ORCID Profile
0000-0003-3961-1688
Current Organisation
University of South Australia
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Publisher: Hindawi Limited
Date: 2018
DOI: 10.1155/2018/4071356
Abstract: Osteocytes, the major type of bone cells embedded in the bone matrix and surrounded by the lacunar and canalicular system, can serve as biomechanosensors and biomechanotranducers of the bone. Theoretical analytical methods have been employed to investigate the biomechanical responses of osteocytes in vivo the poroelastic properties have not been taken into consideration in the three-dimensional (3D) finite element model. In this study, a 3D poroelastic idealized finite element model was developed and was used to predict biomechanical behaviours (maximal principal strain, pore pressure, and fluid velocity) of the osteocyte-lacunar-canalicular system under 150-, 1000-, 3000-, and 5000-microstrain compressive loads, respectively, representing disuse, physiological, overuse, and pathological overload loading stimuli. The highest local strain, pore pressure, and fluid velocity were found to be highest at the proximal region of cell processes. These data suggest that the strain, pore pressure, and fluid velocity of the osteocyte-lacunar-canalicular system increase with the global loading and that the poroelastic material property affects the biomechanical responses to the compressive stimulus. This new model can be used to predict the mechanobiological behaviours of osteocytes under the four different compressive loadings and may provide an insight into the mechanisms of mechanosensation and mechanotransduction of the bone.
Publisher: Elsevier BV
Date: 02-2017
Publisher: SAGE Publications
Date: 04-2019
Publisher: Hindawi Limited
Date: 2015
DOI: 10.1155/2015/652183
Abstract: A novel stage hydraulic monitoring system based on Internet of Things (IoT) is proposed in this paper. Compared with the traditional wired system, the proposed system is a flexible working method and can save the cost. Furthermore, it has the low power consumption, high safety, and large scale network. The real-time pressure and flow data can be collected by using the nodes in ZigBee network. The fault detection and diagnosis process was used in this study, which was facilitated by measuring pressure of flow. When the monitored data exceeds the normal range, some failure may occur in the stage hydraulic system. If any failure occurs in the circuit, the maintainers can be informed immediately, which can greatly improve maintenance efficiency, ensuring the failure to be eliminated in time. Meanwhile, we can take advantage of wireless sensor network (WSN) to connect the multiple loops and then monitor the loops by using ZigBee technology, which greatly improves the efficiency of monitoring.
Publisher: Springer Science and Business Media LLC
Date: 24-11-2015
DOI: 10.1038/SREP17168
Abstract: Peripheral nerves are important pathways for receiving afferent sensory impulses and sending out efferent motor instructions, as carried out by sensory nerve fibers and motor nerve fibers. It has remained a great challenge to functionally reconnect nerve internal fiber bundles (or fascicles) in nerve repair. One possible solution may be to establish a 3D nerve fascicle visualization system. This study described the key technology of 3D peripheral nerve fascicle reconstruction. Firstly, fixed nerve segments were embedded with position lines, cryostat-sectioned continuously, stained and imaged histologically. Position line cross-sections were identified using a trained support vector machine method and the coordinates of their central pixels were obtained. Then, nerve section images were registered using the bilinear method and edges of fascicles were extracted using an improved gradient vector flow snake method. Subsequently, fascicle types were identified automatically using the multi-directional gradient and second-order gradient method. Finally, a 3D virtual model of internal fascicles was obtained after section images were processed. This technique was successfully applied for 3D reconstruction for the median nerve of the hand-wrist and cubital fossa regions and the gastrocnemius nerve. This nerve internal fascicle 3D reconstruction technology would be helpful for aiding peripheral nerve repair and virtual surgery.
Publisher: Springer Science and Business Media LLC
Date: 08-09-2016
Publisher: Hindawi Limited
Date: 2015
DOI: 10.1155/2015/642810
Abstract: The settlement control is critical for the safety of road based on high filled embankment. The traditional construction methods have the characteristic with less soil thickness compacted at a time. There are many advantages to compact the gravel soil with blasting. The cavity in soil is formed by blasting and its fillings to form a composite foundation for the embankment. The field data show this composite foundation can meet the requirement of loading and settlement control with less construction time. In geotechnical blasting, the high temperature due to blasting will swell the material around, so its worthy to do the coupled analysis with thermal mechanics (TM) and blasting compaction in the high filled embankment. In this paper, a 3D model is built with FLAC3D to simulate a single hole to predict the range and degree of thermal propagation. Then, the thermal strains got from the model are used to estimate the displacement of surrounding soil to predict the degree of compaction and optimize the distribution of blast holes in plan.
