Gene therapy for islet transplantation. Improved understanding of aetiology of type I diabetes. Development of islet transplantation as a clinical therapeutic for type I diabetes. Improved efficacy of islet transplantation. Improved health for subjects with type I diabetes. Decreased diabetic complications. Improved quality of life for subjects with type I diabetes. Reduced burden on health system for management of diabetic complications for subjects with type I diabetes
Enhancing our understanding of metallochemistry in neurobiology with modern electron paramagnetic resonance (EPR) spectroscopy. Many neurological diseases involve protein accumulation that appears causally linked to abnormal levels of metal ions in the brain. This project will use a special technique called electron paramagnetic resonance to uncover how these metals interact with specific proteins at the molecular level and how drug treatments can modify these interactions.
New materials for manipulating intracellular communication. This project aims to identify new techniques for incorporating cell-signalling triggers into macromolecules, therefore enabling the development of next-generation stimuli-responsive nanoparticles that can emit signalling molecules on demand. Harnessing nanomaterials to stimulate specific sub-cellular processes is a neglected area in nanotechnology research. These nanoparticles could potentially be used to deliver signalling molecules fo ....New materials for manipulating intracellular communication. This project aims to identify new techniques for incorporating cell-signalling triggers into macromolecules, therefore enabling the development of next-generation stimuli-responsive nanoparticles that can emit signalling molecules on demand. Harnessing nanomaterials to stimulate specific sub-cellular processes is a neglected area in nanotechnology research. These nanoparticles could potentially be used to deliver signalling molecules for agricultural, pharmaceutical and veterinary applications. The project is expected to develop a new suite of materials that could ultimately be used to improve the yield of important commercial crops, or revitalise the use of medicines limited by their poor side effect profile.Read moreRead less
Developing a geomorphological framework to underpin management decision-making on the Great Barrier Reef. The paucity of data on coral reef growth histories inhibits attempts to integrate regional reef growth data into coral reef management - despite the major influence on habitat type and diversity. This project will gather such data for one region of the Great Barrier Reef, and develop such datasets to support future reef management decision-making.
The grand challenge of predicting human movement energetics. This Project aims to advance our understanding of how the neuromuscular system uses energy during movement by exploring the interplay of different factors that influence movement energetics. The Project will explore different levels of organisation; from how muscle fibres consume energy to how those fibres interact and are subsequently controlled within a complex neuromuscular system. Expected outcomes of this Project will be an improv ....The grand challenge of predicting human movement energetics. This Project aims to advance our understanding of how the neuromuscular system uses energy during movement by exploring the interplay of different factors that influence movement energetics. The Project will explore different levels of organisation; from how muscle fibres consume energy to how those fibres interact and are subsequently controlled within a complex neuromuscular system. Expected outcomes of this Project will be an improved capacity to predict energy expenditure of the vast array of movements that humans perform. This will enable accurate monitoring of human energy expenditure and will provide benefits for individualised exercise prescription, enhancing work productivity or designing devices to augment human performance.Read moreRead less
Testing theoretical propositions concerning the onset and progression of child-sex offending, and field testing a new sexual abuse prevention model. Child sexual abuse poses serious threats to the health and well-being of Australian children. Data from a variety of sources indicate that, for a variety of reasons, Indigenous children are exposed to a heightened risk of sexual abuse. The present project is expected to lead to new discoveries about the causes of sexual abuse and to new evidence-bas ....Testing theoretical propositions concerning the onset and progression of child-sex offending, and field testing a new sexual abuse prevention model. Child sexual abuse poses serious threats to the health and well-being of Australian children. Data from a variety of sources indicate that, for a variety of reasons, Indigenous children are exposed to a heightened risk of sexual abuse. The present project is expected to lead to new discoveries about the causes of sexual abuse and to new evidence-based prevention methods both within Indigenous communities and in the wider community. The project will therefore contribute at a national level, as well as at a local community level, to broader efforts to improve the life chances of Australian children.Read moreRead less
Understanding the molecular mechanisms of intellectual disability. Intellectual disability is frequent in the population, with one in every fifty people in the world directly affected. This project will improve our understanding of the correct development and function of the brain required for cognition by investigating specific roles and regulation of key molecules involved.
Mechanisms and innovative technologies for machining nanoscale multilayered thin film solar panels. This project addresses an important manufacturing bottleneck in the solar energy industry by addressing significant limitations in machining multilayered solar panels. A successful outcome will provide an important breakthrough in machining technology applicable not only to solar panels but other material science applications.
Pentecostal Connections: Migration, Missionaries, Mobility and Media between Australia and Brazil. This project investigates the rise of global Pentecostalism by exploring a Pentecostal transnational religious field between Australia and Brazil. In particular, it aims to investigate the role of Pentecostalism in the social welfare of migrants in Australia. This research contributes significant new knowledge to the ways in which religion is globalised and localised in everyday life, the role of r ....Pentecostal Connections: Migration, Missionaries, Mobility and Media between Australia and Brazil. This project investigates the rise of global Pentecostalism by exploring a Pentecostal transnational religious field between Australia and Brazil. In particular, it aims to investigate the role of Pentecostalism in the social welfare of migrants in Australia. This research contributes significant new knowledge to the ways in which religion is globalised and localised in everyday life, the role of religion in assisting migrants, and the continuing vitality and renewed public role of religion in late modernity. It will broaden the official vision of Brazil-Australia relations, encouraging policy to extend beyond the economic and political to include the cultural and social.Read moreRead less
Diagram categories and transformation semigroups. A structural understanding of diagram categories is essential in many branches of mathematics and science. Despite this, very few methods for studying such categories are available, a fact this pure mathematics project seeks to rectify. By building strong bridges between diagram categories and semigroup theory, a field of abstract algebra that models transformation and change, the structure of diagram categories may be unlocked with powerful semi ....Diagram categories and transformation semigroups. A structural understanding of diagram categories is essential in many branches of mathematics and science. Despite this, very few methods for studying such categories are available, a fact this pure mathematics project seeks to rectify. By building strong bridges between diagram categories and semigroup theory, a field of abstract algebra that models transformation and change, the structure of diagram categories may be unlocked with powerful semigroup tools developed by the applicant investigator. Diagrammatic insights will also yield new ways to study semigroups, and the many other mathematical structures they interact with. Outcomes will have a lasting impact on both theories as well as the many fields influenced by them.Read moreRead less