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  • Funded Activity

    Aging Lungs In European Cohorts

    Funder
    National Health and Medical Research Council
    Funding Amount
    $470,342.00
    Summary
    This project will investigate the causes of respiratory disease and poor lung function across the life course. Using existing lung health data from Australia and Europe, we will determine which behavioral, environmental, occupational, nutritional, other modifiable lifestyle, or genetic factors play a role in lung health. This research will enable the development of a personalised risk predictor application for implementation with patients and health care providers as well as the general public.
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    Funded Activity

    ELders AT Ease Program (ELATE): A Cluster Randomised Controlled Trial Of A Sustainable And Scalable Mental Health Service For Australian Residential Aged Care Facilities

    Funder
    National Health and Medical Research Council
    Funding Amount
    $999,551.00
    Summary
    Elders living in residential facilities suffer significant levels of depression or anxiety. This study examines an innovative program to improve mental health of residents living in such facilities. The program involves counselling, staff training and family support. The study uses a cluster randomised controlled trial of facilities to evaluate the impact of ELATE: Elders at Ease Program” on residents’ psychological wellbeing, staff knowledge, family carer stress and, health care costs.
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    Funded Activity

    Models Of Child Health Appraised

    Funder
    National Health and Medical Research Council
    Funding Amount
    $321,054.00
    Summary
    The European Commission study - Models of Child Health Appraised (MOCHA) will examine the most effective model of primary health care (medical and non-medical) for children. We will complement this work through specific Australian studies on (1) experiences at the primary/secondary care interface, (2) development and testing of paediatric quality measures and (3) determining if and how primary care addresses inequity; ensuring all the results are translatable outside the European context.
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    Funded Activity

    Identifying Novel Lipid And Genetic Signatures Of Metabolic Disease In Early Childhood

    Funder
    National Health and Medical Research Council
    Funding Amount
    $354,592.00
    Summary
    Both our genetic makeup and environment can contribute to the development of obesity, diabetes and heart disease. Although onset usually occurs in adulthood, the progression towards disease can start in early life. Early childhood represents an opportunity for intervention to avoid adverse health outcomes in adulthood. This proposal combines two established birth cohorts from Singapore (GUSTO) and Australia (BIS) to examine the genetic and environmental origins of metabolic diseases.
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    Funded Activity

    Understanding The Impact Of Social, Economic And Geographic Disadvantage On The Health Of Australians In Mid - Later Lif

    Funder
    National Health and Medical Research Council
    Funding Amount
    $1,943,571.00
    Summary
    This research will examine the ways in which social, economic and environmental factors contribute to the health of Australians in mid to later life. It will help identify ways in which policy and preventive programs can contribute to improving health in mid to later life particularly among disadvantaged Australians. We will explore in detail social, economic and environmental factors in 100,000 people aged 45 and over; this will be the largest study of its kind ever undertaken in Australia. We .... This research will examine the ways in which social, economic and environmental factors contribute to the health of Australians in mid to later life. It will help identify ways in which policy and preventive programs can contribute to improving health in mid to later life particularly among disadvantaged Australians. We will explore in detail social, economic and environmental factors in 100,000 people aged 45 and over; this will be the largest study of its kind ever undertaken in Australia. We will examine the relationship between these social, economic factors, and lifestyle factors such as smoking, physical activity, environmental and obesity. This will enable us to identify where programs and policies should be directed to most rapidly improve the health of disadvantaged Australians.
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    Funded Activity

    Novel Assessment And Intervention For Dementia: An Inter-disciplinary Translational Approach

    Funder
    National Health and Medical Research Council
    Funding Amount
    $720,021.00
    Summary
    This program of research focuses on i) a highly novel internationally competitive program of work focusing on the neural network correlates of sleep in dementia, sleep as a risk factor and the efficacy of sleep-wake interventions in reducing cognitive decline; ii) Innovative technologies for widespread screening of preclinical dementia and early intervention and iii) clinical trials focused on the testing of a of novel, highly translatable dementia risk reduction interventions.
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    Funded Activity

    The Role Of Oligodendrocytes In Frontotemporal Dementia

    Funder
    National Health and Medical Research Council
    Funding Amount
    $625,292.00
    Summary
    Dementia affects 35.6 million people world-wide; this number is projected to double every 20 years. Frontotemporal dementia (FTD) is the second most common type and has been found to have similar cause and pathology to common neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). We ultimately require treatments to slow, stop and repair the damaged brain of FTD patients and this is only possible by understanding the mechanisms involved in the onset and progression of disease.
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    Funded Activity

    Improving The Management Of Diabetes In Pregnancy In Remote Australia

    Funder
    National Health and Medical Research Council
    Funding Amount
    $2,117,449.00
    Summary
    This study aims to optimise the management of diabetes in pregnancy (both gestational diabetes and pre-existing type 2 diabetes) and post-partum follow-up of these high risk women in order to reduce the risk of future chronic disease among women and their children. The proposal involves scale-up of successful initiatives that we have developed as part of the NT DIP Partnership, scale-up within the Northern Territory (NT) and to Far North Queensland (FNQ).
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    Funded Activity

    What Can Tau Deposition Tell Us About The Appearance Of Subjective And Objective Cognitive Decline In Older Adults?

    Funder
    National Health and Medical Research Council
    Funding Amount
    $674,077.00
    Summary
    Subjective memory concerns are common in older adults, but it is uncertain how they relate to Alzheimer’s disease (AD) biomarkers. Novel neuroimaging techniques have been developed for measuring tau deposition, a hallmark feature of AD. Using this technique, I aim to determine whether tau is sensitive to certain types of subjective concerns. My findings will reveal which concerns are indicative of AD risk, and which arise from unrelated factors, such as inattention or stress.
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    Funded Activity

    Optimising Speech Assessment And Treatment In Frontotemporal Dementia

    Funder
    National Health and Medical Research Council
    Funding Amount
    $722,210.00
    Summary
    Frontotemporal dementia has a devastating impact on our ability to speak and understand others. This proposal aims to improve our understanding of how to best assess, diagnose and treat these debilitating impairments. By bringing together an international consortium of clinics, these findings will lead to significant advances in our understanding of disease progression and patient care.
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