ORCID Profile
0000-0001-9606-6255
Current Organisation
Swinburne University of Technology
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Chemical Thermodynamics And Energetics | Analytical Chemistry | Biochemistry And Cell Biology Not Elsewhere Classified | Nanotechnology | Solid State Chemistry | Nanotechnology | Colloid And Surface Chemistry | Analytical Spectrometry | Materials Engineering | Chemical Characterisation of Materials | Alloy Materials |
Inorganic industrial chemicals | Energy storage | Gas—conversion to liquid fuels | Clinical health not specific to particular organs, diseases and conditions | Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences | Treatments (e.g. chemicals, antibiotics) | Physical sciences | Expanding Knowledge in the Medical and Health Sciences
Publisher: The Chemical Society of Japan
Date: 05-03-2013
DOI: 10.1246/CL.2013.235
Publisher: Elsevier BV
Date: 09-2015
DOI: 10.1016/J.BIOS.2015.04.061
Abstract: A novel ultrasensitive immunoassay method was developed by combination of the enzymatically catalytic gold deposition with the prepared gold nanoprobe and the gold stripping analysis at an electrochemical chip based immunosensor. The immunosensor was constructed through covalently immobilizing capture antibody at a carbon nanotube (CNT) modified screen-printed carbon electrode. The gold nanoprobe was prepared by loading signal antibody and high-content glucose oxidase (GOD) on the nanocarrier of gold nanorod (Au NR). After sandwich immunoreaction, the GOD-Au NR nanoprobe could be quantitatively captured onto the immunosensor surface and then induce the deposition of gold nanoparticles (Au NPs) via the enzymatically catalytic reaction. Based on the electrochemical stripping analysis of the Au NR nanocarriers and the enzymatically produced Au NPs, sensitive electrochemical signal was obtained for the immunoassay. Both the GOD-induced deposition of Au NPs by the nanoprobe and the sensitive electrochemical stripping analysis on the CNTs based sensing surface greatly lified the signal response, leading to the ultrahigh sensitivity of this method. Using carcinoembryonic antigen as a model analyte, excellent analytical performance including a wide linear range from 0.01 to 100 ng/mL and a detection limit down to 4.2 pg/mL was obtained. In addition, this immunosensor showed high specificity and satisfactory reproducibility, stability and reliability. The relatively positive detection potential excluded the conventional interference from dissolved oxygen. Thus this electrochemical chip based immunosensing method provided great potentials for practical applications.
Publisher: Elsevier BV
Date: 06-2018
Publisher: American Chemical Society (ACS)
Date: 10-05-2003
DOI: 10.1021/AC0340049
Abstract: Polyelectrolyte (PE)-encapsulated catalase microcrystals were assembled onto gold electrodes by their sequential deposition with oppositely charged PEs, utilizing electrostatic interactions to form enzyme thin films for biosensing. The PE coating around the microcrystals provided a regular surface charge, thus facilitating the stepwise film growth, and it effectively prevented catalase leakage from the assembled films. The encapsulated catalase was shown to retain both its biological and its electrochemical activity. Direct electron transfer between catalase molecules and the gold electrode was achieved without the aid of any electron mediator. In pH 5.0 phosphate buffer solution, the apparent formal potential (E(o)') of catalase was -0.131 V (vs Ag/AgCl). As a H2O2 biosensor, films consisting of one layer of the encapsulated catalase displayed considerably higher (approximately 5-fold) and more stable electrocatalytic responses to the reduction of H2O2 than did corresponding films made of one layer of nonencapsulated catalase or solubilized catalase. An increase in either the number of "precursor" PE layers between the gold electrodes and the catalase microcrystal layers in the film or the number of PE layers encapsulating the catalase microcrystals was found to decrease the electrocatalytic activity of the electrode. At low precursor PE layer numbers (approximately 2) and PE encapsulating layers (approximately 4), the current response was proportional to the H2O2 concentration in the range 3.0 x 10(-6) to 1.0 x 10(-2) M. The overall electroactivity of the multilayer film increased for the first two layers of encapsulated catalase, after which a plateau was observed. This was attributed to the increasing difficulty of electron transfer and substrate diffusion limitations. The current approach of using immobilized PE-encapsulated enzyme microcrystals for biosensing provides a versatile method to prepare high enzyme content films with high and tailored enzyme activities.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5RA02661J
Abstract: Sensitive electrochemical nitrite sensors based on in situ stepwise formation of Pd nanoparticles and reduced graphene oxide on electrodes.
Publisher: Wiley
Date: 15-05-2020
Abstract: Polymeric hollow capsules have attracted increasing interest for the development of controlled drug delivery systems due to their capacities to load high amount of drugs and be able to finely tune the drug release profile. Various methods and strategies for capsule preparation and drug loading have been developed over time. Besides that, the controlled drug release from hollow capsules upon external and internal triggers is of great interest and has been a research focus in this area. This article aims to give the most recent progress review on hollow capsule based controlled drug delivery systems with a highlight on strategies being used for drug loading and stimuli‐release. In detail, the fabrication of hollow capsules using template‐assisted or template‐free methods will be introduced first. This will be followed by current strategies for pre‐loading and post‐loading of therapeutic agents into capsules. The article will then be particularly focused on discussing erse drug‐release systems corresponding to various stimuli conditions including temperature, pH, ultrasound, light irradiation and enzyme degradation.
Publisher: American Scientific Publishers
Date: 02-2009
Abstract: Three-dimensional (3D) colloidal crystals with polyelectrolyte (PE)/nanoparticles (NPs) hybrid shells were fabricated by crystallization of PE multilayer-coated colloidal particles on quartz substrates followed by in-situ synthesis of NPs within the PE shell via ion-exchange and chemical reduction. Both metal (Ag) and semiconductor (CdS) NPs could be formed on the particle shell. It was also demonstrated that the position of the stop band of the colloidal crystal could be finely tuned by adjusting the shell composition.
Publisher: Frontiers Media SA
Date: 28-08-2018
Publisher: Informa UK Limited
Date: 15-09-2012
Publisher: Elsevier BV
Date: 2020
Publisher: Public Library of Science (PLoS)
Date: 11-11-2016
Publisher: Springer Science and Business Media LLC
Date: 08-01-2018
DOI: 10.1007/S00604-017-2646-9
Abstract: Nitrogen doped carbon dots (NCDs) were synthesized using a low temperature approach and used to modify a glassy carbon electrode (GCE) via dipping. The oxygen groups on the surface of the NCDs, and the charge delocalization of the NCDs warrant an excellent electrocatalytic activity of the GCE toward oxidation of paracetamol (PA) and reduction of H
Publisher: Elsevier BV
Date: 06-2019
Publisher: Cambridge University Press (CUP)
Date: 23-03-2012
DOI: 10.1017/S147474641200005X
Abstract: Internationally, over the past two decades the theme of personalisation has driven significant reforms within health and social care services. In the Australian context, the principles of ‘entitlement based on need’ and ‘personalisation’ frame the proposed National Disability Long-Term Care and Support Scheme (LTCSS). In this article, we critically examine the interpretations and ambiguities of need and personalisation. We consider the administrative complexities of applying these principles in practice and the uncertainties about the roles of state and the market, and use in idual case ex les to illustrate areas of potential tension. Whether principles translate to deliver personalised services and avoid harmful trade-offs between access, equity and choice is the true test of social policy.