Publisher: Informa UK Limited
Date: 03-2020
DOI: 10.2147/NDT.S238455
Publisher: Springer Science and Business Media LLC
Date: 23-03-2016
Publisher: Wiley
Date: 24-06-2020
DOI: 10.1111/JCMM.15528
Publisher: eLife Sciences Publications, Ltd
Date: 09-02-2020
Publisher: SAGE Publications
Date: 03-2019
Abstract: As one of the dynamic disasters of deep mining, rockburst significantly affects the safety of underground environment especially at great depth. First, the elastic energy and dissipative energy are deduced to characterize rockburst process separately employing the theoretical analysis and test technique. Then, a series of split-Hopkinson pressure bar system tests are conducted. After calculation, the percentage of fractured dissipative energy occupied in total input dynamic energy is obtained. Subsequently, the dynamic mechanical parameters of rock specimens and dynamic impact factors are fitted. Finally, a three-dimensional model is developed using the mechanical property of the host rock, constitutive model, and in situ geostress. The contours of energy and the damage conditions of host rock are predicted, and the tendentiousness of rockburst is estimated.
Publisher: Springer Science and Business Media LLC
Date: 12-2019
DOI: 10.1186/S12893-019-0649-7
Abstract: When restoring the appearance and function of the fingers, hand surgeons face a challenge in choosing a suitable surgical method to repair finger skin defects. In this study, we designed a long elliptical flap based on a propeller perforator flap and located slightly toward the dorsal lateral aspect of the finger. The flap with a pedicle consisting of the dorsal perforator of the distal digital artery and dorsal digital artery perforator chain is rotated to cover a large wound on the distal end. From December 2014 to December 2017, 10 patients with finger soft tissue defects were treated with the propeller perforator flap described in this study. All flaps survived after surgery, and 2 had a transient venous congestion. After a follow-up period of 3 to 12 months, the static two-point discrimination of the flap was 8.06 ± 1.75 mm, and the range of motion was 149.4 ± 12.9°. This designed flap can span several angiosomes supplied by the perforators. Due to the inclusion of a vessel chain between the dorsal digital artery perforators, the length-to-width ratio of the flap can be up to 3:1. This technique increases the size of flap that can be harvested safely while retaining a reliable blood supply. The present study describes a new method for repairing soft tissue defects of the finger by using the technique of propeller perforator flaps based on dorsal digital artery perforator chains. The registration number of this study is ChiCTR1800014588 it has been retrospectively registered with Chinese Clinical Trial Registry ( chictr.org.cn ), 18/11/2019.
Publisher: Hindawi Limited
Date: 2015
DOI: 10.1155/2015/294239
Abstract: Gadolinium substituted cobalt ferrite CoGd x Fe 2− x O 4 ( x = 0, 0.04, 0.08) powders have been prepared by a sol-gel autocombustion method. XRD results indicate the production of a single cubic phase of ferrites. The lattice parameter increases and the average crystallite size decreases with the substitution of Gd 3+ ions. SEM shows that the ferrite powers are nanoparticles. Room temperature Mössbauer spectra of CoGd x Fe 22− x O 4 are two normal Zeeman-split sextets, which display ferrimagnetic behavior. The saturation magnetization decreases and the coercivity increases by the Gd 3+ ions.
Publisher: Elsevier BV
Date: 06-2016
Publisher: World Scientific Pub Co Pte Lt
Date: 06-2018
DOI: 10.1142/S0219455418500797
Abstract: This paper addresses the compressive local buckling behavior of an infinitely long laminated composite plate resting on a tensionless elastic foundation (Winkler foundation). The analytical solution to the contact buckling coefficient of a laminated composite plate is derived using a one-dimensional analytical method. Numerical ex les are considered to investigate the influence of the ply angle and foundation stiffness on the contact buckling coefficients of laminated composite plates under uniaxial compression. The lateral boundary conditions including cl ed and simply-supported edges are treated. Finally, finite element (FE) analysis is conducted to provide an independent check on the analytical solutions.
Publisher: SAGE Publications
Date: 11-2017
Publisher: SAGE Publications
Date: 2017
Abstract: In this study, a visual grading system of vegetable grafting machine was developed. The study described key technology of visual grading system of vegetable grafting machine. First, the contrasting experiment was conducted between acquired images under blue background light and natural light conditions, with the blue background light chosen as lighting source. The Visual C++ platform with open-source computer vision library (Open CV) was used for the image processing. Subsequently, maximum frequency of total number of 0-valued pixels was predicted and used to extract the measurements of scion and rootstock stem diameters. Finally, the developed integrated visual grading system was experimented with 100 scions and rootstock seedlings. The results showed that success rate of grading reached up to 98%. This shows that selection and grading of scion and rootstock could be fully automated with this developed visual grading system. Hence, this technology would be greatly helpful for improving the grading accuracy and efficiency.
