ORCID Profile
0000-0002-4446-518X
Current Organisation
Deakin University
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Research Topics
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Top 5 Research Topics
ANZSRC Field of Research (FoR)
Medicinal and Biomolecular Chemistry | Biologically Active Molecules | Biocatalysis and Enzyme Technology | Bioprocessing, Bioproduction and Bioproducts | Industrial Chemistry | Organic Chemistry | Separation Science | Organic Green Chemistry | Food Engineering | Medical Biochemistry: Lipids | Food Sciences | Analytical Biochemistry |
ANZSRC Socio-Economic Objective (SEO)
Management of Solid Waste from Plant Production | Service Industries Standards and Calibrations | Health Related to Ageing | Nutraceuticals and Functional foods | Inorganic Industrial Chemicals | Health related to ageing | Preventive medicine | Organic Industrial Chemicals (excl. Resins, Rubber and Plastics) | Nutrition | Immune System and Allergy
Related Links
Publications
Solvent-induced 7R-dioxygenase activity of soybean 15-lipoxygenase-1 in the formation of omega-3 DPA-derived resolvin analogs
Publisher: Elsevier BV
Date: 10-2014
Any Old Radical Won’t Do: An EPR Study of the Selective Excitation and Quenching Mechanisms of [Ru(bipy)3]2+ Chemiluminescence and Electrochemiluminescence
Publisher: Wiley
Date: 07-06-2011
Evaluation of tris(4,7-diphenyl-1,10-phenanthrolinedisulfonate)ruthenium(II) as a chemiluminescence reagent
Publisher: Elsevier BV
Date: 02-2009
DOI: 10.1016/J.ACA.2008.12.030
Abstract: Previous studies have suggested that tris(4,7-diphenyl-1,10-phenanthrolinedisulfonate)ruthenium(II) (Ru(BPS)(3)(4-)) has great potential as a chemiluminescence reagent in acidic aqueous solution. We have evaluated four different s les of this reagent (two commercially available and two synthesised in our laboratory) in comparison with tris(2,2'-bipyridine)ruthenium(II) (Ru(bipy)(3)(2+)) and tris(1,10-phenanthroline)ruthenium(II) (Ru(phen)(3)(2+)), using a range of structurally erse analytes. In general, Ru(BPS)(3)(4-) produced more intense chemiluminescence, but the oxidised Ru(BPS)(3)(3-) species is less stable in aqueous solution than Ru(bipy)(3)(3+) and produced a greater blank signal than Ru(bipy)(3)(3+) or Ru(phen)(3)(3+), which had a detrimental effect on sensitivity. Although the complex is often depicted with the sulfonate groups of the BPS ligand in the para position on the phenyl rings, NMR characterisation revealed that the commercially available BPS material used in this study was predominantly the meta isomer.
The importance of chain length for the polyphosphate enhancement of acidic potassium permanganate chemiluminescence
Publisher: Elsevier BV
Date: 09-2014
DOI: 10.1016/J.ACA.2014.07.012
Abstract: Sodium polyphosphate is commonly used to enhance chemiluminescence reactions with acidic potassium permanganate through a dual enhancement mechanism, but commercially available polyphosphates vary greatly in composition. We have examined the influence of polyphosphate composition and concentration on both the dual enhancement mechanism of chemiluminescence intensity and the stability of the reagent under analytically useful conditions. The average chain length (n) provides a convenient characterisation, but materials with similar values can exhibit markedly different distributions of phosphate oligomers. There is a minimum polyphosphate chain length (∼6) required for a large enhancement of the emission intensity, but no further advantage was obtained using polyphosphate materials with much longer average chain lengths. Providing there is a sufficient average chain length, the optimum concentration of polyphosphate is dependent on the analyte and in some cases, may be lower than the quantities previously used in routine detection. However, the concentration of polyphosphate should not be lowered in permanganate reagents that have been partially reduced to form high concentrations of the key manganese(III) co-reactant, as this intermediate needs to be stabilised to prevent formation of insoluble manganese(IV).
