ORCID Profile
0000-0001-5673-5899
Current Organisations
University of South Australia
,
Oslo University Hospital
,
University of Oslo, Institute of Clinical Medicine
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Publications
Assessing Superhuman Speed as a Gamified Reward in a Virtual Reality Bike Exergame
Publisher: ACM
Date: 19-04-2023
Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders
Publisher: Elsevier BV
Date: 2022
Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders
Publisher: Cold Spring Harbor Laboratory
Date: 17-08-2020
DOI: 10.1101/2020.08.13.249813
Abstract: Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders suggest possible shared sex-dependent genetic risk. We conducted the largest to date genome-wide genotype–by–sex (GxS) interaction of risk for these disorders, using 85,735 cases (33,403 SCZ, 19,924 BIP, 32,408 MDD) and 109,946 controls from the Psychiatric Genomics Consortium (PGC) and iPSYCH. Across disorders, genome-wide significant SNP-by-sex interaction was detected for a locus encompassing NKAIN2 (rs117780815 p =3.2×10 −8 ), that interacts with sodium otassium-transporting ATPase enzymes implicating neuronal excitability. Three additional loci showed evidence ( p ×10 −6 ) for cross-disorder GxS interaction (rs7302529, p =1.6×10 −7 rs73033497, p =8.8×10 −7 rs7914279, p =6.4×10 −7 ) implicating various functions. Gene-based analyses identified GxS interaction across disorders ( p =8.97×10 −7 ) with transcriptional inhibitor SLTM . Most significant in SCZ was a MOCOS gene locus (rs11665282 p =1.5×10 −7 ), implicating vascular endothelial cells. Secondary analysis of the PGC-SCZ dataset detected an interaction (rs13265509 p =1.1×10 −7 ) in a locus containing IDO2 , a kynurenine pathway enzyme with immunoregulatory functions implicated in SCZ, BIP, and MDD. Pathway enrichment analysis detected significant GxS of genes regulating vascular endothelial growth factor (VEGF) receptor signaling in MDD ( p FDR .05). In the largest genome-wide GxS analysis of mood and psychotic disorders to date, there was substantial genetic overlap between the sexes. However, significant sex-dependent effects were enriched for genes related to neuronal development, immune and vascular functions across and within SCZ, BIP, and MDD at the variant, gene, and pathway enrichment levels.
Comparing gaze-supported modalities with empathic mixed reality interfaces in remote collaboration
Publisher: IEEE
Date: 10-2022
Near-gaze visualisations of empathic communication cues in mixed reality collaboration
Publisher: ACM
Date: 25-07-2022
CADET: a collaborative agile data exploration tool for mixed reality
Publisher: IEEE
Date: 10-2023
What I see and what I feel: the influence of deceptive visual cues and interoceptive accuracy on affective valence and sense of effort during virtual reality cycling
Publisher: PeerJ
Date: 04-10-2023
DOI: 10.7717/PEERJ.16095
Related Organisations
Related Funding Activities
No related grants have been discovered for Jeremy McDade.