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Fluid mechanics and physiology of blockages in vascular systems. Vascular disease is a major health problem both in Australia and worldwide. In particular, cardiovascular disease is a major killer of adult Australians. Engineers and mathematicians working with biologists will gain a greater understanding of vascular diseases, a major health problem, including cardiovascular disease, which is one of the biggest killers worldwide, as well as tackling renal circulation problems, which are a signifi ....Fluid mechanics and physiology of blockages in vascular systems. Vascular disease is a major health problem both in Australia and worldwide. In particular, cardiovascular disease is a major killer of adult Australians. Engineers and mathematicians working with biologists will gain a greater understanding of vascular diseases, a major health problem, including cardiovascular disease, which is one of the biggest killers worldwide, as well as tackling renal circulation problems, which are a significant problem and may contribute to hypertension. Detailed measurement and prediction will be undertaken of the mechanical loading and response of cells to their microenvironment, an important first step to controlling pathological responses which lead to a variety of autoimmune problems.Read moreRead less
Control of Transitions in Wakes and Swirling Flows. We will attack industrially-important problems in fluid mechanics by building new, and substantially enhancing existing, international collaborations between key complementary teams of internationally-recognised French and Australian researchers. Funding will support the exchange of 6 senior staff and 3 graduate students, which, in turn, will measurably benefit the research output of a further 20 graduate students and 7 post-doctoral fellows as ....Control of Transitions in Wakes and Swirling Flows. We will attack industrially-important problems in fluid mechanics by building new, and substantially enhancing existing, international collaborations between key complementary teams of internationally-recognised French and Australian researchers. Funding will support the exchange of 6 senior staff and 3 graduate students, which, in turn, will measurably benefit the research output of a further 20 graduate students and 7 post-doctoral fellows associated with closely-related projects. From the Australian perspective, the planned exchanges will bring new research expertise, knowledge and skills, which will be focussed on a diverse range of applications. Target industries (with existing collaborations) include Airbus and Dassault Aviation in Europe, and Aerosonde and Warman pumps in Australia. Read moreRead less
Design of Welded Steel Tubular Connections. Steel tubes are widely used in building, road transportation, defence, recreation, and agriculture industries. The proposed program will develop static design procedures for welded tubular connections to ensure safe and economic structures. The program will also investigate the behaviour of a popular tubular connection utilizing very high strength steel tubes to extend the existing design scope and enhance the utilization of Australian produced innovat ....Design of Welded Steel Tubular Connections. Steel tubes are widely used in building, road transportation, defence, recreation, and agriculture industries. The proposed program will develop static design procedures for welded tubular connections to ensure safe and economic structures. The program will also investigate the behaviour of a popular tubular connection utilizing very high strength steel tubes to extend the existing design scope and enhance the utilization of Australian produced innovative tubular sections. The notch toughness of steel tubes will also be investigated to avoid fracture failure of welded connections under dynamic loading. The program will build strong ongoing collaboration between University of Toronto and Monash University.Read moreRead less
Microanalysis of novel carbon thin films. Carbon coatings are technologically important and have many applications in automotive and biomedical industries worldwide. An example automotive application is as a coating for high performance fuel injectors. Carbon coatings have significant unrealised potential for applications in hostile environments such as those encountered in high performance engineering components and in the human body. Electrical devices can be fabricated with these films suitab ....Microanalysis of novel carbon thin films. Carbon coatings are technologically important and have many applications in automotive and biomedical industries worldwide. An example automotive application is as a coating for high performance fuel injectors. Carbon coatings have significant unrealised potential for applications in hostile environments such as those encountered in high performance engineering components and in the human body. Electrical devices can be fabricated with these films suitable for use in compact electrical devices requiring high current density. This project will add to the techniques used for the analysis of carbon coatings being developed in Australia. Read moreRead less
The Future of Oceans Governance in Polar Areas. Australia has a compelling national interest in maintaining its sovereignty and security in the Antarctic. Australian government goals include maintaining the Antarctic Treaty System (ATS); enhancing Australia's influence within the system; protecting the Antarctic environment; understanding the role of Antarctica in the global climate system; and undertaking scientific work of practical, economic and national significance. This project directly ad ....The Future of Oceans Governance in Polar Areas. Australia has a compelling national interest in maintaining its sovereignty and security in the Antarctic. Australian government goals include maintaining the Antarctic Treaty System (ATS); enhancing Australia's influence within the system; protecting the Antarctic environment; understanding the role of Antarctica in the global climate system; and undertaking scientific work of practical, economic and national significance. This project directly addresses national research priorities through analysis of oceans governance issues that centre on Australian interests. This project will also contribute to national benefit by focusing on issues central to the International Polar Year.Read moreRead less
Physical factors affecting deposition of combustion submicrometer particles in the human lung. Particles generated from combustion sources have a profound effect on human health, yet there is lack of scientific understanding of the role of different physical mechanisms on particle deposition in the lung. This program will advance scientific knowledge in this field through multidisciplinary efforts of a team from QUT and the University of Salzburg, Austria. It aims at quantification of particle d ....Physical factors affecting deposition of combustion submicrometer particles in the human lung. Particles generated from combustion sources have a profound effect on human health, yet there is lack of scientific understanding of the role of different physical mechanisms on particle deposition in the lung. This program will advance scientific knowledge in this field through multidisciplinary efforts of a team from QUT and the University of Salzburg, Austria. It aims at quantification of particle deposition in human lung through experimental studies and advanced modelling. The program will enhance and strengthen the existing collaboration between the universities and its outcome will be of significance in the vital area of human health and risk assessment.Read moreRead less
New inhibitors of HIV based on cellular enzymes. Over 39 million people are infected with HIV worldwide. However, none of the most highly affected countries have yet reached the peak in AIDS-related illness and death, thus the global impact of HIV/AIDS will get significantly worse, before it gets better.
