ORCID Profile
0000-0003-4882-9400
Current Organisation
Swinburne University of Technology
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Research Topics
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Top 5 Research Topics
ANZSRC Field of Research (FoR)
Nanotechnology | Functional Materials | Nanotechnology | Optical Physics | Fluidization And Fluid Mechanics | Biological Physics | Materials Engineering | Optics And Opto-Electronic Physics | Signal Processing | Colloid And Surface Chemistry | Condensed Matter Physics | Sensor Technology (Chemical aspects) | Microelectronics and Integrated Circuits | Analytical Spectrometry | Artificial Intelligence and Image Processing | Medical Biotechnology | Optical Physics Not Elsewhere Classified | Medical Biotechnology | Manufacturing Engineering | Safety And Quality | Manufacturing Processes and Technologies (excl. Textiles) | Biosensor Technologies | Metals and Alloy Materials | Biomedical Engineering Not Elsewhere Classified | Interdisciplinary Engineering | Medical Biotechnology Diagnostics (incl. Biosensors) | Nonlinear Optics and Spectroscopy | Analytical Chemistry | Biomedical Instrumentation | Medical Devices | Colloid and Surface Chemistry | Biomedical Engineering | Physical Chemistry (Incl. Structural) | Electrical and Electronic Engineering | Structural Chemistry and Spectroscopy | Nanophotonics | Nanoscale Characterisation | Nanomanufacturing | Nanomaterials | Image Processing | Engineering Instrumentation | Quantum Optics | Soft Condensed Matter | Nanobiotechnology | Condensed Matter Characterisation Technique Development | Nanoelectronics | Pattern Recognition | Nanofabrication, Growth and Self Assembly
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in the Physical Sciences | Expanding Knowledge in Engineering | Physical sciences | Integrated Circuits and Devices | Expanding Knowledge in Technology | Expanding Knowledge in the Chemical Sciences | Emerging Defence Technologies | Diagnostics | Scientific instrumentation | Medical Instruments | Scientific Instruments | National Security | Biological sciences | Chemical sciences | Automotive equipment | Ceramics, glass and industrial mineral products not elsewhere classified | Hearing, vision, speech and their disorders | Clinical health not specific to particular organs, diseases and conditions | Treatments (e.g. chemicals, antibiotics) | Occupational Health | Metals (e.g. Composites, Coatings, Bonding) | Manufacturing not elsewhere classified | Medical instrumentation | Surgical methods and procedures | Diagnostic Methods | Expanding Knowledge in the Biological Sciences | Health Status (e.g. Indicators of Well-Being) |
Related Links
Publications
Light-induced reflectivity transients in black-Si nanoneedles
Publisher: Elsevier BV
Date: 2016
Optical fibers for miniaturized surface-enhanced Raman-scattering probes
Publisher: The Optical Society
Date: 25-11-2013
DOI: 10.1364/AO.52.008388
Trends and Applications of U-Shaped Fiber Optic Sensors: A Review
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2021
Nanofabrication of surface-enhanced Raman scattering substrates for optical fiber sensors
Publisher: SPIE
Date: 05-03-2013
DOI: 10.1117/12.2004019
Nanostructured optical fibre for chemical sensing using surface-enhanced Raman scattering
Publisher: IEEE
Date: 07-2006
The Optical Fiber Tip: An Inherently Light‐Coupled Microscopic Platform for Micro‐ and Nanotechnologies
Publisher: Wiley
Date: 05-03-2014
Abstract: The flat tip of an optical fiber is a unique and unconventional platform for micro and nanotechnologies. The small cross-section and large aspect ratio of the fiber provide an inherently light-coupled substrate that is uniquely suited to remote, in vivo and in situ applications. However, these same characteristics challenge established fabrication technologies, which are best suited to large planar substrates. This review presents a broad overview of strategies for patterning the flat tip of an optical fiber. Techniques discussed include self-assembly, numerous lithographies, through-fiber patterning, hybrid techniques, and strategies for mass manufacture, while the erse applications are discussed in context throughout.
Infrared neural stimulation: Influence of stimulation site spacing and repetition rates on heating
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 12-2013
Synthesis of Self-Assembled Island-Structured Complex Oxide Dielectric Films
Publisher: American Chemical Society (ACS)
Date: 09-2009
DOI: 10.1021/JP904832Z
Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states
Publisher: Springer Science and Business Media LLC
Date: 30-09-2021
The effect of metal microstructure on the initial attachment ofEscherichia colito 1010 carbon steel
Publisher: Informa UK Limited
Date: 09-2013
DOI: 10.1080/08927014.2013.820826
Abstract: Metallurgical features have been shown to play an important role in the attachment of microorganisms to metal surfaces. In the present study, the influence of the microstructure of as-received (AR) and heat-treated (HT) 1010 carbon steel on the initial attachment of bacteria was investigated. Heat treatment was carried out with the aim of increasing the grain size of the carbon steel coupons. Mirror-polished carbon steel coupons were immersed in a minimal medium inoculated with Escherichia coli (ATCC 25922) to investigate the early (15, 30 and 60 min) and relatively longer-term (4 h) stages of bacterial attachment. The results showed preferential colonisation of bacteria on the grain boundaries of the steel coupons. The bacterial attachment to AR steel coupons was relatively uniform compared to the HT steel coupons where an increased number of localised aggregates of bacteria were found. Quantitative analysis showed that the ratio of the total number of isolated (i.e., single) bacteria to the number of bacteria in aggregates was significantly higher on the AR coupons than the HT coupons. Longer-term immersion studies showed production of extracellular polymeric substances by the bacteria and corrosion at the grain boundaries on both types of steel coupon tested.
Raman spectroscopic identification of single bacterial cells at different stages of their lifecycle
Publisher: Elsevier BV
Date: 09-2016
Polarisation Control in Arrays of Microlenses and Gratings: Performance in Visible–IR Spectral Ranges
Publisher: MDPI AG
Date: 31-03-2023
DOI: 10.3390/MI14040798
Abstract: Microlens arrays (MLAs) which are increasingly popular micro-optical elements in compact integrated optical systems were fabricated using a femtosecond direct laser write (fs-DLW) technique in the low-shrinkage SZ2080TM photoresist. High-fidelity definition of 3D surfaces on IR transparent CaF2 substrates allowed to achieve ∼50% transmittance in the chemical fingerprinting spectral region 2–5 μm wavelengths since MLAs were only ∼10 μm high corresponding to the numerical aperture of 0.3 (the lens height is comparable with the IR wavelength). To combine diffractive and refractive capabilities in miniaturised optical setup, a graphene oxide (GO) grating acting as a linear polariser was also fabricated by fs-DLW by ablation of a 1 μm-thick GO thin film. Such an ultra-thin GO polariser can be integrated with the fabricated MLA to add dispersion control at the focal plane. Pairs of MLAs and GO polarisers were characterised throughout the visible–IR spectral window and numerical modelling was used to simulate their performance. A good match between the experimental results of MLA focusing and simulations was achieved.
Diffraction-limited ultrasensitive molecular nano-arrays with singular nano-cone scattering
Publisher: AIP Publishing
Date: 03-2014
DOI: 10.1063/1.4869694
Abstract: Large-library fluorescent molecular arrays remain limited in sensitivity (1 × 106 molecules) and dynamic range due to background auto-fluorescence and scattering noise within a large (20–100 μm) fluorescent spot. We report an easily fabricated silica nano-cone array platform, with a detection limit of 100 molecules and a dynamic range that spans 6 decades, due to point (10 nm to 1 μm) illumination of preferentially absorbed tagged targets by singular scattering off wedged cones. Its fluorescent spot reaches diffraction-limited submicron dimensions, which are 104 times smaller in area than conventional microarrays, with comparable reduction in detection limit and lification of dynamic range.
