ORCID Profile
0000-0002-8653-0074
Current Organisations
Queensland University of Technology
,
University of South Australia
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Publisher: American Chemical Society (ACS)
Date: 19-08-2016
DOI: 10.1021/ACS.LANGMUIR.6B02312
Abstract: Artificial neural networks (ANNs) form a class of powerful multivariate analysis techniques, yet their routine use in the surface analysis community is limited. Principal component analysis (PCA) is more commonly employed to reduce the dimensionality of large data sets and highlight key characteristics. Herein, we discuss the strengths and weaknesses of PCA and ANNs as methods for investigation and interpretation of a complex multivariate s le set. Using time-of-flight secondary ion mass spectrometry (ToF-SIMS) we acquired spectra from an antibody and its proteolysis fragments with three primary-ion sources to obtain a panel of 72 spectra and a characteristic peak list of 775 fragment ions. We describe the use of ANNs as a means to interpret the ToF-SIMS spectral data, highlight the optimal neural network design and computational parameters, and discuss the technique limitations. Further, employing Bi3(+) as the primary-ion source, ANNs can accurately classify antibody fragments from the parent antibody based on ToF-SIMS spectra.
Publisher: Elsevier BV
Date: 05-2012
DOI: 10.1016/J.BIOS.2012.03.019
Abstract: Untreated recycled water, such as sewage and graywater, will almost always contain a wide range of agents that are likely to present risks to human health, including chemicals and pathogenic microorganisms. The microbial hazards, such as large numbers of enteric pathogens that can cause gastroenteric illness if ingested, are the main cause of concern for human health. The presence of the enteropathogenic Escherichia coli (EPEC) serotype is of particular concern, as this group of bacteria is responsible for causing severe infant and travelers' diarrhea, gastroenteritis and hemolytic uremic syndrome. A biosensing system based on an optical Fabry-Pérot (FP) cavity, capable of directly detecting the presence of EPEC within 5 min, has been developed using a simple micro-thin double-sided adhesive tape and two semi-transparent FP mirror plates. The system utilizes a poly(methyl methacrylate) (PMMA) or glass substrates sputtered by 40-nm-thick gold thin films serving as FP mirrors. Mirrors have been activated using 0.1M mercaptopropionic acid, influencing an immobilization density of the translocated intimin receptor (TIR) of 100 ng/cm(2). The specificity of recognition was confirmed by exposing TIR functionalized surfaces to four taxonomically related and/or distantly related bacterial strains. It was found that the TIR-functionalized surfaces did not show any bacterial capture for these other bacterial strains within a 15 min incubation period.
Publisher: American Chemical Society (ACS)
Date: 26-03-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0TC02751K
Abstract: Multi-material 3D microstructures with photochemically adaptive mechanical properties are fabricated and we explore how their photo-responsiveness is related to the parameters that are used during their creation via 3D laser lithography.
Publisher: Wiley
Date: 30-01-2020
Publisher: Springer Science and Business Media LLC
Date: 07-2001
DOI: 10.1007/BF02373562
Publisher: American Chemical Society (ACS)
Date: 17-10-2022
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6NR01179A
Abstract: Electrochemical energy production and storage at large scale and low cost, is a critical bottleneck in renewable energy systems.
Publisher: Informa UK Limited
Date: 10-06-2014
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7DT00139H
Abstract: A nanostructured ternary metal molybdate using glutamic acid as biopolymer for hybrid device is reported with improved pseudocapacitive behaviour.