Electrochemically, Spectrally, and Spatially Resolved Annihilation‐Electrogenerated Chemiluminescence of Mixed‐Metal Complexes at Working and Counter Electrodes
Publisher: Wiley
Date: 08-05-2018
Chemiluminescence Detector with a Serpentine Flow Cell
Publisher: American Chemical Society (ACS)
Date: 17-11-2008
DOI: 10.1021/AC801842Q
Abstract: We present a new chemiluminescence detector, with solution channels that have been machined into a Teflon disk and sealed with a sapphire window. The configuration of the flow cell can be conveniently modified by replacing the Teflon disk. A comparison of some existing and novel designs, using the chemiluminescence reaction of morphine with acidic potassium permanganate and the bioluminescence reaction of ATP with the commercially available "BacTiter-Glo" reagent, has revealed that a serpentine channel allows greater quantities of light to be captured than a spiral channel, due to more efficient mixing of the analyte and reagent solutions within the cell.
Manganese(III) and manganese(IV) as chemiluminescence reagents: A review
Publisher: Elsevier BV
Date: 08-2008
DOI: 10.1016/J.ACA.2008.06.041
Abstract: Although potassium permanganate [Mn(VII)] has been used extensively as a chemiluminescence reagent for many decades, other manganese-based oxidants have only recently been explored for this purpose. There is strong evidence to suggest that, like permanganate, manganese(III) and manganese(IV) oxidants react with many molecules to produce an excited manganese(II) species that emits light. However, these reagents differ markedly in terms of selectivity, and possess characteristics that provide new avenues for detection, such as the immobilisation of solid manganese dioxide, the production of 'soluble' manganese(IV) nanoparticles, and the electrochemical generation of manganese(III). In this review we examine the emergence of these alternative manganese oxidants as chemiluminescence reagents.
Chemiluminescence detection of cannabinoids and related compounds with acidic potassium permanganate
Publisher: Wiley
Date: 29-03-2012
DOI: 10.1002/DTA.1328
Abstract: This is the first report of chemiluminescence from the reaction of cannabinoids with acidic potassium permanganate, which we have applied to the high performance liquid chromatography (HPLC) determination of cannabidiol (CBD) in industrial-grade hemp. The intensities of the light-producing reactions with two commercially available cannabinoid standards were compared to that of seven model phenolic analytes. Resorcinol, representing the parent phenolic moiety of the cannabinoid class, was shown to react with the permanganate reagents in a manner more similar to phenol than to its hydroxyphenol positional isomers, pyrocatechol and hydroquinone. Alkyl substituents on the phenolic ring, however, have a considerable impact on emission intensity that is dependent upon the position of the groups and the composition of the permanganate reagent. This analytical approach has potential for the determination of other cannabinoids including Δ(9) -tetrahydrocannabinol in drug-grade cannabis.
Determination of Citrus aurantium protoalkaloids using HPLC with acidic potassium permanganate chemiluminescence detection
Publisher: Elsevier BV
Date: 15-03-2010
DOI: 10.1016/J.TALANTA.2009.10.052
Abstract: Acidic potassium permanganate chemiluminescence was explored as a sensitive and selective mode of detection for phenolic phenethylamines (adrenergic amines) in consumer products containing Citrus aurantium extracts. Nine commercially available weight-loss products were analysed using rapid reversed-phase chromatography with a monolithic column (separation time of 4 min). The results were in good agreement with package labelling, with some notable exceptions. The products contained a wide concentration range of synephrine and total adrenergic amines, and the difference in consumer intake was even greater when the manufacturers' recommended daily consumption was considered. The quantity of the extract, often specified on the packaging as equivalent grams of dry C. aurantium fruit, was a poor indicator of the concentration of the active ingredients. Methionine, a thioether amino acid contained in some weight-loss products, was identified as a potential interferent for this mode of detection.
Determination of selected neurotransmitter metabolites using monolithic column chromatography coupled with chemiluminescence detection
Publisher: Elsevier BV
Date: 15-09-2005
DOI: 10.1016/J.TALANTA.2005.03.007
Abstract: The oxidation of selected clinically important neurotransmitter metabolites with acidic potassium permanganate in the presence of polyphosphates evokes chemiluminescence of sufficient intensity to enable the sensitive determination of these species. Limits of detection for 5-hydroxyindole-3-acetic acid (5-HIAA), vanilmandelic acid (VMA alpha,4-dihydroxy-3-methoxybenzeneacetic acid), 4-hydroxy-3-methoxyphenylglycol (MHPG), homovanillic acid (HVA, 4-hydroxy-3-methoxyphenylacetic acid) and 3,4-dihydroxyphenylacetic acid (DOPAC) were between 5x10(-9) and 4x10(-8)M, using flow-injection analysis methodology. In addition, we demonstrate the rapid determination of homovanillic acid and 5-hydroxyindole-3-acetic acid in human urine - without the need for extraction procedures - using monolithic column chromatography with chemiluminescence detection.
