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In vitro expression and crystallization of proteins from the thermohalophile, Halothermothrix orenii. The project proposal is to develop enabling state-of-the-art protein technologies for biotechnology. We will for the first time develop a rapid and high throughput technique for the expression, purification and crystallisation of proteins from the extreme thermohalophile, Halothermothrix orenii. This important break through in protein technology will assist in determining structure and function ....In vitro expression and crystallization of proteins from the thermohalophile, Halothermothrix orenii. The project proposal is to develop enabling state-of-the-art protein technologies for biotechnology. We will for the first time develop a rapid and high throughput technique for the expression, purification and crystallisation of proteins from the extreme thermohalophile, Halothermothrix orenii. This important break through in protein technology will assist in determining structure and function relationships of thermohalophilic proteins. It is expected that such an understanding together with comparative bioinformatics will assist researchers to develop "designer proteins" with improved functions for different uses in biotechnology. It is also expected that this technology will be amenable for use with other thermohalophilic microbes.Read moreRead less
Australia's Nuclear Choices. Australia's nuclear choices will be made in the context of a challenging and fluid international strategic environment characterised in Australia's immediate region by heightened global concerns regarding such transnational dilemmas as terrorism, energy security and nuclear proliferation. This project, through exploring the nature, evolution and consequences of contemporary strategic, military and civil nuclear developments impacting on the international non-prolifer ....Australia's Nuclear Choices. Australia's nuclear choices will be made in the context of a challenging and fluid international strategic environment characterised in Australia's immediate region by heightened global concerns regarding such transnational dilemmas as terrorism, energy security and nuclear proliferation. This project, through exploring the nature, evolution and consequences of contemporary strategic, military and civil nuclear developments impacting on the international non-proliferation regime will enable Australian policy-makers to better calibrate the costs and benefits of potential policy changes across these strategic, regime and market realms of Australia's nuclear interests.Read moreRead less
Development of a Novel One Step Process for Gas Conversion to Liquid. Australia has a rich natural gas reserve, most of which is in remote locations. This project will lead to a new technology to use the remote gas that would be flared into the atmosphere, thus benefiting both Australian economy and green house gas reduction. It will also reduce the risk of relying on importing oil from Overseas thus contributing to Australia's energy security. In addition, while crude-based oil emits SOx, NOx a ....Development of a Novel One Step Process for Gas Conversion to Liquid. Australia has a rich natural gas reserve, most of which is in remote locations. This project will lead to a new technology to use the remote gas that would be flared into the atmosphere, thus benefiting both Australian economy and green house gas reduction. It will also reduce the risk of relying on importing oil from Overseas thus contributing to Australia's energy security. In addition, while crude-based oil emits SOx, NOx and particulates etc into air, the liquid fuels from gas are pure and burns cleanly thus also contributing to air pollution control. Read moreRead less
Deep Downunder: designing a deep-sea exploration and discovery capability for Australia. Exploration of the deep-sea with the modern technologies to be developed by Deep-Downunder is a first for Australia. We aim to explore and discover life at depths from 50-3000m off The Great Barrier Reef, around the seamounts of Lord Howe Island and Tasmania and in the deep canyons of WA and SA. We expect to discover new species, hope for a glimpse of giant squid at home and will answer specific questions on ....Deep Downunder: designing a deep-sea exploration and discovery capability for Australia. Exploration of the deep-sea with the modern technologies to be developed by Deep-Downunder is a first for Australia. We aim to explore and discover life at depths from 50-3000m off The Great Barrier Reef, around the seamounts of Lord Howe Island and Tasmania and in the deep canyons of WA and SA. We expect to discover new species, hope for a glimpse of giant squid at home and will answer specific questions on Australia's ocean biology, fisheries and biotechnology never before approachable. To be effective guardians of Australian waters we must learn what lies in the depths we can't see from a boat.Read moreRead less
An evaluation of novel aluminosilicate materials based on modified kaolins for environmental applications. We have shown that simple and inexpensive modification of kaolin produces materials that adsorb large amounts of ammonium (N) and phosphate (P). We intend to evaluate and develop these materials for water treatment, so as to reduce N, P inputs into rivers and wetlands. The materials can then be used as fertilisers. Similarly addition of the materials to sandy soils to reduce leaching losses ....An evaluation of novel aluminosilicate materials based on modified kaolins for environmental applications. We have shown that simple and inexpensive modification of kaolin produces materials that adsorb large amounts of ammonium (N) and phosphate (P). We intend to evaluate and develop these materials for water treatment, so as to reduce N, P inputs into rivers and wetlands. The materials can then be used as fertilisers. Similarly addition of the materials to sandy soils to reduce leaching losses of N, P from fertilisers will be investigated. The major outcome of this research will be effective and inexpensive procedures for reducing eutrophication due to N, P from waste water and fertilisers.Read moreRead less