Publisher: SAGE Publications
Date: 05-2020
Abstract: This prospective study was performed to investigate the distribution of proximal ulnar artery perforating vessels through three-dimensional blood vessel reconstruction and examine the presence and consistency of the perforating vessels intraoperatively. For anatomical guidance, three-dimensional blood vessel reconstruction was performed to determine the consistent presence of perforating vessels in the proximal ulnar artery. A free proximal ulnar artery perforator flap was then transferred in 17 patients to resurface skin defects on the hands. Color Doppler ultrasound was used to identify and mark the perforating vessels. Intraoperative evaluation was conducted to check for anastomosis of the perforating vessels at the marked sites and assess the vessel anastomosis conditions. No vascular crisis, flap necrosis, or wound infection occurred after surgery in 15 patients. Postoperative follow-up was conducted for 6 to 36 months. The appearance of the flap was satisfactory, the texture of the flap was soft, sensation was well restored, and hand function was not limited. The mean two-point discrimination of the flap was 7.6 ± 2.2 mm. Free sensory proximal ulnar artery perforator flap transfer is a safe and reliable surgical technique with respect to restoration of both the appearance and sensory function of the hand.
Publisher: Spandidos Publications
Date: 21-08-2020
Publisher: Springer Science and Business Media LLC
Date: 22-10-2018
Publisher: American Society of Civil Engineers (ASCE)
Date: 09-2016
Publisher: JVE International Ltd.
Date: 15-05-2017
Abstract: Feature extraction is one of the core problems in condition monitoring and fault diagnosis of mechanical equipment. In this study, an OMP-NWE method of feature extraction is proposed, aiming at the problem of low accuracy of existing feature extraction method. The OMP-NWE method integrates the strengths of orthogonal matching pursuit (OMP) algorithm with the benefits of nonparametric waveform estimation (NWE). Signal feature extraction model is constructed by design of filter bank and adaptive template signal. Then the vibration signal is linearly decomposed into a set of best matching waveform, which solves the problem that the basis function must be chosen in advance in OMP algorithm. The OMP-NWE method is applied to the feature extraction of the simulation and experimental vibration signal of rolling bearing, compared with the traditional OMP algorithm. Results show that the SNR of the extracted feature signal using OMP-NWE method increased by 19.22 % compared with that using the OMP method, which illustrates that OMP-NWE method has a higher accuracy in the feature extraction of unknown complex vibration signals. This work provides a new idea and a successful ex le for the feature extraction of vibration signal in the condition monitoring and fault diagnosis of mechanical equipment.
Publisher: Springer Science and Business Media LLC
Date: 10-07-2020
DOI: 10.1186/S12891-020-03370-7
Abstract: Complicated acetabular fractures comprise the most challenging field for orthopedists. The purpose of this study was to develop three-dimensional printed patient-specific (3DPPS) Ti-6Al-4 V plates to treat complicated acetabular fractures involving quadrilateral plate (QLP) disruption and to evaluate their efficacy. Fifty patients with acetabular fractures involving QLP disruption were selected between January 2016 and June 2017. Patients were ided into a control group (Group A, 35 patients) and an experimental group (Group B, 15 patients), and were treated by the conventional method of shaping reconstruction plates or with 3DPPS Ti-6AL-4 V plates, respectively. The efficacy of Ti-6AL-4 V plates was evaluated by blood loss, operative time, reduction quality, postoperative residual displacement, and complications. The operative time and blood loss in Group B were reduced compared to Group A, and the difference was statistically significant ( P 0.05). There was no significant difference in reduction quality between the two groups ( P 0.05). Reduction quality in Group B was anatomic in 10 (66.7%), satisfactory in four (26.7%), and poor in one (6.7%). In Group A, they were anatomic in 18 (51.4%), satisfactory in 13 (37.1%), and poor in four (11.4%). Residual displacement in Group B was less than that in Group A, and the difference was statistically significant ( P 0.05). In Group B, one case exhibited loosening of the pubic screw postoperatively. In Group A, there was one case of wound infection, one of deep vein thrombosis (DVT) in the ipsilateral lower limb, one case of traumatic arthritis and two obturator nerve injuries. The 3DPPS Ti-6AL-4 V plate is a feasible, accurate and effective implant for acetabular fracture treatment.