Kinetics and selectivity of permanganate chemiluminescence: A study of hydroxyl and amino disubstituted benzene positional isomers
Publisher: Elsevier BV
Date: 11-2011
DOI: 10.1016/J.ACA.2011.09.024
Abstract: Examination of the chemiluminescence reactions of dihydroxybenzenes, aminophenols and phenylenediamines with acidic potassium permanganate has provided a new understanding of the relationships between analyte structure, reaction conditions, kinetics of the light-producing pathway and emission intensity, with broad implications for this widely utilised chemiluminescence detection system. Using a permanganate reagent prepared in a polyphosphate solution and adjusted to pH 2.5, large differences in the rate of reaction with different positional isomers were observed, with the meta-substituted forms reacting far slower and therefore exhibiting much lower chemiluminescence intensities in flow analysis systems. The preliminary partial reduction of permanganate to form significant concentrations of Mn(III) increased the rate of reaction with all analytes tested, resulting in comparable or (in the case of aminophenol and phenylenediamine) even greater emission intensities for the meta-isomers, demonstrating the opportunity to tune the selectivity of the reagent towards certain classes of compound or even specific positional isomers of the same compound. Using more acidic permanganate reagents, in which polyphosphates are not required, the discrepancy between the chemiluminescence intensities was still observed, but was less prominent due to the generally faster rates of reaction. The enhancement of these chemiluminescence reactions by on-line addition of formic acid or formaldehyde can in part also be attributed to the generation of significant pools of the key Mn(III) precursor to the emitting species.
Designing Carbon Fiber Composite Interfaces: Reactive Sizing Derived from Terpenes
Publisher: American Chemical Society (ACS)
Date: 07-02-2023
Determination of neurotransmitters and their metabolites using one- and two-dimensional liquid chromatography with acidic potassium permanganate chemiluminescence detection
Publisher: Springer Science and Business Media LLC
Date: 07-12-2013
DOI: 10.1007/S00216-013-7514-9
Abstract: High-performance liquid chromatography with chemiluminescence detection based on the reaction with acidic potassium permanganate and formaldehyde was explored for the determination of neurotransmitters and their metabolites. The neurotransmitters norepinephrine and dopamine were quantified in the left and right hemispheres of rat hippoc us, nucleus accumbens and prefrontal cortex, and the metabolites vanillylmandelic acid, 3,4-dihydrophenylacetic acid, 5-hydroxyindole-3-acetic acid and homovanillic acid were identified in human urine. Under optimised chemiluminescence reagent conditions, the limits of detection for these analytes ranged from 2.5 × 10(-8) to 2.5 × 10(-7) M. For the determination of neurotransmitter metabolites in urine, a two-dimensional high-performance liquid chromatography (2D-HPLC) separation operated in heart-cutting mode was developed to overcome the peak capacity limitations of the one-dimensional separation. This approach provided the greater separation power of 2D-HPLC with analysis times comparable to conventional one-dimensional separations.
Comparison of homoleptic and heteroleptic 2,2′-bipyridine and 1,10-phenanthroline ruthenium complexes as chemiluminescence and electrochemiluminescence reagents in aqueous solution
Publisher: Elsevier BV
Date: 03-2009
DOI: 10.1016/J.ACA.2008.12.042
Abstract: We have conducted a comprehensive comparative study of Ru(bipy)(3)(2+), Ru(bipy)(2)(phen)(2+), Ru(bipy)(phen)(2)(2+), and Ru(phen)(3)(2+) as chemiluminescence and electrochemiluminescence (ECL) reagents, to address several previous conflicting observations and gain a greater insight into their potential for chemical analysis. Clear trends were observed in many of their spectroscopic and electrochemical properties, but the relative chemiluminescence or ECL intensity with a range of analytes/co-reactants is complicated by the contribution of numerous (sometimes opposing) factors. Significantly, the reversibility of cyclic voltammetric responses for the complexes decreased as the number of phenanthroline ligands was increased, due to the lower stability of their ruthenium(III) form in the aqueous solvent. This trend was also evident over a longer timescale when the ruthenium(III) form was spectrophotometrically monitored after chemical oxidation of the ruthenium(II) complexes. In general, the greater stability of Ru(bipy)(3)(3+) resulted in lower blank signals, although this effect was less pronounced with ECL, where the reagent is oxidised in the presence of the co-reactants. Nevertheless, this shows the need to compare signal-to-blank ratios or detection limits, rather than the more common comparisons of overall signal intensity for different ruthenium complexes. Furthermore, our results support previous observations that, compared to Ru(bipy)(3)(2+), Ru(phen)(3)(2+) provides greater ECL and chemiluminescence intensities with oxalate, which in some circumstances translates to superior detection limits, but they do not support the subsequent generalised notion that Ru(phen)(3)(2+) is a more sensitive reagent than Ru(bipy)(3)(2+) for all analytes.
