David Lange

Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms

Publisher: Elsevier BV

Date: 07-2022

DOI: 10.1016/J.JAAC.2021.11.035

Abstract: To investigate the genetic architecture of internalizing symptoms in childhood and adolescence. In 22 cohorts, multiple univariate genome-wide association studies (GWASs) were performed using repeated assessments of internalizing symptoms, in a total of 64,561 children and adolescents between 3 and 18 years of age. Results were aggregated in meta-analyses that accounted for s le overlap, first using all available data, and then using subsets of measurements grouped by rater, age, and instrument. The meta-analysis of overall internalizing symptoms (INT Genetic correlations indicate that childhood and adolescent internalizing symptoms share substantial genetic vulnerabilities with adult internalizing disorders and other childhood psychiatric traits, which could partially explain both the persistence of internalizing symptoms over time and the high comorbidity among childhood psychiatric traits. Reducing phenotypic heterogeneity in childhood s les will be key in paving the way to future GWAS success.

Maximum allowable damage approach to fire safety performance quantification

Publisher: Elsevier BV

Date: 03-2022

DOI: 10.1016/J.FIRESAF.2022.103537

A Comparison of the Conditions in a Fire Resistance Furnace When Testing Combustible and Non-combustible Construction

Publisher: Springer Science and Business Media LLC

Date: 25-01-2020

DOI: 10.1007/S10694-020-00946-6

Genome-wide association meta-analysis of childhood and adolescent internalising symptoms

Publisher: Cold Spring Harbor Laboratory

Date: 13-09-2020

DOI: 10.1101/2020.09.11.20175026

Abstract: Internalising symptoms in childhood and adolescence are as heritable as adult depression and anxiety, yet little is known of their molecular basis. This genome-wide association meta-analysis of internalising symptoms included repeated observations from 64,641 in iduals, aged between 3 and 18. The N-weighted meta-analysis of overall internalising symptoms (INT overall ) detected no genome-wide significant hits and showed low SNP heritability (1.66%, 95% confidence intervals 0.84-2.48%, N effective =132,260). Stratified analyses indicated rater-based heterogeneity in genetic effects, with self-reported internalising symptoms showing the highest heritability (5.63%, 95% confidence intervals 3.08-8.18%). Additive genetic effects on internalising symptoms appeared stable over age, with overlapping estimates of SNP heritability from early-childhood to adolescence. Genetic correlations were observed with adult anxiety, depression, and the wellbeing spectrum (| r g | 0.70), as well as with insomnia, loneliness, attention-deficit hyperactivity disorder, autism, and childhood aggression (range | r g |=0.42-0.60), whereas there were no robust associations with schizophrenia, bipolar disorder, obsessive-compulsive disorder, or anorexia nervosa. The pattern of genetic correlations suggests that childhood and adolescent internalising symptoms share substantial genetic vulnerabilities with adult internalising disorders and other childhood psychiatric traits, which could partially explain both the persistence of internalising symptoms over time and the high comorbidity amongst childhood psychiatric traits. Reducing phenotypic heterogeneity in childhood s les will be key in paving the way to future GWAS success.

A competency framework for fire safety engineering

Publisher: Elsevier BV

Date: 2022

DOI: 10.1016/J.FIRESAF.2021.103511

Compressive strength and MoE of solid softwood at elevated temperatures

Publisher: The University of Queensland

Date: 30-11-2020

DOI: 10.14264/30065C4

The response of exposed timber in open plan compartment fires and its impact on the fire dynamics

Publisher: The University of Queensland

Date: 30-11-2020

DOI: 10.14264/5D97785

Factors influencing the fire dynamics in open-plan compartments with an exposed timber ceiling

Publisher: Elsevier BV

Date: 05-2022

DOI: 10.1016/J.FIRESAF.2022.103564

Experimental study of concrete elements subjected to travelling fires

Publisher: The University of Queensland

Date: 30-11-2020

DOI: 10.14264/CF93893

Norwegian Institute Of Public Health

Location: Norway

View Organisation

University Of Oslo

Location: Norway

View Organisation

Industrial Transformation Research Hubs - Grant ID: IH220100002

Start Date: 04-2024

End Date: 04-2029

Amount: $4,999,700.00

Funder: Australian Research Council

Industrial Transformation Research Hubs - Grant ID: IH200100010

Start Date: 07-2021

End Date: 07-2026

Amount: $5,000,000.00

Funder: Australian Research Council

Industrial Transformation Research Hubs - Grant ID: IH220100016

Start Date: 10-2023

End Date: 10-2028

Amount: $2,959,803.00

Funder: Australian Research Council