Activity of Retinal Neurons Can Be Modulated by Tunable Near-Infrared Nanoparticle Sensors
Publisher: American Chemical Society (ACS)
Date: 02-2023
Wavelength and refractive index dependence of the geometrical enhancement in surface‐enhanced Raman scattering
Publisher: Wiley
Date: 07-07-2017
DOI: 10.1002/JRS.5190
Influence of electric field on SERS: Frequency effects, intensity changes, and susceptible bonds
Publisher: American Chemical Society (ACS)
Date: 12-2012
DOI: 10.1021/JA208893Q
Abstract: The fundamental mechanism proposed to explain surface-enhanced Raman scattering (SERS) relies on electromagnetic field enhancement at optical frequencies. In this work, we demonstrate the use of microfabricated, silver nanotextured electrode pairs to study, in situ, the influence of low frequency (5 mHz to 1 kHz) oscillating electric fields on the SERS spectra of thiophenol. This applied electric field is shown to affect SERS peak intensities and influence specific vibrational modes of the analyte. The applied electric field perturbs the polar analyte, thereby altering the scattering cross section. Peaks related to the sulfurous bond which binds the molecule to the silver nanotexture exhibit strong and distinguishable responses to the applied field, due to varying bending and stretching mechanics. Density functional theory simulations are used to qualitatively verify the experimental observations. Our experimental and simulation results demonstrate that the SERS spectral changes relate to electric field induced molecular reorientation, with dependence on applied field strength and frequency. This demonstration creates new opportunities for external dynamic tuning and multivariate control of SERS measurements.
Nanostructured optical fibre arrays for high-density biochemical sensing and remote imaging
Publisher: Springer Science and Business Media LLC
Date: 15-11-2009
DOI: 10.1007/S00216-009-3211-0
Abstract: Optical fibre bundles usually comprise a few thousand to tens of thousands of in idually clad glass optical fibres. The ordered arrangement of the fibres enables coherent transmission of an image through the bundle and therefore enables analysis and viewing in remote locations. In fused bundles, this architecture has also been used to fabricate arrays of various micro to nano-scale surface structures (micro/nanowells, nanotips, triangles, etc.) over relatively large areas. These surface structures have been used to obtain new optical and analytical capabilities. Indeed, the imaging bundle can be thought of as a "starting material" that can be sculpted by a combination of fibre drawing and selective wet-chemical etching processes. A large variety of bioanalytical applications have thus been developed, ranging from nano-optics to DNA nanoarrays. For instance, nanostructured optical surfaces with intrinsic light-guiding properties have been exploited as surface-enhanced Raman scattering (SERS) platforms and as near-field probe arrays. They have also been productively associated with electrochemistry to fabricate arrays of transparent nanoelectrodes with electrochemiluminescent imaging properties. The confined geometry of the wells has been loaded with biosensing materials and used as femtolitre-sized vessels to detect single molecules. This review describes the fabrication of high-density nanostructured optical fibre arrays and summarizes the large range of optical and bioanalytical applications that have been developed, reflecting the versatility of this ordered light-guiding platform.
Hybrid optogenetic and electrical stimulation for greater spatial resolution and temporal fidelity of cochlear activation.
Publisher: IOP Publishing
Date: 10-2020
Abstract: Compared to electrical stimulation, optogenetic stimulation has the potential to improve the spatial precision of neural activation in neuroprostheses, but it requires intense light and has relatively poor temporal kinetics. We tested the effect of hybrid stimulation, which is the combination of subthreshold optical and electrical stimuli, on spectral and temporal fidelity in the cochlea by recording multiunit activity in the inferior colliculus of channelrhodopsin (H134R variant) transgenic mice. Pulsed light or biphasic electrical pulses were delivered to cochlear spiral ganglion neurons of acutely deafened mice, either as in idual stimuli or as hybrid stimuli for which the timing of the electrical pulse had a varied delay relative to the start of the optical pulse. Response thresholds, spread of activation and entrainment data were obtained from multi-unit recordings from the auditory midbrain. Facilitation occurred when subthreshold electrical stimuli were applied at the end of, or up to 3.75 ms after subthreshold optical pulses. The spread of activation resulting from hybrid stimulation was significantly narrower than electrical-only and optical-only stimulation (p < 0.01), measured at equivalent suprathreshold levels of loudness that are relevant to cochlear implant users. Furthermore, temporal fidelity, measured as maximum following rates to 300 ms pulse trains bursts up to 240 Hz, was 2.4-fold greater than optical-only stimulation (p < 0.05). By significantly improving spectral resolution of electrical- and optical-only stimulation and the temporal fidelity of optical-only stimulation, hybrid stimulation has the potential to increase the number of perceptually independent stimulating channels in a cochlear implant.
Changes in spectral properties of fibre Bragg gratings owing to bending
Publisher: Institution of Engineering and Technology (IET)
Date: 2011
DOI: 10.1049/EL.2011.0816
Whole cell patch clamp for investigating the mechanisms of infrared neural stimulation
Publisher: MyJove Corporation
Date: 31-07-2013
DOI: 10.3791/50444
Response of primary auditory neurons to stimulation with infrared light in vitro.
Publisher: IOP Publishing
Date: 18-03-2021
Abstract: Objective. Infrared light can be used to modulate the activity of neuronal cells through thermally-evoked capacitive currents and thermosensitive ion channel modulation. The infrared power threshold for action potentials has previously been found to be far lower in the in vivo cochlea when compared with other neuronal targets, implicating spiral ganglion neurons (SGNs) as a potential target for infrared auditory prostheses. However, conflicting experimental evidence suggests that this low threshold may arise from an intermediary mechanism other than direct SGN stimulation, potentially involving residual hair cell activity. Approach. Patch-cl recordings from cultured SGNs were used to explicitly quantify the capacitive and ion channel currents in an environment devoid of hair cells. Neurons were irradiated by a 1870 nm laser with pulse durations of 0.2–5.0 ms and powers up to 1.5 W. A Hodgkin-Huxley-type model was established by first characterising the voltage dependent currents, and then incorporating laser-evoked currents separated into temperature-dependent and temperature-gradient-dependent components. This model was found to accurately simulate neuronal responses and allowed the results to be extrapolated to stimulation parameter spaces not accessible during this study. Main results. The previously-reported low in vivo SGN stimulation threshold was not observed, and only subthreshold depolarisation was achieved, even at high light exposures. Extrapolating these results with our Hodgkin-Huxley-type model predicts an action potential threshold which does not deviate significantly from other neuronal types. Significance. This suggests that the low-threshold response that is commonly reported in vivo may arise from an alternative mechanism, and calls into question the potential usefulness of the effect for auditory prostheses. The step-wise approach to modelling optically-evoked currents described here may prove useful for analysing a wider range of cell types where capacitive currents and conductance modulation are dominant.
Nanostructured optical fibre for surface-enhanced Raman scattering sensing
Publisher: SPIE
Date: 19-09-2008
DOI: 10.1117/12.797582
Black-CuO: Surface-enhanced Raman scattering and infrared properties
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5NR04783H
Abstract: Conformally Au coated nano-textured cupric Cu( ii ) oxide surfaces function as high performance substrates for surface enhanced Raman scattering spectroscopy.
Heat requirements for loquat fruit development may be assessed with a Beta model approach
Publisher: International Society for Horticultural Science (ISHS)
Date: 12-2018
On the need for more realistic experimental conditions in laboratory-based microbiologically influenced corrosion testing
Publisher: Elsevier BV
Date: 07-2017
Light enhancement in surface-enhanced Raman scattering at oblique incidence
Publisher: Springer Science and Business Media LLC
Date: 10-07-2012
Electric field induced surface-enhanced Raman spectroscopy for multianalyte detection
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4CP04912H
Abstract: This work demonstrates the ability to detect and isolate an analyte from a multianalyte mixture by SERS sensing.
Black-Si as a platform for sensing
Publisher: SPIE
Date: 07-12-2013
DOI: 10.1117/12.2033707
Detecting Mild Water Stress in Olive with Multiple Plant-Based Continuous Sensors
Publisher: MDPI AG
Date: 11-01-2021
Abstract: A comprehensive characterization of water stress is needed for the development of automated irrigation protocols aiming to increase olive orchard environmental and economical sustainability. The main aim of this study is to determine whether a combination of continuous leaf turgor, fruit growth, and sap flow responses improves the detection of mild water stress in two olive cultivars characterized by different responses to water stress. The sensitivity of the tested indicators to mild stress depended on the main mechanisms that each cultivar uses to cope with water deficit. One cultivar showed pronounced day to day changes in leaf turgor and fruit relative growth rate in response to water withholding. The other cultivar reduced daily sap flows and showed a pronounced tendency to reach very low values of leaf turgor. Based on these responses, the sensitivity of the selected indicators is discussed in relation to drought response mechanisms, such as stomatal closure, osmotic adjustment, and tissue elasticity. The analysis of the daily dynamics of the monitored parameters highlights the limitation of using non-continuous measurements in drought stress studies, suggesting that the time of the day when data is collected has a great influence on the results and consequent interpretations, particularly when different genotypes are compared. Overall, the results highlight the need to tailor plant-based water management protocols on genotype-specific physiological responses to water deficit and encourage the use of combinations of plant-based continuously monitoring sensors to establish a solid base for irrigation management.
