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Neural circuit control of effort under stress . This Project aims to investigate how the ‘decision’ to persist in exerting effort to obtain a reward is encoded in the the brain and affected by stress. This work will generate new knowledge on the neural mechanisms through which stress modifies neural activity to control decision making processes underpinning adaptive behaviours essential for survival. The expected outcomes of this work include enhanced capacity at the interface of behavioural a ....Neural circuit control of effort under stress . This Project aims to investigate how the ‘decision’ to persist in exerting effort to obtain a reward is encoded in the the brain and affected by stress. This work will generate new knowledge on the neural mechanisms through which stress modifies neural activity to control decision making processes underpinning adaptive behaviours essential for survival. The expected outcomes of this work include enhanced capacity at the interface of behavioural and computational neuroscience, that will in turn provide significant benefits through greater insight into brain functions essential for survival, with long ranging implications for performance optimisation and brain-inspired computing. Read moreRead less
Transforming museum industry to cryopreserve Australia’s diverse wildlife. This project aspires to develop methods for collecting, culturing and cryopreserving cells from wildlife in line with museum industry practice. The project expects to generate new knowledge about the collection of live cells from animals under field conditions and their long-term maintenance in museum collections. Expected outcomes of the project include enhanced capacity of museums to build live cell collections and to s ....Transforming museum industry to cryopreserve Australia’s diverse wildlife. This project aspires to develop methods for collecting, culturing and cryopreserving cells from wildlife in line with museum industry practice. The project expects to generate new knowledge about the collection of live cells from animals under field conditions and their long-term maintenance in museum collections. Expected outcomes of the project include enhanced capacity of museums to build live cell collections and to support and collaborate with cellular biologists. Growth of live cell collections in Australian museums will fuel innovation in cellular technologies, advance fundamental biological knowledge, and shift museums from the role of documenting losses of genetic variation to preserving that genetic variation in living form.
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Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying ....Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying regulators of lipid metabolism. The large diversity in humans necessitate sufficient sample sizes to identify true genetic regulators, but to date techniques capturing phenotypic data (lipids) have been largely limited. It is anticipated that this study will identify new regulators of lipid metabolism in humans.Read moreRead less
Migration-Dependent Signalling in Macrophages . The project aims to investigate a mechanism of communication used by immune cells to guide each other towards sites of damage. The project will characterise newly revealed cell signalling membrane trails left behind by migrating cells, utilising biochemistry, innovative imaging and microscopy and a transparent zebrafish model to view cell migration through living tissues. Expected outcomes include new fundamental knowledge in the area of immune cel ....Migration-Dependent Signalling in Macrophages . The project aims to investigate a mechanism of communication used by immune cells to guide each other towards sites of damage. The project will characterise newly revealed cell signalling membrane trails left behind by migrating cells, utilising biochemistry, innovative imaging and microscopy and a transparent zebrafish model to view cell migration through living tissues. Expected outcomes include new fundamental knowledge in the area of immune cell migration with relevance to the basic biology of inflammation, repair and regeneration and new innovations for cell imaging. Significant benefits are expected to arise from this new knowledge and from advanced skills training and improved national capabilities in bio-imaging and analysis.Read moreRead less
Towards 2050 - managing recovery of Australia's coral reefs. The coral reefs of Australia contribute over $6 bn each year to the economy. However, the reefs of Australia, in addition to those worldwide, are threatened by coral bleaching driven by anthropogenic climate change. If we are to preserve the economic, social and ecosystem value of these environments, it is essential that we are able to better manage the recovery of reefs from bleaching events. This project will utilise a variety of mul ....Towards 2050 - managing recovery of Australia's coral reefs. The coral reefs of Australia contribute over $6 bn each year to the economy. However, the reefs of Australia, in addition to those worldwide, are threatened by coral bleaching driven by anthropogenic climate change. If we are to preserve the economic, social and ecosystem value of these environments, it is essential that we are able to better manage the recovery of reefs from bleaching events. This project will utilise a variety of multi-disciplinary approaches, ranging from future climate models, historical satellite data to in-field experimentation to fill fundamental knowledge gaps in our understanding of coral bleaching recovery and delivery a variety of management and stakeholder relevant outputs.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100054
Funder
Australian Research Council
Funding Amount
$1,341,398.00
Summary
