ORCID Profile
0000-0002-1122-5593
Current Organisations
University of South Australia
,
University of South Australi
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Publisher: Elsevier BV
Date: 15-08-2003
DOI: 10.1016/S0165-0270(03)00142-0
Abstract: This study investigated the effect of short periods of simultaneous weak anodal direct current (DC) stimulation and peripheral ulnar nerve (ES) stimulation on corticospinal excitability. The experiments involved repeated testing of ten normal subjects with four different protocols: (1) No Stimulation (2) DC only (3) ES only (4) DC plus ES. Motor evoked potentials (MEP) were recorded from the First Dorsal Interosseous (FDI) Abductor Digiti Minimi (ADM) and Flexor Carpi Ulnaris (FCU). The baseline MEP litude was compared with that obtained immediately after the first set of stimulation, after the second set of stimulation, 15 min post stimulation and 30 min after stimulation. No significant change was seen with the No Stimulation and ES Only protocols. FDI showed a significant change in the DC protocol after the second set of stimulation but the changes were not present 15 or 30 min after. The DC plus ES protocol showed FDI changes that were significant after the second set of stimulation with the elevations persisting when tested 15 and 30 min post intervention. These observations show that a period of anodal DC stimulation preceding a period of ulnar nerve stimulation resulted in significant and persistent elevations in cortical excitability.
Publisher: Springer Science and Business Media LLC
Date: 02-09-2023
Publisher: Springer Science and Business Media LLC
Date: 08-08-2019
Publisher: Informa UK Limited
Date: 03-05-2023
Publisher: Springer Science and Business Media LLC
Date: 13-06-2016
Publisher: Elsevier BV
Date: 08-2003
DOI: 10.1016/S1388-2457(03)00115-9
Abstract: Changes in afferent input have been shown to be capable of inducing reorganisations of motor cortex in humans. Using TCMS we examined the efficacy of a new associative afferent stimulation paradigm in inducing motor cortical reorganisation in humans. Using TCMS, stimulus response curves were constructed before and following a 1 h period of associative stimulation of two muscles motor points. The effect of an asynchronous peripheral stimulation paradigm was investigated in a separate series of control experiments. One hour of associative stimulation of two muscles motor points resulted in a significant increase in the excitability of the corticospinal projection to those stimulated muscles. The increase in excitability peaked 1 h following the stimulation period. This increase in excitability did not generalise to either adjacent or more remote muscles. The control stimulation paradigm produced no significant change in corticospinal excitability. These results confirm the importance of associative input for the induction of plasticity in the human motor cortex. The findings reported here further elucidate the role of afferent input in motor cortical reorganisation. These findings have implications for our understanding of the mechanisms of motor learning and may also be relevant to the design of new afferent stimulation therapies.
Publisher: Springer Science and Business Media LLC
Date: 2002
Abstract: Cortical representation maps derived by transcranial magnetic stimulation (TMS) are often used, inter alia, in studying the plasticity of the brain. Parameters such as map area, map volume, optimal stimulation site and centre of gravity are commonly used to quantify changes in the topography of the motor cortex. However, reports on the stability of these parameters over time has not been conclusive. In the present study, the areas of the scalp from which responses were evoked from corticospinal cells projecting to three intrinsic hand muscles were systematically mapped with TMS at intervals of 24 hours, one week and two weeks from eight normal subjects. The area, "volume" and centre of gravity of these maps did not change significantly over this period. It is concluded that mapping with TMS is suitable for studies which aim to study the effect of various interventions on the cortical representation of in idual muscles in human subjects.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 13-10-2003
DOI: 10.1212/01.WNL.0000078809.33581.1F
Abstract: Combined peripheral nerve and brain stimulation ("dual stimulation") induces changes in the excitability of normal motor cortex. The authors sought to establish whether dual stimulation would also induce motor cortex plasticity and associated functional improvements in nine stroke patients with chronic stable hemiparesis. Following 4 weeks of daily dual stimulation, improvements were seen in some neurophysiological and functional measures. This technique may offer therapeutic opportunities in some stroke patients.
Publisher: Springer Science and Business Media LLC
Date: 2004
No related grants have been discovered for Jeric Uy.