Strain-based health assessment of bonded composite repairs
Publisher: Elsevier BV
Date: 11-2006
Surface-enhanced Raman scattering: effective optical constants for electric field modelling of nanostructured Ag films
Publisher: SPIE
Date: 17-09-2016
DOI: 10.1117/12.2236169
Black silicon as a platform for bacterial detection
Publisher: AIP Publishing
Date: 11-2015
DOI: 10.1063/1.4934966
Abstract: Surface-enhanced Raman scattering (SERS) shows promise for identifying single bacteria, but the short range nature of the effect makes it most sensitive to the cell membrane, which provides limited information for species-level identification. Here, we show that a substrate based on black silicon can be used to impale bacteria on nanoscale SERS-active spikes, thereby producing spectra that convey information about the internal composition of the bacterial capsule. This approach holds great potential for the development of microfluidic devices for the removal and identification of single bacteria in important clinical diagnostics and environmental monitoring applications.
Polycaprolactone porous template facilitates modulated release of molecules from alginate hydrogels
Publisher: Elsevier BV
Date: 12-2018
A low-cost and temperature-insensitive fibre Bragg grating sensor for monitoring localized strain concentrations
Publisher: IOP Publishing
Date: 17-12-2008
Patterning of biomaterials by aerosol jet printing: A parametric study
Publisher: Elsevier BV
Date: 06-2020
User-Centered Design of Wearable Assistive Devices for the Aging Population
Publisher: IGI Global
Date: 2016
DOI: 10.4018/978-1-4666-9530-6.CH006
Abstract: Due to modern medicine, the lifespan of the average person is increasing, with a concomitant increase in the need for care. According to the German Federal Statistical Office, DeStatis, there will be a deficit of 260,000 caregivers by 2025, which is not only an issue in Germany, but worldwide. New technologies, including wearable devices, will be crucial to manage this challenge, but there is a huge amount of research and investment required to incorporate wearable assistive devices into the lives of elderly users. It is crucially important that any new devices are fit for purpose, taking into account the specific needs of elderly people. This chapter, therefore, summarises and reviews the current state of wearable assistive devices, formalises the current design practice with respect to user needs, and presents design considerations such as wearability and usability, in order to assist in the future development of wearable assistive devices for the aging population.
Modeling of bend effects on fiber Bragg gratings
Publisher: SPIE
Date: 31-01-2012
DOI: 10.1117/12.915939
A Niche for Cowpea in Sub-Tropical Australia?
Publisher: MDPI AG
Date: 19-08-2021
Abstract: Pulses have emerged as important rotation crops in Australia. Some are in demand in agricultural production systems due to their high potential market value, because of their roles as grain or forage crops, their nitrogen fixation capability, and because they provide a disease break or improve soil health. While several pulse crops have been identified for winter-season cropping, there are few adapted legumes apart from mungbean that are appropriate for dryland summer cropping. Currently, short-duration crops of mungbean are commonly used, but yields are highly variable and susceptible to drought. Here, we propose that cowpea has the potential to become an alternative rotation crop in dryland summer cropping zones, providing a competitive and profitable alternative pulse crop option where its drought tolerance could enable better performance under inconsistent in-crop rainfall. We demonstrate that cowpea has nutritional properties and putative uses that could prove valuable in emerging plant-based protein and aquaculture markets.
Double Clad Fiber Improves the Performance of a Single-Ended Optical Fiber Sensor
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 15-09-2018
Reduction of polarization-induced artifacts in grating-based spectrometers
Publisher: Optica Publishing Group
Date: 10-10-2005
DOI: 10.1364/AO.44.006123
Abstract: An optical device that converts unpolarized light into a single polarization state is described. The device is based on a polarizing beam splitter that separates the two polarization directions. The beam splitter is combined with two pairs of equilateral prisms that are used to collimate the two beams in terms of both propagation and polarization directions. When it is used in combination with a blazed diffraction grating, this device is shown to effectively remove the polarization dependence of the first-order diffracted power. The device has an insertion loss of approximately 14% for purely s-polarized light. However, for unpolarized light incident upon the two gratings studied here, the increased throughput of the p-polarized component leads to an average relative gain in overall efficiency of 13%-19%, depending on the grating. In collimating the two polarization directions, the device may cause a reduction in spectral resolution for a rectangular entrance slit. As a result, the device is more likely to find use in spectrometers that have a circular aperture, such as that provided by an optical fiber.
A tissue-engineered neural interface with photothermal functionality
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3BM00139C
Abstract: Neural interfaces are well-established as a tool to understand the behaviour of the nervous system via recording and stimulation of living neurons, as well as serving as neural prostheses.
Combined optogenetic and electrical stimulation of auditory neurons increases effective stimulation frequency—an in vitro study
Publisher: IOP Publishing
Date: 19-02-2020
Abstract: The performance of neuroprostheses, including cochlear and retinal implants, is currently constrained by the spatial resolution of electrical stimulation. Optogenetics has improved the spatial control of neurons in vivo but lacks the fast-temporal dynamics required for auditory and retinal signalling. The objective of this study is to demonstrate that combining optical and electrical stimulation in vitro could address some of the limitations associated with each of the stimulus modes when used independently. The response of murine auditory neurons expressing ChR2-H134 to combined optical and electrical stimulation was characterised using whole cell patch cl electrophysiology. Optogenetic costimulation produces a three-fold increase in peak firing rate compared to optical stimulation alone and allows spikes to be evoked by combined subthreshold optical and electrical inputs. Subthreshold optical depolarisation also facilitated spiking in auditory neurons for periods of up to 30 ms without evidence of wide-scale Na These findings may contribute to the development of spatially and temporally selective optogenetic-based neuroprosthetics and complement recent developments in 'fast opsins'.
Nanoscale optical voltage sensing in biological systems
Publisher: Elsevier BV
Date: 02-2021
First-approximation simulation of dopant diffusion in nanostructured silica optical fibres
Publisher: Elsevier BV
Date: 11-2008
Theoretical Model and Design Considerations of U-Shaped Fiber Optic Sensors: A Review
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 15-12-2020
Challenges and opportunities in neurophotonics discussed at the International Conference on Biophotonics 2017
Publisher: SPIE-Intl Soc Optical Eng
Date: 30-10-2018
Distributed fluorescence sensing using exposed core microstructured optical fiber
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 09-2010
High-temperature elastic constants of yttrium aluminum garnet
Publisher: AIP Publishing
Date: 06-1993
DOI: 10.1063/1.354019
Abstract: Elastic constants of yttrium aluminum garnet have been measured in the temperature range 300–1450 K using a combination of Brillouin scattering and refractive index measurements. Associated quantities such as the bulk modulus, anisotropy ratio, and thermo-optic coefficient have been determined.
Avalanching nanoparticles bring new light to cardiovascular imaging
Publisher: Oxford University Press (OUP)
Date: 20-04-2021
DOI: 10.1093/CVR/CVAB092
Accumulation of radioactive corrosion products on steel surfaces of VVER type nuclear reactors. I. 110mAg
Publisher: Elsevier BV
Date: 03-1999
Evanescently coupled dewpoint sensor based on a silicon waveguide
Publisher: Elsevier BV
Date: 04-2006
Temperature measurement in the microscopic regime: a comparison between fluorescence lifetime‐ and intensity‐based methods
Publisher: Wiley
Date: 22-03-2013
DOI: 10.1111/JMI.12033
Abstract: Thermally sensitive fluorescent indicators have been proposed to monitor temperature changes in microfluidic systems, mainly based on fluorescence intensity or lifetime. However, measuring temperature in a structured environment, such as biological tissue, presents additional challenges due to the chemical and structural complexity. Here, we investigate the potential for resolving temperature distributions within the volume of a single cell. Rhodamine B (RhB) dye was employed as a temperature indicator to compare fluorescence intensity- and lifetime-based techniques. The relationship between the fluorescence lifetime and temperature was found to be highly dependent on the biological environment. The intensity-based method allowed the temperature distribution to be mapped with partial success within the volume of a single cell. Under ideal circumstances, the temperature can be mapped pixel by pixel with a resolution better than ±0.3°C within the cell cytoplasm, but this accuracy was reduced to ±1.8°C by environmental variations. These results suggest that the fluorophore should be encapsulated and immobilized in the biological tissue in order to reduce the influence of environmental factors on temperature measurements at the cellular level.