Publisher: American Chemical Society (ACS)
Date: 19-12-2020
DOI: 10.1021/ACS.ANALCHEM.9B05002
Abstract: When the target biorecognition-triggered assembly of two Mg
Publisher: Wiley
Date: 18-07-2016
Publisher: Elsevier BV
Date: 06-1997
Publisher: Elsevier BV
Date: 07-2012
Publisher: Elsevier BV
Date: 10-2015
DOI: 10.1016/J.SAA.2015.04.049
Abstract: A simple method was developed to synthesize Ag dendrites/reduced graphene oxide (AgD/RGO) composites based on the galvanic displacement method. AgNO3 was used as the precursor for Ag dendrites and aluminum foils served as the sacrifice metal. The as-synthesized AgD/RGO composite was characterized by SEM, FTIR, UV-vis spectroscopy and Raman spectroscopy. The results showed that the graphene oxide was successfully incorporated into the Ag dendritic structure and was reduced during the galvanic displacement between Ag(+) ions and the aluminum foil. XRD analysis revealed that the Ag formed in the composite was in the cubic phase. The surface-enhanced Raman scattering (SERS) property of the as synthesized AgD/RGO composite was evaluated using Rhodamine B as a probe. The composite deposited substrate exhibited a much higher SERS activity compared with substrates modified with Ag dendrites or GO, indicating that the AgD/RGO could potentially be used as a highly sensitive SERS substrate for molecule detecting applications.
Publisher: Elsevier BV
Date: 07-2016
Publisher: Universitat Politecnica de Valencia
Date: 03-10-2011
DOI: 10.4995/WRS.2011.866
Publisher: Elsevier BV
Date: 04-2020
Publisher: Elsevier BV
Date: 12-2015
DOI: 10.1016/J.BIOS.2015.07.026
Abstract: A Prussian blue (PB) functionalized mesoporous carbon nanosphere (MCN) composite was prepared for loading signal antibody and high-content glucose oxidase (GOD) to obtain a new nanoprobe for sensitive electrochemical immunoassay. The MCN nanocarrier with an average diameter of 180 nm was synthesized by using mesoporous silica nanosphere as a hard template in combination with a hydrothermal carbonization method. This hydrophilic carbon nanomaterial provided an ideal platform for in situ deposition of high-content PB to form the MCN-PB nanocomposite. Based on the step-wise assembly of polyelectrolyte and gold nanoparticles (Au NPs) on the negative-charged nanocomposite, signal antibody and high-content GOD were loaded on this nanocarrier to obtain the nanoprobe. After a sandwich immunoreaction at an Au NPs-modified screen-printed carbon electrode based immunosensor, the nanoprobes were quantitatively captured on the electrode surface to produce sensitive electrochemical response with a PB-mediated GOD catalytic reaction for immunoassay. The high loading of PB and GOD on the nanoprobe greatly lified the electrochemical signal, leading to the development of a new immunoassay method with high sensitivity. Using human immunoglobulin G as a model analyte, excellent analytical performance including a wide linear range from 0.01 to 100 ng/mL and a low detection limit down to 7.8 pg/mL was obtained. Additionally, the immunosensor showed high specificity, satisfactory stability and repeatability as well as acceptable reliability. The PB-mediated GOD electrochemical system well excluded the conventional interference from the dissolved oxygen. Thus this immunoassay method provides great potentials for practical applications.
Publisher: Wiley
Date: 08-08-2019
Abstract: Since the first time mussel-inspired polymer polydopamine (PDA) was discovered, it has gained enormous attention from numerous scientists, especially those working in the field of drug delivery and bacterial and tumor treatment, due to its distinctive properties, such as surface chemistry, biocompatibility, capability to adhere to any surface, and excellent photothermal conversion. Studies using PDA in various types of structures for therapeutic purposes have been carried out extensively in recent years. Considering the rapid development in the area, this review aims to cover and highlight the latest achievements (from 2016 to present) with respect to PDA-based materials for therapeutic purposes. A description of the erse structures of PDA and its formation strategy, including colloidal particles, hollow structures, and coating films, are discussed. In addition, the main focus of this review is on the therapeutic applications of these PDA nanostructures.
Publisher: Wiley
Date: 18-07-2005
Publisher: Elsevier BV
Date: 2019
DOI: 10.20964/2019.01.64
Publisher: Wiley
Date: 12-04-2007
Publisher: Elsevier BV
Date: 04-2017
DOI: 10.1016/J.ACA.2017.01.030
Abstract: A new colorimetric immunoassay method was developed for the rapid and sensitive detection of a tumor biomarker of carcinoembryonic antigen (CEA) by combination of a magnetic bead (MB)-based sandwich immunoassay and a copper chromogenic reaction. The magnetic immunoassay platform was constructed through the covalent immobilization of the capture antibody on the surface of carboxylated magnetic beads. After immuno-recognition of CEA, signal antibody-functionalized copper oxide nanoparticle (CuO NP) probes were applied for sandwich immunoreaction to form an immunocomplex. The CuO NP labels quantitatively captured onto the immunocomplex were then dissolved in acid solution to release high-content copper ions. Based on the coordination of these ions with the newly synthesized chromogenic agent of 1,2-diphenyl-2-(2-(pyridin-2-yl)hydrazono)ethanone, a red complex was produced for the colorimetric signal readout, resulting in the successful construction of a sensitive immunoassay method for CEA detection. Under the optimum conditions, this method showed a wide linear range over three orders of magnitude and a low detection limit of 26 pg/mL. Besides, this method showed excellent performance with low cost, rapid and convenient operation as well as satisfactory reproducibility, stability and accuracy, thus providing great potentials for practical applications.
Publisher: Wiley
Date: 23-05-2014
Abstract: The smaller, the more fluorescent: The hydrothermal reaction of phenol with hexamethylenetetramine (HMT) leads to two morphologies of phenol formaldehyde resin (PFR), namely, bigger nanoparticles with feeble green fluorescence and smaller amorphous polymers with strong blue-green fluorescence. It reveals that both of them are doped with nitrogen, and the blue-green photoluminescent polymer is confirmed to sense ferric ion (Fe(3+) ) with high selectivity.
Publisher: American Scientific Publishers
Date: 06-2013
Publisher: Elsevier BV
Date: 05-2009
DOI: 10.1016/J.JCIS.2009.01.036
Abstract: We reported the stepwise formation of biocompatible poly(L-lysine) oly(L-glutamic acid) (PLL/PGA) multilayer films on mesoporous silica (MS) spheres via layer-by-layer (LbL) self-assembly technique. In-situ QCM revealed the nonlinear (exponential) growth of PLL/PGA multilayer films at both pH 5.5 and pH 7.0 conditions. Xi-potential measurements of the multilayer coated particles indicated that the multilayer surface was being charge-overcompensated in each adsorption step, thereby facilitating adsorption of the next oppositely charged polypeptide onto the MS spheres. Hollow polypeptide capsules could be obtained by subsequently removing silica cores in HF solution. By using enzyme-preloaded MS spheres as capsule templates, a general approach was developed for encapsulating enzymes in biocompatible microcapsules with high loading and retained bioactivity. The loading amount for several enzymes with different sizes and their bioactivity after encapsulation were also reported.
