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Enhanced sensitivity of electrospray ionization mass spectrometry. Enhanced sensitivity of electrospray ionization mass spectrometry. This project aims to enhance the sensitivity of nano-electrospray ionization mass spectrometry (nanoESI-MS) by an order of magnitude by simultaneously overcoming the two interdependent limitations in ion generation and transmission efficiency. This project will design glass capillaries and tubes with complex structures to enable both multiplexing ion generation fr ....Enhanced sensitivity of electrospray ionization mass spectrometry. Enhanced sensitivity of electrospray ionization mass spectrometry. This project aims to enhance the sensitivity of nano-electrospray ionization mass spectrometry (nanoESI-MS) by an order of magnitude by simultaneously overcoming the two interdependent limitations in ion generation and transmission efficiency. This project will design glass capillaries and tubes with complex structures to enable both multiplexing ion generation from a single capillary and geometrically matching the bore of the tube collecting the emitted ion plume. NanoESI-MS has become an indispensable analytical tool for proteomics and synthetic chemistry. The significant enhancement of nanoESI-MS sensitivity in this project is expected to accelerate progress in disease research, biomarker discovery and drug development.Read moreRead less
Smart design technology enabling the mid-infrared revolution. While mid-infrared (MIR) lasers have become indispensable to key industries ranging from research and healthcare to defence, industrial deployment of this technology has been hampered by the lack of cost-effective MIR optical fibres. This project aims to overcome this barrier through the creation of an innovative design toolkit for the fabrication of complex optical fibre structures. This efficient and commercially viable concept-to-m ....Smart design technology enabling the mid-infrared revolution. While mid-infrared (MIR) lasers have become indispensable to key industries ranging from research and healthcare to defence, industrial deployment of this technology has been hampered by the lack of cost-effective MIR optical fibres. This project aims to overcome this barrier through the creation of an innovative design toolkit for the fabrication of complex optical fibre structures. This efficient and commercially viable concept-to-manufacture development process will pave the way towards the MIR fibre technology revolution and will yield significant economic benefits spanning industrial process controls and environmental monitoring to hazardous chemical detection and biological sensing.Read moreRead less