Pronounced anharmonicity in the classical high-Tc superconductor Nb3Sn
Publisher: Elsevier BV
Date: 05-1990
Recovering inspiration in the spaces of creative writing
Publisher: Wiley
Date: 07-04-2010
Laser fabricated ripple substrates for surface‐enhanced Raman scattering
Publisher: Wiley
Date: 10-09-2012
User-Centered Design of Wearable Assistive Devices for the Aging Population
Publisher: IGI Global
Date: 2018
DOI: 10.4018/978-1-5225-5484-4.CH024
Abstract: Due to modern medicine, the lifespan of the average person is increasing, with a concomitant increase in the need for care. According to the German Federal Statistical Office, DeStatis, there will be a deficit of 260,000 caregivers by 2025, which is not only an issue in Germany, but worldwide. New technologies, including wearable devices, will be crucial to manage this challenge, but there is a huge amount of research and investment required to incorporate wearable assistive devices into the lives of elderly users. It is crucially important that any new devices are fit for purpose, taking into account the specific needs of elderly people. This chapter, therefore, summarises and reviews the current state of wearable assistive devices, formalises the current design practice with respect to user needs, and presents design considerations such as wearability and usability, in order to assist in the future development of wearable assistive devices for the aging population.
In situ SERS probing of nano-silver coated individual yeast cells
Publisher: Elsevier BV
Date: 11-2013
DOI: 10.1016/J.BIOS.2013.05.053
Abstract: For understanding cells functionalities and their communications, there is a need for highly sensitive cell analysis platforms capable of assessing non-specific chemicals on the surface and in the vicinity of cells. We report a microfluidic system integrating dielectrophoresis and surface enhanced Raman scattering (SERS) for the trapping and real time monitoring of cell functions in isolated and grouped cell clusters. Yeast cells are coated with silver nanoparticles to enable highly sensitive SERS analysis. The SERS responses of cells are examined under various conditions: live vs. dead and isolated vs. grouped. This work illustrates the feasibility of the system for in situ cell monitoring and analysis of secreted chemicals during their growth, metabolism, proliferation and apoptosis.
Towards Safer Primers: A Review
Publisher: MDPI AG
Date: 18-10-2019
DOI: 10.3390/TECHNOLOGIES7040075
Abstract: Primers are used to reliably initiate a secondary explosive in a wide range of industrial and defence applications. However, established primer technologies pose both direct and indirect risks to health and safety. This review analyses a new generation of primer materials and ignition control mechanisms that have been developed to address these risks in firearms. Electrically or optically initiated metal, oxide and semiconductor-based devices show promise as alternatives for heavy metal percussive primers. The prospects for wider use of low-cost, safe, reliable and non-toxic primers are discussed in view of these developments.
Microstructural refinement of aluminium-zinc-silicon coated steels
Publisher: Elsevier BV
Date: 11-2016
Gold-Nanorod-Assisted Near-Infrared Stimulation of Primary Auditory Neurons
Publisher: Wiley
Date: 05-05-2014
Abstract: Infrared stimulation offers an alternative to electrical stimulation of neuronal tissue, with potential for direct, non-contact activation at high spatial resolution. Conventional methods of infrared neural stimulation (INS) rely on transient heating due to the absorption of relatively intense laser beams by water in the tissue. However, the water absorption also limits the depth of penetration of light in tissue. Therefore, the use of a near-infrared laser at 780 nm to stimulate cultured rat primary auditory neurons that are incubated with silica-coated gold nanorods (Au NRs) as an extrinsic absorber is investigated. The laser-induced electrical behavior of the neurons is observed using whole-cell patch cl electrophysiology. The nanorod-treated auditory neurons (NR-ANs) show a significant increase in electrical activity compared with neurons that are incubated with non-absorbing silica-coated gold nanospheres and control neurons with no gold nanoparticles. The laser-induced heating by the nanorods is confirmed by measuring the transient temperature increase near the surface of the NR-ANs with an open pipette electrode. These findings demonstrate the potential to improve the efficiency and increase the penetration depth of INS by labeling nerves with Au NRs and then exposing them to infrared wavelengths in the water window of tissue.
Brillouin-scattering measurements of surface-acoustic-wave velocities in silicon at high temperatures
Publisher: American Physical Society (APS)
Date: 15-06-1995
Nano-cone optical fiber array sensors for MiRNA profiling
Publisher: SPIE
Date: 11-09-2013
DOI: 10.1117/12.2023727
Sub‐15nm Optical Fiber Nanoimprint Lithography: A Parallel, Self‐aligned and Portable Approach
Publisher: Wiley
Date: 22-11-2010
Dark-field microspectroscopic analysis of gold nanorods in spiral Ganglion neurons
Publisher: SPIE
Date: 07-12-2013
DOI: 10.1117/12.2033767
Laser exposure of gold nanorods can increase neuronal cell outgrowth
Publisher: Wiley
Date: 26-03-2013
DOI: 10.1002/BIT.24889
Abstract: The usage of gold nanoparticles (Au NPs) in biological applications has risen significantly over the last 10 years. With the wide variety of chemical and biological functionalization available and their distinctive optical properties, Au NPs are currently used in a range of biological applications including sensing, labeling, drug delivery, and imaging applications. Among the available particles, gold nanorods (Au NRs) are particularly useful because their optical absorption can be tuned across the visible to near infrared region. Here, we present a novel application of Au NRs associated with low power laser exposure of NG108-15 neuronal cells. When cells were irradiated with a 780 nm laser, the average number of neurons with neurites increased. A similar stimulatory effect was observed for cells that were cultured with poly-(4-styrenesulfonic acid)-coated and silica-coated Au NRs. Furthermore, when the NG108-15 cells were cultured with both bare and coated Au NRs and then irradiated with 1.2-7.5 W/cm(2) at 780 nm, they showed a neurite length increase of up to 25 µm versus control. To the best of our knowledge, this effect has never been reported before. While the pathways of the stimulation is not yet clear, the data presented here demonstrates that it is linked to the absorption of light by the Au NRs. These initial results open up new opportunities for peripheral nerve regeneration treatments and for novel approaches to addressing central nervous system axons following spinal cord injury.
From Fundamental toward Applied SERS: Shared Principles and Divergent Approaches
Publisher: Wiley
Date: 25-06-2018
Biological Considerations of Optical Interfaces for Neuromodulation
Publisher: Wiley
Date: 11-07-2019
Stimulation of Primary Auditory Neurons Mediated by Near-Infrared Excitation of Gold Nanorods
Publisher: Springer New York
Date: 2018
Optical properties of chitin: surface-enhanced Raman scattering substrates based on antireflection structures on cicada wings
Publisher: IOP Publishing
Date: 06-01-2006
Additional Enhancement of Electric Field in Surface-Enhanced Raman Scattering due to Fresnel Mechanism
Publisher: Springer Science and Business Media LLC
Date: 08-2013
DOI: 10.1038/SREP02335
Corrosion of carbon steel by sulphate reducing bacteria: Initial attachment and the role of ferrous ions
Publisher: Elsevier BV
Date: 04-2015
Ultra-pure, water-dispersed Au nanoparticles produced by femtosecond laser ablation and fragmentation
Publisher: Informa UK Limited
Date: 07-2013
DOI: 10.2147/IJN.S44163
Far-side geometrical enhancement in surface-enhanced Raman scattering with Ag plasmonic films
Publisher: SPIE
Date: 02-01-2018
DOI: 10.1117/12.2283335
Microfluidics and raman microscopy: Current applications and future challenges
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3CS35515B
Abstract: Raman microscopy systems are becoming increasingly widespread and accessible for characterising chemical species. Microfluidic systems are also progressively finding their way into real world applications. Therefore, it is anticipated that the integration of Raman systems with microfluidics will become increasingly attractive and practical. This review aims to provide an overview of Raman microscopy-microfluidics integrated systems for researchers who are actively interested in utilising these tools. The fundamental principles and application strengths of Raman microscopy are discussed in the context of microfluidics. Various configurations of microfluidics that incorporate Raman microscopy methods are presented, with applications highlighted. Data analysis methods are discussed, with a focus on assisting the interpretation of Raman-microfluidics data from complex s les. Finally, possible future directions of Raman-microfluidic systems are presented.
