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Curvature flows and spectral estimates. Curvature flows are a class of geometrically motivated equations, modelled on the heat equation. Recently, researchers have developed new methods for studying the regularity of solutions to these equations, and applied them to a different problem, that of estimating quantities depending on the smaller eigenvalues of a Schroedinger operator. This project builds on the early success of this research and will produce a new understanding of the behaviour of ei ....Curvature flows and spectral estimates. Curvature flows are a class of geometrically motivated equations, modelled on the heat equation. Recently, researchers have developed new methods for studying the regularity of solutions to these equations, and applied them to a different problem, that of estimating quantities depending on the smaller eigenvalues of a Schroedinger operator. This project builds on the early success of this research and will produce a new understanding of the behaviour of eigenvalues, establish sharp estimates for spectral quantities, particularly on manifolds with curvature bounds, and find optimal conditions under which non-compact solutions to curvature flows are stable.Read moreRead less
Excessive sitting and population health: strengthening the science and the relevance to policy and practice. The majority of Australian adults spend most of their waking hours sitting; this increases the likelihood of developing diseases of inactivity, including diabetes, heart disease and some cancers. New research will investigate what factors encourage excessive sitting and what the health benefits are for people who deliberately do less sitting.
Demographic consequences of environmental change for wild bird populations. The project intends to improve our understanding of how climate drives shifts in body size and shape in wildlife populations, and the implications of such responses for population viability. Populations of plants and animals are showing a range of responses to recent, rapid shifts in the Earth’s climate. The ecological and evolutionary significance of these responses and the mechanisms that drive them remain largely unkn ....Demographic consequences of environmental change for wild bird populations. The project intends to improve our understanding of how climate drives shifts in body size and shape in wildlife populations, and the implications of such responses for population viability. Populations of plants and animals are showing a range of responses to recent, rapid shifts in the Earth’s climate. The ecological and evolutionary significance of these responses and the mechanisms that drive them remain largely unknown. Focusing on Australian birds, the project plans to integrate long-term records from citizen science, museum collections and field studies to conduct a comprehensive investigation of the pattern and process of morphological change. Understanding the processes driving change may help in developing strategies to manage our biodiversity as climate changes. Read moreRead less
Global Scale Cycling of Noble Gases and Halogens. A novel approach for combined measurement of halogens and noble gases will be used to provide the first constraints on the concentrations of these elements in key reservoirs within subduction zones. The data will revolutionise our understanding of how noble gases and halogens transfer between the Earth's atmosphere and mantle, which has profound implications for our planet's origin and evolution. In addition, the study will provide practical info ....Global Scale Cycling of Noble Gases and Halogens. A novel approach for combined measurement of halogens and noble gases will be used to provide the first constraints on the concentrations of these elements in key reservoirs within subduction zones. The data will revolutionise our understanding of how noble gases and halogens transfer between the Earth's atmosphere and mantle, which has profound implications for our planet's origin and evolution. In addition, the study will provide practical information about how economically important hydrothermal ore deposits form on the seafloor and it will test models for orogenic gold mineralisation. Read moreRead less
Psyllids as biosecurity threats to plantation and native eucalypts in Australia and internationally. Psyllids are tiny cicada-like insects that are economic pests of forestry and horticulture because the saliva injected when feeding causes leaf death and some vector plant diseases. Advanced technologies and procedures will be used to determine what makes plants susceptible to psyllids and to improve Australian preparedness ahead of an incursion.
Expanding the molecular tool set for structural studies of proteins and their complexes. Many applications in medical science and drug development depend on our ability to determine the 3D structures of proteins, protein assemblies and protein-ligand complexes. This project will develop novel lanthanide-binding tags and crosslinking agents that can be coupled to unnatural amino acids introduced into proteins with advanced protein chemistry techniques. These new tools will facilitate the collecti ....Expanding the molecular tool set for structural studies of proteins and their complexes. Many applications in medical science and drug development depend on our ability to determine the 3D structures of proteins, protein assemblies and protein-ligand complexes. This project will develop novel lanthanide-binding tags and crosslinking agents that can be coupled to unnatural amino acids introduced into proteins with advanced protein chemistry techniques. These new tools will facilitate the collection of structure restraints by nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR) and mass spectrometry, which are needed to generate accurate models of proteins and their complexes with other molecules. Major beneficial outcome will include an increase in the number of protein targets amenable to rational drug design and improved methods for generating new drug leads.Read moreRead less
Environmentally sustainable shipping through improved understanding and management of wall-bounded turbulence. The thin region of turbulent flow that is pulled along by a ship's hull as it moves through the water accounts for up to 90 per cent of the overall resistance and a large amount of the fuel burnt. This project aims to control or tame recurrent flow patterns within these turbulent regions to reduce resistance, overall fuel cost and emissions from shipping.
Mental health, job quality and workforce participation: evidence from population health research to address complex problems and conflicting policies. Mental disorders such as depression are a major cause of disability. Improving mental health can increase productivity and workforce participation. However, the psychosocial quality of work is a factor that overlays the relationship between work and health. Poor quality work (for example, unreasonable time pressure, insecurity) increases the risk ....Mental health, job quality and workforce participation: evidence from population health research to address complex problems and conflicting policies. Mental disorders such as depression are a major cause of disability. Improving mental health can increase productivity and workforce participation. However, the psychosocial quality of work is a factor that overlays the relationship between work and health. Poor quality work (for example, unreasonable time pressure, insecurity) increases the risk of poor mental health, absenteeism, and exit from the workforce. This project will analyse data following people over time to investigate the long-term health and employment consequences of poor psychosocial job quality, and consider the special case of mature age workers. It will identify those individuals at greatest risk, and factors that can buffer against the adverse effects of poor quality work.Read moreRead less
The origin and evolution of heavy elements in the early universe. Everything in our Solar System, including all life on Earth, was created long ago out of material forged inside fiery stellar furnaces. The latest theoretical simulations of element production in red giant stars reveals the processes that gave us our existence, as well as help us to understand the origin of the galaxy that we inhabit.
Epidemics, mortality and longevity in Tasmania, 1838-1930. This project will investigate areas of contemporary importance that can only be explored using historic-demographic data. National benefits include (1) gaining a better understanding of how epidemics spread through families and communities, and possible mortality and case-fatality rates, to assist in preparation for future epidemics; (2) improved accuracy in projecting older-age mortality and population ageing in Australia and other coun ....Epidemics, mortality and longevity in Tasmania, 1838-1930. This project will investigate areas of contemporary importance that can only be explored using historic-demographic data. National benefits include (1) gaining a better understanding of how epidemics spread through families and communities, and possible mortality and case-fatality rates, to assist in preparation for future epidemics; (2) improved accuracy in projecting older-age mortality and population ageing in Australia and other countries; and (3) more precise estimates of women's capacity to naturally conceive and carry to term by characteristics such as her age, her partner's age, and her number of previous births. The project will also result in augmentation of a unique publicly available dataset.Read moreRead less