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LIPID AND LIPOPROTEIN ADSORPTION AT BIOMATERIALS AND BIO-DIAGNOSTICS INTERFACES. This project aims to investigate molecular mechanisms involved in the formation of undesired biological deposits on synthetic materials and thereby help establish the scientific basis for the rational design of materials with improved compatibility with biological fluids and the engineering of a new generation of biomedical implant devices and bio-diagnostic devices. It is well known that proteins accumulate on synt ....LIPID AND LIPOPROTEIN ADSORPTION AT BIOMATERIALS AND BIO-DIAGNOSTICS INTERFACES. This project aims to investigate molecular mechanisms involved in the formation of undesired biological deposits on synthetic materials and thereby help establish the scientific basis for the rational design of materials with improved compatibility with biological fluids and the engineering of a new generation of biomedical implant devices and bio-diagnostic devices. It is well known that proteins accumulate on synthetic solid surfaces. This project proposes to investigate whether lipids and lipoproteins also play key roles in the initiation of biological adsorption processes. Combined with the study of the interfacial forces responsible, this information will guide the design of preventative strategies.Read moreRead less
How responsive are continental interiors to the geodynamic evolution of plate margins? An Australian case study. The outcomes of this project will advance our understanding of the evolution and dynamics of the Australian plate by improving knowledge of the way plate driving forces shaped the continental interior. This will lead to a refinement of existing geological models describing the history of the Australian continent, and will provide a valuable backdrop for the current focus on the cont ....How responsive are continental interiors to the geodynamic evolution of plate margins? An Australian case study. The outcomes of this project will advance our understanding of the evolution and dynamics of the Australian plate by improving knowledge of the way plate driving forces shaped the continental interior. This will lead to a refinement of existing geological models describing the history of the Australian continent, and will provide a valuable backdrop for the current focus on the contemporary state of the Australian plate. The study will also provide a framework for petroleum exploration models in the central Australian basins, since they rely crucially on the thermal and structural datasets that will be produced in this project.Read moreRead less
Modelling applications of nanomaterials in biology and medicine. This proposal will address fundamental issues related to nanomaterials and their applications in biology and medicine. Accurate mathematical models will be formulated, leading to new practical techniques in nanobiotechnology, safe and effective methods to diagnose and cure diseases including cancer via targeted drug and gene delivery, and detection methods for biological hazards, such as those arising from biological terrorism. The ....Modelling applications of nanomaterials in biology and medicine. This proposal will address fundamental issues related to nanomaterials and their applications in biology and medicine. Accurate mathematical models will be formulated, leading to new practical techniques in nanobiotechnology, safe and effective methods to diagnose and cure diseases including cancer via targeted drug and gene delivery, and detection methods for biological hazards, such as those arising from biological terrorism. The research facility proposed involves significant training of applied mathematicians at honours, PhD and postdoctoral levels and multidisciplinary collaboration, ensuring that Australia maintains and develops an expertise in nanobiotechnology well into the future.Read moreRead less
Structure and activity of host-defence peptides from Australian anurans: anticancer agents, neuropeptides and nNOS inhibitors. We have discovered peptides that may have clinical applications. This is significant as these molecules may have one or more of the following properties. They may have anti-cancer effects; they may increase the effectiveness of the immune system by enhancing lymphocyte formation; and, they may act to reduce inflammation, stroke or cardiac conditions by controlling nitri ....Structure and activity of host-defence peptides from Australian anurans: anticancer agents, neuropeptides and nNOS inhibitors. We have discovered peptides that may have clinical applications. This is significant as these molecules may have one or more of the following properties. They may have anti-cancer effects; they may increase the effectiveness of the immune system by enhancing lymphocyte formation; and, they may act to reduce inflammation, stroke or cardiac conditions by controlling nitric oxide formation. Another national benefit is that personnel involved in this project are trained to the highest international standards in peptide chemistry/mass spectrometry/nuclear magnetic resonance: currently, there are not enough trained scientists in this area to meet demand.Read moreRead less
A biography of Roma Flinders Mitchell 1913-2000. Dame Roma Mitchell is best known for her outstanding succession of public achievements. A biography of a prominent and widely-admired figure is no innovation. But a biography of such a figure who is also a woman, necessarily moves onto new ground. It brings questions of gender, gender-difference, and the relation of both to public life and power to the fore of its analysis. This project will compose a biography which is also a social history, and ....A biography of Roma Flinders Mitchell 1913-2000. Dame Roma Mitchell is best known for her outstanding succession of public achievements. A biography of a prominent and widely-admired figure is no innovation. But a biography of such a figure who is also a woman, necessarily moves onto new ground. It brings questions of gender, gender-difference, and the relation of both to public life and power to the fore of its analysis. This project will compose a biography which is also a social history, and a social history which is distinctive because it is focussed on the life of a woman.Read moreRead less