Effect of substrate temperature on the splat formation of flame sprayed polypropylene
Publisher: Elsevier BV
Date: 12-2011
Internet of things-based hydrocarbon sensing for real-Time environmental monitoring
Publisher: IEEE
Date: 04-2019
Characterization of time-resolved fluorescence response measurements for distributed optical-fiber sensing
Publisher: The Optical Society
Date: 10-11-2010
DOI: 10.1364/AO.49.006385
Novel aluminum near field transducer and highly integrated micro-nano-optics design for heat-assisted ultra-high-density magnetic recording
Publisher: IOP Publishing
Date: 07-2014
DOI: 10.1088/0957-4484/25/29/295202
Abstract: Heat-assisted magnetic recording (HAMR) has attracted increasing attention as one of the most promising future techniques for ultra-high-density magnetic recording beyond the current limit of 1 Tb in(-2). Localized surface plasmon resonance plays an important role in HAMR by providing a highly focused optical spot for heating the recording medium within a small volume. In this work, we report an aluminum near-field transducer (NFT) based on a novel bow-tie design. At an operating wavelength of 450 nm, the proposed transducer can generate a 35 nm spot size inside the magnetic recording medium, corresponding to a recording density of up to 2 Tb in(-2). A highly integrated micro-nano-optics design is also proposed to ensure process compatibility and corrosion-resistance of the aluminum NFT. Our work has demonstrated the feasibility of using aluminum as a plasmonic material for HAMR, with advantages of reduced cost and improved efficiency compared to traditional noble metals.
Investigating Shape Comparison Tools for Benchmarking Differences in Product Appearance During Product Styling
Publisher: Springer India
Date: 24-12-2014
Fabrication of a Biocompatible Liquid Crystal Graphene Oxide–Gold Nanorods Electro‐ and Photoactive Interface for Cell Stimulation
Publisher: Wiley
Date: 06-03-2019
Abstract: For decades, electrode-tissue interfaces are pursued to establish electrical stimulation as a reliable means to control neuronal cells behavior. However, spreading of electrical currents in tissues limits its spatial precision. Thus, optical cues, such as near-infrared (NIR) light, are explored as alternatives. Presently, NIR stimulation requires higher energy input than electrical methods despite introduction of light absorbers, e.g., gold nanoparticles. As potential solution, NIR and electrical costimulation are proposed but with limited interfaces capable of sustaining this stimulation technique. Here, a novel electroactive nanocomposite with photoactive properties in the NIR range is constructed by N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride/N-hydroxysulfosuccinimide sodium (EDC)/NHS conjugation of liquid crystal graphene oxide (LCGO) to protein-coated gold nanorods (AuNR). The liquid crystal graphene oxide-gold nanorod nanocomposite (LCGO-AuNR) is fabricated into a hydrophilic electrode-coating via drop-casting, making it appropriate for versatile electrode-tissue interface fabrication. UV-vis spectrophotometry results demonstrate that LCGO-AuNR presents an absorbance peak at 798 nm (NIR range). Cyclic voltammetry measurements further confirm its electroactive capacitive properties. Furthermore, LCGO-AuNR coating supports cell adhesion, proliferation, and differentiation of NG108-15 neuronal cells. This biocompatible interface is anticipated, with ideal electrical and optical properties for NIR and electrical costimulation, to enable further development of the technique for energy-efficient and precise neuronal cell modulation.
Effects of laser-exposed gold nanorods on biochemical pathways of neuronal cells
Publisher: SPIE
Date: 07-12-2013
DOI: 10.1117/12.2033575
Measurement of forces at the tip of a cochlear implant during insertion
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 04-2014
Optical material processing by synchrotron radiation
Publisher: IEEE
Date: 07-2006
Fibre Bragg grating sensor for respiratory monitoring
Publisher: IEEE
Date: 07-2006
Nanoimprinting on optical fiber end faces for chemical sensing
Publisher: SPIE
Date: 14-04-2008
DOI: 10.1117/12.785975
Influence of the dielectric substrate on the effective optical constants of silver plasmonic films
Publisher: The Optical Society
Date: 26-07-2019
DOI: 10.1364/AO.58.006038
Quasielastic light scattering in silicon
Publisher: American Physical Society (APS)
Date: 15-12-2000
Integrated Polarisation Control in Microlens Arrays: Performance at Visible-Ir Spectral Ranges
Publisher: MDPI AG
Date: 06-03-2023
DOI: 10.20944/PREPRINTS202303.0106.V1
Abstract: Microlens arrays (MLAs) which are increasingly popular micro-optical elements in compact integrated optical systems were fabricated by femtosecond direct laser write (fs-DLW) technique in the low-shrinkage SZ2080TM photoresist. High fidelity definition of 3D surfaces on IR transparent CaF2 substrates allowed to achieve & sim 50% transmittance at chemical fingerprinting spectral region 2-5 & mu m wavelengths since MLAs were only & sim 10 & mu m high corresponding to the numerical aperture of 0.3 (the lens height is comparable with the IR wavelength). To combine diffractive and refractive capabilities in miniaturised optical setup, a graphene oxide (GO) grating acting as a linear polariser was also fabricated by fs-DLW by ablation of a 1 & mu m-thick GO thin film. Such an ultra-thin GO polariser can be integrated with the fabricated MLA to add dispersion control at the focal plane. Pairs of MLAs and GO polarisers were characterised throughout visible-IR spectral window and numerical modeling was used to simulate their performance. Good match between experimental results of MLA focusing and simulations was achieved.
Infrared nerve stimulation: Modelling of photon transport and heat conduction
Publisher: SPIE
Date: 15-02-2013
DOI: 10.1117/12.2003477
Molecular imaging of red blood cells by Raman spectroscopy
Publisher: CSIRO Publishing
Date: 2011
DOI: 10.1071/CH11136
Abstract: Raman spectroscopy allows visualization of 2D and 3D chemical distributions at high spatial resolution in a wide range of s les. It is insensitive to water, which makes it particularly attractive for applications in the biological sciences. At the same time, technical advances have allowed the laser excitation power to be reduced on thermally sensitive s les, without sacrificing acquisition times. This review highlights the analytical and diagnostic potential of Raman imaging techniques by reference to recent studies of red blood cells. In the case of red blood cells infected with low-pigmented forms of the malaria parasite, molecular images reveal sub-micron-inclusions of haemozoin, which suggests that the technique has potential for early-stage diagnosis of the disease.
Optical fibre SERS sensors
Publisher: Springer Science and Business Media LLC
Date: 30-04-2009
DOI: 10.1007/S00216-009-2797-6
Abstract: Surface-enhanced Raman scattering (SERS) has established itself as an important analytical technique. However, efforts to transfer the technology from the laboratory to the production line, clinic or field have been frustrated by the lack of robust affordable substrates and the complexity of interfacing between s le and spectrometer. Prompted by the success of optical fibre systems for implementing normal Raman scattering spectroscopy in remote locations and biomedical applications, attention has now shifted to the development of SERS-active optical fibres. Other workers have attempted to develop SERS probes with extended interaction lengths and both far-field and near-field SERS imaging techniques for high-resolution chemical mapping of surfaces. This review discusses the development of these technologies and presents the current state of the art. Although recent developments show great promise, some outstanding challenges and opportunities remain to be addressed.
