ORCID Profile
0000-0003-3274-6248
Current Organisations
University of South Australia
,
University of Adelaide
,
Policlinico San Matteo Pavia Fondazione IRCCS
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Publisher: Informa UK Limited
Date: 11-2007
Publisher: Informa UK Limited
Date: 29-03-2023
Publisher: Informa UK Limited
Date: 11-2010
Publisher: Informa UK Limited
Date: 08-2011
Publisher: Oxford University Press (OUP)
Date: 24-03-2021
DOI: 10.1093/BJS/ZNAB101
Abstract: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351 best case 196, worst case 816) or non-cancer surgery (733 best case 407, worst case 1664). Both exceeded the NNV in the general population (1840 best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year. As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population.
Publisher: Wiley
Date: 09-08-2021
DOI: 10.1111/ANAE.15560
Abstract: We aimed to determine the impact of pre‐operative isolation on postoperative pulmonary complications after elective surgery during the global SARS‐CoV‐2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre‐defined sub‐group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS‐CoV‐2 infection. Patients who isolated pre‐operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS‐CoV‐2 incidence and high‐income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05–1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre‐operative testing use of COVID‐19‐free pathways or community SARS‐CoV‐2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4–7 days or ≥ 8 days of 1.25 (1.04–1.48), p = 0.015 and 1.31 (1.11–1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care.
Publisher: AFRICAN SUN MeDIA
Date: 23-07-2018
Publisher: Informa UK Limited
Date: 15-12-2022
Publisher: Informa UK Limited
Date: 21-11-2014
Publisher: Informa UK Limited
Date: 08-03-2023
Publisher: Wiley
Date: 09-03-2021
DOI: 10.1111/ANAE.15458
Abstract: Peri‐operative SARS‐CoV‐2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS‐CoV‐2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Surgical patients with pre‐operative SARS‐CoV‐2 infection were compared with those without previous SARS‐CoV‐2 infection. The primary outcome measure was 30‐day postoperative mortality. Logistic regression models were used to calculate adjusted 30‐day mortality rates stratified by time from diagnosis of SARS‐CoV‐2 infection to surgery. Among 140,231 patients (116 countries), 3127 patients (2.2%) had a pre‐operative SARS‐CoV‐2 diagnosis. Adjusted 30‐day mortality in patients without SARS‐CoV‐2 infection was 1.5% (95%CI 1.4–1.5). In patients with a pre‐operative SARS‐CoV‐2 diagnosis, mortality was increased in patients having surgery within 0–2 weeks, 3–4 weeks and 5–6 weeks of the diagnosis (odds ratio (95%CI) 4.1 (3.3–4.8), 3.9 (2.6–5.1) and 3.6 (2.0–5.2), respectively). Surgery performed ≥ 7 weeks after SARS‐CoV‐2 diagnosis was associated with a similar mortality risk to baseline (odds ratio (95%CI) 1.5 (0.9–2.1)). After a ≥ 7 week delay in undertaking surgery following SARS‐CoV‐2 infection, patients with ongoing symptoms had a higher mortality than patients whose symptoms had resolved or who had been asymptomatic (6.0% (95%CI 3.2–8.7) vs. 2.4% (95%CI 1.4–3.4) vs. 1.3% (95%CI 0.6–2.0), respectively). Where possible, surgery should be delayed for at least 7 weeks following SARS‐CoV‐2 infection. Patients with ongoing symptoms ≥ 7 weeks from diagnosis may benefit from further delay.
Publisher: Begell House
Date: 2006
Publisher: Begell House
Date: 2006
Publisher: SAGE Publications
Date: 03-2009
DOI: 10.5153/SRO.1905
Abstract: Foucault's work has given rise to increased methodological sensitivity of the political dangers associated with traditional qualitative approaches in the social sciences. There is a growing awareness that the widespread use of the research interview is not indicative of a deepening insight into the workings of culture, but is part of a broader social technology for its reproduction. In an effort to re-imagine interview methodology, scholars have read Foucault to suggest the need for greater attention to the active co-construction of research conclusions arising from interview based research. This has led in turn to the view that post modern approaches produce localized, temporally specific knowledge that fails to shed light on deeper, more enduring social structures. This paper questions these interpretations of Foucault's work, arguing that they fail to accurately represent his genealogical method or to consider its implications for research ethics. Foucault rejects a view of knowledge as emerging from the active social constructions of agents or of institutionalised ‘interests’. Rather, Foucault sees knowledge as an outcome, often accidental, of interrelated historical practices and discourses that produce the subjects and objects of social science discourse itself. The implications of Foucault's work for thinking about research ethics is not a return to authenticity or to analyses of social structure, but a rejection of the centralised, regulatory claims of an organised scientific discourse. The paper comprises a review of social science responses to post structural insights, coverage of the critical epistemological differences between Foucault's method and other key social theory paradigms, and a discussion of the critical ethical issues these differences raise for the social sciences.