Publisher: Hindawi Limited
Date: 2015
DOI: 10.1155/2015/597313
Abstract: A suspected pulmonary nodule detection method was proposed based on dot-filter and extracting centerline algorithm. In this paper, we focus on the distinguishing adhesion pulmonary nodules attached to vessels in two-dimensional (2D) lung computed tomography (CT) images. Firstly, the dot-filter based on Hessian matrix was constructed to enhance the circular area of the pulmonary CT images, which enhanced the circular suspected pulmonary nodule and suppresses the line-like areas. Secondly, to detect the nondistinguishable attached pulmonary nodules by the dot-filter, an algorithm based on extracting centerline was developed to enhance the circle area formed by the end or head of the vessels including the intersection of the lines. 20 sets of CT images were used in the experiments. In addition, 20 true/false nodules extracted were used to test the function of classifier. The experimental results show that the method based on dot-filter and extracting centerline algorithm can detect the attached pulmonary nodules accurately, which is a basis for further studies on the pulmonary nodule detection and diagnose.
Publisher: Springer Science and Business Media LLC
Date: 02-06-2015
Publisher: Elsevier BV
Date: 08-2015
Publisher: Wiley
Date: 15-11-2021
DOI: 10.1111/JCMM.16410
Abstract: Osteoporosis is characterized by increased bone fragility, and the drugs used at present to treat osteoporosis can cause adverse reactions. Gentiopicroside (GEN), a class of natural compounds with numerous biological activities such as anti‐resorptive properties and protective effects against bone loss. Therefore, the aim of this work was to explore the effect of GEN on bone mesenchymal stem cells (BMSCs) osteogenesis for a potential osteoporosis therapy. In vitro, BMSCs were exposed to GEN at different doses for 2 weeks, whereas in vivo, ovariectomized osteoporosis was established in mice and the therapeutic effect of GEN was evaluated for 3 months. Our results in vitro showed that GEN promoted the activity of alkaline phosphatase, increased the calcified nodules in BMSCs and up‐regulated the osteogenic factors (Runx2, OSX, OCN, OPN and BMP2). In vivo, GEN promoted the expression of Runx2, OCN and BMP2, increased the level of osteogenic parameters, and accelerated the osteogenesis of BMSCs by activating the BMP pathway and Wnt/β‐catenin pathway, effect that was inhibited using the BMP inhibitor Noggin and Wnt/β‐catenin inhibitor DKK1. Silencing the β‐catenin gene and BMP2 gene blocked the osteogenic differentiation induced by GEN in BMSCs. This block was also observed when only β‐catenin was silenced, although the knockout of BMP2 did not affect β‐catenin expression induced by GEN. Therefore, GEN promotes BMSC osteogenesis by regulating β‐catenin‐BMP signalling, providing a novel strategy in the treatment of osteoporosis.
Publisher: SAGE Publications
Date: 2020
Publisher: Public Library of Science (PLoS)
Date: 29-06-2015
Publisher: Hindawi Limited
Date: 2015
DOI: 10.1155/2015/891212
Abstract: Two scale-model tests were separately conducted in standard Toyoura sand with relative density of 50% and 80%. The effect of sand relative density on pile-soil interaction was investigated through the response of a laterally loaded pile and the sand movement around the pile. At a displacement of 3.6 mm of the loading point, the applied loads in loose and dense sand were 4.775 N and 21.025 N, respectively, and the maximum moment and soil resistance of the pile in dense sand were over 4 times those in loose sand. However, the deflection of the pile in dense sand was less than that in loose sand additionally, the depth of zero deflection in dense sand was also less than that in loose sand. At the same time, the maximum displacements of loose sand in the vertical profile and ground surface were over 1.5 times those of dense sand. These characteristics occurred because the relative stiffness ratio of soil and pile increased as the relative density increased, which caused the behavior of the pile in dense sand to be elastic rather than rigid. In addition, the compacted sand particles did not move as easily as the loose sand particles.