A model of the mind which explains the role of emotions in normal cognition and affective disorder. Depression is recognised as one of the most burdensome diseases in Australia. Though we of course make no claims, as philosophers, to cure depression our contribution is to engage philosophy productively with a vital national area of empirical research. The other area of national benefit is to consolidate Australia's developing reputation as a site for the involvement of philosophy in interdiscipl ....A model of the mind which explains the role of emotions in normal cognition and affective disorder. Depression is recognised as one of the most burdensome diseases in Australia. Though we of course make no claims, as philosophers, to cure depression our contribution is to engage philosophy productively with a vital national area of empirical research. The other area of national benefit is to consolidate Australia's developing reputation as a site for the involvement of philosophy in interdisciplinary projects which link the humanities to the sciences. Furthermore, with the project's anchoring in the humanities, there is hope that a focus on, and increased understanding of, depression will have flow-on effects in the Australian community that will help ease the stigmatisation that is still felt by many of its sufferers.Read moreRead less
Order-disorder behaviour in Bi-tellurides: a tool to monitor gold scavenging by Bi-Te melts. This project addresses a group of minerals (bismuth tellurides) that are often part of the exotic assemblages present in gold deposits, yet their potential to model the gold-forming processes is only recently apparent. These minerals also have the capacity to record their genetic history due to crystal modularity. Materials scientists target the analogous synthetic compounds because of the same structura ....Order-disorder behaviour in Bi-tellurides: a tool to monitor gold scavenging by Bi-Te melts. This project addresses a group of minerals (bismuth tellurides) that are often part of the exotic assemblages present in gold deposits, yet their potential to model the gold-forming processes is only recently apparent. These minerals also have the capacity to record their genetic history due to crystal modularity. Materials scientists target the analogous synthetic compounds because of the same structural modularity for applications in nanotechnology. The dataset on the mineral compounds, using the geological environment as a natural laboratory, will serve materials science research, as much as delivering key information relevant to understanding the reasons for gold enrichment in economically important types of ores. Read moreRead less
The High Court of Australia: A Biographical Study. The High Court of Australia has shaped the legal, political and social landscapes of Australia. Yet despite its wide-ranging importance the Court has largely been the subject of a legal inquiry focusing on its substantial case law. This project seeks to fill a significant gap in the literature with the publication of an institutional history of the Court. Central to this project is a commitment to a multi-disciplinary approach that explores the ....The High Court of Australia: A Biographical Study. The High Court of Australia has shaped the legal, political and social landscapes of Australia. Yet despite its wide-ranging importance the Court has largely been the subject of a legal inquiry focusing on its substantial case law. This project seeks to fill a significant gap in the literature with the publication of an institutional history of the Court. Central to this project is a commitment to a multi-disciplinary approach that explores the Court beyond a merely legal paradigm. The outcomes of this project will be publications that situate the law, the judiciary and Australian history within a single explanatory narrative.Read moreRead less
The geometry of impossible, or contradictory objects and its applications to computing and cognition. The principal aim is pure research, the increase of knowledge within the Theory of Inconsistency and particularly its mathematical aspects, to be available to the national and world community. Additionally, a new stock of hitherto-unseen images (still, moving and three-dimensional) will be constructed in a virtual reality environment. In addition to enhancing Australia's strong reputation in log ....The geometry of impossible, or contradictory objects and its applications to computing and cognition. The principal aim is pure research, the increase of knowledge within the Theory of Inconsistency and particularly its mathematical aspects, to be available to the national and world community. Additionally, a new stock of hitherto-unseen images (still, moving and three-dimensional) will be constructed in a virtual reality environment. In addition to enhancing Australia's strong reputation in logic, there are spin-offs for mathematics, cognitive science, computer studies, and the arts and entertainment industries.Read moreRead less
Robust fluid mixing through topological chaos. The Australian chemicals and plastics industry has an annual turnover of over $20 billion and employs over 77,000 people; fluid mixing is fundamental to this industry, yet the industry is recognised as underinvesting in research and development in this essential area. Furthermore, frontier technologies such as biotechnology and the next generation of smart materials also crucially rely on fluid mixing. This project aims to evaluate a new paradigm ( ....Robust fluid mixing through topological chaos. The Australian chemicals and plastics industry has an annual turnover of over $20 billion and employs over 77,000 people; fluid mixing is fundamental to this industry, yet the industry is recognised as underinvesting in research and development in this essential area. Furthermore, frontier technologies such as biotechnology and the next generation of smart materials also crucially rely on fluid mixing. This project aims to evaluate a new paradigm (topological chaos) for the design of mixers, to provide better and more robust mixers that work from microscopic to industrial scales.Read moreRead less