Assimilation of architectural and services design in early design modelling. How can buildings in a climate as varied as Australia's balance the best environmental comfort standards for their human occupants, cost and at the same time meet the urgent imperative of reduced energy consumption and associated carbon emissions? This practice-based research will develop tools to support more informed decision making in the earliest stage of an integral approach to services in the design of buildings. ....Assimilation of architectural and services design in early design modelling. How can buildings in a climate as varied as Australia's balance the best environmental comfort standards for their human occupants, cost and at the same time meet the urgent imperative of reduced energy consumption and associated carbon emissions? This practice-based research will develop tools to support more informed decision making in the earliest stage of an integral approach to services in the design of buildings. It will provide knowledge about designing architecture that is more environmentally responsive, can provide comfortable air in more optimised ways, that consume less energy and do this through promoting smarter use of information in practice.Read moreRead less
Making better decisions about built assets: learning by doing. This research will assist the built environment professions and their clients to make better decisions about new developments through a novel 'learning by doing' approach. Used successfully in other fields such as natural resource management, this idea will capitalise on the large number of asset investments undertaken to benchmark original stakeholder intentions and aspirations against the reality of current performance. Decisions w ....Making better decisions about built assets: learning by doing. This research will assist the built environment professions and their clients to make better decisions about new developments through a novel 'learning by doing' approach. Used successfully in other fields such as natural resource management, this idea will capitalise on the large number of asset investments undertaken to benchmark original stakeholder intentions and aspirations against the reality of current performance. Decisions will be re-evaluated in the context of contemporary economic, social and environmental criteria to enable existing multi-criteria models to deliver more sustainable outcomes that are also feasible and in the national interest, and consequently minimise the industry's current exposure to future climate change.Read moreRead less
Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not re ....Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not respond to the current TNF treatments. Improved anti-TNF strategies would provide enhanced health outcomes and welcome relief to many Australians. In addition, the economic benefit of the TNF market is very substantial. Therefore the potential impact of this research is very high both for health care and economical potential.Read moreRead less
Reforming the procurement of construction and financing of Australian infrastructure: Advancing capacity, competition and investment. The project will significantly assist Federal and State governments in delivering value for money in the provision of a substantial infrastructure pipeline. The project will promote the transformation of the domestic construction industry in Australia, in terms of saving unnecessary transaction costs, promoting productivity, advancing training and accessing the wo ....Reforming the procurement of construction and financing of Australian infrastructure: Advancing capacity, competition and investment. The project will significantly assist Federal and State governments in delivering value for money in the provision of a substantial infrastructure pipeline. The project will promote the transformation of the domestic construction industry in Australia, in terms of saving unnecessary transaction costs, promoting productivity, advancing training and accessing the world's best knowledge and skills. In total, the project will help ensure that new infrastructure contributes to Australia's economic growth and counters inflationary pressures. Finally, the transferable knowledge outcomes of this project have potential to capture global attention and promote Australia as a leading nation in the provision of infrastructure.Read moreRead less
Wave Climate in the Southern Great Barrier Reef. Sea surface roughness has a major influence on global climate modelling. This project will provide a better understanding of the variability of sea waves in coastal waters. New technology of HF ocean radar can map wave fields over coastal waters and thus fill a gap between the open ocean satellite measurements and the point measurements from wave buoys. In this project we will improve the analysis of the radar echoes to produce sea wave spectra, a ....Wave Climate in the Southern Great Barrier Reef. Sea surface roughness has a major influence on global climate modelling. This project will provide a better understanding of the variability of sea waves in coastal waters. New technology of HF ocean radar can map wave fields over coastal waters and thus fill a gap between the open ocean satellite measurements and the point measurements from wave buoys. In this project we will improve the analysis of the radar echoes to produce sea wave spectra, and evaluate focussing of waves by complex currents on the continental shelf to help improve wave forecasting in coastal waters. The HF radar will be used to experimentally test current theories of wind wave spreading.Read moreRead less