Publisher: SAGE Publications
Date: 12-12-2017
Abstract: As the main bearing components of vehicle wheel/rail systems, railway bearings take on the main load of wheel/rail system. These bearings can be easily damaged after a long-term load, which causes vibrations and significant deterioration of force distribution and directly affects the driving stability of the locomotive. Current systems available for modeling the dynamics of wheel/rail systems rarely consider nonlinear contact load bearing, which causes errors in the calculation of wheel/rail system dynamics. According to the bearing structure characteristics and working features of a specific system, this paper thoroughly evaluates the flexible deformation of shaft and bearing, time-varying nonlinear contact load, track irregularity, and bearing to establish a wheel/rail system coupling dynamics model. Then, based on the coupling dynamics theoretical model, the wheel/rail system’s coupling nonlinear dynamic characteristics are studied under random load. Then, this theoretical model of the wheel–bearing–rail system dynamics is verified using the railway bearing as an ex le. Finally, the model is applied to the process of rail/wheel low force design. Results show that under irregular stimulation, the maximum contact load increased by 71.2% and the maximum contact stress increased by 19.6%. After moderate wear, the wheel/rail system vibration and loading condition deteriorate rapidly. Under the low rail/wheel force, the wheel tread and diameter had significant effects on wheel/rail contact force distribution. The rail specifications are found to affect the wheel/rail system’s vibration significantly. This paper has important theoretical value and practical significance for developing reliable railway bearings and wheel/rail systems with good static/dynamic characteristics that can withstand dynamic impact load.
Publisher: American Scientific Publishers
Date: 05-2016
Publisher: Springer Science and Business Media LLC
Date: 30-08-2016
Publisher: Wiley
Date: 14-10-2018
DOI: 10.1002/JCP.27456
Abstract: Long noncoding RNAs (lncRNAs) play a critical role in the initiation and progression of colorectal cancer (CRC), but little is known about the function of lncRNAs in the colorectal liver metastasis (CLM). This study was designed to identify specific lncRNAs correlating to liver metastasis of CRC, and to further assess their clinical value. Seventeen patients with primary CRC lesions, adjacent normal mucosa, and synchronous liver metastases lesions were ided into discovery set (six patients) and test set (11 patients). Transcriptome sequencing (RNAseq) was used to screen differential expression of lncRNAs in the discovery set. Based on bioinformatics data, quantitative reverse‐transcription polymerase chain reaction (qRT‐PCR) was used to verify the target lncRNA in test set. The relationships between target lncRNA and clinical values were analysed in an expanded validation set of additional 91 patients. 23 upregulated and 14 downregulated lncRNAs were detected for distinguishing synchronous liver metastases, primary CRC lesions from adjacent normal mucosa in the RNAseq set. The expression levels of four lncRNAs in the 37 lncRNA signature were verified by qRT‐PCR in the test set. Compared with the paired normal mucosa, high expression levels of lnc‐small‐nucleolar RNA host gene 15 (SNHG15) were detected not only in primary CRC lesions but also in liver metastases lesions in the test set. Furthermore, in the expanded validation set, high expression of lnc‐SNHG15 was significantly associated with lymph‐node metastasis and liver metastasis ( p 0.05), and patients displaying high lncRNA‐SNHG15 expression exhibited a shorter median overall survival duration than those displaying low expression (30.7 vs. 35.2 months p = 0.003). Multivariate analyses demonstrated that lncRNA‐SNHG15 overexpression may serve as a poor prognostic biomarker for CRC patients ( p = 0.049 Cox's regression: 2.731). Lnc‐SNHG15 overexpression was significantly associated with CLM and high‐expression of lnc‐SNHG15 in CRC was an independent predictor of poor survival.
Publisher: American Scientific Publishers
Date: 09-2015
Publisher: MDPI AG
Date: 20-11-2015
DOI: 10.3390/MIN5040523
Publisher: American Scientific Publishers
Date: 09-2015
Publisher: American Scientific Publishers
Date: 09-2015
Publisher: Springer Science and Business Media LLC
Date: 11-02-2019
Publisher: Springer Science and Business Media LLC
Date: 11-08-2016
Publisher: MDPI AG
Date: 28-10-2015
DOI: 10.3390/MIN5040520
Publisher: Informa UK Limited
Date: 03-2020
DOI: 10.2147/NDT.S235562
Publisher: Hindawi Limited
Date: 2015
DOI: 10.1155/2015/376474
Abstract: Osteocytes, the major type of bone cells which reside in their lacunar and canalicular system within the bone matrix, function as biomechanosensors and biomechanotransducers of the bone. Although biomechanical behaviour of the osteocyte-lacunar-canalicular system has been investigated in previous studies mostly using computational 2-dimensional (2D) geometric models, only a few studies have used the 3-dimensional (3D) finite element (FE) model. In the current study, a 3D FE model was used to predict the responses of strain distributions of osteocyte-lacunar-canalicular system analyzed under static and cyclic loads. The strain lification factor was calculated for all simulations. Effects on the strain of the osteocyte system were investigated under 500, 1500, 2000, and 3000 microstrain loading magnitudes and 1, 5, 10, 40, and 100 Hz loading frequencies. The maximum strain was found to change with loading magnitude and frequency. It was observed that maximum strain under 3000-microstrain loading was higher than those under 500, 1500, and 2000 microstrains. When the loading strain reached the maximum magnitude, the strain lification factor of 100 Hz was higher than those of the other frequencies. Data from this 3D FE model study suggests that the strain lification factor of the osteocyte-lacunar-canalicular system increases with loading frequency and loading strain increasing.
