Fluid Dynamics of Circulation: Focus on the Kidney. In Australia, about 30% of adults have hypertension, a major risk factor for heart disease, accounting for about 40% of all deaths. Problems in renal circulation are likely factors leading to hypertension. A detailed understanding of the renal circulation, of whose hydraulic characteristics we have limited knowledge, is required before we can cure or prevent hypertension. We will determine how the size, structure and geometry of the blood vesse ....Fluid Dynamics of Circulation: Focus on the Kidney. In Australia, about 30% of adults have hypertension, a major risk factor for heart disease, accounting for about 40% of all deaths. Problems in renal circulation are likely factors leading to hypertension. A detailed understanding of the renal circulation, of whose hydraulic characteristics we have limited knowledge, is required before we can cure or prevent hypertension. We will determine how the size, structure and geometry of the blood vessels influence the function of the kidney. This will lead to predictive models to aid the design and interpretation of physiological studies and the combat of hypertension. It will also help in the ongoing development of bioartificial kidneys to replace present dialysis systems. Read moreRead less
Multiblock copolymer synthesis for nano-engineered materials. This project aims to develop methodology for environmentally friendly and industrially applicable synthesis of new types of advanced polymeric materials comprising multiblock copolymers. Polymeric materials play an important role in society with applications from bulk plastics to advanced technological applications. This would enable the creation of advanced materials with specific engineering targets and applications ranging from nan ....Multiblock copolymer synthesis for nano-engineered materials. This project aims to develop methodology for environmentally friendly and industrially applicable synthesis of new types of advanced polymeric materials comprising multiblock copolymers. Polymeric materials play an important role in society with applications from bulk plastics to advanced technological applications. This would enable the creation of advanced materials with specific engineering targets and applications ranging from nanomedicine to materials science.Read moreRead less
Dynamics and control of fluid-structure-free surface interactions. This project aims to research the apparently opposing effects of vortex shedding and free surface damping, individually and jointly, and the control or excitation of the vibrations for two generic bluff bodies: the cylinder and the sphere. Flow-induced vibrations of bluff bodies under or piercing water surfaces can damage floating off-shore marine structures and tethered bodies. On the other hand, harvesting energy from ocean cur ....Dynamics and control of fluid-structure-free surface interactions. This project aims to research the apparently opposing effects of vortex shedding and free surface damping, individually and jointly, and the control or excitation of the vibrations for two generic bluff bodies: the cylinder and the sphere. Flow-induced vibrations of bluff bodies under or piercing water surfaces can damage floating off-shore marine structures and tethered bodies. On the other hand, harvesting energy from ocean currents needs large flow-induced vibrations. The intended outcomes are new modes of body vibration, wake transitions and means to control fluid-structure interactions. This research could benefit many processes in offshore marine engineering, submarine bodies and mixing vessels, where understanding and controlling fluid-structure interactions of bluff bodies can mitigate costly and dangerous induced vibrations.Read moreRead less
Using data mining methods to remove uncertainties in sensor data streams. This project will develop key techniques for removing uncertainties in sensor data streams and thus improve the monitoring quality of sensor networks. The expected outcomes will benefit Australia by enabling improved, lower-cost monitoring of natural resources and management of stock raising.
Links between bushfires in Victoria and floods in Queensland. This project will investigate connections between bushfires in Victoria and floods in Queensland under the framework that atmospheric blocking can be thought of as a common link. High resolution runs using the Intergovernmental Panel on Climate Change future projections of the energetics of high impact weather will improve climate forecasts in sensitive coastal areas of the country.