Analysis of transmission mode of a matched fiber Bragg grating interrogation scheme
Publisher: The Optical Society
Date: 11-08-2010
DOI: 10.1364/AO.49.004498
Effective optical constants of anisotropic silver nanoparticle films with plasmonic properties: erratum
Publisher: The Optical Society
Date: 07-03-2017
DOI: 10.1364/OL.42.001092
Versatile SERS sensing based on black silicon
Publisher: The Optical Society
Date: 04-03-2015
DOI: 10.1364/OE.23.006763
Analysis of defects patterned by femtosecond pulses inside KBr and SiO2 glass
Publisher: Springer Science and Business Media LLC
Date: 25-02-2016
Trace Level Detection of Water Contamination by SERS
Publisher: AIP
Date: 2010
DOI: 10.1063/1.3482296
Surface Brillouin scattering of opaque solids and thin supported films
Publisher: Elsevier BV
Date: 03-2000
DOI: 10.1016/S0041-624X(99)00199-7
Abstract: Surface Brillouin scattering (SBS) has been used successfully for the study of acoustic excitations in opaque solids and thin supported films, at both ambient and high temperatures. A number of different systems have been investigated recently by SBS including crystalline silicon, amorphous silicon layers produced by ion bombardment and their high temperature recrystallisation, vanadium carbides, and a nickel-based superalloy. The most recent development includes the measurement of a supported gold film at high pressure. The extraction of the elastic constants is successfully accomplished by a combination of the angular dependence of surface wave velocities and the longitudinal wave threshold within the Lamb shoulder. The application of surface Green's function methods successfully reproduces the experimental SBS spectra. The discrepancies often observed between surface wave velocities and by ultrasonics measurements have been investigated and a detailed correction procedure for the SBS measurements has been developed.
Composite scarf repair monitoring using fiber Bragg grating sensors
Publisher: SPIE
Date: 06-04-2007
DOI: 10.1117/12.715516
Optical fibre techniques for distributed corrosion sensing
Publisher: IEEE
Date: 07-2006
MEMS micropump characterization and control utilizing a fibre optic Interferometer
Publisher: SPIE
Date: 11-2002
DOI: 10.1117/12.469401
Metallic nanoparticles for peripheral nerve regeneration: is it a feasible approach?
Publisher: Medknow
Date: 2015
Effect of embedded optical fibres on the mechanical properties of cochlear electrode arrays
Publisher: Elsevier BV
Date: 02-2016
DOI: 10.1016/J.MEDENGPHY.2015.11.015
Abstract: Incorporating optical fibres in cochlear electrode arrays has been proposed to provide sensors to help minimise insertion trauma and also for the delivery of light in optical nerve stimulation applications. However, embedding an optical fibre into an electrode array may change its stiffness properties, which can affect the level of trauma during insertion. This report uses measurements of buckling and deflection force to compare the stiffness properties of a range of cochlear electrode arrays (Nucleus straight array, rat array, cat array and guinea pig array) with custom arrays containing an embedded optical fibre. The cladding diameters of the optical fibres tested were 125 µm, 80 µm and 50 µm. The results show that the stiffness of the optical-fibre-embedded arrays is related to the diameter of the optical fibre. Comparison with wired arrays suggests optical fibres with a diameter of 50 µm could be embedded into an electrode array without significantly changing the stiffness properties of the array.
Chemical sensors based on nanoparticle arrays
Publisher: SPIE
Date: 11-2002
DOI: 10.1117/12.471960
Statistically quantified measurement of an Alzheimer's marker by surface-enhanced Raman scattering
Publisher: Wiley
Date: 13-08-2015
Abstract: Fibrillar forms of the Amyloid-β (Aβ) protein have been implicated in the early stages of Alzheimer's disease (AD), however there are no standardised assays for soluble Aβ oligomer biomarkers that provide the best indication of the disease progression [1,2]. As a step towards a fast and label-free method for testing different AD biomarkers, we have combined laser nano-textured substrates with a SERS mapping technique and validated it using soluble Aβ-40 oligomers [3-5]. The nano-textured SERS substrates provide fast ( min), label-free spectra associated with soluble Aβ-40 oligomers down to a concentration of 10 nM. Statistical analysis of the spectral intensities mapped over the substrate surface shows a quantitative correlation with the oligomer concentration. Schematics of experiments: SERS mapping of Aβ-40 (left figure: measured SERS intensity overlayed with an SEM image of ripples) was carried out on the laser nano-textured (ripple) surface of sapphire and statistical analysis of the SERS intensity was carried out for qualitative (a high SERS intensity at low probability) and quantitative (a moderate SERS intenisty at the highest probability) measures. Quantitative statistical analysis of SERS mapping data can be performed off line for cross correlations with other known SERS signatures.
Fabrication of a range of SERS substrates on nanostructured multicore optical fibres
Publisher: Wiley
Date: 03-12-2006
DOI: 10.1002/JRS.1656
Extending In-Plane Impedance Measurements from 2D to 3D Cultures: Design Considerations
Publisher: MDPI AG
Date: 13-01-2021
DOI: 10.3390/BIOENGINEERING8010011
Abstract: Three-dimensional (3D) cell cultures have recently emerged as tools for biologically modelling the human body. As 3D models make their way into laboratories there is a need to develop characterisation techniques that are sensitive enough to monitor the cells in real time and without the need for chemical labels. Impedance spectroscopy has been shown to address both of these challenges, but there has been little research into the full impedance spectrum and how the different components of the system affect the impedance signal. Here we investigate the impedance of human fibroblast cells in 2D and 3D collagen gel cultures across a broad range of frequencies (10 Hz to 5 MHz) using a commercial well with in-plane electrodes. At low frequencies in both 2D and 3D models it was observed that protein adsorption influences the magnitude of the impedance for the cell-free s les. This effect was eliminated once cells were introduced to the systems. Cell proliferation could be monitored in 2D at intermediate frequencies (30 kHz). However, the in-plane electrodes were unable to detect any changes in the impedance at any frequency when the cells were cultured in the 3D collagen gel. The results suggest that in designing impedance measurement devices, both the nature and distribution of the cells within the 3D culture as well as the architecture of the electrodes are key variables.
Surface-enhanced Raman scattering sensor based on laser nano-textured surfaces
Publisher: IEEE
Date: 12-2012
Optical fiber sensor based on oblique angle deposition
Publisher: The Optical Society
Date: 06-01-2011
DOI: 10.1364/AO.50.000155
Nanoimprinted optical fibres: Biotemplated nanostructures for SERS sensing
Publisher: Elsevier BV
Date: 2009
DOI: 10.1016/J.BIOS.2008.10.016
Abstract: Optical fibre surface-enhanced Raman scattering (SERS) sensors offer a potential solution for monitoring low chemical concentrations in remote or in situ sensing scenarios. The SERS effect relies on the interaction of analyte molecules with nanostructured metal surfaces. We demonstrate a nanoscale biotemplating approach to fabricating these sensors, using nanoimprint lithography to replicate cicada wing antireflective nanostructures onto the end faces of standard silica optical fibres. These SERS-compatible nanoarrays are coated with silver to make them SERS active, and thiophenol and rhodamine 6G are used as test analytes, from which strong SERS spectra are collected using both direct endface illumination and through-fibre interrogation. This combination of biological templates with nanoscale replication and optical fibres demonstrates a high-resolution, low-cost approach to fabricating high-performance optical fibre SERS sensors.
Inhibition or acceleration: Bacterial test media can determine the course of microbiologically influenced corrosion
Publisher: Elsevier BV
Date: 09-2014
Origins of spectral changes in fiber bragg gratings due to macrobending
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 11-2012
Influence of carbon steel grade on the initial attachment of bacteria and microbiologically influenced corrosion
Publisher: Informa UK Limited
Date: 02-01-2016
DOI: 10.1080/08927014.2015.1128528
Abstract: The influence of the composition and microstructure of different carbon steel grades on the initial attachment (≤ 60 min) of Escherichia coli and subsequent longer term (28 days) corrosion was investigated. The initial bacterial attachment increased with time on all grades of carbon steel. However, the rate and magnitude of bacterial attachment varied on the different steel grades and was significantly less on the steels with a higher pearlite phase content. The observed variations in the number of bacterial cells attached across different steel grades were significantly reduced by applying a fixed potential to the steel s les. Longer term immersion studies showed similar levels of biofilm formation on the surface of the different grades of carbon steel. The measured corrosion rates were significantly higher in biotic conditions compared to abiotic conditions and were found to be positively correlated with the pearlite phase content of the different grades of carbon steel coupons.
