ORCID Profile
0000-0001-8344-3824
Current Organisations
University of South Australia
,
University of Queensland
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Publisher: Springer Science and Business Media LLC
Date: 04-08-2018
Publisher: Wiley
Date: 29-05-2018
Publisher: American Chemical Society (ACS)
Date: 02-05-2017
DOI: 10.1021/JACS.6B12622
Abstract: Asymmetric mesoporous silica nanoparticles (MSNs) with controllable head-tail structures have been successfully synthesized. The head particle type is tunable (solid or porous), and the tail has dendritic large pores. The tail length and tail coverage on head particles are adjustable. Compared to spherical silica nanoparticles with a solid structure (Stöber spheres) or large-pore symmetrical MSNs with fully covered tails, asymmetrical head-tail MSNs (HTMSNs) show superior hemocompatibility due to reduced membrane deformation of red blood cells and decreased level of reactive oxygen species. Moreover, compared to Stöber spheres, asymmetrical HTMSNs exhibit a higher level of uptake and in vitro maturation of immune cells including dendritic cells and macrophage. This study has provided a new family of nanocarriers with potential applications in vaccine development and immunotherapy.
Publisher: MDPI AG
Date: 23-03-2023
DOI: 10.3390/PHARMACEUTICS15041037
Abstract: Intracellular bacteria are inaccessible and highly tolerant to antibiotics, hence are a major contributor to the global challenge of antibiotic resistance and recalcitrant clinical infections. This, in tandem with stagnant antibacterial discovery, highlights an unmet need for new delivery technologies to treat intracellular infections more effectively. Here, we compare the uptake, delivery, and efficacy of rif icin (Rif)-loaded mesoporous silica nanoparticles (MSN) and organo-modified (ethylene-bridged) MSN (MON) as an antibiotic treatment against small colony variants (SCV) Staphylococcus aureus (SA) in murine macrophages (RAW 264.7). Macrophage uptake of MON was five-fold that of equivalent sized MSN and without significant cytotoxicity on human embryonic kidney cells (HEK 293T) or RAW 264.7 cells. MON also facilitated increased Rif loading with sustained release, and seven-fold increased Rif delivery to infected macrophages. The combined effects of increased uptake and intracellular delivery of Rif by MON reduced the colony forming units of intracellular SCV-SA 28 times and 65 times compared to MSN-Rif and non-encapsulated Rif, respectively (at a dose of 5 µg/mL). Conclusively, the organic framework of MON offers significant advantages and opportunities over MSN for the treatment of intracellular infections.
Publisher: Wiley
Date: 29-05-2017
Abstract: Mesoporous silica nanoparticles are reported as adjuvants in nanovaccines in generating robust antigen-specific immunity. However, the effect of surface chemistry in initiating and modulating the immune response remains largely unexplored. In this study, mesoporous silica nanorods (MSNRs) are modified with NH
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C7TB02836A
Abstract: This work reports the significance of the carbonisation temperature of mesoporous carbon hollow spheres (MCHS) in therapeutic protein delivery.
Publisher: Elsevier BV
Date: 06-2020
Publisher: EManuscript Technologies
Date: 04-2011
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8CC00327K
Abstract: Asymmetric mesoporous silica nanoparticles with a head–tail structure are potent immunoadjuvants in delivering a peptide antigen, generating higher antibody immune response in mice compared to their symmetric counterparts.
No related grants have been discovered for Manasi Mantri Jambhrunkar.