ORCID Profile
0000-0002-4752-9732
Current Organisations
Burnet Institute
,
University of Oxford
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Publisher: Elsevier BV
Date: 04-2019
Publisher: Springer Science and Business Media LLC
Date: 27-02-2023
DOI: 10.1186/S12874-023-01874-Z
Abstract: Longitudinal studies are critical to informing evolving responses to COVID-19 but can be h ered by attrition bias, which undermines their reliability for guiding policy and practice. We describe recruitment and retention in the Optimise Study, a longitudinal cohort and social networks study that aimed to inform public health and policy responses to COVID-19. Optimise recruited adults residing in Victoria, Australia September 01 2020–September 30 2021. High-frequency follow-up data collection included nominating social networks for study participation and completing a follow-up survey and four follow-up diaries each month, plus additional surveys if they tested positive for COVID-19 or were a close contact. This study compared number recruited to a-priori targets as of September 302,021, retention as of December 31 2021, comparing participants retained and not retained, and follow-up survey and diary completion October 2020–December 2021. Retained participants completed a follow-up survey or diary in each of the final three-months of their follow-up time. Attrition was defined by the number of participants not retained, ided by the number who completed a baseline survey by September 302,021. Survey completion was calculated as the proportion of follow-up surveys or diaries sent to participants that were completed between October 2020–December 2021. At September 302,021, 663 participants were recruited and at December 312,021, 563 were retained giving an overall attrition of 15% ( n = 100/663). Among the 563 retained, survey completion was 90% ( n = 19,354/21,524) for follow-up diaries and 89% ( n = 4936/5560) for monthly follow-up surveys. Compared to participants not retained, those retained were older (t-test, p 0.001), and more likely to be female (χ 2 , p = 0.001), and tertiary educated (χ 2 , p = 0.018). High levels of study retention and survey completion demonstrate a willingness to participate in a complex, longitudinal cohort study with high participant burden during a global pandemic. We believe comprehensive follow-up strategies, frequent dissemination of study findings to participants, and unique data collection systems have contributed to high levels of study retention.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 15-12-2021
Publisher: Informa UK Limited
Date: 09-2018
DOI: 10.2147/CEOR.S171248
Publisher: Elsevier BV
Date: 2021
DOI: 10.2139/SSRN.3785991
Publisher: WHO Press
Date: 03-2022
Publisher: Elsevier BV
Date: 06-2023
Publisher: MDPI AG
Date: 28-01-2022
Abstract: Background: High vaccine uptake requires strong public support, acceptance, and willingness. Methods: A longitudinal cohort study gathered survey data every four weeks between 1 October 2020 and 9 November 2021 in Victoria, Australia. Data were analysed for 686 participants aged 18 years and older. Results: Vaccine intention in our cohort increased from 60% in October 2020 to 99% in November 2021. Vaccine intention increased in all demographics, but longitudinal trends in vaccine intention differed by age, employment as a healthcare worker, presence of children in the household, and highest qualification attained. Acceptance of vaccine mandates increased from 50% in October 2020 to 71% in November 2021. Acceptance of vaccine mandates increased in all age groups except 18–25 years acceptance also varied by gender and highest qualification attained. The main reasons for not intending to be vaccinated included safety concerns, including blood clots, and vaccine efficacy. Conclusion: COVID-19 vaccination c aigns should be informed by understanding of the sociodemographic drivers of vaccine acceptance to enable socially and culturally relevant guidance and ensure equitable vaccine coverage. Vaccination policies should be applied judiciously to avoid polarisation.
Publisher: Oxford University Press (OUP)
Date: 17-05-2015
DOI: 10.1093/CID/CIV396
Publisher: Cold Spring Harbor Laboratory
Date: 02-08-2018
DOI: 10.1101/383125
Abstract: Between-species competition shapes the distribution and abundance of populations. Aedes aegypti and Ae. albopictus are vectors of pathogens such as dengue and are known to compete at the larval stage. The outcome of this inter-species competition has been found to be context dependent, with the strength and direction changing with resource availability and type. We were motivated by this uncertainty, and aimed to elucidate the magnitude and mechanism of competition. We manipulated the larval density of mixed and single species cohorts of larvae, measuring the effects on survivorship and development time. Unlike other related studies, we adjusted the feeding regime so that the per-capita resource availability was kept constant across all density treatments, at a level sufficient for successful development. This ensured that each larvae at least had the opportunity to gain the requisite resources for pupation. Our analysis found that Ae. aegypti suffered notably less mortality due to intra- and interspecific competition. For both species, intra- and interspecific competition led to the survival of faster developing in iduals, with the exception that slower developing Ae. albopictus larvae survived when exposed a combination of both high con- and heterospecific densities. These results show that the competition between Ae. aegypti and Ae. albopictus can still occur even when resources are theoretically adequate for development. This suggests that larvae can alter resource seeking and consumption parameters when exposed to high densities of conspecifics and heterospecifics, leading to contest competition. Evidence for resource-independent mechanisms of competition such as crowding are also found, as is evidence for the importance of demographic stochasticity in population processes.