Publisher: Wiley
Date: 03-05-2005
Publisher: Wiley
Date: 31-08-2016
Publisher: American Chemical Society (ACS)
Date: 12-08-2003
DOI: 10.1021/NL034363J
Publisher: Informa UK Limited
Date: 10-2013
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3GC03094F
Publisher: Springer Science and Business Media LLC
Date: 20-10-2016
Abstract: Rapid DNA sequencing and analysis has been a long-sought goal in remote research and point-of-care medicine. In microgravity, DNA sequencing can facilitate novel astrobiological research and close monitoring of crew health, but spaceflight places stringent restrictions on the mass and volume of instruments, crew operation time, and instrument functionality. The recent emergence of portable, nanopore-based tools with streamlined s le preparation protocols finally enables DNA sequencing on missions in microgravity. As a first step toward sequencing in space and aboard the International Space Station (ISS), we tested the Oxford Nanopore Technologies MinION during a parabolic flight to understand the effects of variable gravity on the instrument and data. In a successful proof-of-principle experiment, we found that the instrument generated DNA reads over the course of the flight, including the first ever sequenced in microgravity, and additional reads measured after the flight concluded its parabolas. Here we detail modifications to the s le-loading procedures to facilitate nanopore sequencing aboard the ISS and in other microgravity environments. We also evaluate existing analysis methods and outline two new approaches, the first based on a wave-fingerprint method and the second on entropy signal mapping. Computationally light analysis methods offer the potential for in situ species identification, but are limited by the error profiles (stays, skips, and mismatches) of older nanopore data. Higher accuracies attainable with modified s le processing methods and the latest version of flow cells will further enable the use of nanopore sequencers for diagnostics and research in space.
Publisher: The Chemical Society of Japan
Date: 05-08-2011
DOI: 10.1246/CL.2011.874
Publisher: Elsevier BV
Date: 08-2019
Publisher: IOP Publishing
Date: 09-10-2007
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6TA06409D
Abstract: We report a facile and general approach for the synthesis of boron nitride nanosheet (BNNS)–metal nanoparticle (NP) composites at room temperature without adding any reducing agent.
Publisher: Informa UK Limited
Date: 12-1996
Publisher: Royal Society of Chemistry (RSC)
Date: 1997
DOI: 10.1039/A607516I
Abstract: Cyclic voltammetry was undertaken to investigate the electrochemical behavior of uric acid at a polyglycine modified electrode. The modified electrode shows catalytic ability for the oxidation of uric acid, reducing the overpotential by 250 mV in pH 7.0 phosphate buffer solution. The enhanced voltammetric response can be used to determine uric acid. The linear range is between 5.0 x 10(-8) and 4.5 x 10(-6) M with a detection limit as low as 5.0 x 10(-9) M. The relative standard deviation is 1.4% (8 runs) at a concentration of 50 microM uric acid. The catalytic effect of the modified electrode resulted in the voltammetric resolution of the overlapping of uric acid and ascorbic acid. This allows the simultaneous detection of uric acid and ascorbic acid in the same s le.
Publisher: American Chemical Society (ACS)
Date: 12-2005
DOI: 10.1021/CM048659H
Publisher: Elsevier BV
Date: 06-2000
Publisher: Elsevier BV
Date: 09-2016
Publisher: MDPI AG
Date: 25-03-2018
DOI: 10.3390/MA11040489
Publisher: American Scientific Publishers
Date: 09-2013
DOI: 10.1166/SL.2013.3018
Publisher: Cold Spring Harbor Laboratory
Date: 17-09-2018
DOI: 10.1101/419374
Abstract: Even in response to apparently simple tasks such as hand moving, human brain activity shows remarkable inter-subject variability. Presumably, this variability reflects genuine behavioural or functional variability. Recently, spatial variability of resting-state features in fMRI - specifically connectivity - has been shown to explain (spatial) task-response variability. Such a link, however, is still missing for M/EEG data and its spectrally rich structure. At the same time, it has recently been shown that task responses in M/EEG can be well represented using transient spectral events bursting at fast time scales. Here, we show that in idual differences in the spatio-spectral structure of M/EEG task responses, can, to a reasonable degree, be predicted from in idual differences in transient spectral events identified at rest. In a MEG dataset of erse task conditions (including motor responses, working memory and language comprehension tasks) and resting-state sessions for each subject (n = 89), we used Hidden-Markov-Modelling to identify transient spectral events as a feature set to learn the mapping of space-time-frequency content from rest to task. Resulting trial-averaged, subject-specific task-response predictions were then compared with the actual task responses in left-out subjects. All task conditions were predicted significantly above chance. Furthermore, we observed a systematic relationship between genetic similarity (e.g. unrelated subjects vs. twins) and predictability. These findings support the idea that subject-specific transient spectral events in resting-state neural activity are linked to, and predictive of, subject-specific trial-averaged task responses in a wide range of experimental conditions.
Publisher: Wiley
Date: 21-01-2014
DOI: 10.1002/PC.22865
Publisher: Informa UK Limited
Date: 07-1997
Publisher: Springer Science and Business Media LLC
Date: 2014
DOI: 10.2478/S11696-014-0582-2
Abstract: Silver dendrites have received immense attention because of their fascinating hierarchical structures and unique properties. Depending on the methods of synthesis, Ag dendrites can be implemented in numerous fields. This review summarizes a variety of Ag dendrites preparation techniques. The involved growth mechanisms are investigated in order to control the formation progress more effectively. With regard to the applications, this article mainly focuses on surface enhanced Raman spectroscopy, catalysis, superhydrophobic surface and surface enhanced fluorescence by using Ag dendrites. The remaining issues of the preparation methods, which impede the practical applications of Ag dendrites, are pointed out to enlighten their future research.
Publisher: Walter de Gruyter GmbH
Date: 04-2019
Abstract: Cellulose nanocrystals (CNC) are a class of nanoscale biopolymers produced from cellulose sources. CNC materials have gained growing interests which can be attributed to their excellent properties such as excellent biocompatibility, good mechanical properties and high aspect ratio whilst also being an inexpensive material that can be produced from green and renewable sources. Due to the abundant hydroxyl functional groups, the surface of CNC materials are ready to be tuned and functionalized via chemical reactions allowing for many different applications, such as being a reinforcing agent to be incorporated into a hydrophobic polymer matrix. In this review paper,we firstly introduce the general methods for producing CNC from different sources. Different strategies used for surface modification ofCNCare then discussed. Finally, the recent progress on the applications of CNC and CNC composite materials are described in detail.
