Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most importa ....Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most important mechano-sensor implicated in cell adhesion, migration, growth and survival. Specifically, it integrates nationally unique cutting-edge techniques including single-molecule force probe, microparticle image velocimetry, microfluidics and molecular dynamics simulation, super resolution and 3D volumetric imaging modalities.Read moreRead less
Portable instrument for quantification and genotyping of Cryptosporidium . Cryptosporidium is a parasitic protozoan, causing more than 48,000 deaths in children under 5 and 7.2 million disability-adjusted-life-years globally. A low-cost device that rapidly detects the parasite in drinking and recreational water is needed to enable effective disease management practices. Partnering with Advanced Universal Diagnotik, Seqwater, ALS Water and Gold Coast Water, this project aims to develop a novel de ....Portable instrument for quantification and genotyping of Cryptosporidium . Cryptosporidium is a parasitic protozoan, causing more than 48,000 deaths in children under 5 and 7.2 million disability-adjusted-life-years globally. A low-cost device that rapidly detects the parasite in drinking and recreational water is needed to enable effective disease management practices. Partnering with Advanced Universal Diagnotik, Seqwater, ALS Water and Gold Coast Water, this project aims to develop a novel device, comprising advanced microfluidics and biosensing technology for parasite quantification, genotyping and viability analysis. Expected outcomes are improved Cryptosporidium management, risk prediction, and rapid mitigation of impending outbreaks. The proposed platform has a great potential for detecting other pathogens.Read moreRead less
Cost-efficient 2D heterostructures for solar overall water splitting. This project aims to develop novel processes to enable water splitting to generate hydrogen and oxygen under sunlight using cost-efficient 2D van der Waals heterostructures. Enhanced optical absorption and reduced charge transfer distance across the interface are expected to improve the photocatalytic activity. Experimental design and theoretical simulations will be combined to modulate the materials and achieve optimum photoc ....Cost-efficient 2D heterostructures for solar overall water splitting. This project aims to develop novel processes to enable water splitting to generate hydrogen and oxygen under sunlight using cost-efficient 2D van der Waals heterostructures. Enhanced optical absorption and reduced charge transfer distance across the interface are expected to improve the photocatalytic activity. Experimental design and theoretical simulations will be combined to modulate the materials and achieve optimum photocatalytic performances. Expected outcomes of this project include expanded chemistry knowledge and techniques in materials design and synthesis, photophysics and photocatalysis mechanism and solar energy conversion. This will provide significant benefits to clean energy and environmental protections.Read moreRead less
A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interac ....A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interactions, which will greatly complement existing meta-omics approaches. The deliverables include a proof-of-concept system validated for gut-liver axis as well as the creation of new knowledge and framework to assimilate design thinking and advanced manufacturing to elevate tissue engineering into physiology engineering. Read moreRead less
Augmented Sociality: Enabling a Socialised Experience of Augmented Reality. This project will explore new socialised uses of Augmented Reality (AR) that expand creativity, social relations, and participation. We seek to better understand how AR content can be leveraged by people to create their own new ways of learning, collaborating, and relating with each other. To do so we will study and prototype new tools and platforms to allow non-experts to create their own AR media. We aim to enable peop ....Augmented Sociality: Enabling a Socialised Experience of Augmented Reality. This project will explore new socialised uses of Augmented Reality (AR) that expand creativity, social relations, and participation. We seek to better understand how AR content can be leveraged by people to create their own new ways of learning, collaborating, and relating with each other. To do so we will study and prototype new tools and platforms to allow non-experts to create their own AR media. We aim to enable people of all ages, education, and background, to imagine and create, and not just passively consume, AR contents, services, and applications. We will generate new applications of AR, a new platform to collaboratively create these applications, and a new theory of 'Augmented Sociality' to guide AR design.
