Fluid Dynamics of Circulation: Focus on the Kidney. In Australia, about 30% of adults have hypertension, a major risk factor for heart disease, accounting for about 40% of all deaths. Problems in renal circulation are likely factors leading to hypertension. A detailed understanding of the renal circulation, of whose hydraulic characteristics we have limited knowledge, is required before we can cure or prevent hypertension. We will determine how the size, structure and geometry of the blood vesse ....Fluid Dynamics of Circulation: Focus on the Kidney. In Australia, about 30% of adults have hypertension, a major risk factor for heart disease, accounting for about 40% of all deaths. Problems in renal circulation are likely factors leading to hypertension. A detailed understanding of the renal circulation, of whose hydraulic characteristics we have limited knowledge, is required before we can cure or prevent hypertension. We will determine how the size, structure and geometry of the blood vessels influence the function of the kidney. This will lead to predictive models to aid the design and interpretation of physiological studies and the combat of hypertension. It will also help in the ongoing development of bioartificial kidneys to replace present dialysis systems. Read moreRead less
Multiblock copolymer synthesis for nano-engineered materials. This project aims to develop methodology for environmentally friendly and industrially applicable synthesis of new types of advanced polymeric materials comprising multiblock copolymers. Polymeric materials play an important role in society with applications from bulk plastics to advanced technological applications. This would enable the creation of advanced materials with specific engineering targets and applications ranging from nan ....Multiblock copolymer synthesis for nano-engineered materials. This project aims to develop methodology for environmentally friendly and industrially applicable synthesis of new types of advanced polymeric materials comprising multiblock copolymers. Polymeric materials play an important role in society with applications from bulk plastics to advanced technological applications. This would enable the creation of advanced materials with specific engineering targets and applications ranging from nanomedicine to materials science.Read moreRead less
Pro-Fluorescent Aryl Nitroxides: New Probes for Polymer Lifetime and Kinetics Research. Internal aryl rings present in novel probes developed for this project impart fluorescence which is efficiently and internally quenched by the presence of a paramagnetic nitroxide group. Scavenging of radicals by the nitroxide however "switches on" the fluorescence and this enables powerful new fluorescence-based detection levels for the technique of nitroxide free radical scavenging. Such sensitivity is a ....Pro-Fluorescent Aryl Nitroxides: New Probes for Polymer Lifetime and Kinetics Research. Internal aryl rings present in novel probes developed for this project impart fluorescence which is efficiently and internally quenched by the presence of a paramagnetic nitroxide group. Scavenging of radicals by the nitroxide however "switches on" the fluorescence and this enables powerful new fluorescence-based detection levels for the technique of nitroxide free radical scavenging. Such sensitivity is applicable to polymerization kinetics studies, as well as providing new means for the determination of materials lifetimes. The development of pro-fluorescent markers as indicators for polymer degradation would be a significant outcome for materials where component failure has a major negative impact.Read moreRead less
Dynamics and control of fluid-structure-free surface interactions. This project aims to research the apparently opposing effects of vortex shedding and free surface damping, individually and jointly, and the control or excitation of the vibrations for two generic bluff bodies: the cylinder and the sphere. Flow-induced vibrations of bluff bodies under or piercing water surfaces can damage floating off-shore marine structures and tethered bodies. On the other hand, harvesting energy from ocean cur ....Dynamics and control of fluid-structure-free surface interactions. This project aims to research the apparently opposing effects of vortex shedding and free surface damping, individually and jointly, and the control or excitation of the vibrations for two generic bluff bodies: the cylinder and the sphere. Flow-induced vibrations of bluff bodies under or piercing water surfaces can damage floating off-shore marine structures and tethered bodies. On the other hand, harvesting energy from ocean currents needs large flow-induced vibrations. The intended outcomes are new modes of body vibration, wake transitions and means to control fluid-structure interactions. This research could benefit many processes in offshore marine engineering, submarine bodies and mixing vessels, where understanding and controlling fluid-structure interactions of bluff bodies can mitigate costly and dangerous induced vibrations.Read moreRead less
Benign recovery of precious metals from deep pristine environments. This project aims to extract precious metals from natural deposits conventional mining methods cannot reach. Glycine-peroxide systems can dissolve precious metals without pollution. Understanding these systems’ behaviour in natural orebodies could lead to in-situ leaching methods that complement conventional mining, especially in low grade deposits. This project intends to use a modern scientific workflow based on exploratory, d ....Benign recovery of precious metals from deep pristine environments. This project aims to extract precious metals from natural deposits conventional mining methods cannot reach. Glycine-peroxide systems can dissolve precious metals without pollution. Understanding these systems’ behaviour in natural orebodies could lead to in-situ leaching methods that complement conventional mining, especially in low grade deposits. This project intends to use a modern scientific workflow based on exploratory, descriptive and explanatory phases to model the coupled multi-physics of precious metals transport, introduce a high performance computing strategy for in-situ leaching, develop an experimental protocol that explains the recovery mechanisms, and propose optimal leaching patterns that maximise productivity.Read moreRead less
