ORCID Profile
0000-0002-8811-3143
Current Organisation
Flinders University
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Publisher: Elsevier BV
Date: 04-2019
Publisher: American Chemical Society (ACS)
Date: 20-07-2018
Abstract: Macroporous bovine serum albumin (BSA) nanoparticles with controllable diameter were readily fabricated in a rapidly rotating angled glass tube in a vortex fluidic device (VFD). Systematically varying the rotational speed and the ratio of BSA, ethanol, and glutaraldehyde led to conditions for generating ca. 600 nm diameter macroporous particles that have intrinsic fluorescence emission at 520 nm when excited at 490 nm. The presence of the macropores increased the absorption efficiency of rhodamine B with potential applications for drug delivery purpose, compared with BSA nanoparticles having surfaces devoid of pores. Further control over the size of BSA nanoparticles occurred in the presence of C-phycocyanin protein during the VFD processing, along with control of their shape, from spheres to pockets, as established in exploring the parameter space of the microfluidic device.
Publisher: Wiley
Date: 03-10-2023
DOI: 10.1002/AGT2.433
Publisher: Wiley
Date: 25-04-2022
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2NA00310D
Abstract: Herein, we have established a sequential two step continuous flow process for generating graphene oxide with properties comparable to the conventional Hummers' GO. The process is high yielding and with a dramatic reduction in the generation of waste.
Publisher: American Chemical Society (ACS)
Date: 20-06-2023
Publisher: Elsevier BV
Date: 12-2023
Publisher: Elsevier BV
Date: 03-2020
Publisher: American Chemical Society (ACS)
Date: 25-01-2022
Publisher: Wiley
Date: 12-04-0006
Abstract: Unlocking the potential of personalized medicine in point‐of‐care settings requires a new generation of biomarker and proteomic assays. Ideally, assays could inexpensively perform hundreds of quantitative protein measurements in parallel at the bedsides of patients. This goal greatly exceeds current capabilities. Furthermore, biomarker assays are often challenging to translate from benchtop to clinic due to difficulties achieving and assessing the necessary selectivity, sensitivity, and reproducibility. To address these challenges, we developed an efficient ( min), robust (comparatively lower CVs), and inexpensive (decreasing reagent use and cost by %) immunoassay method. Specifically, the immunoblot membrane is dotted with the s le and then developed in a vortex fluidic device (VFD) reactor. All assay steps—blocking, binding, and washing—leverage the unique thin‐film microfluidics of the VFD. The approach can accelerate direct, indirect, and sandwich immunoblot assays. The applications demonstrated include assays relevant to both the laboratory and the clinic.
Publisher: American Chemical Society (ACS)
Date: 05-11-2020
Publisher: American Chemical Society (ACS)
Date: 07-08-2019
Publisher: CSIRO Publishing
Date: 24-05-2022
DOI: 10.1071/CH21345
Abstract: Nanospheres comprised of bovine serum albumin (BSA) crosslinked with glutaraldehyde possessing different pore sizes are accessible under continuous flow conditions using a vortex fluidic device (VFD) with a rapidly rotating tube tilt angle θ of −45° which overcomes an otherwise build-up of material occurring at θ +45°. The build-up can also be overcome at +45° under continuous flow using ethanol dehydrating conditions at 80°C without the need for crosslinking using glutaraldehyde. As-prepared BSA nanoparticles (BNPs) of ca. 531 nm in diameter were formed at 5k rpm in a single-step process. Similar rapid processing in the presence of curcumin affords composite BNPs@curcumin particles ca. 615 nm in diameter.
Publisher: Elsevier BV
Date: 10-2018
DOI: 10.1016/J.BIORTECH.2018.06.103
Abstract: A bottleneck in the production of biodiesel from microalgae is the dewatering and lipid extraction process which is the dominant energy penalty and cost. A novel biodiesel production platform based on vortex fluidic device (VFD)-assisted direct transesterification (DT) of wet microalgal biomass of Chloroparva pannonica was developed and evaluated. Fatty acid extraction and fatty acid to FAME conversion efficiencies were used at different parameter settings to evaluate performance of the processing technology in confined and continuous mode. A response surface method based on Box-Behnken experimental design was used to determine the effects of water content, the ratio of biomass to methanol and residence time in the VFD. Average extraction efficiencies were 41% and conversion efficiencies >90% with the processing technology showing a broad tolerance to parameter settings. The findings suggest that VFD-assisted DT is a simple and effective way to produce biodiesel directly from wet microalgae biomass at room temperature.
