ORCID Profile
0000-0002-4773-6627
Current Organisation
University of South Australia
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Publisher: Springer Science and Business Media LLC
Date: 30-10-2023
Publisher: Elsevier BV
Date: 03-2023
Publisher: Elsevier BV
Date: 06-2022
Publisher: Elsevier BV
Date: 2022
DOI: 10.1016/J.IJPHARM.2021.121316
Abstract: Topical patches containing 5-fluorouracil (5-FU) are a feasible alternative to overcome the shortcomings of commercial cream for the treatment of non-melanoma skin cancer (NMSC). Plasticizers are a critical component of drug-in-adhesive (DIA) patches as they can significantly affect the mechanical, adhesive and drug release characteristics of the patches. Eudragit® E (EuE) is a methacrylate-based cationic copolymer capable of producing flexible and adhesive films for topical application. In this study, the effect of plasticizers on the mechanical, adhesive and 5-FU release characteristics of EuE-based patches was comprehensively evaluated. While the elongation at break (%) and adhesion of the films were significantly increased with increasing triacetin, dibutyl sebacate (DBS) and triethyl citrate (TEC) concentrations, the tensile strength showed an inverse relationship. EuE plasticized with 40% triacetin, 30% DBS or 40% w/w TEC produced elastic and adhesive films most suitable for topical application. In vitro release studies of the 5-FU-loaded patches demonstrated an initial burst release pattern during the first 10 min followed by a slow release over 120 min. In summary, this study provides important information on effect of plasticizers for preparation of EuE-based patches with desired mechanical, adhesive and release characteristics of 5-FU towards their potential application in the treatment of NMSC.
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3NR01789C
Abstract: We have unleashed the potential of NAR and its nanoformulation against acne infections. The results of the ex vivo skin deposition study demonstrate the effectiveness of the developed nano gel as a targeted topical therapy for acne.
Publisher: Elsevier BV
Date: 2023
DOI: 10.1016/J.DRUDIS.2022.103414
Abstract: Physiologic pH is vital for the normal functioning of tissues and varies in different parts of the body. The varying pH of the body has been exploited to design pH-sensitive smart oral, transdermal and vaginal drug delivery systems (DDS). The DDS demonstrated promising results in hard-to-treat diseases such as cancer and Helicobacter pylori infection. In some cases, a change in pH of tissues or body fluids has also been employed as a useful diagnostic biomarker. This paper aims to comprehensively review the development and applications of pH-sensitive DDS as well as recent advances in the field.
Publisher: Informa UK Limited
Date: 02-2023
DOI: 10.2147/IJN.S400610
Publisher: Elsevier BV
Date: 06-2023
Publisher: Springer Science and Business Media LLC
Date: 03-10-2020
No related grants have been discovered for Sangseo Kim.