ORCID Profile
0000-0003-4183-1858
Current Organisations
Monash University
,
University of South Australia
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Publisher: American Chemical Society (ACS)
Date: 27-06-2008
DOI: 10.1021/LA8006525
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0NA00857E
Abstract: This study presents the development of a microfluidic device to assess the cytotoxicity of nanoparticles on human immune cells.
Publisher: Elsevier BV
Date: 06-2011
Publisher: Wiley
Date: 29-06-2011
DOI: 10.1096/FJ.11-184861
Publisher: American Chemical Society (ACS)
Date: 02-03-2018
Publisher: Wiley
Date: 07-03-2021
Abstract: Neurological disorders such as Alzheimer's disease, stroke, and brain cancers are difficult to treat with current drugs as their delivery efficacy to the brain is severely h ered by the presence of the blood–brain barrier (BBB). Drug delivery systems have been extensively explored in recent decades aiming to circumvent this barrier. In particular, polymeric nanoparticles have shown enormous potentials owing to their unique properties, such as high tunability, ease of synthesis, and control over drug release profile. However, careful analysis of their performance in effective drug transport across the BBB should be performed using clinically relevant testing models. In this review, polymeric nanoparticle systems for drug delivery to the central nervous system are discussed with an emphasis on the effects of particle size, shape, and surface modifications on BBB penetration. Moreover, the authors critically analyze the current in vitro and in vivo models used to evaluate BBB penetration efficacy, including the latest developments in the BBB‐on‐a‐chip models. Finally, the challenges and future perspectives for the development of polymeric nanoparticles to combat neurological disorders are discussed.
Publisher: American Chemical Society (ACS)
Date: 09-06-2023
Publisher: IEEE
Date: 05-2023
Publisher: American Chemical Society (ACS)
Date: 23-11-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C6LC01261B
Abstract: A crossed flow microfluidic device was used for generation of cell-based arrays aiming for high throughput screening of applied bioactive chemicals to captured cells.
Publisher: American Chemical Society (ACS)
Date: 14-03-2022
Publisher: IOP Publishing
Date: 30-11-2017
Publisher: MDPI AG
Date: 12-04-2017
DOI: 10.3390/MI8040124
Publisher: MDPI AG
Date: 03-09-2023
Publisher: Public Library of Science (PLoS)
Date: 18-01-2012
Publisher: Oxford University Press (OUP)
Date: 2012
DOI: 10.1039/C2IB20036H
Abstract: Receptor-ligand adhesive interactions play a pivotal role in erse biological processes including inflammation and cancer metastasis. Cell adhesion is mediated by the molecular recognition of membrane-bound receptors by their cognate ligands on apposing cells. Cell-cell binding is regulated by distinct parameters such as the receptor-ligand binding kinetics, the tensile strength of in idual bonds, the involvement of multiple bonds and their modulation by hydrodynamic shear. This work aims to investigate the interplay of these parameters on selectin-mediated cell adhesion in shear flow. We designed a microfluidic device that delivers cells in a single file over a receptor-functionalized substrate, thereby permitting accurate determination of the cell flux. The selectin(s) was presented on striped patches of fixed width and varying length. We identified the critical patch lengths of P- and L-selectin for the initiation of HL-60 cell binding in shear flow. This characteristic length is governed by the time required to form multiple-bond interactions, as revealed by a multiple-bond mathematical model. The number of bonds required to support cell binding increases with the applied shear stress (0.5-2 dyn cm(-2)) for L- but not P-selectin. This finding is explained by differences in the tensile strength of P- and L-selectin for PSGL-1. Our integrated experimental and mathematical approach advances our understanding of receptor-mediated cell adhesion in the vasculature. Detailed knowledge of how molecular interactions modulate macroscopic cell binding behavior pertinent to inflammation and metastasis would facilitate the development of promising diagnostic tools to combat these diseases.
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1LC00505G
Abstract: Open coculture microfluidic chambers embedding Matrigel for 3D culture of hPSCderived forebrain and midbrain neurons over 5 months with functional neural activity.
Publisher: American Chemical Society (ACS)
Date: 15-12-2020
Publisher: Wiley
Date: 15-06-2012
DOI: 10.1096/FJ.12-211441
No related grants have been discovered for Ziqiu Tong.