Publisher: American Chemical Society (ACS)
Date: 21-10-2021
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1CC01555A
Abstract: A polymer made from sulfur and canola oil can be used as an oil spill sorbent and then repurposed into a sulfur-rich graphitic carbon for mercury removal from water.
Publisher: Wiley
Date: 12-04-2022
Abstract: Unlocking the potential of personalized medicine in point‐of‐care settings requires a new generation of biomarker and proteomic assays. Ideally, assays could inexpensively perform hundreds of quantitative protein measurements in parallel at the bedsides of patients. This goal greatly exceeds current capabilities. Furthermore, biomarker assays are often challenging to translate from benchtop to clinic due to difficulties achieving and assessing the necessary selectivity, sensitivity, and reproducibility. To address these challenges, we developed an efficient ( min), robust (comparatively lower CVs), and inexpensive (decreasing reagent use and cost by %) immunoassay method. Specifically, the immunoblot membrane is dotted with the s le and then developed in a vortex fluidic device (VFD) reactor. All assay steps—blocking, binding, and washing—leverage the unique thin‐film microfluidics of the VFD. The approach can accelerate direct, indirect, and sandwich immunoblot assays. The applications demonstrated include assays relevant to both the laboratory and the clinic.
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0FO02230F
Abstract: We have developed a simple process for the entrapment of nutrients in shear stress induced non-covalent physically entangled tannic acid-gelatin gel in a thin film vortex fluidic device (VFD) operating under continuous flow.
Publisher: Wiley
Date: 25-01-2018
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8RA08336C
Abstract: Vortex fluidic fabricated h-BN@magnetite under continuous flow in water exhibits recyclable high phosphate ion adsorption capacity.
Publisher: American Chemical Society (ACS)
Date: 14-09-2018
Publisher: American Chemical Society (ACS)
Date: 03-06-2016
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D1SC05829K
Abstract: Micron to submicron size Coriolis and Faraday wave induced high shear topological flow regimes in 45° titled rapidly rotating tubes result in high inter-phase mass transfer of immiscible liquids and spontaneous demixing.
Publisher: MDPI AG
Date: 11-06-2023
DOI: 10.3390/MD21060358
Abstract: Shell wastes pose environmental and financial burdens to the shellfish industry. Utilizing these undervalued shells for commercial chitin production could minimize their adverse impacts while maximizing economic value. Shell chitin conventionally produced through harsh chemical processes is environmentally unfriendly and infeasible for recovering compatible proteins and minerals for value-added products. However, we recently developed a microwave-intensified biorefinery that efficiently produced chitin, proteins eptides, and minerals from lobster shells. Lobster minerals have a calcium-rich composition and biologically originated calcium is more biofunctional for use as a functional, dietary, or nutraceutical ingredient in many commercial products. This has suggested a further investigation of lobster minerals for commercial applications. In this study, the nutritional attributes, functional properties, nutraceutical effects, and cytotoxicity of lobster minerals were analyzed using in vitro simulated gastrointestinal digestion combined with growing bone (MG-63), skin (HaCaT), and macrophage (THP-1) cells. The calcium from the lobster minerals was found to be comparable to that of a commercial calcium supplement (CCS, 139 vs. 148 mg/g). In addition, beef incorporated with lobster minerals (2%, w/w) retained water better than that of casein and commercial calcium lactate (CCL, 21.1 vs. 15.1 and 13.3%), and the lobster mineral had a considerably higher oil binding capacity than its rivals (casein and CCL, 2.5 vs. 1.5 and 1.0 mL/g). Notably, the lobster mineral and its calcium were far more soluble than the CCS (98.4 vs. 18.6% for the products and 64.0 vs. 8.5% for their calcium) while the in vitro bioavailability of lobster calcium was 5.9-fold higher compared to that of the commercial product (11.95 vs. 1.99%). Furthermore, supplementing lobster minerals in media at ratios of 15%, 25%, and 35% (v/v) when growing cells did not induce any detectable changes in cell morphology and apoptosis. However, it had significant effects on cell growth and proliferation. The responses of cells after three days of culture supplemented with the lobster minerals, compared to the CCS supplementation, were significantly better with the bone cells (MG-63) and competitively quick with the skin cells (HaCaT). The cell growth reached 49.9–61.6% for the MG-63 and 42.9–53.4% for the HaCaT. Furthermore, the MG-63 and HaCaT cells proliferated considerably after seven days of incubation, reaching 100.3% for MG-63 and 115.9% for HaCaT with a lobster mineral supplementation of 15%. Macrophages (THP-1 cells) treated for 24 h with lobster minerals at concentrations of 1.24–2.89 mg/mL had no detectable changes in cell morphology while their viability was over 82.2%, far above the cytotoxicity threshold ( %). All these results indicate that lobster minerals could be used as a source of functional or nutraceutical calcium for commercial products.