Publisher: Association for Materials Protection and Performance (AMPP)
Date: 02-10-2018
DOI: 10.5006/2967
Publisher: Elsevier BV
Date: 09-2011
Publisher: American Chemical Society (ACS)
Date: 24-09-2019
DOI: 10.1021/ACS.ANALCHEM.9B03322
Abstract: Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a powerful surface characterization technique capable of producing high spatial resolution hyperspectral images, in which each pixel comprises an entire mass spectrum. Such images can provide insight into the chemical composition across a surface. However, issues arise due to the size and complexity of the data produced. Data are particularly complicated for biological s les, primarily due to overlapping spectra produced by similar components. The traditional approach of selecting in idual ion peaks as representative of particular components is insufficient for such complex data sets. Multivariate analysis (MVA) can help to overcome this significant hurdle. We demonstrate that Kohonen self-organizing maps (SOMs) with a toroidal topology can be used to analyze a ToF-SIMS hyperspectral imaging data set and identify spectral similarities between pixels. We present a method for color-tagging the toroidal SOM output, which reduces the entire data set to a single RGB image in which similar pixels-based on their associated mass spectra-are assigned a similar color. This method was exemplified using a ToF-SIMS image of dried large multilamellar vesicles (LMVs), loaded with the antibiotic cefditoren pivoxil (CP). We successfully identified CP-loaded and empty LMVs without the need for any prior knowledge of the s le, despite their highly similar spectra. We also identified which specific ion peaks were most important in differentiating the two LMV populations. This approach is entirely unsupervised and requires minimal experimenter input. It was developed with the aim of providing a user-friendly yet sophisticated workflow for understanding complex biological s les using ToF-SIMS images.
Publisher: Elsevier BV
Date: 05-2009
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4TA00220B
Abstract: Changes in the electrochemical properties of transition metal oxynitrides upon storage in ambient air are explored for the first time, and the role of passivation is studied.
Publisher: Elsevier BV
Date: 04-0006
DOI: 10.1016/J.ACTBIO.2015.02.027
Abstract: The conformation and orientation of proteins immobilised on synthetic materials determine their ability to bind their antigens and thereby the sensitivity of the microarrays and biosensors employing them. Plasma immersion ion implantation (PIII) of polymers significantly increases both their wettability and protein binding capacity. This paper addresses the hypothesis that a PIII treated polymer surface modifies the native protein conformation less significantly than a more hydrophobic untreated surface and that the differences in surface properties also affect the protein orientation. To prove this, the orientation and conformation of rat anti-mouse CD34 antibody immobilized on untreated and PIII treated polycarbonate (PC) were investigated using ToF-SIMS and FTIR-ATR spectroscopy. Analysis of the primary structure of anti-CD34 antibody and principal component analysis of ToF-SIMS data were applied to detect the difference in the orientation of the antibody attached to untreated and PIII treated PC. The difference in the antibody conformation was analysed using deconvolution of the Amide I peak (in FTIR-ATR spectra) and curve-fitting. It was found that compared to the PIII treated s le, the antibody immobilized on the untreated PC s le has a secondary structure with a lower fraction of β-sheets and a higher fraction of α-helices and disordered fragments. Also, it was found that anti-CD34 antibody has a higher tendency to occur in the inactive 'tail-up' orientation when immobilized on an untreated PC surface than on a PIII treated surface. These findings confirm the above hypothesis.
Publisher: Wiley
Date: 24-05-2017
Publisher: Wiley
Date: 15-07-2019
Publisher: Wiley
Date: 10-01-2011
DOI: 10.1002/APP.33355
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C5CP07141K
Abstract: An attempt has been made to correlate the differences in structural parameters, surface areas, morphology etc. with the electrochemical capacitive behaviour of the EMDs.
Publisher: Wiley
Date: 29-01-2023
Abstract: Amid the rapid development of electric vehicles, a flexible and waterproof radiant heater that can withstand repeated bending and washing is highly desirable. Herein, a freestanding, ultra‐flexible, and washable joule heater is constructed using a biocompatible poly(styrene‐isoprene‐styrene) (SIBS) polymer as binder and carbon black (CB) as heating material. By controlling the amount of CB and the thickness of the film, a minimum resistivity, and conductivity of 26 mΩ cm and 7.4 S cm −1 , respectively, is achieved. Remarkably, the 28% CB/SIBS film can reach a maximum temperature of 201 °C while maintaining a stable temperature at 130 °C for repeated ON/OFF cycles. Time‐of‐flight secondary ion mass spectrometry of post‐mortem material analysis shows that a 1 h stability test at 130 °C has no sign of degradation and the films remain extremely stable. The films also show exceptional electrothermal heater performance after carrying out mechanical property tests such as bending (over 30°), repetitive bending (1000 cycles), twisting (two turns), and washing (soaked in distilled water for over 12 h). These outstanding heater performances incorporate extreme chemical stability and mechanical flexibility proposing that the CB/SIBS‐based electrothermal elements hold great potential for numerous practical applications, such as heating systems in electric vehicles and wearable electronics.