Dedicated High-throughput 3D-Electron Diffractometer. This proposal aims to install the first dedicated high-throughput 3D-electron diffractometer in the Southern Hemisphere, and one of the first in the world. It will be able to rapidly solve the atomic-scale structures of molecules and materials for which this is now extremely difficult and time-consuming – or impossible – due to the inability to grow large enough crystals for traditional X-ray diffraction. It will thus provide a significant ad ....Dedicated High-throughput 3D-Electron Diffractometer. This proposal aims to install the first dedicated high-throughput 3D-electron diffractometer in the Southern Hemisphere, and one of the first in the world. It will be able to rapidly solve the atomic-scale structures of molecules and materials for which this is now extremely difficult and time-consuming – or impossible – due to the inability to grow large enough crystals for traditional X-ray diffraction. It will thus provide a significant advantage for chemists, physicists, biologists, geologists, and engineers who rely on detailed structural knowledge to rationally optimise the properties of their compounds, from pharmaceutical activity to carbon capture to superconductivity, to the substantial benefit of multiple national priority areas.Read moreRead less
Unpacking the immune system with applied mathematics. This project aims to model immune interactions across cells and structures spanning scales of nanometres to millimetres. It expects to develop innovative mathematical insights, improve our understanding of immunology, and consolidate collaborations with top American and European laboratories and groups. Expected outcomes include cutting-edge techniques for multiscale biological modelling and improved prediction and analysis of immune dynami ....Unpacking the immune system with applied mathematics. This project aims to model immune interactions across cells and structures spanning scales of nanometres to millimetres. It expects to develop innovative mathematical insights, improve our understanding of immunology, and consolidate collaborations with top American and European laboratories and groups. Expected outcomes include cutting-edge techniques for multiscale biological modelling and improved prediction and analysis of immune dynamics. The project should provide benefits to industries where highly organised behaviours are important, for example those interested in robot swarming, optimal transportation, and epidemic management. It should also benefit Australian students and researchers with novel overseas training opportunities.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100091
Funder
Australian Research Council
Funding Amount
$1,000,000.00
Summary
Deep imaging for understanding molecular processes in complex organisms. This project aims to establish a new fluorescence-based imaging platform that provides an unprecedented combination of sensitivity and spectral discrimination for investigating molecular processes deep within biological tissues. It aims to generate fundamental knowledge in biology, chemistry and materials science relevant to emerging technologies including synthetic tissue construction, nanoparticle assisted delivery of bio ....Deep imaging for understanding molecular processes in complex organisms. This project aims to establish a new fluorescence-based imaging platform that provides an unprecedented combination of sensitivity and spectral discrimination for investigating molecular processes deep within biological tissues. It aims to generate fundamental knowledge in biology, chemistry and materials science relevant to emerging technologies including synthetic tissue construction, nanoparticle assisted delivery of bioactive compounds, molecular sensors, and designer plants. Expected outcomes are high impact discoveries, training opportunities, cross-disciplinary and cross-institutional collaborations and publications addressing fundamental questions that will ultimately contribute to improved crop production and biomedical products.Read moreRead less
ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. The ARC Centre for the Mathematical Analysis of Cellular Systems aims to deliver the mathematics required to compute life. The Centre will deliver innovation in computational and mathematical biology and establish in silico biology alongside in vivo and in vitro biology. These models will allow us to understand the complexity of life at the cellu ....ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. The ARC Centre for the Mathematical Analysis of Cellular Systems aims to deliver the mathematics required to compute life. The Centre will deliver innovation in computational and mathematical biology and establish in silico biology alongside in vivo and in vitro biology. These models will allow us to understand the complexity of life at the cellular level and enable new ways of combining diverse and heterogenous data. This will allow us to understand the mechanisms underlying cellular behaviour, and to apply rational design engineering methods in order to control the dynamics of biological systems. Read moreRead less
Investigating novel pathways in ferroptosis. This project aims to develop new tools to investigate iron-mediated cell death and uncover new pathways involved in ageing. Accumulation of iron leads to frailty in late life, a process that appears common to all animals. Iron becomes reactive and inappropriately triggers a cell death process called ferroptosis leading to dysfunction. To understand these processes and to identify means to intervene, this project aims to use genetic approaches to ident ....Investigating novel pathways in ferroptosis. This project aims to develop new tools to investigate iron-mediated cell death and uncover new pathways involved in ageing. Accumulation of iron leads to frailty in late life, a process that appears common to all animals. Iron becomes reactive and inappropriately triggers a cell death process called ferroptosis leading to dysfunction. To understand these processes and to identify means to intervene, this project aims to use genetic approaches to identify new cell pathways that regulate ferroptosis. This project also aims to develop new tools to study this process. Outcomes of this project may include the identification of potential strategies to alter late life frailty with an expected benefit to life sciences and biotechnology industries.Read moreRead less