Publisher: Elsevier BV
Date: 10-2011
Publisher: Elsevier BV
Date: 02-2019
Publisher: Wiley
Date: 14-08-2016
Publisher: Elsevier BV
Date: 09-2017
DOI: 10.1016/J.BIOS.2017.04.007
Abstract: A thionine (TH)-doped mesoporous silica nanosphere (MSN) olydopamine (PDA) nanocomposite was synthesized for developing a new signal transduction strategy of electrochemical immunoassay. This nanocomposite was synthesized through one-pot loading of TH and in situ formation of PDA-coating on MSN. After antibody labeling, the obtained nanoprobe was used for the signal tracing of sandwich immunoassay at a magnetic bead-assay platform. Based on the specific capture of the MSN-TH/PDA nanoprobes through sandwich immunoreaction to form a magnetic immunocomplex and the following treatment of the immunocomplex with a NaOH solution, the PDA film coated on MSN was destroyed to release TH tags from the nanoprobe. The released TH was then electrochemically measured at a carbon nanotube (CNT)-modified electrode for the signal transduction of the method. Due to the high loading of TH on the nanoprobe for tag release and effective electrochemical signal enhancement by the electrode modification of CNTs, ultrahigh sensitivity was achieved. Using human IgG as a model analyte, this method showed a wide linear range over four orders of magnitude and a low detection limit of 5.8pg/mL. Additionally, the method has excellent specificity, satisfactory reproducibility and stability as well as acceptable reliability. Due to the simple preparation of the nanoprobe and the low cost, convenient operation of the detection strategy, this nonenzymatic immunoassay method possesses great potentials for practical applications.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7BM00187H
Abstract: An overview of polydopamine derived nanostructures PDA NPs, capsules, core-shell nanostructures and PDA coatings as well as their application in various biomedical fields.
Publisher: Informa UK Limited
Date: 12-1996
Publisher: Elsevier BV
Date: 2018
DOI: 10.1016/J.BIOS.2017.07.045
Abstract: The quality of graphene strongly affects the performance of graphene-based biosensors which are highly demanded for the sensitive and selective detection of biomolecules, such as DNA. This work reported a novel transfer process for preparing a residue-free graphene film using a thin gold supporting layer. A Hall effect device made of this gold-transferred graphene was demonstrated to significantly enhance the sensitivity (≈ 5 times) for hybridization detection, with a linear detection range of 1pM to 100nM for DNA target. Our findings provide an efficient method to boost the sensitivity of graphene-based biosensors for DNA recognition.
Publisher: Elsevier BV
Date: 10-2018
Publisher: American Scientific Publishers
Date: 12-2013
Publisher: Springer Science and Business Media LLC
Date: 31-10-2016
DOI: 10.1038/NSMB.3316
Publisher: Wiley
Date: 05-05-2014
Abstract: Infrared stimulation offers an alternative to electrical stimulation of neuronal tissue, with potential for direct, non-contact activation at high spatial resolution. Conventional methods of infrared neural stimulation (INS) rely on transient heating due to the absorption of relatively intense laser beams by water in the tissue. However, the water absorption also limits the depth of penetration of light in tissue. Therefore, the use of a near-infrared laser at 780 nm to stimulate cultured rat primary auditory neurons that are incubated with silica-coated gold nanorods (Au NRs) as an extrinsic absorber is investigated. The laser-induced electrical behavior of the neurons is observed using whole-cell patch cl electrophysiology. The nanorod-treated auditory neurons (NR-ANs) show a significant increase in electrical activity compared with neurons that are incubated with non-absorbing silica-coated gold nanospheres and control neurons with no gold nanoparticles. The laser-induced heating by the nanorods is confirmed by measuring the transient temperature increase near the surface of the NR-ANs with an open pipette electrode. These findings demonstrate the potential to improve the efficiency and increase the penetration depth of INS by labeling nerves with Au NRs and then exposing them to infrared wavelengths in the water window of tissue.
Publisher: American Chemical Society (ACS)
Date: 10-01-2014
DOI: 10.1021/AC4037119
Abstract: A novel ultrasensitive immunoassay method was developed based on the electrochemical measurement of polyaniline, which was catalytically produced by horseradish peroxidase-functionalized gold nanoparticle (HRP-Au NP) probe at an immunosensor. The immunosensor was prepared step-wise by first modifying the electrode with reduced graphene oxide (rGO)/Au NPs nanocomposite followed by the immobilization of capture antibodies on its surface. After performing a sandwich immunoreaction, the quantitatively captured HRP-Au NP nanoprobes could catalyze oxidation of aniline to produce electroactive polyaniline on the immunosensor surface. The electrochemical measurement of polyaniline enabled a novel detection strategy for HRP-based immunoassay. Both the signal lification of the HRP-Au NP nanoprobe and the electron transfer acceleration of rGO/Au NPs on the immunosensor surface greatly improved the detection sensitivity of the immunoassay method. With the use of human IgG as a model analyte, this method showed a wide linear range over 4 orders of magnitude with a detection limit of 9.7 pg/mL. In addition, the immunosensor had low cost, satisfactory reproducibility and stability, and acceptable reliability. The relatively positive potential range for the polyaniline measurement completely excluded the conventional interference from dissolved oxygen. Thus, this method provides a promising potential for practical applications.
Publisher: Elsevier BV
Date: 08-2018
Publisher: SPIE
Date: 07-12-2013
DOI: 10.1117/12.2033767
Publisher: Wiley
Date: 26-03-2013
DOI: 10.1002/BIT.24889
Abstract: The usage of gold nanoparticles (Au NPs) in biological applications has risen significantly over the last 10 years. With the wide variety of chemical and biological functionalization available and their distinctive optical properties, Au NPs are currently used in a range of biological applications including sensing, labeling, drug delivery, and imaging applications. Among the available particles, gold nanorods (Au NRs) are particularly useful because their optical absorption can be tuned across the visible to near infrared region. Here, we present a novel application of Au NRs associated with low power laser exposure of NG108-15 neuronal cells. When cells were irradiated with a 780 nm laser, the average number of neurons with neurites increased. A similar stimulatory effect was observed for cells that were cultured with poly-(4-styrenesulfonic acid)-coated and silica-coated Au NRs. Furthermore, when the NG108-15 cells were cultured with both bare and coated Au NRs and then irradiated with 1.2-7.5 W/cm(2) at 780 nm, they showed a neurite length increase of up to 25 µm versus control. To the best of our knowledge, this effect has never been reported before. While the pathways of the stimulation is not yet clear, the data presented here demonstrates that it is linked to the absorption of light by the Au NRs. These initial results open up new opportunities for peripheral nerve regeneration treatments and for novel approaches to addressing central nervous system axons following spinal cord injury.
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0AN02187C
Abstract: Herein, we report a Fe 3 O 4 @polydopamine nanocomposite and exonuclease III-assisted homogeneous fluorescence biosensing method for ultrasensitive detection of kanamycin antibiotic.
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6AN00651E
Abstract: A glucose oxidase–ferrocene dually functionalized nanoporous gold nanoprobe was prepared for the electrochemical signal tracing of a protein aptasensor.
Publisher: Elsevier BV
Date: 02-2018
Publisher: Elsevier BV
Date: 12-2001
Publisher: American Scientific Publishers
Date: 02-2015
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C7EW00322F
Abstract: This review presents a broad overview of recent advances in the surface modification of mesoporous silica substrates for improved adsorption capacity and selectivity for both organic and inorganic wastewater pollutants.