Extending Photocatalyst Activity through Choice of Electron Donor
Publisher: American Chemical Society (ACS)
Date: 11-01-2022
Catalyst Luminescence Exploited as an Inherent In Situ Probe of Photoredox Catalysis
Publisher: Wiley
Date: 22-10-2020
The characteristic red chemiluminescence from reactions with acidic potassium permanganate: further spectroscopic evidence for a manganese(ii ) emitter
Publisher: Royal Society of Chemistry (RSC)
Date: 2008
DOI: 10.1039/B714147E
Abstract: A direct comparison of the laser-induced photoluminescence of manganese(ii) with the chemiluminescence from the reaction between acidic potassium permanganate and sodium borohydride was used to confirm that the characteristic red emission from this widely used chemiluminescence reagent emanates from an electronically excited manganese(ii) species.
Chemiluminescence—Liquid Phase
Publisher: Elsevier
Date: 2018
Selective concentration of EPA and DHA using Thermomyces lanuginosus lipase is due to fatty acid selectivity and not regioselectivity
Publisher: Elsevier BV
Date: 05-2013
DOI: 10.1016/J.FOODCHEM.2012.11.007
Abstract: The selectivity of anchovy oil hydrolysis was optimised for Thermomyces lanuginosus lipase, so that docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) were concentrated and partially separated from each other. Enzyme concentration and pH control were important factors for effective hydrolysis. Monitoring percent hydrolysis using capillary chromatography with flame ionisation detector (Iatroscan) and fatty acid selectivity using gas chromatography (GC) indicated that during hydrolysis DHA primarily remained on the glycerol backbone, while EPA was progressively removed. (13)C nuclear magnetic resonance (NMR) data showed that selectivity of hydrolysis was primarily due to fatty acid selectivity and not regioselectivity, with hydrolysis from both sn-1,3 and sn-2 sites being equally favoured.
Chemiluminescence and electrochemiluminescence detection of controlled drugs
Publisher: Wiley
Date: 10-12-2010
DOI: 10.1002/DTA.236
Abstract: We review the determination of various controlled drugs (opioids, tranquilizers, stimulants, and hallucinogens) using flow-analysis methodologies (flow injection analysis, high performance liquid chromatography, capillary electrophoresis, and microfluidic devices) with chemiluminescence and electrochemiluminescence reagents such as luminol, diaryloxalates, tris(2,2'-bipyridine)ruthenium(II), permanganate, manganese(IV), and sulfite, for industrial, clinical, pharmaceutical, and forensic science applications.
A hybrid FIA/HPLC system incorporating monolithic column chromatography
Publisher: Elsevier BV
Date: 09-2007
DOI: 10.1016/J.ACA.2007.03.048
Abstract: We have combined the generation of solvent gradients using milliGAT pumps, chromatographic separations with monolithic columns and chemiluminescence detection in an instrument manifold that approaches the automation and separation efficiency of HPLC, whilst maintaining the positive attributes of flow injection analysis (FIA), such as manifold versatility, speed of analysis and portability. As preliminary demonstrations of this hybrid FIA/HPLC system, we have determined six opiate alkaloids (morphine, pseudomorphine, codeine, oripavine, ethylmorphine and thebaine) and four biogenic amines (vanilmandelic acid, serotonin, 5-hydroxyindole-3-acetic acid and homovanillic acid) in human urine, using tris(2,2'-bipyridyl)ruthenium(III) and acidic potassium permanganate chemiluminescence detection.
Effects of variation in modulator temperature during cryogenic modulation in comprehensive two-dimensional gas chromatography
Publisher: Wiley
Date: 09-2009
Abstract: Many modulation systems in comprehensive 2D GC (GC x GC) are based on cryogenic methods. High trapping temperatures in these systems can result in ineffective trapping of the more volatile compounds, whilst temperatures that are too low can prevent efficient remobilisation of some compounds. To better understand the trapping and release of compounds over a wide range of volatilities, we have investigated a number of different constant temperature modulator settings, and have also examined a constant temperature differential between the cryo-trap and the chromatographic oven. These investigations have led us to modify the temperature regulation capabilities of the longitudinally modulated cryogenic system (LMCS). In contrast to the current system, where the user sets a constant temperature for the cooling chamber, the user now sets the temperature difference between the cryo-trap and the chromatographic oven. In this configuration, the cooling chamber temperature increases during the chromatographic run, tracking the oven temperature r . This produces more efficient, volatility-dependent modulation, and increases the range of volatile compounds that can be analysed under optimal trap-and-release conditions within a single analytical run. This system also reduces cryogenic fluid consumption.