Improved methods for fluorescence background subtraction from Raman spectra
Publisher: Wiley
Date: 02-09-2013
DOI: 10.1002/JRS.4371
Modeling of light absorption in tissue during infrared neural stimulation
Publisher: SPIE-Intl Soc Optical Eng
Date: 06-07-2012
Controlled release from PCL–alginate microspheres via secondary encapsulation using GelMA/HAMA hydrogel scaffolds
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C8SM02575D
Abstract: The release profile of a bioactive-model molecule from alginate/PCL–alginate microspheres resulted depending on the degree of functionalization and the crosslink of 3-dimensional scaffolds.
Infrared neural stimulation fails to evoke neural activity in the deaf guinea pig cochlea.
Publisher: Elsevier BV
Date: 06-2015
DOI: 10.1016/J.HEARES.2015.03.005
Abstract: At present there is some debate as to the processes by which infrared neural stimulation (INS) activates neurons in the cochlea, as the lasers used for INS can potentially generate a range of secondary stimuli e.g. an acoustic stimulus is produced when the light is absorbed by water. To clarify whether INS in the cochlea requires functioning hair cells and to explore the potential relevance to cochlear implants, experiments using INS were performed in the cochleae of both normal hearing and profoundly deaf guinea pigs. A response to laser stimulation was readily evoked in normal hearing cochlea. However, no response was evoked in any profoundly deaf cochleae, for either acute or chronic deafening, contrary to previous work where a response was observed after acute deafening with ototoxic drugs. A neural response to electrical stimulation was readily evoked in all cochleae after deafening. The absence of a response from optical stimuli in profoundly deaf cochleae suggests that the response from INS in the cochlea is hair cell mediated.
Nanostructured optical fiber with surface-enhanced Raman scattering functionality
Publisher: Optica Publishing Group
Date: 15-03-2005
DOI: 10.1364/OL.30.000598
Abstract: A powerful method for the production of reproducible surface-enhanced Raman scattering (SERS) substrates is described based on the scaling properties of glass rods when drawn into fibers. The fabrication process involves chemically eroding the cleaved tips of drawn silica imaging fibers and then coating them with silver. For an appropriate choice of final diameter the drawn and eroded tips show clearly defined and regular triangular formations on a scale of approximately 80 nm. The favorable SERS properties of these structures have been demonstrated by the observation of enhancement factors of approximately 10(6).
UV illumination for electron and ion beam microscopy and nanofabrication
Publisher: SPIE
Date: 09-09-2019
DOI: 10.1117/12.2528681
Corrigendum: Novel aluminum near field transducer and highly integrated micro-nano-optics design for heat-assisted ultra-high-density magnetic recording (2014 Nanotechnology 25 295202)
Publisher: IOP Publishing
Date: 20-10-2014
High-temperature elastic properties of a nickel-based superalloy studied by surface Brillouin scattering
Publisher: IOP Publishing
Date: 22-02-2001
Confocal fluorescence polarization microscopy for linear unmixing of spectrally similar labels
Publisher: Elsevier BV
Date: 02-2009
DOI: 10.1016/J.MICRON.2008.09.005
Abstract: Studies of biological s les often call for simultaneous identification of multiple molecular or structural components. Multiple labelling fluorescence techniques are a powerful way of achieving this. However, the ability to distinguish a number of fluorescent probes unambiguously can be restricted by the fact that fluorescence spectra are generally broad and overlapping. Recently a technique known as linear unmixing has been combined with spectral imaging to discriminate between multiple fluorophores. In this study a scheme is proposed whereby fluorescence polarization information is used to expand the capability of the linear unmixing technique to accommodate additional fluorescent probes. As a proof-of-concept, it is shown that this polarization-based technique can be used to ide the signals generated by two spectrally similar fluorescent probes into their separate components.
High-temperature studies of surface acoustic wave velocities in silicon by Brillouin scattering
Publisher: Elsevier BV
Date: 04-1996
Development of an optical fiber SERS microprobe for minimally invasive sensing applications
Publisher: SPIE
Date: 20-02-2018
DOI: 10.1117/12.2289227
Gold Nanoparticles for Modulating Neuronal Behavior
Publisher: MDPI AG
Date: 24-04-2017
DOI: 10.3390/NANO7040092
Thermal damage threshold of neurons during infrared stimulation
Publisher: Optica Publishing Group
Date: 27-03-2020
DOI: 10.1364/BOE.383165
Abstract: In infrared neural stimulation (INS), laser-evoked thermal transients are used to generate small depolarising currents in neurons. The laser exposure poses a moderate risk of thermal damage to the target neuron. Indeed, exogenous methods of neural stimulation often place the target neurons under stressful non-physiological conditions, which can hinder ordinary neuronal function and hasten cell death. Therefore, quantifying the exposure-dependent probability of neuronal damage is essential for identifying safe operating limits of INS and other interventions for therapeutic and prosthetic use. Using patch-cl recordings in isolated spiral ganglion neurons, we describe a method for determining the dose-dependent damage probabilities of in idual neurons in response to both acute and cumulative infrared exposure parameters based on changes in injection current. The results identify a local thermal damage threshold at approximately 60 ° C, which is in keeping with previous literature and supports the claim that damage during INS is a purely thermal phenomenon. In principle this method can be applied to any potentially injurious stimuli, allowing for the calculation of a wide range of dose-dependent neural damage probabilities. Unlike histological analyses, the technique is well-suited to quantifying gradual neuronal damage, and critical threshold behaviour is not required.
Active control of silver nanoparticles spacing using dielectrophoresis for surface-enhanced Raman scattering
Publisher: American Chemical Society (ACS)
Date: 11-04-2012
DOI: 10.1021/AC203381N
Abstract: We demonstrate an active microfluidic platform that integrates dielectrophoresis for the control of silver nanoparticles spacing, as they flow in a liquid channel. By careful control of the nanoparticles spacing, we can effectively increase the surface-enhanced Raman scattering (SERS) signal intensity based on augmenting the number of SERS-active hot-spots, while avoiding irreversible aggregation of the particles. The system is benchmarked using dipicolinate (2,6-pyridinedicarboxylic acid) (DPA), which is a biomarker of Bacillus anthracis. The validity of the results is discussed using several complementing characterization scenarios.
Tuning drug dosing through matching optically active polymer composition and NIR stimulation parameters
Publisher: Elsevier BV
Date: 02-2020
DOI: 10.1016/J.IJPHARM.2019.118976
Abstract: Controlled release is at the forefront of modern bioscience as it aims to address challenges associated with the dosing of drugs within required levels for therapeutic effect. Many materials and approaches can be used to control the release from different reservoirs including nanoparticles, liposomes and hydrogels. Using thermoresponsive hydrogels, near infrared illumination of plasmonic nanoparticles can be used to control the hydrogel through localised surface plasmon resonance heating. This work extends beyond a material level and pursues detailed examination of the drug release characteristics of a variable acrylic acid poly(N-isopropylacrylamide) coated gold nanorod system using dexamethasone as a model drug. Release was examined under different irradiation power densities and exposure times. Bulk heating effects in all stimulation protocols did not exceed the lower critical solution temperature of the system, but a marked increase in release was seen following stimulation. This was likely due to more intense heating occurring around the nanorods. A release model was established to describe the amount of drug eluted relative to input energy, suggesting that shorter irradiation periods release the drug more efficiently. The data reported establishes plasmonically modulated thermosensitive hydrogels as a candidate material that can be tailored to specific clinical applications of stimulated release.