Publisher: Wiley
Date: 06-2016
Publisher: Elsevier BV
Date: 07-2012
Publisher: Springer Science and Business Media LLC
Date: 02-2015
DOI: 10.1007/S10856-015-5444-0
Abstract: Mesoporous silica nanoparticles (MSNs) have been explored as controlled drug delivery systems since the early 2000s, but many fundamental questions remain for this important application. We sought to design a pH controlled delivery system of gentamicin, an aminoglycoside antibiotic, based on MSNs. Under optimal conditions, MSN was able to load 219 µg gentamicin per mg MSNs. Polymeric networks encompassing gentamicin loaded MSNs were then established to tune the release kinetics. Embedding of drug pre-loaded MSNs was performed by an efficient layer-by-layer (LbL) self-assemble strategy using polystyrene sulfonate (PSS) and poly (allylamine hydrochloride) (PAH). We characterised the release kinetics by nonlinear mixed-effects modelling in the S-ADAPT software. The mean release time from uncoated MSNs was 3.6 days at pH 7.4 and 0.4 days at pH 1.4. A further slower release was achieved by diffusion through one or two PSS/PAH bilayer(s) which had a mean transit time of 6.0 days at pH 7.4 and 3.5 days at pH 1.4. The number of bilayers affected the shape of the release profile. The developed nano-drug carriers combined with the self-assembled polyelectrolyte coating allowed us to tune the release kinetics by pH and the number of bilayers.
Publisher: Springer Science and Business Media LLC
Date: 02-02-2013
Publisher: SPIE
Date: 09-08-2013
DOI: 10.1117/12.2026129
Publisher: Elsevier BV
Date: 02-2009
DOI: 10.1016/J.JCIS.2008.10.030
Abstract: We report the construction of three-dimensional (3D) colloidal crystal arrays (CCA) and hollow colloidal crystal arrays (HCCA) derived from the self-assembly of polyelectrolytes (PE)-coated polystyrene (PS) particles and their use as models of high surface area systems to immobilize peroxidase (POD). POD molecules could infiltrate into the deep layers of CCA and HCCA through their interconnected pores and strongly adsorbed at the PE shell of the colloidal particles. And the total enzyme loading amount and bioactivities increased linearly with the thickness of the CCA till ca. 10 mum. Compared with flat substrates with the same geometrical area, CCA and HCCA exhibit much higher enzyme loading abilities (approximately 43 and 53 times respectively) and the resulting bioactivities (approximately 35 and 41 times respectively) due to their inherently higher surface area and 3D interconnected porous structures. In addition, HCCA could load approximately 30% more POD than CCA because some POD molecules could infiltrate into the interior of the hollow capsule under salt condition.
Publisher: Wiley
Date: 11-05-2010
Publisher: Wiley
Date: 06-1997
Publisher: Informa UK Limited
Date: 03-07-2013
Publisher: Elsevier BV
Date: 09-2018
Publisher: Informa UK Limited
Date: 30-09-2001
DOI: 10.1081/AL-100107301
Publisher: American Chemical Society (ACS)
Date: 26-11-2004
DOI: 10.1021/NL0348443
Publisher: Wiley
Date: 22-09-2016
Publisher: Elsevier BV
Date: 10-2019
Publisher: Elsevier BV
Date: 11-2018
Publisher: Elsevier BV
Date: 04-2015
Publisher: Informa UK Limited
Date: 03-1997
Publisher: Springer Science and Business Media LLC
Date: 12-2009
Publisher: Informa UK Limited
Date: 2000
Publisher: Royal Society of Chemistry (RSC)
Date: 2006
DOI: 10.1039/B601490A
Abstract: Biocompatible polypeptide capsules with high enzyme loading and activity prepared by templating mesoporous silica spheres were used as biomimetic reactors for performing CaCO3 synthesis exclusively inside the capsule interior via urease-catalyzed urea hydrolysis.
Publisher: American Chemical Society (ACS)
Date: 27-02-2019
Publisher: Royal Society of Chemistry (RSC)
Date: 2009
DOI: 10.1039/B909805D
Abstract: A sensitive and selective electrochemical method for the determination of norepinephrine (NE) was developed by using a calix[4]arene crown-4 ether (CACE) film modified glassy carbon electrode (GCE). The fabrication of the CACE film and its electrocatalytic effect for electrochemical oxidation of NE were investigated by electrochemical impedance spectroscopy (EIS) and voltammetric methods. It was found that the electrochemical behavior of NE on the CACE film modified electrode depended on the film thickness of CACE. Based on the electrochemical data, the CACE film surface coverage (theta), the charge transfer number (z) and the amount of the surface-bound NE (Gamma) were calculated. The effects of the experimental variables such as the solution pH and the applied potential were investigated for optimum analytical performance. Excellent linear relationships were obtained in two concentration ranges of NE: one was from 0.55 to 9.7 microM and the other was 9.7 to 230 microM. The detection limit (S/N = 3) of NE obtained by steady-state erometry was 0.28 microM. The relative standard deviation (RSD) for 10 successive measurements of 0.05 mM NE was 2.2%. This method could be applied for the direct determination of NE in injection s les. In addition, effects of possible interferences (e.g. ascorbic acid, AA) were investigated. The present work provides an effective method for erometric determination of NE by using a CACE modified electrode.
Publisher: Wiley
Date: 19-03-2012
DOI: 10.1002/JCTB.3771
Publisher: Springer Science and Business Media LLC
Date: 05-08-2015
Publisher: American Chemical Society (ACS)
Date: 06-06-2008
DOI: 10.1021/AC800430M
Abstract: A novel class of fluorescent immuno-biolabeling systems with extremely high F/P ratio (approximately 1000-6000) were prepared by combining the template method and layer-by-layer (LbL) technique. Labels were constructed by loading organic dye fluorescein diacetate (FDA) molecules onto hollow periodic mesoporous organosilica (H-PMO) particles followed by ployelectrolyte encapsulation and antibody attachment. The labeling systems were stimuli-responsive to the addition of concentrated NaOH with the loaded dye molecules being released and detected in a well-controlled manner. When applied in sandwich immunoassays, results indicated that the biolabels were immuno-active and generated an optimal signal that was approximately 50 times higher than the conventional dye labelled antibody system.
Publisher: IOP Publishing
Date: 10-03-2017
Publisher: Elsevier BV
Date: 2019
DOI: 10.1016/J.FOODCHEM.2018.07.127
Abstract: By combination of the aptamer biorecognition with the colorimetric signal transduction of a DNAzyme-functionalized nanoprobe, a new biosensing method was developed for the rapid and sensitive detection of chlor henicol (CAP). The nanoprobe was prepared through the functionalization of gold nanoparticles with the complementary oligonucleotide against aptamer and high-content hemin/G-quadruplex DNAzyme. When one-step incubating the nanoprobe and CAP at a constructed aptamer-magnetic bead (MB) biosensing platform, due to the competitive biorecognition reaction, the nanoprobes related with CAP amounts were quantitative captured onto the MB surface. Based on the catalytic reaction of the peroxidase-mimicking DNAzyme, a colored substance was produced for the colorimetric signal transduction of the method. Due to the great signal lification of the nanoprobe, a very low detection limit down to 0.13 pg/mL was obtained. Considering the excellent performance of the aptasensing method and satisfactory results for milk s le experiments, it indicates good reliability for practical applications.
Publisher: Informa UK Limited
Date: 31-07-2014
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9AN02633A
Abstract: Glucoamylase–nanoprobe induced gold deposition at vertically aligned carbon nanotubes enables the successful development of a novel electrochemical immunosensing method.
Publisher: The Chemical Society of Japan
Date: 10-2003
DOI: 10.1246/CL.2003.934
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5RA12520K
Abstract: A sensitive electrochemical sensor of paracetamol was developed based on a β-CD/reduced graphene oxide modified electrode.