Near-ultraviolet chemiluminescence from the reaction of ammonia with hypobromite in aqueous solution
Publisher: Elsevier BV
Date: 11-2006
DOI: 10.1016/J.SAA.2005.12.033
Abstract: The chemiluminescence arising from the oxidation of ammonium chloride by sodium hypobromite in aqueous alkaline solution includes a series of peaks in the near-ultraviolet, which is not commonly observed in liquid-phase chemiluminescence. The dominant peak in that region has an intensity maximum at 292 nm and smaller peaks are observed at 313, 334 and 356 nm. The emitted photons are of similar energy to the Vergard-Kaplan transition of molecular nitrogen, a major product of this reaction. However, the spectral distribution is different to that of previously reported gas-phase chemiluminescence attributed to the Vergard-Kaplan transition.
Proceedings of the 2015 meeting of the Australasian section of the American oil chemists’ society (AAOCS)
Publisher: MDPI AG
Date: 02-12-2015
DOI: 10.3390/NU7125518
Chemiluminescence—Gas-Phase
Publisher: Elsevier
Date: 2018
Precision milled flow-cells for chemiluminescence detection
Publisher: Royal Society of Chemistry (RSC)
Date: 2009
DOI: 10.1039/B914595H
Abstract: Novel flow-cells with integrated confluence points and reaction channels designed for efficient mixing of fast chemiluminescence systems were constructed by machining opposing sides of a polymer chip and sealing the channels with transparent epoxy-acetate films. A hole drilled through the chip provided the conduit from the confluence point on one side to the centre of the reaction zone on the other side, allowing rapid presentation of the reacting mixture to the photodetector. The effectiveness of each flow-cell was evaluated by comparing the chemiluminescence intensity using flow injection analysis methodology, and examining the distribution of light emanating from the reaction zone (captured by photography in a dark room) when the reactants were continuously merged. Although previously reported chemiluminescence detectors constructed by machining channels into polymers have almost exclusively been prepared using transparent materials, we obtained far greater emission intensities using an opaque white chip with a thin transparent seal, which minimised the loss of light through surfaces not exposed to the photomultiplier tube. Furthermore, this approach enabled the exploration of reactor designs that could not be incorporated in traditional coiled-tubing flow-cells.
Emitting Species in Chemiluminescence Reactions with Acidic Potassium Permanganate: A Re-Evaluation Based on New Spectroscopic Evidence
Publisher: Springer Science and Business Media LLC
Date: 08-04-2009
DOI: 10.1007/S10895-009-0485-8
Abstract: The reaction of acidic potassium permanganate with a wide range of compounds is known to produce a broad red emission, and there is strong evidence for an excited manganese(II) emitting species. Nevertheless, numerous researchers have proposed other emitters for reactions with acidic potassium permanganate, particularly for systems where fluorescent compounds were present, either as enhancers or reaction products. We have examined many reactions of this type and found that, in most cases, the same red emission was produced. There were, however, some exceptions, including the oxidation of dihydralazine, certain thiols and sulphite (each in the presence of an enhancer).
Chemiluminescence spectra for the oxidation of sulphite in the presence of fluorescent and non-fluorescent enhancers
Publisher: Elsevier BV
Date: 10-2009
DOI: 10.1016/J.ACA.2009.06.013
Abstract: The spectral distribution of chemiluminescence provides key evidence in the elucidation of the reaction mechanism and emitting species. We have collected chemiluminescence spectra for the oxidation of sodium sulphite and captopril in the presence of a range of fluorescent and non-fluorescent enhancers. This evidence was used to evaluate several previously proposed light-producing pathways, and revealed some new approaches to enhance the chemiluminescent oxidation of sulphite and thiol compounds. Chemiluminescence reactions between sulphite and permanganate produce two potential emitters: one derived from the oxidation of sulphite (in some cases via energy transfer to a more efficient luminophore) and another derived from the reduction of permanganate. This second light-producing pathway is rarely considered in discussions on the chemiluminescent oxidation of sulphite, but can make a significant contribution to the overall emission. Non-fluorescent enhancers of sulphite chemiluminescence result in several distinct spectral distributions and, contrary to previous postulation, these reactions are unlikely to lead to the same emitting species. Non-fluorescent enhancers of sulphite chemiluminescence can also significantly increase the weak emission from the oxidation of thiol compounds such as captopril.