Publisher: Elsevier BV
Date: 2017
Publisher: Informa UK Limited
Date: 11-2019
DOI: 10.2147/OTT.S224618
Publisher: Elsevier BV
Date: 06-2020
Publisher: Springer Science and Business Media LLC
Date: 10-10-2017
Publisher: Elsevier BV
Date: 2019
Publisher: Wroclaw Medical University
Date: 29-04-2020
DOI: 10.17219/ACEM/116749
Publisher: Elsevier BV
Date: 06-2016
Publisher: Springer Science and Business Media LLC
Date: 03-02-2017
Publisher: Wiley
Date: 27-09-2018
DOI: 10.1002/JCB.27768
Abstract: While previous studies have shown that the number of circulating tumor cells (CTCs) alone is not sufficient to reflect tumor progression and that cyclooxygenase‐2 (COX‐2) expression is correlated with colorectal cancer (CRC) metastasis, COX‐2 expression status and its potential functions in CTCs of CRC patients are unknown. Here, epithelial‐mesenchymal transition (EMT) phenotype‐based subsets of CTCs and the COX‐2 expression status in CTCs were identified and their potential clinical values were assessed in 91 CRC patients. CTCs were enumerated in peripheral blood and subsets of CTCs (epithelial [eCTCs], mesenchymal [mCTCs], and biophenotypic [bCTCs]) and the COX‐2 expression status were determined using the RNA in situ hybridization method. CTCs were detected in 80.2% (73 of 91) patients. Neither the total CTC nor eCTC numbers were found to significantly associate with any of the clinicopathological features. However, the number of mCTCs was significantly associated with distance metastasis ( P = 0.035) and had a trend of being associated with lymph node metastasis ( P = 0.055). Among the 73 patients enrolled for evaluating COX‐2 expression, 52.5% (38 of 73) were found to express COX‐2 in CTCs, and COX‐2 expression in CTCs was not found to associate with the clinicopathological factors. However, COX‐2 expression in mCTCs tended to have a higher rate in patients with metastasis compared with those without metastasis (72.0% vs 42.8% P = 0.072). Furthermore, COX‐2 expression and mCTC marker expression correlated positively ( R = 0.287 P = 0.017). Further studies are required to investigate the clinical value of the expression of COX‐2 in mCTCs, especially in CRC patients with the advanced tumor stage and distant metastasis.
Publisher: Elsevier BV
Date: 10-2018
Publisher: IEEE
Date: 2000
Publisher: Hindawi Limited
Date: 2015
DOI: 10.1155/2015/854840
Abstract: Zinc substituted magnesium ferrite nanomaterials M g 1 - x Z n x F e 2 O 4 ( x = 0, 0.1, 0.3, 0.5, 0.7) powders have been prepared by a sol-gel autocombustion method. The lattice parameter increases with increase in Zn concentration, but average crystallite size tends to decrease by increasing the zinc content. SEM results indicate the distribution of grains and morphology of the s les. Some particles are agglomerated due to the presence of magnetic interactions among particles. Room temperature Mössbauer spectra of M g 1 - x Z n x F e 2 O 4 shows that the A Mössbauer absorption area decreases and the B Mössbauer absorption area increases with zinc concentration increasing. The change of the saturation magnetization can be explained with Néel’s theory. It was confirmed that the transition from ferrimagnetic to superparamagnetic behaviour depends on increase in zinc concentration by Mössbauer spectra at room temperature. Saturation magnetization increases and coercivity decreases with Zn content increasing.