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Enabling Situated Immersive Science Collaboration with Remote Sensing Data . This project aims to help scientists communicate and collaborate in immersive environments. Fieldwork is more valuable to scientists than looking at abstract remote data, but expense, danger, or inaccessible locations often stand in the way. This project will address this issue by researching and designing immersive environments that combine remote data with visualisations and new interaction tools for science teams to ....Enabling Situated Immersive Science Collaboration with Remote Sensing Data . This project aims to help scientists communicate and collaborate in immersive environments. Fieldwork is more valuable to scientists than looking at abstract remote data, but expense, danger, or inaccessible locations often stand in the way. This project will address this issue by researching and designing immersive environments that combine remote data with visualisations and new interaction tools for science teams to make sense of spatial and temporal aspects of data. Outcomes will include new presentation and interaction methods, an evaluation with geoscientists, and a framework for designing interactive systems that enable situated interactions. Benefits will include helping Australian scientists overcome distance in their research. Read moreRead less
Redefining tissue-specific endothelial cells through bioengineered matrices. This project aims to improve our understanding of the biological mechanisms that drive blood vessel formation and function. The endothelial cells that make up each blood vessel are inherently unique across different sites within the human body and this project expects to generate new knowledge regarding their organ specificity. Using advanced bioengineering approaches, this project will map human endothelial cell specif ....Redefining tissue-specific endothelial cells through bioengineered matrices. This project aims to improve our understanding of the biological mechanisms that drive blood vessel formation and function. The endothelial cells that make up each blood vessel are inherently unique across different sites within the human body and this project expects to generate new knowledge regarding their organ specificity. Using advanced bioengineering approaches, this project will map human endothelial cell specificity and develop state-of-the-art modelling technologies to improve knowledge of environmental influence on endothelial cell fate and function. This should provide a new framework to modulate the adaptive capacities of endothelial cells and can potentially enable more predictive and targeted drug efficacy and safety testing.Read moreRead less
Framing and Enabling Children’s Active Play using Novel Technology. This project aims to address inactivity in the 3-5 age group through understanding and exploring innovative interactive active play experiences for children, with a view to increasing their physical activity over the long term. This project will be based on empirical research with real children undertaking real interactive experiences in real contexts, in order to understand issues around sustained engagement with these types of ....Framing and Enabling Children’s Active Play using Novel Technology. This project aims to address inactivity in the 3-5 age group through understanding and exploring innovative interactive active play experiences for children, with a view to increasing their physical activity over the long term. This project will be based on empirical research with real children undertaking real interactive experiences in real contexts, in order to understand issues around sustained engagement with these types of systems. We will design and develop solutions that may address the issues and test those interventions in a longitudinal manner. The outcome will be a framework which can be applied in a variety of situations and modalities by designers and developers of such systems, and feed into childhood technology guidelines.
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Australian Laureate Fellowships - Grant ID: FL160100089
Funder
Australian Research Council
Funding Amount
$2,600,796.00
Summary
In situ electron microscopy toward new materials and applications. In situ electron microscopy toward new materials and applications. This project aims to develop materials for structural and green energy applications, using spatially-resolved, dynamic in situ transmission electron microscopy to research fundamental mechanical, electrical, thermal, optical, optoelectronic and photovoltaic properties of diverse nanostructures. These techniques measure nanomaterial (one-dimensional nanotubes and n ....In situ electron microscopy toward new materials and applications. In situ electron microscopy toward new materials and applications. This project aims to develop materials for structural and green energy applications, using spatially-resolved, dynamic in situ transmission electron microscopy to research fundamental mechanical, electrical, thermal, optical, optoelectronic and photovoltaic properties of diverse nanostructures. These techniques measure nanomaterial (one-dimensional nanotubes and nanowires and two-dimensional graphene-like nanosheets) response to external stimuli, including mechanical, electrical, optical and thermal stimuli. Anticipated outcomes are new ultralight and superstrong structural composites and ‘green-energy’ nanomaterials, such as solar cells, touch panels, batteries, supercapacitors, field-effect transistors, light sensors and displays.Read moreRead less
Regulation of 3D Cell Migration by Microtubule-Dependent Processes. The overarching aim of this research is to elucidate the molecular mechanisms that cells use to move in 3D environments: a basic biological function essential to development and homeostasis. During these processes, cells interact with their surroundings where they translate biophysical forces into biochemical signals to adapt their shape to move. This requires distinct signalling, controlled in space and time, to regulate the cr ....Regulation of 3D Cell Migration by Microtubule-Dependent Processes. The overarching aim of this research is to elucidate the molecular mechanisms that cells use to move in 3D environments: a basic biological function essential to development and homeostasis. During these processes, cells interact with their surroundings where they translate biophysical forces into biochemical signals to adapt their shape to move. This requires distinct signalling, controlled in space and time, to regulate the crosstalk between organelles and the cytoskeleton. To date, the role of microtubules remains elusive. Using interdisciplinary approaches combining advanced imaging technology with novel cell biology methods, the project aims to uncover fundamental knowledge about how cells interact with their environment.Read moreRead less