Acidic potassium permanganate as a chemiluminescence reagent—A review
Publisher: Elsevier BV
Date: 10-2007
DOI: 10.1016/J.ACA.2007.08.027
Abstract: A critical and comprehensive review of acidic potassium permanganate chemiluminescence is presented. This includes discussion on reaction conditions, the influence of enhancers such as polyphosphates, formaldehyde and sulfite, the relationship between analyte structure and chemiluminescence intensity, and the application of this chemistry to determine a wide variety of compounds, such as pharmaceuticals, biomolecules, antioxidants, illicit drugs, pesticides and pollutants. Previous proposals for the nature of the emitting species are re-evaluated in light of recent evidence.
Chemiluminescence evidence supporting the selective role of ligands in the permanganate oxidation of micropollutants
Publisher: American Chemical Society (ACS)
Date: 20-09-2013
DOI: 10.1021/JP405985Y
Abstract: The selective increase in the oxidation rate of certain organic compounds with permanganate in the presence of environmental "ligands" and reduced species has been ascribed to the different reactivity of the target compounds toward Mn(III), which bears striking similarities to recent independent investigations into the use of permanganate as a chemiluminescence reagent. In spite of the importance of Mn(III) in the light-producing pathway, the dependence of the oxidation mechanism for any given compound on this intermediate could not be determined solely through the emission intensity. However, target compounds susceptible to single-electron oxidation by Mn(III) (such as bisphenol A and triclosan) can be easily distinguished by the dramatic increase in chemiluminescence intensity when a permanganate reagent containing high, stable concentrations of Mn(III) is used. The differences are accentuated under the low pH conditions that favor the chemiluminescence emission due to the greater reactivity of Mn(III) and the greater influence of complexing agents. This study supports the previously postulated selective role of ligands and reducing agents in permanganate oxidations and demonstrates a new approach to explore the chemistry of environmental manganese redox processes.
The Tandem Photoredox Catalysis Mechanism of [Ir(ppy)2(dtb-bpy)]+ Enabling Access to Energy Demanding Organic Substrates
Publisher: American Chemical Society (ACS)
Date: 23-09-2019
DOI: 10.1021/JACS.9B07370
Abstract: We report the discovery of a tandem catalytic process to reduce energy demanding substrates, using the [Ir(ppy)
Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase
Publisher: Elsevier BV
Date: 05-2013
DOI: 10.1194/JLR.M036186
Chemiluminescence detection of opium poppy (Papaver somniferum) alkaloids
Publisher: Elsevier BV
Date: 11-2008
DOI: 10.1016/J.JPBA.2008.06.022
Abstract: A review with 98 references. The determination of the opium poppy (Papaver somniferum) alkaloids and their semi-synthetic derivatives has important applications in industrial process monitoring, clinical analysis and forensic science. Liquid-phase chemiluminescence reagents such as tris(2,2'-bipyridyl)ruthenium(II) and acidic potassium permanganate exhibit remarkable sensitivity and complementary selectivity for many P. somniferum alkaloids, which has been exploited in the development of a range of analytical procedures using flow analysis, high-performance liquid chromatography, capillary electrophoresis and microfluidic instrumentation.
Enhanced permanganate chemiluminescence
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C0AN00588F
Abstract: The significant enhancement of acidic potassium permanganate chemiluminescence by Mn(II) results from the concomitant presence of permanganate and Mn(III) in the reagent solution, which enables rapid production of the excited Mn(II) emitter with a wide range of analytes. Furthermore, the key Mn(III) co-reactant can be quickly generated by reducing permanganate with sodium thiosulfate, instead of the slow (~24 h) equilibration required when Mn(ii) is used. The emission from reactions with analytes such as tyrosine and fenoterol was over two orders of magnitude more intense than with the traditional permanganate reagent.