Publisher: Springer Science and Business Media LLC
Date: 09-06-2017
Publisher: Elsevier BV
Date: 03-2018
Publisher: Wiley
Date: 19-11-2020
DOI: 10.1111/JCMM.16109
Publisher: Hindawi Limited
Date: 2015
DOI: 10.1155/2015/705471
Abstract: A soil incubation method was used to investigate the solubility characteristics and slow-release mechanism of organic-inorganic compound coated urea at temperature of 10, 20, and 30°C. The membrane microstructure with and without incubation was tested via scanning electron microscopy (SEM). Slow release of nitrogen (N) from different inorganic minerals was analysed by the activation energy from the nutrient solubility system. The rate of nitrogen solubility increased with temperature increasing. The first-order reaction kinetic equation described the solubility process of coated urea. The rate constant k also increased with temperature increasing. Moreover, the SEM images showed that the microstructure of the coating layer changed into a flocculent structure and the number of tiny pores and holes on the membrane surface increased significantly with temperature increasing, which increased N solubility rate. The Arrhenius equation indicated that activation energy was closely related to k during the solubility process the activation energy was reduced with k rising, which resulted in N solubility rate increasing. Overall, the N solubility rate of coated urea was affected by temperature.
Publisher: Elsevier BV
Date: 02-2018
Publisher: Informa UK Limited
Date: 11-2019
DOI: 10.2147/NDT.S230688
Publisher: Springer Science and Business Media LLC
Date: 09-12-2015
Publisher: Informa UK Limited
Date: 03-2020
DOI: 10.2147/TCRM.S237851
Publisher: Wiley
Date: 10-10-2019
DOI: 10.1113/JP278478
Abstract: There is a close relationship between skeletal muscle physiology and Ca 2+ /calmodulin (CaM) signalling. Despite the effects of Ca 2+ /CaM signalling on immune and inflammatory responses having been extensively explored, few studies have investigated the role of CaM pathway activation on the post‐injury muscle inflammatory response. In this study, we investigated the role of CaM‐dependent signalling in muscle inflammation in cardiotoxin induced myoinjuries in mice. The Ca 2+ /calmodulin‐dependent protein kinase II (CaMII), Ca 2+ /calmodulin‐dependent protein kinase IV (CaMKIV), and nuclear factor of activated T cells (NFAT) pathways are likely to be simultaneously activated in muscle cells and in infiltrating lymphocytes and to regulate the immune behaviours of myofibres in an inflammatory environment, and these pathways ultimately affect the outcome of muscle inflammation. Calcium/calmodulin (Ca 2+ /CaM) signalling is essential for immune and inflammatory responses in tissues. However, it is unclear if Ca 2+ /CaM signalling interferes with muscle inflammation. Here we investigated the roles of CaM‐dependent signalling in muscle inflammation in mice that had acute myoinjuries in the tibialis anterior muscle induced by intramuscular cardiotoxin (CTX) injections and received intraperitoneal injections of either the CaM inhibitor calmidazolium chloride (CCL) or CaM agonist calcium‐like peptide 1 (CALP1). Multiple inflammatory parameters, including muscle autoantigens and toll‐like receptors, mononuclear cell infiltration, cytokines and chemokines associated with peripheral muscle inflammation, were examined after the injury and treatment. CALP1 treatment enhanced intramuscular infiltration of monocytes/macrophages into the damaged tibialis anterior muscle and up‐regulated mRNA and protein levels of muscle autoantigens (Mi‐2, HARS and Ku70) and Toll‐like receptor 3 (TLR3), and mRNA levels of tumor necrosis factor α (TNF‐α), interleukin‐6 (IL‐6), Monocyte chemoattractant protein‐1 (MCP1), Monocyte chemoattractant protein‐3 (MCP3) and Macrophage inflammatory protein‐1(MIP‐1α) in damaged muscle. In contrast, CCL treatment decreased the intramuscular cell infiltration and mRNA levels of the inflammatory mediators. After CALP1 treatment, a substantial up‐regulation in Ca 2+ /calmodulin‐dependent protein kinase II (CaMKII), Ca 2+ /calmodulin‐dependent protein kinase IV (CaMKIV) and nuclear factor of activated T cells (NFAT) activity was detected in CD45 + cells isolated from the damaged muscle. More pro‐inflammatory F4/80 + Ly‐6C + cells were detected in CD45‐gated cells after CALP1 treatment than in those after CCL treatment or no treatment. Consistently, in interferon‐γ‐stimulated cultured myoblasts and myotubes, CALP1 treatment up‐regulated the activities of CaMKII, CaMKIV and NFAT, and levels of class I/II major histocompatibility complexes (MHC‐I/II) and TLR3. Our findings demonstrated that CaM‐dependent signalling pathways mediate the injury‐induced acute muscle inflammatory response.