Publisher: Elsevier BV
Date: 06-2022
DOI: 10.1016/J.MBS.2022.108811
Abstract: The mosquito Aedes polynesiensis inhabits Pacific islands and territories and transmits arboviruses and parasites. In the context of rapid environmental change, understanding the effects of environmental heterogeneity on mosquitoes is crucial. First, empirical field data and remote sensing data were combined to model spatial heterogeneity in the environmental suitability for Ae. polynesiensis. Second, a model of mosquito population dynamics was applied to predict mosquito distributions over a heterogeneous landscape assuming different dispersal behaviours. Motu Tautau, French Polynesia, was used as a case study of the utility of this methodological approach. Ae. polynesiensis use land crab Cardisoma carnifex burrows for oviposition in French Polynesia environmental suitability was therefore quantified using C. carnifex burrow density. Micro-regions with large Ae. polynesiensis populations facilitated by high C. carnifex burrow density were accurately captured by our methodology. Preferential dispersal towards oviposition sites promoted larger population sizes than non-preferential dispersal but did not offer greater resilience to environmental change. Reduced environmental suitability for Ae. polynesiensis resulted in spatially non-linear effects upon the mosquito distribution. Environmental change has complex spatial effects upon mosquito populations. Mosquito control strategies must carefully balance spatial effects with net effects.
Publisher: Elsevier BV
Date: 04-2020
Publisher: Wiley
Date: 02-06-2020
DOI: 10.1111/EEN.12877
Publisher: AMPCo
Date: 18-11-2020
DOI: 10.5694/MJA2.50845
Publisher: Elsevier BV
Date: 02-2023
Publisher: Cold Spring Harbor Laboratory
Date: 12-06-2020
Publisher: Public Library of Science (PLoS)
Date: 19-08-2021
DOI: 10.1371/JOURNAL.PONE.0256400
Abstract: WHO recommends use of rapid dual HIV/syphilis tests for screening pregnant women (PW) during antenatal care to prevent mother-to-child transmission. Scale-up of testing implies a need to accurately forecast and procure benzathine penicillin (BPG) to treat the additionally identified PW with syphilis. Country-reported ANC coverage, PW syphilis screening and treatment coverage values in 2019 were scaled linearly to EMTCT targets by 2030 (constant increasing slope from 2019 figures to 95% in 2030) for 11 focus countries. Antenatal syphilis screening coverage was substituted with HIV screening coverage to estimate potential contribution of rapid dual HIV/syphilis tests in identifying additional PW with syphilis. BPG demand was calculated for 2019–2030 accordingly. The estimated demand for BPG (in 2.4 million unit vials) using current maternal syphilis prevalence and treatment coverage will increase from a baseline of 414,459 doses in 2019 to 683,067 doses (+65%) in 2021 assuming immediate replacement of single HIV test kits with rapid dual HIV/syphilis tests for these 11 countries. Continued scale up of syphilis screening and treatment coverage to reach elimination coverage of 95% will result in an estimated demand increase of 160%, (663,969 doses) from 2019 baseline for a total demand of 1,078,428 BPG doses by 2030. Demand for BPG will increase following adoption of rapid dual HIV/syphilis test kits due to increases in maternal diagnoses of syphilis. To eliminate congenital syphilis, MNCH clinical programs will need to synergize with disease surveillance programs to accurately forecast BPG demand with scale up of antenatal syphilis screening to ensure adequate treatment is available for pregnant women diagnosed with syphilis.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 10-2014
DOI: 10.1002/HEP.27455
Publisher: Elsevier BV
Date: 2020
DOI: 10.2139/SSRN.3696865
Publisher: Research Square Platform LLC
Date: 29-04-2022
Publisher: Research Square Platform LLC
Date: 16-09-2022
Publisher: Frontiers Media SA
Date: 02-06-2023
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Katherine Heath.