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Moral frontiers: When the needs of humans and nonhumans collide. Decision making about resources is not simply based on human needs alone. Issues relating to animal rights, biodiversity, and environmental protection weigh heavily in these debates. These issues are receiving increased attention at a time when the human (over)population of the planet is already placing pressure on scare resources, creating conflict between the needs of humans and non-humans. It is along our moral frontiers where t ....Moral frontiers: When the needs of humans and nonhumans collide. Decision making about resources is not simply based on human needs alone. Issues relating to animal rights, biodiversity, and environmental protection weigh heavily in these debates. These issues are receiving increased attention at a time when the human (over)population of the planet is already placing pressure on scare resources, creating conflict between the needs of humans and non-humans. It is along our moral frontiers where these conflicts will erupt and the rights and needs of humans and non-humans alike are given merit or discarded. This project will examine the psychological processes involved in extending moral concern to non-humans and the benefits and costs of this extended morality for the satisfaction of human needs.Read moreRead less
Breaching membrane barriers. This project will endeavour to develop novel molecular transporters to deliver macromolecules inside cells or microorganisms. Cell membranes are barriers to macromolecules. The ability to cross these barriers and deliver biological macromolecules into cells represents a major achievement with endless opportunities to modulate pathways and to introduce biomarkers, therapeutics and research tools. The project’s novel platform technology would be based on stable cyclic ....Breaching membrane barriers. This project will endeavour to develop novel molecular transporters to deliver macromolecules inside cells or microorganisms. Cell membranes are barriers to macromolecules. The ability to cross these barriers and deliver biological macromolecules into cells represents a major achievement with endless opportunities to modulate pathways and to introduce biomarkers, therapeutics and research tools. The project’s novel platform technology would be based on stable cyclic peptides to deliver genes, proteins, probes or biomarkers into distinct cell types that can monitor or modulate specific pathways and be translated into new knowledge and specific industrial applications.Read moreRead less
The systems biology of stem cells. Using new bioinformatic methods, this project aims to identify new classifiers of different stem cell populations, develop statistical models that address population heterogeneity and provide molecular predictors of the differentiation potential of stem cells. Understanding, predicting and directing the processes of differentiation are major goals in the disciplines of stem cell biology, developmental biology, tissue engineering and regenerative medicine. Molec ....The systems biology of stem cells. Using new bioinformatic methods, this project aims to identify new classifiers of different stem cell populations, develop statistical models that address population heterogeneity and provide molecular predictors of the differentiation potential of stem cells. Understanding, predicting and directing the processes of differentiation are major goals in the disciplines of stem cell biology, developmental biology, tissue engineering and regenerative medicine. Molecular atlas projects have successfully revealed rules of genome output and regulation, by mining patterns that are evident across multiple cell types and datasets. By applying this philosophy to relevant, well-curated stem cell experiments, this project aims to create new methods for the integration and interrogation of smaller individual datasets. These methods should have broad utility and enable new avenues in tissue engineering.Read moreRead less
Ocean acidification and marine fish: an evolutionary perspective. The overarching aim of this project is to advance knowledge on the long-term impacts of ocean acidification on marine fish and fisheries. An interrelated set of projects will be developed that tests the capacity of marine fish to adapt to projected future rises in ocean carbon dioxide and will investigate the effects of ocean acidification on apex predators and key fisheries species. The research will address critical knowledge ga ....Ocean acidification and marine fish: an evolutionary perspective. The overarching aim of this project is to advance knowledge on the long-term impacts of ocean acidification on marine fish and fisheries. An interrelated set of projects will be developed that tests the capacity of marine fish to adapt to projected future rises in ocean carbon dioxide and will investigate the effects of ocean acidification on apex predators and key fisheries species. The research will address critical knowledge gaps in ocean acidification research and provide advice about the impacts of ocean acidification on marine biodiversity and fisheries productivity on time scales relevant to strategic management and policy decision-making in Australia and internationally.Read moreRead less
Animal social behaviour and emerging infectious fungal diseases in nature. This project aims to improve knowledge about the central role that animal social behaviour plays in the spread of emerging infectious fungal diseases in nature. Applying approaches from behavioural ecology, network modelling and quantitative genetics, and utilising rare empirical pre- and post-infection data, the project expects to generate new understandings about how fungal diseases spread through animal populations, ho ....Animal social behaviour and emerging infectious fungal diseases in nature. This project aims to improve knowledge about the central role that animal social behaviour plays in the spread of emerging infectious fungal diseases in nature. Applying approaches from behavioural ecology, network modelling and quantitative genetics, and utilising rare empirical pre- and post-infection data, the project expects to generate new understandings about how fungal diseases spread through animal populations, how animal social behaviour influences disease transmission, and how disease-status affects animal social behaviour. This project should have international impact, and advance current knowledge about disease dynamics. Applied outcomes should inform much-needed control strategies to benefit wildlife and preserve biodiversity. Read moreRead less
