiting both p-type and n-type conductivity. It builds on the recent demonstration at the University of Melbourne of superconductivity in nanowire devices at length-scales suitable for realisation of a broad range of superconducting device structures and utilises standard semiconductor-industry processes. This project will create a new platform for superconducting device development in silicon with potential for building devices with new functionality and improved performance for applications in quantum information technologies, enhancing Australia’s global reputation in quantum information science and assisting emerging industries in this high-valued added area.Read moreRead less