Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989127
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
A High-Throughput Neutron Spectrometer for The Study of Atomic and Molecular Motion at ANSTO. Neutron scattering enables new science across a broad range of disciplines, and for this reason it is undergoing major expansion in the USA, Europe, Japan and Australia. Various diffactometers and spectrometers have recently been built at ANSTO, but an instrumental option for a high-throughput cross-discipline spectroscopy is urgently needed. Fortunately, it is fairly straightforward to add this type of ....A High-Throughput Neutron Spectrometer for The Study of Atomic and Molecular Motion at ANSTO. Neutron scattering enables new science across a broad range of disciplines, and for this reason it is undergoing major expansion in the USA, Europe, Japan and Australia. Various diffactometers and spectrometers have recently been built at ANSTO, but an instrumental option for a high-throughput cross-discipline spectroscopy is urgently needed. Fortunately, it is fairly straightforward to add this type of option to an existing spectrometer that will broaden its user-base from specialised applications in physics to more general applications in physics, chemistry, materials-science and biology. This additional option provides a totally new way for Australian scientists to study atomic and molecular motions. Read moreRead less
TOWARDS A COMPLETE DESCRIPTION OF HOW ENZYMES WORK: development of simulation methods and protocols, blind test predictions, and experimental validation. Enzymes catalyze quite fantastic chemistry under mild physiological conditions. Many special chemical concepts (such as "transition-state stabilization" and "entropy-enthalpy compensation") proposed to explain these powers are unnecessary. Uniquely for a catalyst, these powers are integral to the structure, properties and dynamics of the protei ....TOWARDS A COMPLETE DESCRIPTION OF HOW ENZYMES WORK: development of simulation methods and protocols, blind test predictions, and experimental validation. Enzymes catalyze quite fantastic chemistry under mild physiological conditions. Many special chemical concepts (such as "transition-state stabilization" and "entropy-enthalpy compensation") proposed to explain these powers are unnecessary. Uniquely for a catalyst, these powers are integral to the structure, properties and dynamics of the protein, as constrained and selected by evolution. The question is how do they work? Answering this requires energetic and thermodynamic analysis beyond current experimental techniques, but accessible by computer simulation. We aim to develop a robust toolkit of simulation methods and protocols, blind test them by predicting the mechanism of a new enzyme, with followup experimental validation.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668100
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
High Resolution Simultaneous DSC/DTA-TGA-FTIR System. National Research Priorities including 'New Materials' 'Frontier Technologies for Building and Transforming Australian Industries' and 'Developing Deep Earth Resources' will all be addressed and the benefits will include new materials such as carbon nanotubes and layered silicate composites. It will also contribute economically through technological development, supporting existing Australian companies in the development of more effective pro ....High Resolution Simultaneous DSC/DTA-TGA-FTIR System. National Research Priorities including 'New Materials' 'Frontier Technologies for Building and Transforming Australian Industries' and 'Developing Deep Earth Resources' will all be addressed and the benefits will include new materials such as carbon nanotubes and layered silicate composites. It will also contribute economically through technological development, supporting existing Australian companies in the development of more effective products and help keep pace with new and innovative advances in technology and to bring in vitality to strategic alliances with industry already launched by the University through a Sustainable Regions Program grant titled 'Building nanotechnology business potential in the Campbelltown-Camden region'.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989539
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
Purchase of a state-of-the-art high resolution inductively coupled plasma mass spectrometer. This new state-of-the-art mass spectrometer with enhanced capability will allow Tasmanian researchers to accurately determine the elemental composition of their samples of interest. The instrument will be extremely sensitive and will be able to detect elements to very low concentrations. It will be used to support a diverse range of local research projects of international significance, for example the ....Purchase of a state-of-the-art high resolution inductively coupled plasma mass spectrometer. This new state-of-the-art mass spectrometer with enhanced capability will allow Tasmanian researchers to accurately determine the elemental composition of their samples of interest. The instrument will be extremely sensitive and will be able to detect elements to very low concentrations. It will be used to support a diverse range of local research projects of international significance, for example the environmental assessment of clean and contaminated sites, chemical synthesis on a miniature scale using micro-chips, and the monitoring of selected elements of key importance for human health.Read moreRead less