Publisher: American Scientific Publishers
Date: 12-2010
DOI: 10.1166/SL.2010.1357
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C8CC10107H
Abstract: Aptamer biorecognition-triggered DNAzyme liberation and Exo III-assisted target recycling enable the ultrasensitive homogeneous colorimetric bioassay of kanamycin antibiotic.
Publisher: Wiley
Date: 06-06-2019
Publisher: Wiley
Date: 04-05-2016
Publisher: Trans Tech Publications, Ltd.
Date: 08-2014
DOI: 10.4028/WWW.SCIENTIFIC.NET/AMR.1004-1005.10
Abstract: Silver dendrites were synthesized via a simple and straightforward strategy based on the galvanic displacement between Ag ions and aluminum foil in the room temperature. Because the presence of Al 2 O 3 thin layer on the surface of aluminum foil, the NaCl was added to accelerates the reaction rate. The formed Ag dendrites was characterized by UV-vis spectroscopy, SEM and XRD. The as-prepared Ag dendrites were developed as a catalyst by mixed with reduced graphene oxide and used for degradation of methylene blue when the presence of NaBH 4 . Moreover, the optimal conditions of degradation were also investigated.
Publisher: Bentham Science Publishers Ltd.
Date: 04-2010
Publisher: The Chemical Society of Japan
Date: 05-11-2012
DOI: 10.1246/CL.2012.1492
Publisher: MDPI AG
Date: 14-12-2018
DOI: 10.3390/NANO8121050
Abstract: It is of great significance to distinguish enantiomers due to their different, even completely opposite biological, physiological and pharmacological activities compared to those with different stereochemistry. A sp3-to-sp2 converted highly stable and regenerative graphene/diamond electrode (G/D) was proposed as an enantiomer recognition platform after a simple β-cyclodextrin (β-CD) drop casting process. The proposed enantiomer recognition sensor has been successfully used for d and l-phenylalanine recognition. In addition, the G/D electrode can be simply regenerated by half-minute sonication due to the strong interfacial bonding between graphene and diamond. Therefore, the proposed G/D electrode showed significant potential as a reusable sensing platform for enantiomer recognition.
Publisher: Springer Science and Business Media LLC
Date: 22-06-2016
Publisher: Elsevier BV
Date: 04-2018
DOI: 10.1016/J.TALANTA.2017.12.058
Abstract: A simple water immersing treatment has been established for regulating the electrocatalytic activity of commercial graphene ink. This process enables to remove additives in graphene ink and consequently expose the surface defects. A graphene ink coated glass has been fabricated as an ex le platform for simultaneous determination of ascorbic acid (AA), dopamine (DA), and uric acid (UA). Cyclic voltammetry studied indicated electrocatalytic reaction can be initiated after the additives leaching during the water immersing treatment. Under optimal conditions, the linear calibration curves were achieved in the range of 50-1000, 3-140, and 0.5-150μM, with detection limits of 17.8, 1.44 and 0.29μM for AA, DA, and UA, respectively. This work demonstrated that the removal of additives of the graphene ink after film coating could be applied as a simple and cost-effective electrochemical platform for sensing application.
Publisher: Elsevier BV
Date: 05-2019
Publisher: Springer Science and Business Media LLC
Date: 02-12-2007
DOI: 10.1007/S00216-007-1748-3
Abstract: A new kind of magnetic dextran microsphere (MDMS) with uniform shape and narrow diameter distribution has been prepared from magnetic iron nanoparticles and dextran. Horseradish peroxidase (HRP) was successfully immobilized on the surface of an MDMS-modified glassy-carbon electrode (GCE), and the immobilized HRP displayed excellent electrocatalytic activity in the reduction of H(2)O(2) in the presence of the mediator hydroquinone (HQ). The effects of experimental variables such as the concentration of HQ, solution pH, and the working potential were investigated for optimum analytical performance. This biosensor had a fast response to H(2)O(2) of less than 10 s and an excellent linear relationship was obtained in the concentration range 0.20 micromol L(-1)-0.68 mmol L(-1), with a detection limit of 0.078 micromol L(-1) (S/N = 3) under the optimum conditions. The response showed Michaelis-Menten behavior at larger H(2)O(2) concentrations, and the apparent Michaelis-Menten constant K(M)(app) was estimated to be 1.38 mmol L(-1). Moreover, the selectivity, stability, and reproducibility of the biosensor were evaluated, with satisfactory results.
Publisher: Elsevier BV
Date: 10-2016
Publisher: Elsevier BV
Date: 2001
DOI: 10.1016/S0021-9673(00)00985-7
Abstract: A copper microparticle-modified carbon fiber microdisk array electrode was fabricated and employed in capillary electrophoresis for the simultaneous determination of the five aminoglycoside antibiotics (AGs) including netilmicin, tobramycin, lincomycin, kanamycin and amikacin. The array electrode exhibited high catalytic activity for AGs, good reproducibility and stability. Under the optimum separation conditions (separation voltage of 6.2 kV, electrophoretic medium of 125 mM NaOH), the five AGs above were baseline separated within 20 min. At a working electrode potential of 0.7 V (versus saturated calomel electrode), the calibration curves were linear over two orders of magnitude of concentration, and the detection limits (SIN=3) were below 2 microM except for lincomycin (6.7 microM). The developed method was successfully employed for the simultaneous determination of the five AGs studied in pharmaceutical injections. The feasibility of this method for the simultaneous determination of lincomycin, kanamycin and amikacin in urine s le was also demonstrated.
Publisher: Elsevier BV
Date: 06-2018
DOI: 10.1016/J.BIOELECHEM.2017.12.013
Abstract: A chitosan based hydrogel has been fabricated using silver ions as crosslinking agent. Silver redox behavior in the hydrogel is suppressed due to complexation. However, hydrogen peroxide induced hydroxyl radicals could attract the glucoside bonds and consequently restore silver redox behavior. Therefore, we used this hydroxyl radical induced chitos and epolymerization mechanism as an indicator for antioxidant capacity evaluation. Therefore, we used this hydroxyl radical induced chitos and epolymerization as an indicator for antioxidant capacity evaluation. Due to the low cost, portability and avoidance of the need for electrode modification, we believe the proposed hydrogel sensing platform shows great potential for antioxidant screening applications.
Publisher: Informa UK Limited
Date: 02-1997
Publisher: Springer Science and Business Media LLC
Date: 27-10-2012
Publisher: Elsevier BV
Date: 06-2018
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8TA03404D
Abstract: New emerging graphene-supported 2D transition metal oxide heterostructures are attracting interest for high-efficiency energy storage and energy conversion devices.
Publisher: American Scientific Publishers
Date: 06-2015
Abstract: Multipod ZnO-multi-walled carbon nanotube (MWCNT)-reduced graphene oxide (RGO) ternary nanocomposites were synthesized via a simple one-pot hydrothermal process using graphene oxide (GO)-dispersed MWCNT and zinc nitrate as raw materials. Scanning electron microscopy analysis indicated the formation of multipod structure of ZnO in the presence of MWCNT. XRD confirmed that the ZnO multipod was in a hexagonal phase while UV-vis and FTIR spectroscopy confirmed that the graphene oxide in the resulting material was in the reduced form. The as-prepared MWCNT-RGO-ZnO composites displayed excellent photocatalytic performance towards the degradation of methylene blue. More specifically, the degradation rate constant of using MWCNT-RGO-ZnO composites were twice and thrice higher than those of using RGO-ZnO composites and bare ZnO material, respectively. The main reason of enhanced photocatalytic property might be due to the internal stepwise energy level of the three components, which helped the electron separation and hinder the charge recombination.