Mathematical Methods for Next Generation Sequencing. The emergence of a new generation of high throughput genomic sequencing technologies is providing unprecedented opportunities for biological research. Hidden within the huge amounts of data generated by this technology is information about the expression and regulation of genes, and the complex functional purpose of non-coding, so called 'junk', DNA. Development of mathematical and statistical tools is essential to interpreting these data. The ....Mathematical Methods for Next Generation Sequencing. The emergence of a new generation of high throughput genomic sequencing technologies is providing unprecedented opportunities for biological research. Hidden within the huge amounts of data generated by this technology is information about the expression and regulation of genes, and the complex functional purpose of non-coding, so called 'junk', DNA. Development of mathematical and statistical tools is essential to interpreting these data. The proposed research will enhance Australia's reputation for developing novel quantitative techniques at the cutting edge of modern biology. The proposed project has a broad range of potential applications in biotechnology, particularly in the medical and agricultural industries.Read moreRead less
SenShaMart: A Trusted Internet of Things Marketplace for Sensor Sharing. This project aims to devise a novel Internet of Things (IoT) sensor sharing marketplace that permits IoT applications to discover, integrate, and pay for any IoT sensor data that is made available by other parties. The project will devise highly-scalable sensor classification, query processing, and transactions solutions and incorporate them in a pair of novel blockchains that work in tandem to securely manage all the infor ....SenShaMart: A Trusted Internet of Things Marketplace for Sensor Sharing. This project aims to devise a novel Internet of Things (IoT) sensor sharing marketplace that permits IoT applications to discover, integrate, and pay for any IoT sensor data that is made available by other parties. The project will devise highly-scalable sensor classification, query processing, and transactions solutions and incorporate them in a pair of novel blockchains that work in tandem to securely manage all the information and contracts needed by IoT applications to discover, integrate, pay, and use sensors provided by another parties. These IoT advancements will provide significant economic, environmental, and social benefits via making low-cost and immediate sensing available across the world.Read moreRead less
Advanced Materials from Automated Synthesis of Sequence-Defined Polymers. The project aims to develop industrially scalable and environmentally friendly methods for synthesis of sequence-defined multiblock copolymers (polymer chains containing segments of different polymer types) using automated synthesis methods. The materials to be explored will be largely based on renewable biomass-derived monomeric building blocks. Such polymers are able to undergo microphase separation into spatially period ....Advanced Materials from Automated Synthesis of Sequence-Defined Polymers. The project aims to develop industrially scalable and environmentally friendly methods for synthesis of sequence-defined multiblock copolymers (polymer chains containing segments of different polymer types) using automated synthesis methods. The materials to be explored will be largely based on renewable biomass-derived monomeric building blocks. Such polymers are able to undergo microphase separation into spatially periodic compositional patterns, thereby providing access to a vast range of nano-engineered materials. This would enable design and synthesis of new advanced materials, making use of renewable resources and supporting the circular economy, with diverse potential applications ranging from nanomedicine to materials science.Read moreRead less
Physics-aware machine learning for data-driven fire risk prediction. The 2019/20 Australian fire season was unprecedented in its extent, impact, and the response of fire agencies. In this project, we aim to answer the question: was the scale of these fires driven by known drivers of fire (drought, weather, fuels and ignitions), or were fundamentally new undescribed processes and phenomena involved? We will accomplish this by developing an innovative, physics-aware machine learning model of fire ....Physics-aware machine learning for data-driven fire risk prediction. The 2019/20 Australian fire season was unprecedented in its extent, impact, and the response of fire agencies. In this project, we aim to answer the question: was the scale of these fires driven by known drivers of fire (drought, weather, fuels and ignitions), or were fundamentally new undescribed processes and phenomena involved? We will accomplish this by developing an innovative, physics-aware machine learning model of fire risk and spread, trained and validated on a two-decade satellite fire record. The predictive ability of the model will be tested on the 2019/20 fire season to determine if novel drivers of fire can be identified, and the model itself will be operationalised into a novel short-to-mid term fire risk prediction tool. Read moreRead less
The Great Barrier Reef in 2100. Our research aims to answer fundamental geomorphic questions about the future of coral reefs, focusing on the Great Barrier Reef (GBR). We will develop cutting-edge, fully open-source numerical models to quantify the eco-morphodynamic evolution of the GBR under IPCC climate-change scenarios. Our geomorphic numerical models will consider biotic/abiotic feedbacks including synergistic effects of multiple stressors such as waves, temperature, acidification and sedime ....The Great Barrier Reef in 2100. Our research aims to answer fundamental geomorphic questions about the future of coral reefs, focusing on the Great Barrier Reef (GBR). We will develop cutting-edge, fully open-source numerical models to quantify the eco-morphodynamic evolution of the GBR under IPCC climate-change scenarios. Our geomorphic numerical models will consider biotic/abiotic feedbacks including synergistic effects of multiple stressors such as waves, temperature, acidification and sediment transport, at individual reef scales. We will model the future of the GBR’s ecosystem-services, allowing for a quantum leap in the geomorphic knowledge and understanding of coral reef ecosystems. Expected outcomes include a gamechanger tool for future management of the GBR.Read moreRead less