Luminescence: Overview
Publisher: Elsevier
Date: 2018
Advances in the use of acidic potassium permanganate as a chemiluminescence reagent: A review
Publisher: Elsevier BV
Date: 2014
DOI: 10.1016/J.ACA.2013.11.016
Abstract: We review the analytical applications of acidic potassium permanganate chemiluminescence published since our previous comprehensive review in mid-2007 to early 2013. This includes a critical evaluation of evidence for the emitting species, the influence of additives such as polyphosphates, formaldehyde, sulfite, thiosulfate, lanthanide complexes and nanoparticles, the development of a generalized reaction mechanism, and the use of this chemistry in pharmaceutical, clinical, forensic, food science, agricultural and environmental applications.
A review of recent advances in chemiluminescence detection using nano-colloidal manganese(IV)
Publisher: Elsevier BV
Date: 10-2014
DOI: 10.1016/J.ACA.2014.06.008
Abstract: The application of 'soluble' (colloidal) manganese(IV) for chemiluminescence detection is reviewed, focussing on papers published since the last comprehensive review of the subject in 2008. Advances in this reagent system include: the on-line formation of manganese(IV) new insight into the light-producing pathway and selectivity of the reagent its application to assess total antioxidants in plant derived s les and oxidative stress in biological fluids and tissues and the replacement of the formaldehyde enhancer with ethanol.
Chemiluminescence: Overview
Publisher: Elsevier
Date: 2018
Determination of glyphosate mono-isopropylamine salt in process samples using flow injection analysis with tris(2,2′-bipyridyl)ruthenium(II) chemiluminescence detection
Publisher: Elsevier BV
Date: 08-10-2004
DOI: 10.1016/J.TALANTA.2004.03.024
Abstract: The mono-isopropylamine salt of glyphosate was selectively determined directly in industrial and commercial formulations using flow injection analysis with tris(2,2'-bipyridyl)ruthenium(II) chemiluminescence detection without the need for separation. Glyphosate and its mono-isopropylamine salt furnished detection limits of 7x10(-9) and 3.5x10(-10)M and relative standard deviations of 0.4% at 1x10(-7)M and 0.8% at 5x10(-8)M, respectively. The methodology is robust and reliable with s les subjected only to aqueous dilution prior to analysis.
Chemiluminescence methods for the determination of ofloxacin
Publisher: Elsevier BV
Date: 06-2005
Peak modeling approach to accurate assignment of first-dimension retention times in comprehensive two-dimensional chromatography
Publisher: American Chemical Society (ACS)
Date: 23-07-2009
DOI: 10.1021/AC900960N
Abstract: Modeling of first-dimension retention of peaks based on modulation phase and period allows reliable prediction of the modulated peak distributions generated in the comprehensive two-dimensional chromatography experiment. By application of the inverse process, it is also possible to use the profile of the modulated peaks (their heights or areas) to predict the shape and parameters of the original input chromatographic band (retention time, standard deviation, area) for the primary column dimension. This allows an accurate derivation of the first-dimension retention time (RSD 0.02%) which is equal to that for the non-modulated experiment, rather than relying upon the retention time of the major modulated peak generated by the modulation process (RSD 0.16%). The latter metric can produce a retention time that differs by at least the modulation period employed in the experiment, which displays a discontinuity in the retention time vs modulation phase plot at the point of the 180 degrees out-of-phase modulation. In contrast, the new procedure proposed here gives a result that is essentially independent of modulation phase and period. This permits an accurate value to be assigned to the first-dimension retention. The proposed metric accounts for the time on the second-dimension, the phase of the distribution, and the hold-up time that the s led solute is retained in the modulating interface. The approach may also be based on the largest three modulated peaks, rather than all modulated peaks. This simplifies the task of assigning the retention time with little loss of precision in band standard deviation or retention time, provided that these peaks are not all overloaded in the first or second dimension.
A screening test for heroin based on sequential injection analysis with dual-reagent chemiluminescence detection
Publisher: Elsevier BV
Date: 30-07-2008
DOI: 10.1016/J.TALANTA.2008.04.012
Abstract: A sequential injection analysis procedure with dual-reagent chemiluminescence detection was applied to the screening of street drug seizure s les for the presence of heroin. The chemiluminescence reagents (acidic potassium permanganate and tris(2,2'-bipyridine)ruthenium(III)) were aspirated from either side of a s le aliquot that was sufficiently large to prevent interdispersion of the reagent zones, and therefore two different chemical reactions could be performed simultaneously at either end of the s le zone. The presence of heroin in seizure s les was indicated by a strong response with the tris(2,2'-bipyridine)ruthenium(III) reagent and confirmed by a significant increase in the response with the permanganate reagent when the s le was treated with sodium hydroxide to hydrolyse the heroin to morphine. Nicomorphine (a morphine-derived pharmaceutical) was synthesised and tested under the same conditions. The responses with the permanganate reagent were similar to those for heroin, which supports the proposed chemical basis for the test. However, the responses with tris(2,2'-bipyridine)ruthenium(III) were far lower for nicomorphine than heroin (approximately 5-fold for the s les that had not been hydrolysed).