In Australia, HIV is again on the rise. Ironically, improved treatments that have extended life expectancy will cause the number of HIV infected Australians to rise for many years to come. ....New inhibitors of HIV based on cellular enzymes. Over 39 million people are infected with HIV worldwide. However, none of the most highly affected countries have yet reached the peak in AIDS-related illness and death, thus the global impact of HIV/AIDS will get significantly worse, before it gets better.
In Australia, HIV is again on the rise. Ironically, improved treatments that have extended life expectancy will cause the number of HIV infected Australians to rise for many years to come. Therefore many Australians will suffer from the combined impact of the AIDS illness itself, opportunistic infections, the side-effects of treatment and natural aging. We aim to develop new drugs to combat this disease to help people everywhere lead happier, healthier and more productive lives.Read moreRead less
Materials World Network Synthesis and Processing Optoelectronic Materials in Supercritical and Condensed Phase Carbon Dioxide. The Australian partner will have leveraged access to the skill base and facilities of the Cornell Center for Materials Research, and the NSF MRSEC that leads the world in frontier technologies in advanced materials. The partnership will deliver to Australia progress in national priority goals "Frontier Technologies" and new manufacturing technologies in environmentally ....Materials World Network Synthesis and Processing Optoelectronic Materials in Supercritical and Condensed Phase Carbon Dioxide. The Australian partner will have leveraged access to the skill base and facilities of the Cornell Center for Materials Research, and the NSF MRSEC that leads the world in frontier technologies in advanced materials. The partnership will deliver to Australia progress in national priority goals "Frontier Technologies" and new manufacturing technologies in environmentally friendly media that will enhance the national research priority "An Environmentally Sustainable Australia". New transferable skills will be acquired by the participants in the project. Technology transfer could result in the formation of spinoff companies to exploite the intellectual property arising in the project.Read moreRead less
Characterisation and fabrication of nanophotonic devices based on multi-layer stacks. The aim of this proposal is to continue the existing collaborative project on fabrication and characterisation of nanophotonic devices based on the multi-layer stack method. The project will integrate the state-of-the-art techniques in the respective collaborating universities to fabricate a nano-probe which can produce an evanescent field approximately four orders of magnitude stronger than that under the conv ....Characterisation and fabrication of nanophotonic devices based on multi-layer stacks. The aim of this proposal is to continue the existing collaborative project on fabrication and characterisation of nanophotonic devices based on the multi-layer stack method. The project will integrate the state-of-the-art techniques in the respective collaborating universities to fabricate a nano-probe which can produce an evanescent field approximately four orders of magnitude stronger than that under the conventional condition. This novel probe provides a key to the successful fabrication of innovative nanophotonic devices including photonic transistors, photonic circuits, high-density data storage disks and drives, nano-motors and biochips, which underpin biotechnology, information technology and optical computing technology.Read moreRead less
High temperature limits of leaf function. In arid and semi-arid central Australia, Acacia spp. dominate the over-storey, but this shifts to Eucalyptus and Corymbia spp. in more mesic coastal regions. Areas of central Australia are extremely hot, dry and sunny, and it is this combination of stresses that likely excludes Eucalyptus spp. from many landforms. There has been little research on high temperature tolerance of Acacia and Eucalyptus, despite the putative importance of this stress, in co ....High temperature limits of leaf function. In arid and semi-arid central Australia, Acacia spp. dominate the over-storey, but this shifts to Eucalyptus and Corymbia spp. in more mesic coastal regions. Areas of central Australia are extremely hot, dry and sunny, and it is this combination of stresses that likely excludes Eucalyptus spp. from many landforms. There has been little research on high temperature tolerance of Acacia and Eucalyptus, despite the putative importance of this stress, in combination with other stresses, in limiting species? distributions. Our program of collaborative research will examine the tolerance of Acacia and Eucalyptus to a combination of high temperatures, drought and high light.Read moreRead less