Publisher: Wiley
Date: 24-08-2021
DOI: 10.1111/ANAE.15563
Abstract: SARS‐CoV‐2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri‐operative or prior SARS‐CoV‐2 were at further increased risk of venous thromboembolism. We conducted a planned sub‐study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 days of surgery. SARS‐CoV‐2 diagnosis was defined as peri‐operative (7 days before to 30 days after surgery) recent (1–6 weeks before surgery) previous (≥7 weeks before surgery) or none. Information on prophylaxis regimens or pre‐operative anti‐coagulation for baseline comorbidities was not available. Postoperative venous thromboembolism rate was 0.5% (666/123,591) in patients without SARS‐CoV‐2 2.2% (50/2317) in patients with peri‐operative SARS‐CoV‐2 1.6% (15/953) in patients with recent SARS‐CoV‐2 and 1.0% (11/1148) in patients with previous SARS‐CoV‐2. After adjustment for confounding factors, patients with peri‐operative (adjusted odds ratio 1.5 (95%CI 1.1–2.0)) and recent SARS‐CoV‐2 (1.9 (95%CI 1.2–3.3)) remained at higher risk of venous thromboembolism, with a borderline finding in previous SARS‐CoV‐2 (1.7 (95%CI 0.9–3.0)). Overall, venous thromboembolism was independently associated with 30‐day mortality (5.4 (95%CI 4.3–6.7)). In patients with SARS‐CoV‐2, mortality without venous thromboembolism was 7.4% (319/4342) and with venous thromboembolism was 40.8% (31/76). Patients undergoing surgery with peri‐operative or recent SARS‐CoV‐2 appear to be at increased risk of postoperative venous thromboembolism compared with patients with no history of SARS‐CoV‐2 infection. Optimal venous thromboembolism prophylaxis and treatment are unknown in this cohort of patients, and these data should be interpreted accordingly.
Publisher: Informa UK Limited
Date: 06-10-2017
Publisher: Emerald
Date: 09-05-2016
DOI: 10.1108/IJRD-02-2015-0004
Abstract: The purpose of this paper is to describe an experiment in a non-credit bearing series of social philosophy workshops offered to social science and humanities disciplines in an Australian university. The paper outlines the design rationale and learning objectives for the workshop series. The data set includes qualitative student responses to 501 post-workshop questionnaires and 14 in-depth qualitative responses to a follow-up online questionnaire. The data suggest that social philosophy methodology curriculum offered within a multi-discipline peer context can facilitate an appreciation among students of the centrality of theory and the value of erse discipline approaches in research. The last part of the paper explores what underpins this – a kind of un-learning or uncertainty regarding the veracity of different philosophical approaches to research, tied to a de-centring of research subjectivity that allows for the co-existence of multiple voices. Language learning, the inclusion of post-modern perspectives and an unbiased presentation of a wide range of thinkers within a challenging intellectual context are central to this. The emerging trend towards university-wide doctoral training offers opportunities for useful innovations in research education. University-wide social philosophy curriculum can play a role in facilitating constructive negotiation of theoretical complexity both within and across social science and humanities disciplines. The contemporary social science and humanities research context is a challenging space, characterised by intra-discipline methodological plurality, and the risk of marginalisation by more dominant instrumentalist, end-user and science-driven perspectives. The trend towards bringing different methodological perspectives together within inter-disciplinary research and team supervision of doctoral students can lead to conceptual misunderstanding and research delays. The capacity to negotiate and translate conceptual perspectives, often within complex research relationships, has then become an increasingly important academic skill. Within this context, university-wide doctoral training has emerged, but there has been little discussion of doctoral curricula beyond that devised for professional doctorates within the discipline in the non-US higher education literature. This paper contributes to emerging scholarship on research education by describing the sorts of relational, textual and conceptual processes that might be created in the multi-discipline social science and humanities context to produce an appreciation for the different philosophical foundations of research knowledge.
Location: Italy
No related grants have been discovered for Antonio Bozzani.