Publisher: Impact Journals, LLC
Date: 14-06-2016
Publisher: American Chemical Society (ACS)
Date: 02-07-2009
DOI: 10.1021/LA900953A
Abstract: UV-vis absorption, atomic force microscopy (AFM), contact angle, and X-ray reflectivity experiments were performed on thin films deposited on crystalline silicon substrates as alternating layers of a porphyrin with anionic functionality, tetra-5,10,15,20-(4-sulfonatophenyl)porphine (TSPP) or the metalated version, Cu(II)TSPP, and the cationic polyelectrolyte, poly(diallyldimethylammonium chloride) (PDDA). The films were made by dipping in alternating aqueous solutions containing film components (layer-by-layer deposition). Modeling of the X-ray reflectivity data revealed differences in the films' thickness depending on the method of film deposition. An unusual decrease in film thickness after each polyelectrolyte dip was also observed for films using TSSP. UV-vis measurements revealed that a similar amount of TSSP was included within films despite the method of formation. UV-vis measurements also revealed the presence of free-base, H-aggregate, and J-aggregate forms of the porphyrin after TSPP dipping, and the subsequent disappearance of the J-aggregate after dipping in the PDDA solution. A model of film formation was proposed on the basis of the concept of two different types of porphyrin aggregates being present after dipping in porphyrin solution. A layer of porphyrin molecules initially attach to the Si surface such that the planar molecules are arranged side by side as H-aggregates with an excess of J-aggregated material on top. The J-aggregate is then removed and replaced by a layer of PDDA. A change in contact angle of 14 degrees was observed between porphyrin and polyelectrolyte layers due to the more hydrophobic nature of the polymer. The presence of the J-aggregate was confirmed in AFM images obtained from the porphyrin layer. Exposure of the films to solutions of alternating pHs of 10 and 1.8 resulted in reproducible switching of the UV-vis spectra, indicating a possible sensing application.
Publisher: Springer Science and Business Media LLC
Date: 08-04-2011
DOI: 10.1007/S00216-011-4932-4
Abstract: A new micellar electrokinetic chromatography (MEKC) method using beta-cyclodextrins (β-CDs) and 1-butyl-3-methylimidazolium hexafluorophosphates (ionic liquids) as additives was successfully developed for determination of para-, meta-, and ortho-phenylenediamines isomers (p-P, m-P, and o-P) in hair dyes. To improve the sensitivity of the MEKC-UV, a simple and cheap flow injection (FI) technique using a micro-column packed with coal cinders (the by-products from combustion in a boiler) as solid-phase extractant was also investigated. In the presence of 20 mmol L(-1) phosphates at pH 5.5, addition of 12 mmol L(-1) ionic liquids and 8 mmol L(-1) β-CDs greatly improved the separation efficiency. The three analytes could be quantitatively adsorbed by coal cinders, and desorbed readily with 0.15 mL of 0.01 mol L(-1) NaOH. Under the optimum conditions, an enrichment factor (EF) of 33.3 was obtained, and determination limits of p-P, m-P, and o-P were 1.97 × 10(-7), 0.99 × 10(-7), and 0.61 × 10(-7) mol L(-1), respectively. The adsorption capacities of the coal cinders micro-column for p-P, m-P, and o-P were all 1.20 mg g(-1). The presented procedure was successfully applied to the determination of p-P, m-P, and o-P in hair dyes with satisfactory results.
Publisher: Wiley
Date: 04-11-2003
Publisher: Elsevier BV
Date: 06-2012
Publisher: Elsevier BV
Date: 11-2019
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D2MH01218A
Abstract: This review introduces fundamental aspects of the electrocatalytic CO 2 RR process together with a systematic examination of recent developments in Cu-based electrocatalysts for the electroreduction of CO 2 to various high-value multicarbon products.
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4AY00020J
Abstract: The lified inhibition of the electrochemical signal of graphene–thionine nanocomposites using silica nanoprobes enabled a novel ultrasensitive immunoassay method.
Publisher: American Chemical Society (ACS)
Date: 20-07-2022
Publisher: Elsevier BV
Date: 06-2022
DOI: 10.1016/J.CHEMOSPHERE.2022.134127
Abstract: The residues of antibiotics in the environment pose a potential health hazard, so highly sensitive detection of antibiotics has always appealed to analytical chemists. With the widespread use of new low-dimensional materials, graphene-modified electrochemical sensors have emerged as an excellent candidate for highly sensitive detection of antibiotics. Graphene, its derivatives and its composites have been used in this field of exploration in the last decade. In this review, we have not only described the field using traditional summaries, but also used bibliometrics to quantify the development of the field. The literature between 2011 and 2021 was included in the analysis. Also, the sensing performance and detection targets of different sensors were compared. We were able to trace not only the flow of research themes, but also the future areas of development. Graphene is a material that has a high potential to be used on a large scale in the preparation of electrochemical sensors. How to design a sensor with selectivity and low cost is the key to bring this material from the laboratory to practical applications.
Publisher: Wiley
Date: 07-08-2007
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8TA00132D
Abstract: 2D layered organic–inorganic heterostructures are some of the most promising materials for a broad range of high-efficiency clean energy devices.
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4RA03633F
Abstract: PVA/PAA/SiO 2 ternary organic–inorganic composite nanofibrous mats are successfully prepared by a cooperative fabrication via electrospinning. The reaction between PVA, PAA and hydrolytic TEOS are proposed to endow the ternary nanofibers with remarkable solvent and temperature resistance, as well as the great mechanical property.
Publisher: Elsevier BV
Date: 2016
DOI: 10.1016/J.ACA.2015.11.014
Abstract: A nanoprobe-induced signal inhibition mechanism was designed for ultrasensitive electrochemical immunoassay at a chitosan-ferrocene (CS-Fc) based immunosensor. The nanoprobe was prepared by covalently loading signal antibody and high-content horseradish peroxidase (HRP) on the graphene oxide (GO) nanocarrier. The immunosensor was prepared through the stepwise assembly of gold nanoparticles (Au NPs) and capture antibody at a CS-Fc modified electrode. After sandwich immunoreaction, the GO-HRP nanoprobes were quantitatively captured onto the immunosensor surface and thus induced the production of a layer of insoluble film through the enzymatically catalytic reaction of the HRP labels. Both the dielectric immunocomplex formed on the immunosensor surface and the enzymatic precipitate with low electroconductivity led to the electrochemical signal decease of the Fc indicator, which was greatly lified by the multi-enzyme signal lification of the nanoprobe. Based on this lified signal inhibition mechanism, a new ultrasensitive electrochemical immunoassay method was developed. Using carcinoembryonic antigen as a model analyte, this method showed a wide linear range over 5 orders of magnitude with a detection limit down to 0.54 pg/mL. Besides, the immunosensor showed good specificity, acceptable reproducibility and stability as well as satisfactory reliability for the serum s le analysis.