Publisher: Wiley
Date: 25-04-2022
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0CC07165J
Abstract: The manipulation of topological fluid flow to fabricate spicular C 60 coated polystyrene beads under shear stress in the vortex fluidic device (VFD).
Publisher: Wiley
Date: 21-10-2019
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9RA03970H
Abstract: Exfoliation or scrolling of h-BN occurs in a vortex fluidic device under downward continuous flow.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C7RE00197E
Abstract: High shear vortex fluidics coupled with NIR affords luminescent carbon dots as a scalable process.
Publisher: MDPI AG
Date: 05-04-2023
DOI: 10.3390/MOLECULES28073244
Abstract: Hydrogels have various promising prospects as a successful platform for detecting biomarkers, and human serum albumin (HSA) is an important biomarker in the diagnosis of kidney diseases. However, the difficult-to-control passive diffusion kinetics of hydrogels is a major factor affecting detection performance. This study focuses on using hydrogels embedded with aggregation-induced emission (AIE) fluorescent probe TC426 to detect HSA in real time. The vortex fluidic device (VFD) technology is used as a rotation strategy to control the reaction kinetics and micromixing during measurement. The results show that the introduction of VFD could significantly accelerate its fluorescence response and effectively improve the diffusion coefficient, while VFD processing could regulate passive diffusion into active diffusion, offering a new method for future sensing research.
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1NA00195G
Abstract: A rapidly rotating tube in the vortex fluidic device imparts submicron topological mass transport regimes, as moulded through crystallisation, polymerisation, and ‘molecular drilling’.
Publisher: American Chemical Society (ACS)
Date: 26-05-2022
Publisher: Elsevier BV
Date: 03-2017
Publisher: Public Library of Science (PLoS)
Date: 30-05-2019
Publisher: MDPI AG
Date: 09-07-2015
DOI: 10.3390/MD13074231
Publisher: American Chemical Society (ACS)
Date: 18-06-2021
Publisher: American Chemical Society (ACS)
Date: 28-10-2020
DOI: 10.26434/CHEMRXIV.13141352.V1
Abstract: Induced mechanical energy in a thin film of liquid in an inclined rapidly rotating tube in the vortex fluidic device (VFD) can be harnessed for generating non-equilibrium conditions, which are optimal at 45 o tilt angle, but the nature of the fluid flow is not understood. Through understanding that the fluid exhibits resonance behaviours from the confining boundaries of the glass surface and the meniscus that determines the liquid film thickness, we have established specific topological mass transport regimes. These topologies have been established through materials processing, as circular flow normal to the surface of the tube, double-helical flow across the thin film, and spicular flow, a transitional region where both effects contribute. This includes new phenomenological shear stressed crystallization and molecular drilling. The manifestation of these patterns has been observed by monitoring mixing times, temperature profiles, and film thickness against rotational speed of liquids in the tube. The grand sum of the different behavioural regimes is a general fluid flow model that accounts for all processing in the VFD at an optimal tilt angle of 45 o , and provides a new concept in the fabrication of novel nanomaterials and controlling the organisation of matter.
Publisher: Frontiers Media SA
Date: 30-03-2022
DOI: 10.3389/FMARS.2022.872775
Abstract: Reproductive and sexual health issues, including infertility and sexual dysfunctions (SD), are common concerns affecting millions of reproductive age worldwide. Scattered literature reports that marine animals such as oysters, sea cucumbers, seahorses and spoon worms have unique bioactive compounds like saponins, steroids, seahorse-derived hydrolysates, polypeptide, oligopeptides and essential trace elements that significantly improve infertility, hormonal imbalance, SD, and impotence. In addition, these compounds have exhibited pharmacological properties against reproductive problems due to diabetes and exposure to electromagnetic fields, cyclophosphamide, or a high exercise load. This review presents the first critical assessment of the advances in understanding and applying bioactives from marine organisms to support human reproductive health. Key knowledge and technical gaps have been identified for future research to improve the lack of in-depth understanding of the mechanism and action of these bioactives in human clinical studies. There is a need to develop simple, selective, low-cost, and scalable processes to isolate and purify in idual bioactive compounds for industrial applications. The optimizing culturing and farming conditions for specific bioactive compounds from targeted species are suggested for sustainable production. The review indicates a promising future of extracts and marine-derived bioactives as functional foods in preventing and managing human reproductive health issues, but mechanistic studies and further clinical trials are urgently required to evaluate their efficacy and safety.
No related grants have been discovered for Xuan Luo.