Publisher: American Vacuum Society
Date: 10-11-2016
DOI: 10.1116/1.4967442
Abstract: Ensuring the optimum orientation, conformation, and density of substrate-bound antibodies is critical for the success of sandwich enzyme-linked immunosorbent assays (ELISAs). In this work, the authors utilize a diethylene glycol dimethyl ether plasma polymer (DGpp) coating, functionalized with chromium within a 96 well plate for the enhanced immobilization of a capture antibody. For an equivalent amount of bound antibody, a tenfold improvement in the ELISA signal intensity is obtained on the DGpp after incubation with chromium, indicative of improved orientation on this surface. Time-of-flight secondary-ion-mass-spectrometry (ToF-SIMS) and principal component analysis were used to probe the molecular species at the surface and showed ion fragments related to lysine, methionine, histidine, and arginine coupled to chromium indicating candidate antibody binding sites. A combined x-ray photoelectron spectroscopy and ToF-SIMS analysis provided a surface molecular characterization that demonstrates antibody binding via the chromium complex. The DGpp+Cr surface treatment holds great promise for improving the efficacy of ELISAs.
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9RA04289J
Abstract: Biowaste eggshell can be used as a cathode while in its calcined form and it is found to be suitable as an anode in an electrochemical cell.
Publisher: Wiley
Date: 26-04-2016
Abstract: Surface enhanced Raman spectroscopy (SERS) is a useful multidisciplinary analytic technique. However, it is still a challenge to produce SERS substrates that are highly sensitive, reproducible, stable, reusable, and scalable. Herein, we demonstrate that atomically thin boron nitride (BN) nanosheets have many unique and desirable properties to help solve this challenge. The synergic effect of the atomic thickness, high flexibility, stronger surface adsorption capability, electrical insulation, impermeability, high thermal and chemical stability of BN nanosheets can increase the Raman sensitivity by up to two orders, and in the meantime attain long-term stability and extraordinary reusability not achievable by other materials. These advances will greatly facilitate the wider use of SERS in many fields.
Publisher: Wiley
Date: 23-03-2018
DOI: 10.1002/SIA.6417
Publisher: Wiley
Date: 24-07-2014
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D2NR06942C
Abstract: To improve operational stability of perovskite (PSK) LEDs, we used red-emitting hydrophobic carbon dots to impart structural stability to 2D PSK and reduce band offset, improving the operational stability of device to 8 hours from less than 2 hours.
Publisher: Wiley
Date: 05-03-2021
Abstract: Chemically patterned surfaces for biotechnology applications often require sub‐micron patterns to match specific sub‐cellular structures and control the presentation of proteins to single cell arrays. Plasma polymer coatings are used extensively in the biotechnology sector for biomaterials, cell culture and tissue engineering, but their patterning has not been investigated at the sub‐micron level. The resolution limit of plasma polymerized patterns with designed line widths of 900 to 20 nm is investigated via dual chemistry patterns of plasma polymerized acrylic acid and allylamine created with poly (methyl methacrylate) resist and electron beam lithography (EBL). Line widths are characterized via scanning electron microscopy and atomic force microscopy with surface chemistry analysis via time‐of‐flight secondary‐ion mass spectrometry (ToF‐SIMS). The smallest line width measured is 29 nm for a designed line width of 20 nm. High‐resolution nanoscale imaging is achieved using ToF‐SIMS, with lines down to ≈60 nm in width visible. This work demonstrates the successful fabrication and characterization of sub 100 nm dual plasma polymer patterns using EBL, establishing a clear route for large scale production of plasma polymerized nanopatterning.
Publisher: Wiley
Date: 20-05-2016
Publisher: Springer Science and Business Media LLC
Date: 12-05-2005
Publisher: Elsevier BV
Date: 12-2008
Publisher: IOP Publishing
Date: 02-2017
No related grants have been discovered for Robert Jones.