Nanoparticle-enhanced infrared neural stimulation
Publisher: IOP Publishing
Date: 24-11-2014
DOI: 10.1088/1741-2560/11/6/065002
Abstract: Recent research has demonstrated that nerves can be stimulated by transient heating associated with the absorption of infrared light by water in the tissue. There is a great deal of interest in using this technique in neural prostheses, due to the potential for increased localization of the stimulus and minimization of contact with the tissue. However, thermal modelling suggests that the full benefits of increased localization may be reduced by cumulative heating effects when multiple stimulus sites and/or high repetition rates are used. Here we review recent in vitro and in vivo results suggesting that the transient heating associated with plasmon absorption in gold nanorods can also be used to stimulate nerves. Patch cl experiments on cultured spiral ganglion neurons exhibited action potentials when exposed to 780 nm light at the plasmon absorption peak, while the litude of compound action potentials in the rat sciatic nerve were increased by laser irradiation of gold nanorods in the vicinity of the plasma membrane. Similarly, calcium imaging studies of NG108-15 neuronal cells incubated with Au nanorods revealed an increased level of intracellular calcium activity synchronized with laser exposure. Given that the plasmon absorption peak of gold nanorods can be matched with the transparency window of biological tissues, these results demonstrate that nanorod absorbers hold great promise to enhance the process of infrared neural stimulation for future applications in neural prostheses and fundamental studies in neuroscience.
The Effect of the Cladding Refractive Index on an Optical Fiber Evanescent-Wave Sensor
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 10-2013
Surface‐enhanced Raman scattering sensing on black silicon
Publisher: Wiley
Date: 17-06-2013
Gold Nanorod-assisted Optical Stimulation of Neuronal Cells
Publisher: MyJove Corporation
Date: 27-04-2015
DOI: 10.3791/52566
Fluorescence-based distributed chemical sensing for structural health monitoring
Publisher: SPIE
Date: 26-12-2008
DOI: 10.1117/12.814703
Parametric study of surface melting in zinc-aluminium coated steels
Publisher: Inderscience Publishers
Date: 2014
Laser exposure of gold nanorods can induce intracellular calcium transients
Publisher: Wiley
Date: 25-06-2013
Abstract: Uncoated and poly(styrene sulphonate) (PSS)-coated gold nanorods were taken up by NG108-15 neuronal cells. Exposure to 780 nm laser light at the plasmon resonance wavelength of the gold nanorods was found to induce intracellular Ca(2+) transients. The higher Ca(2+) peaks were observed at lower laser doses, with the highest levels obtained at a radiant exposure of 0.33 J/cm(2) . In contrast, the cells without nanoparticles showed a consistently small response, independent of the laser dose. These initial results open up new opportunities for peripheral nerve regeneration treatments and for more efficient optical stimulation techniques.
Nano-rescaling of gold films on polystyrene: Thermal management for SERS
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C6NR06904E
Abstract: Nano-textured Au surfaces were prepared on pre-stretched 2D polystyrene (PS) sheets sputtered with different thicknesses of Au. The Au-coated PS was subjected to thermal annealing above the glass transition temperature at ∼150 °C, thus undergoing surface area rescaling via a volume phase transition. The yellow color of the Au changed from the typical mirror-like appearance to a diffusive dark yellow, progressing to dark brown at the smallest feature size, hence, electromagnetic energy was coupled into the substrate. While the surface area footprint is the same after shrinking the PS, the roughness can be modified from the nano- to the micro-scale for different initial thicknesses of sputtered Au. The nanometer-sized features of surface wrinkles on the Au films make them suitable for surface-enhanced Raman scattering (SERS) sensors that can reach ∼10
Optical fibers and sensors for biomedical applications: Bend effects
Publisher: SPIE
Date: 15-05-2011
DOI: 10.1117/12.885877
Temperature-independent Bragg grating-based sensor for monitoring regions of localised strain concentration
Publisher: SPIE
Date: 26-03-2009
DOI: 10.1117/12.817498
Dielectrophoresis-Raman spectroscopy system for analysing suspended nanoparticles
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C0LC00481B
Abstract: A microfluidic dielectrophoresis platform consisting of curved microelectrodes was developed and integrated with a Raman spectroscopy system. The electrodes were patterned on a quartz substrate, which has insignificant Raman response, and integrated with a microfluidic channel that was imprinted in poly-dimethylsiloxane (PDMS). We will show that this novel integrated system can be efficiently used for the determination of suspended particle types and the direct mapping of their spatial concentrations. We will also illustrate the system's unique advantages over conventional optical systems. Nanoparticles of tungsten trioxide (WO(3)) and polystyrene were used in the investigations, as they are Raman active and can be homogeneously suspended in water.
Dynamic optical clamp: A novel electrophysiology tool and a technique for closed-loop stimulation
Publisher: Elsevier BV
Date: 08-2023
All Femtosecond Optical Pump and X-Ray Probe: Holey-Axicon for Free Electron Laser
Publisher: MDPI AG
Date: 26-05-2020
DOI: 10.20944/PREPRINTS202005.0416.V1
Abstract: We put forward a co-axial pump(optical)-probe(X-rays) experimental concept and show performance of the optical component. A Bessel beam generator with a central 100 micrometers-diameter hole (on the optical axis) was fabricated using femtosecond (fs) laser structuring inside a silica plate. This flat-axicon optical element produces a needle-like axial intensity distribution which can be used for the optical pump pulse. The fs-X-ray free electron laser (X-FEL) beam of sub-1 micrometer diameter can be introduced through the central hole along the optical axis onto a target as a probe. Different realisations of optical pump are discussed. Such optical elements facilitate alignment of ultra-short fs-pulses in space and time and can be used in light-matter interaction experiments at extreme energy densities on the surface and in the volume of targets. Full advantage of ultra-short 10 fs X-FEL probe pulses with fs-pump(optical) opens an unexplored temporal dimension of phase transitions and the fastest laser-induced rates of material heating and quenching. A wider field of applications of fs-laser-enabled structuring of materials and design of specific optical elements for astrophotonics is presented.
Modeling of the temporal effects of heating during infrared neural stimulation
Publisher: SPIE-Intl Soc Optical Eng
Date: 07-03-2013
Nanoimprinted optical fibres: Biotemplated nanostructures for SERS sensing
Publisher: IEEE
Date: 07-2008
Effective optical constants of anisotropic silver nanoparticle films with plasmonic properties
Publisher: The Optical Society
Date: 22-11-2016
DOI: 10.1364/OL.41.005495
Health monitoring of bonded composite repairs using fibre optic sensors
Publisher: SPIE
Date: 16-03-2006
DOI: 10.1117/12.658414
Plasmonic properties of gold nanoparticles can promote neuronal activity
Publisher: SPIE
Date: 15-02-2013
DOI: 10.1117/12.2002291
Additional enhancement in surface-enhanced Raman scattering due to excitation geometry
Publisher: SPIE
Date: 31-01-2012
DOI: 10.1117/12.915963
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Amount: $300,000.00
Funder: Australian Research Council
View Funded ActivitySpecial Research Initiatives - Grant ID: SR0354658
Start Date: 01-2004
End Date: 12-2003
Amount: $10,000.00
Funder: Australian Research Council
View Funded ActivityLinkage Projects - Grant ID: LP0883584
Start Date: 07-2008
End Date: 02-2012
Amount: $180,000.00
Funder: Australian Research Council
View Funded ActivityLinkage Infrastructure, Equipment And Facilities - Grant ID: LE0989726
Start Date: 2009
End Date: 12-2009
Amount: $250,000.00
Funder: Australian Research Council
View Funded ActivityLinkage Infrastructure, Equipment And Facilities - Grant ID: LE170100072
Start Date: 04-2017
End Date: 06-2019
Amount: $600,000.00
Funder: Australian Research Council
View Funded ActivityLinkage Infrastructure, Equipment And Facilities - Grant ID: LE140100162
Start Date: 2014
End Date: 2015
Amount: $300,000.00
Funder: Australian Research Council
View Funded ActivityLinkage Infrastructure, Equipment And Facilities - Grant ID: LE220100150
Start Date: 08-2022
End Date: 07-2023
Amount: $320,000.00
Funder: Australian Research Council
View Funded ActivityLinkage Infrastructure, Equipment And Facilities - Grant ID: LE150100001
Start Date: 2015
End Date: 12-2015
Amount: $410,000.00
Funder: Australian Research Council
View Funded ActivityLinkage Infrastructure, Equipment And Facilities - Grant ID: LE140100090
Start Date: 04-2014
End Date: 12-2016
Amount: $200,000.00
Funder: Australian Research Council
View Funded ActivityLinkage Projects - Grant ID: LP120100264
Start Date: 2012
End Date: 07-2015
Amount: $410,000.00
Funder: Australian Research Council
View Funded Activity