ORCID Profile
0000-0001-7253-1167
Current Organisation
University of South Australia
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Publisher: Routledge
Date: 22-11-2017
Publisher: Informa UK Limited
Date: 15-03-2023
Publisher: Routledge
Date: 17-04-2018
Publisher: Elsevier BV
Date: 03-2019
Publisher: Springer Science and Business Media LLC
Date: 07-01-2021
DOI: 10.1038/S41419-020-03283-2
Abstract: Interleukin-38 has recently been shown to have anti-inflammatory properties in lung inflammatory diseases. However, the effects of IL-38 in viral pneumonia remains unknown. In the present study, we demonstrate that circulating IL-38 concentrations together with IL-36α increased significantly in influenza and COVID-19 patients, and the level of IL-38 and IL-36α correlated negatively and positively with disease severity and inflammation, respectively. In the co-cultured human respiratory epithelial cells with macrophages to mimic lung microenvironment in vitro, IL-38 was able to alleviate inflammatory responses by inhibiting poly(I:C)-induced overproduction of pro-inflammatory cytokines and chemokines through intracellular STAT1, STAT3, p38 MAPK, ERK1/2, MEK, and NF-κB signaling pathways. Intriguingly, transcriptomic profiling revealed that IL-38 targeted genes were associated with the host innate immune response to virus. We also found that IL-38 counteracts the biological processes induced by IL-36α in the co-culture. Furthermore, the administration of recombinant IL-38 could mitigate poly I:C-induced lung injury, with reduced early accumulation of neutrophils and macrophages in bronchoalveolar lavage fluid, activation of lymphocytes, production of pro-inflammatory cytokines and chemokines and permeability of the alveolar-epithelial barrier. Taken together, our study indicates that IL-38 plays a crucial role in protection from exaggerated pulmonary inflammation during poly(I:C)-induced pneumonia, thereby providing the basis of a novel therapeutic target for respiratory viral infections.
Publisher: Routledge
Date: 22-11-2017
Publisher: MDPI AG
Date: 05-05-2021
DOI: 10.3390/SU13095158
Abstract: This paper evaluates the method Social Life Cycle Assessment (S-LCA) from the perspectives of Indigenous methodologies and Indigenous standpoint, in order to identify some strengths and limitations of using S-LCA in Indigenous contexts. Life Cycle Assessment (LCA) is used to measure environmental impacts connected with all stages of the life cycle of a commercial product, process, or service. S-LCA is a methodology designed to include the social aspects of sustainability in the LCA methodology. S-LCA emphasizes stakeholder involvement and the United Nations Environment Programme (UNEP) S-LCA guidelines (2020) lists Indigenous communities as possible stakeholders. With a focus on Indigenous communities in the Arctic region we also include comparative aspects from Australia to generate new conceptualizations and understandings. The paper concludes that S-LCA has the potential to facilitate opposing worldviews and with some further developments can be a valuable methodology for Indigenous contexts.
Publisher: MDPI AG
Date: 23-08-2019
DOI: 10.3390/SU11174589
Abstract: Aboriginal tourism entrepreneurs operating in remote regions of Australia draw on their 60,000 years of heritage to offer unique and distinct cultural experiences to domestic and international tourists. Living and operating in remote climates presents challenges to achieving successful and sustainable enterprises, including extreme weather, substandard infrastructure, distance from policy makers, distance from markets and the commercialisation of culture, which is customarily owned by and for use by traditional custodians, to produce and deliver a market-ready tourism product. However, many remote Aboriginal tourism entrepreneurs nevertheless achieve success and sustainability. This paper builds on the work of Foley to identify the characteristics of successful remote Aboriginal tourism enterprises and Aboriginal entrepreneurs in remote areas and the resourceful and creative business practices used by remote Aboriginal entrepreneurs to overcome barriers to success and finds that ongoing connections to community and culture are a key factor in that success. It also draws on the United Nation’s Sustainable Development Goals to identify how the characteristics of remote tourism entrepreneurs and enterprises promote or inhibit the achievement of sustainability and suggests that they offer a framework for effective support of remote Aboriginal entrepreneurs. It concludes by noting that the industry would benefit from further investigation of the contributions made to sustainability by remote Aboriginal tourism enterprises and their stakeholders.
Publisher: Informa UK Limited
Date: 16-01-2020
Publisher: Informa UK Limited
Date: 08-10-2023
Publisher: SAGE Publications
Date: 18-12-2023
DOI: 10.1177/14707853221145845
Abstract: Indigenous groups voices have often been missing from the marketing research collegiate. The Aboriginal and Torres Strait Islander Peoples of the land now known as Australia, for ex le, are among the most researched peoples in the world (Martin & Mirraboopa, 2003), yet are underrepresented among research practitioners. The present underrepresentation among practitioners is only slowly, and occasionally haphazardly, being addressed by the growing number of more junior Indigenous researchers entering the field. Until greater representation among senior researchers is achieved, research teams are likely to include a mixture of Indigenous and non-Indigenous researchers. Such teams must therefore address a unique combination of power imbalance and minority inclusion in how they work. This need for inclusion can become more challenging for research teams when the research topic addresses issues impacting Indigenous peoples. And while numerous ethical and research guidelines exist for how researchers work with participants who are members of a minority group and are likely to have less power, there are few frameworks addressing how such challenges should be managed for the researchers within a research team. In this paper, we use an action research method to critically reflect on how to manage research teams that include more junior Indigenous researchers whose voices are vital to the research project. Reflexive and proactive processes were developed to ensure a culture of reflection both regarding interactions within the research team and in the project. To structure and share these reflections, the team developed and enunciated a fit-for-purpose framework. This framework was informed by the work of Narungga Professor Rigney (1999) that lists foundational Indigenist research methods. The framework also draws on the layers of reflexivity proposed by Nicholls (2009) and insider/outsider group theory previously advocated for (Ameka, 2018).
No related grants have been discovered for Skye Akbar.