Hydrogen: an overlooked intermediate during anoxia in permeable sediments. This project aims to quantify the respiratory pathways and the importance of hydrogen as an intermediate during anoxia in permeable (sand) sediments which dominate our coastline. It is anticipated the findings of this project will enable more accurate fundamental understanding of sediment diagenetic processes which control nutrient regeneration and loss pathways in the marine environment. This will enable better manageme ....Hydrogen: an overlooked intermediate during anoxia in permeable sediments. This project aims to quantify the respiratory pathways and the importance of hydrogen as an intermediate during anoxia in permeable (sand) sediments which dominate our coastline. It is anticipated the findings of this project will enable more accurate fundamental understanding of sediment diagenetic processes which control nutrient regeneration and loss pathways in the marine environment. This will enable better management of these environments in the face of increasing coastal population growth.Read moreRead less
Revolutionising protection against air pollution. This interdisciplinary project aims to develop a personalised air pollution exposure monitoring system, leveraging the ubiquitousness and advancements in mobile phone technology and state of the art miniaturisation of monitoring sensors, data transmission and analysis. Airborne pollution is one of the top contemporary risks faced by humans; however, at present individuals have no way to recognise that they are at risk or need to protect themselve ....Revolutionising protection against air pollution. This interdisciplinary project aims to develop a personalised air pollution exposure monitoring system, leveraging the ubiquitousness and advancements in mobile phone technology and state of the art miniaturisation of monitoring sensors, data transmission and analysis. Airborne pollution is one of the top contemporary risks faced by humans; however, at present individuals have no way to recognise that they are at risk or need to protect themselves. It is expected that the outcome will empower individuals to control and minimise their own exposures. This is expected to lead to significant national socioeconomic benefits and bring global advancement in acquiring and utilising environmental information.Read moreRead less
FLOW STUDIES OF CELL CULTURE BIOREACTORS. The proposed research program consists of a number of stages, amongst which is the study of flows within mixed flasks, the study of a small-scale Taylor-Couette vessel, and the development of a three-dimensional Holographic Particle Image Velocimetry flow measurement system. A successful project will be a valuable contribution to the development of cell and tissue scale up systems. In the long term, such systems will potentially provide the means of grow ....FLOW STUDIES OF CELL CULTURE BIOREACTORS. The proposed research program consists of a number of stages, amongst which is the study of flows within mixed flasks, the study of a small-scale Taylor-Couette vessel, and the development of a three-dimensional Holographic Particle Image Velocimetry flow measurement system. A successful project will be a valuable contribution to the development of cell and tissue scale up systems. In the long term, such systems will potentially provide the means of growing cell and tissue in quantities suitable for implantation or use in other therapeutic applications that are currently deemed impossible.Read moreRead less
Wake Transitions and Fluid-Structure Interactions of Rotating Bluff Bodies. Flow-induced vibrations of bluff bodies can lead to severe damage in many applications, such as off-shore marine structures and tethered bodies. Rotation of bluff bodies can result in huge increases in lift forces, which may promote these vibrations, whereas a nearby free surface may stabilise the vibrations. This project aims to discover the mechanisms underpinning the apparently opposing effects of vibration and free s ....Wake Transitions and Fluid-Structure Interactions of Rotating Bluff Bodies. Flow-induced vibrations of bluff bodies can lead to severe damage in many applications, such as off-shore marine structures and tethered bodies. Rotation of bluff bodies can result in huge increases in lift forces, which may promote these vibrations, whereas a nearby free surface may stabilise the vibrations. This project aims to discover the mechanisms underpinning the apparently opposing effects of vibration and free surface, individually and jointly, and the excitation of two- and three-dimensional instabilities in the wakes of two generic bluff bodies: the cylinder and the sphere. The expected outcomes are the discovery of new modes of body vibration, wake transitions and means to control fluid-structure interactions.Read moreRead less
The cellular basis of branching morphogenesis during kidney development. This project aims to study the process of branching morphogenesis which drives the development of the kidney. Previous studies group have demonstrated, in general terms, how branching progresses during gestation. However, little is known about the fundamental cellular events which trigger or characterise this basic developmental process. This project expects to provide deep insights into the cellular basis of tissue and org ....The cellular basis of branching morphogenesis during kidney development. This project aims to study the process of branching morphogenesis which drives the development of the kidney. Previous studies group have demonstrated, in general terms, how branching progresses during gestation. However, little is known about the fundamental cellular events which trigger or characterise this basic developmental process. This project expects to provide deep insights into the cellular basis of tissue and organ development. In studying this process the project should provide critical insights into how cells act, individually and collectively, to build tissues.Read moreRead less