Chemiluminescence detectors for liquid chromatography
Publisher: Wiley
Date: 03-2011
DOI: 10.1002/DTA.132
Abstract: In this tutorial we describe the construction of chemiluminescence detectors for high performance liquid chromatography (HPLC), comprising the components required to deliver the chemiluminescence reagent, a coiled-tubing flow cell, photomultiplier tube and detector housing, and various options for data acquisition. We also discuss two state-of-the-art commercially available chemiluminescence detectors for HPLC and other flow analysis methodology.
Mechanism of Permanganate Chemiluminescence
Publisher: American Chemical Society (ACS)
Date: 07-04-2010
DOI: 10.1021/AC100363S
Abstract: Spectroscopic and synthetic methods have been exploited to deduce the mechanism for acidic potassium permanganate chemiluminescence. We have employed electron paramagnetic resonance (EPR) spectroscopy with a continuous flow assembly to monitor the formation of radical intermediates in real time generated from substrate oxidation by manganese(VII). These transient species react with manganese(III) in solution to produce the previously characterized manganese(II)* emission source. Using UV-vis, EPR, attenuated total reflection (ATR)-FT-IR, and chemiluminescence spectroscopies, we have established that there are two distinct enhancement mechanisms that in combination afford a 50-fold increase in emission intensity when the reaction is conducted in the presence of phosphate oligomers. In addition to preventing disproportionation of the manganese(III) precursor, the phosphate oligomers form protective "cagelike" structures around the manganese(II)* emitter, thus preventing nonradiative relaxation pathways.
Mixed annihilation electrogenerated chemiluminescence of iridium(iii ) complexes
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8CP01737A
Abstract: The annihilation electrogenerated chemiluminescence of mixtures of Ir( iii ) complexes is eliminated by manipulating reduction potentials through subtle changes in ligand structure.
Detection of biogenic amines in pet food ingredients by RP‐HPLC with automated dansyl chloride derivatization
Publisher: Wiley
Date: 02-11-2018
Abstract: The detection of biogenic amines is of significant interest to the food industry, as they can be used as indicators of food spoilage and they are potentially toxic. Because of their importance, there is a need for automated methods suitable for industry use that can detect a wide range of biogenic amines at sufficient levels for food analysis. In this work, optimized conditions for the automated determination of biogenic amines (histamine, putrescine, cadaverine, spermine, spermidine, tyramine, and tryptamine) derivatized with dansyl chloride are presented. Limits of detection below 0.2 ppm were achieved for seven biogenic amines and percentage recoveries were between 80 and 109% for the seven analytes spiked into meat meal s les. The method is simple and compared well to an existing method for the detection of biogenic amines in pet food ingredients.
Chemiluminescence detection of arginine-containing peptides separated with monolithic high-performance liquid chromatography
Publisher: Elsevier BV
Date: 2005
Pollen baiting facilitates the isolation of marine thraustochytrids with potential in omega-3 and biodiesel production
Publisher: Oxford University Press (OUP)
Date: 11-2013
DOI: 10.1007/S10295-013-1324-0
Abstract: Marine heterotrophic microbes are capable of accumulating large amounts of lipids, omega-3 fatty acids, carotenoids, and have potential for biodiesel production. Pollen baiting using Pinus radiata pollen grain along with direct plating techniques were used in this study as techniques for the isolation of oil-producing marine thraustochytrid species from Queenscliff, Victoria, Australia. Thirteen isolates were obtained using either direct plating or using pine pollen, with pine pollen acting as a specific substrate for the surface attachment of thraustochytrids. The isolates obtained from the pollen baiting technique showed a wide range of docosahexaenoic acid (DHA) accumulation, from 11 to 41 % of total fatty acid content (TFA). Direct plating isolates showed a moderate range of DHA accumulation, from 19 to 25 % of TFA. Seven isolates were identified on the basis of 18S rRNA sequencing technique as Thraustochytrium species, Schizochytrium species, and Ulkenia species. Although both methods appear to result in the isolation of similar strains, pollen baiting proved to be a simpler method for the isolation of these relatively slow-growing organisms.
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