Understanding, prediction and control of polymorphism in pharmaceuticals. The proposed research will lead, through a better understanding of polymorphism, to more efficient production of pharmaceuticals and will enhance the establishment and protection of patents. The work will have flow-on in other areas such as the manufacture of pigments, dyes and explosives. The project uses methodology for the elucidation of local structure and function at the atomic to nanoscale level in which Australia is ....Understanding, prediction and control of polymorphism in pharmaceuticals. The proposed research will lead, through a better understanding of polymorphism, to more efficient production of pharmaceuticals and will enhance the establishment and protection of patents. The work will have flow-on in other areas such as the manufacture of pigments, dyes and explosives. The project uses methodology for the elucidation of local structure and function at the atomic to nanoscale level in which Australia is a world leader. The project will further enhance our standing in this field and will provide excellent research training opportunities in areas particularly pertinent to future exploitation of the Australian Synchrotron and the new Research Reactor OPAL, which open in 2007. Read moreRead less
An integrated approach towards the development of new generation RF/microwave dielectric materials. The ultimate aim of this project is to rationally design and optimize new types of environmentally-sustainable, cost-effective and high performance microwave dielectric materials and devices for advanced information and communication technology (ICT) applications. This is a designated National Research Priority area. Our fundamental understanding of dielectric materials and their properties will b ....An integrated approach towards the development of new generation RF/microwave dielectric materials. The ultimate aim of this project is to rationally design and optimize new types of environmentally-sustainable, cost-effective and high performance microwave dielectric materials and devices for advanced information and communication technology (ICT) applications. This is a designated National Research Priority area. Our fundamental understanding of dielectric materials and their properties will be enhanced considerably by working on this project. Further, we will promote the relationship between the fundamental science of polar crystalline materials and practical applications. If successful, the results will enhance Australia's capacity and standing in this highly competitive area. Read moreRead less
Cellular and network basis of information processing in the mammalian visual system. The project aims to discover the strategies by which cells in the brain interact with each other to code the sensory input efficiently. It is expected that simultaneous recording of the activity of many neurones from the visual cortex of anaesthetised cats during visual stimulation will reveal how the biophysics of synaptic integration combined with excitatory and inhibitory inputs from different sources sculpt ....Cellular and network basis of information processing in the mammalian visual system. The project aims to discover the strategies by which cells in the brain interact with each other to code the sensory input efficiently. It is expected that simultaneous recording of the activity of many neurones from the visual cortex of anaesthetised cats during visual stimulation will reveal how the biophysics of synaptic integration combined with excitatory and inhibitory inputs from different sources sculpts the output of individual neurones. The experiments will be extended to the study of possible interactions between different areas of the brain and the study of mechanisms by which the cortical network and higher cognitive factors such as attention and memory might influence the coding of sensory information in awake animals.Read moreRead less
Importance of conformational and electrostatic contributions in simulations of enzyme reaction mechanisms. The research will contribute to the development of biomolecular simulation in Australia by demonstrating its potential to complement experiment, and also promote the effective use of APAC (Australian national supercomputer facilities) resources by providing advanced programs and computational protocols for other researchers. It will assist the diffusion of computational biology technology i ....Importance of conformational and electrostatic contributions in simulations of enzyme reaction mechanisms. The research will contribute to the development of biomolecular simulation in Australia by demonstrating its potential to complement experiment, and also promote the effective use of APAC (Australian national supercomputer facilities) resources by providing advanced programs and computational protocols for other researchers. It will assist the diffusion of computational biology technology into industrial applications such as rational drug design and protein engineering, as, for example, in our associated Linkage project grant, and provide novel insights into protein engineering and other sorts of design, which transcend concepts currently used in biomimetic chemistry.Read moreRead less
Tailoring the microwave dielectric properties of promising electroceramics for use in wireless telecommunication components and devices. This project aims to develop and tailor the microwave dielectric properties of promising electroceramic materials specifically targeting next generation wireless telecommunications applications. The partnership between the ANU and the Australian company Microwave and Materials Designs has the potential to enable new microwave electroceramic materials to be disc ....Tailoring the microwave dielectric properties of promising electroceramics for use in wireless telecommunication components and devices. This project aims to develop and tailor the microwave dielectric properties of promising electroceramic materials specifically targeting next generation wireless telecommunications applications. The partnership between the ANU and the Australian company Microwave and Materials Designs has the potential to enable new microwave electroceramic materials to be discovered and then incorporated into new microwave components and/or devices developed in response to the requirements of the international wireless telecommunications market. The requested PhD student will gain experience in both the industrial and academic worlds and the skills needed to be part of Australia's high-tech workforce. Read moreRead less