ORCID Profile
0000-0003-0255-1060
Current Organisation
University of South Australia
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Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 03-2015
DOI: 10.1109/MC.2015.77
Publisher: SCITEPRESS - Science and Technology Publications
Date: 2022
Publisher: Foundation of Computer Science
Date: 15-07-2016
Publisher: ACM
Date: 15-10-2018
Publisher: Springer International Publishing
Date: 2023
Publisher: IEEE
Date: 06-2015
Publisher: American Scientific Publishers
Date: 08-2016
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 11-2015
Publisher: IEEE
Date: 03-2015
Publisher: Elsevier BV
Date: 04-2011
DOI: 10.1016/J.TOXICON.2011.01.013
Abstract: The aim of this study was to compare the mode of action of the commonly used BK inhibitor paxilline with that of the more recently discovered lolitrem B. Similarities and differences in characteristics of inhibition between the two compounds were investigated. We have previously shown that lolitrem B does not affect the BK channel G-V, in contrast to the rightward shift produced by paxilline. These different effects on the voltage-dependence of activation suggest different modes of action for these two compounds. In this study we show that inhibition by both paxilline and lolitrem B is characterized by an open state preference for BK (hSlo) channels. Both compounds had a 3-fold higher apparent affinity under conditions likely to favour the open state, suggesting they have a similar BK conformational preference for binding. Furthermore, both compounds had a calcium concentration-dependence to their inhibitory effects. The G-V shift induced by paxilline was calcium concentration-dependent.
Publisher: Elsevier BV
Date: 03-2014
DOI: 10.1016/J.NEURON.2014.03.004
Abstract: Expression of δ-opioid receptors in sensory neurons is controversial. In this issue of Neuron, Bardoni et al. (2014) present evidence that DOPrs are expressed on mechanosensory neurons involved in detecting nonnoxious touch but are very sparse in μ-opioid receptor-rich nociceptive neurons.
Publisher: IEEE
Date: 10-2013
Publisher: Mary Ann Liebert Inc
Date: 10-2015
Publisher: Springer Singapore
Date: 2017
Publisher: Public Library of Science (PLoS)
Date: 14-01-2010
Publisher: Elsevier BV
Date: 03-2018
Publisher: Elsevier BV
Date: 04-2012
Publisher: Elsevier BV
Date: 10-2012
Publisher: Elsevier BV
Date: 10-2012
Publisher: Elsevier BV
Date: 04-2013
DOI: 10.1016/J.CUB.2013.02.021
Abstract: General anesthesia remains a mysterious phenomenon, even though a number of compelling target proteins and processes have been proposed [1]. General anesthetics such as isoflurane abolish behavioral responsiveness in all animals, and in the mammalian brain, these erse compounds probably achieve this in part by targeting endogenous sleep mechanisms [2, 3]. However, most animals sleep [4], and they are therefore likely to have conserved sleep processes. A decade of neurogenetic studies of arousal in Drosophila melanogaster have identified a number of different neurons and brain structures that modulate sleep duration in the fly brain [5-9], but it has remained unclear until recently whether any neurons might form part of a dedicated circuit that actively controls sleep and wake states in the fly brain, as has been proposed for the mammalian brain [10]. We studied general anesthesia in Drosophila by measuring stimulus-induced locomotion under isoflurane gas exposure. Using a syntaxin1A gain-of-function construct, we found that increasing synaptic activity in different Drosophila neurons could produce hypersensitivity or resistance to isoflurane. We uncover a common pathway in the fly brain controlling both sleep duration and isoflurane sensitivity, centered on monoaminergic modulation of sleep-promoting neurons of the fan-shaped body.
Publisher: Society for Neuroscience
Date: 16-05-2012
DOI: 10.1523/JNEUROSCI.3717-11.2012
Abstract: Pre-mRNA alternative splicing is an important mechanism for the generation of synaptic protein ersity, but few factors governing this process have been identified. From a screen for Drosophila mutants with aberrant synaptic development, we identified beag , a mutant with fewer synaptic boutons and decreased neurotransmitter release. Beag encodes a spliceosomal protein similar to splicing factors in humans and Caenorhabditis elegans . We find that both beag mutants and mutants of an interacting gene dsmu1 have changes in the synaptic levels of specific splice isoforms of Fasciclin II (FasII), the Drosophila ortholog of neural cell adhesion molecule. We show that restoration of one splice isoform of FasII can rescue synaptic morphology in beag mutants while expression of other isoforms cannot. We further demonstrate that this FasII isoform has unique functions in synaptic development independent of transsynaptic adhesion. beag and dsmu1 mutants demonstrate an essential role for these previously uncharacterized splicing factors in the regulation of synapse development and function.
Publisher: IEEE
Date: 07-2016
Publisher: Springer Nature Switzerland
Date: 2023
Publisher: IEEE
Date: 10-2016
Publisher: International Council for Research and Innovation in Building and Construction
Date: 19-04-2022
DOI: 10.36680/J.ITCON.2022.016
Abstract: This research proposes recommendations that could improve interoperability in the architecture, engineering, construction and operations (AECO) sector, by connecting domains, building lifecycles, and software systems with each other and the web. The objective has been to identify methods that promote evolution from file-based formats by advancing object-based data exchange solutions. The research design is a mapping of standards and systems that have affected the nature of object-based data exchanges, and which have either been proposed or implemented in AECO and the Oil & Gas sector. This is an approach which allows for the range and ersity of information to be examined. A review of the Oil & Gas sector confirms a norm where object-based, rather than file-based, transactions have shaped data exchange models, formats, use case methodologies, and collaboration mechanisms, thus contributing towards semantic connectivity across its erse systems. Key research questions address the nature of these sectors, the promise that object-based data exchange offers, and examine recommendations that would improve standards and systems. The paper affirms that measures taken to improve interoperability in the Oil & Gas sector have relevance for the AECO sector, and that better understanding, and recognition of the structure of AECOs interoperability ecosystem is central to effecting lasting and significant change. Thus, we make recommendations that acknowledge the hybrid nature of AECO data exchanges and propose an interoperability ecosystem that connects both distributed and centralised federated models. Improved standards to define application programming interfaces (APIs) and adaptors, based on a modular approach, would be central to this proposal. We also make recommendations to improve use case definitions, and to ensure that semantic connectivity at the object level is scalable to web-based transactions. Finally, we assert that, to realise these changes, the developers and vendors of its systems should recognise and address the AECO sector’s pressing needs and concerns.
No related grants have been discovered for Karamjit Kaur.