Publisher: Elsevier BV
Date: 02-2017
Publisher: Elsevier BV
Date: 02-2019
Publisher: SAGE Publications
Date: 07-2018
Abstract: The soil and vegetation on the ground surface are affected when the zinc content in the soil is excessively high. It is of great importance to choose suitable additives for the solidification/stabilization treatment of zinc-contaminated silt soil. Research focus on the stress–strain, shear strength, and durability of dry–wet cycle for solidified soil contaminated with different contents of zinc is scarce. In this study, the strength, microscopic, and stability of solidified silt are examined and analyzed, and the solidification agent with the best effect is identified. The silt near the mouth of the Pearl River in China is collected, the different contents of zinc are added, and then 15% cement and 15% cement + 5% slag or 15% cement + 10% slag are added to the mixture for curing. The effects of solidification with different additives at the different zinc contents are determined through test, for ex le, unconfined compressive strength, leaching, scanning electron microscopy, triaxial undrained solidification, X-ray diffraction, and dry–wet cycling experiments. The results show that the admixture that contained 15% cement + 10% slag has a better effect on solidification/stabilization of zinc-contaminated silt. Thus, this study provides a reference for the treatment of zinc-contaminated soft soil.
Publisher: Hindawi Limited
Date: 2015
DOI: 10.1155/2015/604683
Abstract: In the tunnel and underground space engineering, the blasting wave will attenuate from shock wave to stress wave to elastic seismic wave in the host rock. Also, the host rock will form crushed zone, fractured zone, and elastic seismic zone under the blasting loading and waves. In this paper, an accurate mathematical dynamic loading model was built. And the crushed zone as well as fractured zone was considered as the blasting vibration source thus deducting the partial energy for cutting host rock. So this complicated dynamic problem of segmented differential blasting was regarded as an equivalent elastic boundary problem by taking advantage of Saint-Venant’s Theorem. At last, a 3D model in finite element software FLAC3D accepted the constitutive parameters, uniformly distributed mutative loading, and the cylindrical attenuation law to predict the velocity curves and effective tensile curves for calculating safety criterion formulas of surrounding rock and tunnel liner after verifying well with the in situ monitoring data.
Publisher: Springer Science and Business Media LLC
Date: 05-02-2020
Publisher: eLife Sciences Publications, Ltd
Date: 03-03-2020
DOI: 10.7554/ELIFE.52570
Abstract: The cell cycle regulator p16 is known as a biomarker and an effector of aging. However, its function in intervertebral disc degeneration (IVDD) is unclear. In this study, p16 expression levels were found to be positively correlated with the severity of human IVDD. In a mouse tail suspension (TS)-induced IVDD model, lumbar intervertebral disc height index and matrix protein expression levels were reduced significantly were largely rescued by p16 deletion. In TS mouse discs, reactive oxygen species levels, proportions of senescent cells, and the senescence-associated secretory phenotype (SASP) were all increased, cell cycling was delayed, and expression was downregulated for Sirt1, superoxide dismutase 1/2, cyclin-dependent kinases 4/6, phosphorylated retinoblastoma protein, and transcription factor E2F1/2. However, these effects were rescued by p16 deletion. Our results demonstrate that p16 plays an important role in IVDD pathogenesis and that its deletion attenuates IVDD by promoting cell cycle and inhibiting SASP, cell senescence, and oxidative stress.
Publisher: Elsevier BV
Date: 07-2016
Publisher: Wiley
Date: 27-11-2019
DOI: 10.1002/JCP.27753
Abstract: The purpose of this study was to develop a novel approach to treat bone osteosarcoma using a multipurpose scaffold aiming for local drug delivery. The slowly releasing microspheres was designed to deliver the chemotherapy drug adriamycin (ADM) and a decellularized (D) periosteum scaffold (which is known to be able to promote bone regeneration) was used to carry these microspheres. D‐periosteum was obtained by physical and chemical decellularization. Histological results showed that the cellular components were effectively removed. The D‐periosteum showed an excellent cytocompatibility and the ability to promote adhesion and growth of fibroblasts. Two kinds of slowly releasing microspheres, adriamycin gelatin microspheres (ADM‐GMS) and adriamycin poly (dl‐lactide‐co‐glycolide) gelatin microspheres (ADM‐PLGA‐GMS), were prepared and anchored to D‐periosteum, resulting in two types of drug‐releasing regenerative scaffolds. The effectiveness of these two scaffolds in killing human osteosarcoma cells was tested by evaluating cell viability overtime of the cancer cells cultured with the scaffolds. In summary, a gelatin/decellularized periosteum‐based biologic scaffold material was designed aiming for local delivery of chemotherapy drugs for osteosarcoma, with the results showing ability of the scaffolds in sustaining release of the cancer drug and in suppressing growth of the cancer cells in vitro.
No related grants have been discovered for Jianghui Dong.