Extinct hominins and early humans on the Indonesian island of Sulawesi. This project aims to research the archaic hominins of Sulawesi and discover when and why they became extinct. Recent discoveries of ancient stone tools on Sulawesi show that an archaic and as-yet unidentified hominin species inhabited this remote Indonesian island before modern humans arrived around 50,000 years ago. This project will search for the earliest traces of habitation, attempt to uncover the Sulawesi hominins’ fos ....Extinct hominins and early humans on the Indonesian island of Sulawesi. This project aims to research the archaic hominins of Sulawesi and discover when and why they became extinct. Recent discoveries of ancient stone tools on Sulawesi show that an archaic and as-yet unidentified hominin species inhabited this remote Indonesian island before modern humans arrived around 50,000 years ago. This project will search for the earliest traces of habitation, attempt to uncover the Sulawesi hominins’ fossil record, and look for evidence of hominin-modern human interaction on this island. This project is expected to illuminate a previously unknown chapter in the human story.Read moreRead less
The unknown ‘Ice Age’ artists of Borneo. This project aims to shift the focus of the search for art’s origins onto important new horizons. Who were the first artists? When and why did it become second nature for humans not simply to exist within the natural world, but to encode it with images of things both real and imagined? The discovery of cave paintings in Sulawesi and more recently in Borneo dating to at least 40,000 years ago has altered our understanding of the origins and spread of the f ....The unknown ‘Ice Age’ artists of Borneo. This project aims to shift the focus of the search for art’s origins onto important new horizons. Who were the first artists? When and why did it become second nature for humans not simply to exist within the natural world, but to encode it with images of things both real and imagined? The discovery of cave paintings in Sulawesi and more recently in Borneo dating to at least 40,000 years ago has altered our understanding of the origins and spread of the first painting traditions. This project will build upon these breakthrough discoveries by constructing the first detailed portrait of the cultural and symbolic worlds of the unknown artists of Pleistocene Borneo. By doing so, it will further our knowledge about the process of the emergence of figurative art, one of the most fundamental cultural developments in the evolution of humankind.Read moreRead less
The grand challenge of predicting human movement energetics. This Project aims to advance our understanding of how the neuromuscular system uses energy during movement by exploring the interplay of different factors that influence movement energetics. The Project will explore different levels of organisation; from how muscle fibres consume energy to how those fibres interact and are subsequently controlled within a complex neuromuscular system. Expected outcomes of this Project will be an improv ....The grand challenge of predicting human movement energetics. This Project aims to advance our understanding of how the neuromuscular system uses energy during movement by exploring the interplay of different factors that influence movement energetics. The Project will explore different levels of organisation; from how muscle fibres consume energy to how those fibres interact and are subsequently controlled within a complex neuromuscular system. Expected outcomes of this Project will be an improved capacity to predict energy expenditure of the vast array of movements that humans perform. This will enable accurate monitoring of human energy expenditure and will provide benefits for individualised exercise prescription, enhancing work productivity or designing devices to augment human performance.Read moreRead less
Statistical Methods for Next Generation Genome-Wide Association Studies. This project aims to develop cutting-edge statistical methods to analyse large genomic datasets and identify genetic variants associated with inter-individual differences in various human traits. Knowledge of trait-associated DNA variants is instrumental in understanding how natural selection has shaped human traits. By integrating genomic data from diverse and underrepresented populations, this project further expects to c ....Statistical Methods for Next Generation Genome-Wide Association Studies. This project aims to develop cutting-edge statistical methods to analyse large genomic datasets and identify genetic variants associated with inter-individual differences in various human traits. Knowledge of trait-associated DNA variants is instrumental in understanding how natural selection has shaped human traits. By integrating genomic data from diverse and underrepresented populations, this project further expects to contribute to the equitable use of genomic technologies in humans, regardless of geographical origins. Expected outcomes of this research include novel analysis methods and software tools, which should broadly and significantly benefit gene discovery in other species, including those of agricultural relevance.Read moreRead less
Testing theoretical propositions concerning the onset and progression of child-sex offending, and field testing a new sexual abuse prevention model. Child sexual abuse poses serious threats to the health and well-being of Australian children. Data from a variety of sources indicate that, for a variety of reasons, Indigenous children are exposed to a heightened risk of sexual abuse. The present project is expected to lead to new discoveries about the causes of sexual abuse and to new evidence-bas ....Testing theoretical propositions concerning the onset and progression of child-sex offending, and field testing a new sexual abuse prevention model. Child sexual abuse poses serious threats to the health and well-being of Australian children. Data from a variety of sources indicate that, for a variety of reasons, Indigenous children are exposed to a heightened risk of sexual abuse. The present project is expected to lead to new discoveries about the causes of sexual abuse and to new evidence-based prevention methods both within Indigenous communities and in the wider community. The project will therefore contribute at a national level, as well as at a local community level, to broader efforts to improve the life chances of Australian children.Read moreRead less