Publisher: Springer Science and Business Media LLC
Date: 05-07-2017
Publisher: Elsevier BV
Date: 06-2022
Publisher: Elsevier BV
Date: 2000
DOI: 10.1016/S0021-9673(99)01083-3
Abstract: The simultaneous determination of polycarboxylic acids including oxalic acid, citric acid, malonic acid, malic acid, tartaric acid, aspartic acid and glutamic acid was achieved by capillary electrophoresis with a copper disk electrode (d = 200 microm). In the system. 0.2 mmol/l cetylpridinium bromide (CPB) was used as an electroosmotic flow (EOF) modifier to reverse the direction of EOF. The effects of the solution pH and CPB concentration on separation were evaluated to achieve the optimum separation conditions. At the working potential of +0.14 V (vs. saturated calomel electrode), the calibration curves for all polycarboxylic acids studied were linear with 2 approximately 3-orders of magnitude and all the detection limits (S/N = 3) were below 15 fmol except malonic acid. Furthermore, the oxalic and citric acids in urine were successfully separated and determined with high sensitivity.
Publisher: Elsevier BV
Date: 07-2018
DOI: 10.1016/J.BIOS.2018.04.006
Abstract: Graphene is widely recognized as a promising nanomaterial for the construction of high-performance electrochemical biosensors. However, the lack of strong interfacial forces between graphene and conductive substrates is a bottleneck in the fabrication of highly stable graphene electrodes. In this work, few-layer graphene was directly formed on a high pressure high temperature (HPHT) diamond substrate via sp
Publisher: Springer Science and Business Media LLC
Date: 24-05-2018
Publisher: Elsevier BV
Date: 03-2020
Publisher: Informa UK Limited
Date: 07-1995
Publisher: American Chemical Society (ACS)
Date: 31-03-2007
DOI: 10.1021/LA0634746
Abstract: We report the influence of polyelectrolyte (PE) multilayer films prepared from poly(styrene sulfonate)-poly(acrylic acid) (PSS-PAA) blends, deposited in alternation with poly(allylamine hydrochloride) (PAH), on film wettability and the adsorption behavior of the protein immunoglobulin G (IgG). Variations in the chemical composition of the PAH/(PSS-PAA) multilayer films, controlled by the PSS/PAA blend ratio in the dipping solutions, were used to systematically control film thickness, surface morphology, surface wettability, and IgG adsorption. Spectroscopic ellipsometry measurements indicate that increasing the PSS content in the blend solutions results in a systematic decrease in film thickness. Increasing the PSS content in the blend solutions also leads to a reduction in film surface roughness (as measured by atomic force microscopy), with a corresponding increase in surface hydrophobicity. Advancing contact angles (theta) range from 7 degrees for PAH/PAA films through to 53 degrees for PAH/PSS films. X-ray photoelectron spectroscopy measurements indicate that the increase in film hydrophobicity is due to an increase in PSS concentration at the film surface. In addition, the influence of added electrolyte in the PE solutions was investigated. Adsorption from PE solutions containing added salt favors PSS adsorption and results in more hydrophobic films. The amount of IgG adsorbed on the multilayer films systematically increased on films assembled from blends with increasing PSS content, suggesting strong interactions between PSS in the multilayer films and IgG. Hence, multilayer films prepared from blended PE solutions can be used to tune film thickness and composition, as well as wetting and protein adsorption characteristics.
Publisher: Wiley
Date: 28-01-2014
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9AN00898E
Abstract: The aptamer-initiated hybridization chain reaction and urease-induced biomineralization enable the development of a Cu 2+ -based colorimetric biosensing method for CEA analysis.
Publisher: Wiley
Date: 20-06-2018
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9NR02543J
Abstract: The one-step biorecognition at a vertically aligned SWCNT-based biosensor and T7 exonuclease-assisted target recycling enable the ultrasensitive bioassay of microRNA-21.
Publisher: Wiley
Date: 17-12-2019
Publisher: Elsevier BV
Date: 09-2013
DOI: 10.1016/J.BIOS.2013.03.029
Abstract: A novel gold nanoprobe was prepared for the signal tracing of ultrasensitive nonenzymatic electrochemical immunoassay at a carbon nanotubes (CNTs)-based disposable immunosensor. The gold nanoprobe was prepared via in situ deposition of gold nanoparticles (Au NPs) on the polydopamine functionalized silica nanosphere followed by the labeling of signal antibodies. The immunosensor was prepared through the covalent immobilization of capturing antibodies on the CNTs modified screen-printed carbon electrode. After a sandwich-type immunoreaction on the immunosensor surface, the gold nanoprobes were captured onto the electrode surface to form immunocomplex. The multiple Au NPs on the attached nanoprobe composites were then measured by electrochemical stripping analysis to obtain signal response. This method provided a simple and controllable way to prepare a novel gold nanoprobe which greatly lified the signal response of every single immuno-recognition event. The modification of electrode surface with CNTs also facilitated the stripping current enhancement of Au NPs resulting in the ultrahigh sensitivity of this immunoassay method. Using human IgG as a model analyte, the proposed method showed a wide linear range over three orders of magnitude with the detection limit down to 6.9pg/mL. Besides, this method showed excellent analytical performance with low cost, good portability, and acceptable reproducibility, stability and accuracy, thus providing great potentials for clinical applications.
Publisher: Springer Science and Business Media LLC
Date: 03-2017
Publisher: Springer Science and Business Media LLC
Date: 20-09-2016
DOI: 10.1038/SREP33650
Abstract: The 70-kD heat shock proteins (Hsp70s) are highly conserved molecular chaperones that play essential roles in cellular processes including abiotic stress responses. Physcomitrella patens serves as a representative of the first terrestrial plants and can recover from serious dehydration. To assess the possible relationship between P. patens Hsp70s and dehydration tolerance, we analyzed the P. patens genome and found at least 21 genes encoding Hsp70s. Gene structure and motif composition were relatively conserved in each subfamily. The intron-exon structure of PpcpHsp70-2 was different from that of other PpcpHsp70s this gene exhibits several forms of intron retention, indicating that introns may play important roles in regulating gene expression. We observed expansion of Hsp70s in P. patens , which may reflect adaptations related to development and dehydration tolerance and results mainly from tandem and segmental duplications. Expression profiles of rice, Arabidopsis and P. patens Hsp70 genes revealed that more than half of the Hsp70 genes were responsive to ABA, salt and drought. The presence of overrepresented cis -elements (DOFCOREZM and GCCCORE) among stress-responsive Hsp70s suggests that they share a common regulatory pathway. Moss plants overexpressing PpcpHsp70-2 showed salt and dehydration tolerance, further supporting a role in adaptation to land. This work highlights directions for future functional analyses of Hsp70s.
Publisher: Oxford University Press (OUP)
Date: 08-2018
Publisher: Elsevier BV
Date: 12-2019
Publisher: Elsevier BV
Date: 05-2018
Publisher: Informa UK Limited
Date: 05-01-2002
DOI: 10.1081/AL-120003167
Publisher: Informa UK Limited
Date: 31-01-2019
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C7TA08748A
Abstract: 2D and 3D graphene-based hybrid composites are the most promising materials for a broad range of high-efficiency energy storage and conversion devices.
Publisher: Elsevier BV
Date: 08-2004
Publisher: SPIE
Date: 15-02-2013
DOI: 10.1117/12.2002291
Start Date: 2009
End Date: 12-2009
Amount: $150,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 08-2007
End Date: 12-2013
Amount: $150,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 06-2020
End Date: 06-2022
Amount: $482,055.00
Funder: Australian Research Council
View Funded Activity