ORCID Profile
0000-0003-1670-6211
Current Organisations
Amirkabir University of Technology Department of Chemical Engineering
,
McGill University
,
University of South Australia
,
National Service of Commercial Learning
,
Paulista Association of Dental Surgeons
,
Private Practice
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Publications
The development of 5-fluorouracil biodegradable implants: A comparative study of PCL/PLGA blends
Publisher: Elsevier BV
Date: 03-2023
Managing risk in the public sector – The interaction between vernacular and formal risk management systems
Publisher: Wiley
Date: 17-10-2018
DOI: 10.1111/FAAM.12179
ANALYSIS OF PARACETAMOL, PSEUDOEPHEDRINE AND BROMPHENIRAMINE IN COMTREX® TABLETS USING CHEMOMETRIC METHODS
Publisher: World Journal of Pharmacy and Pharmaceutical Sciences
Date: 06-2017
Development and application of a chromatographic method for simultaneous quantification of 5-fluorouracil and imiquimod in drug-in-adhesive topical patches
Publisher: Elsevier BV
Date: 06-2022
Insight into the Self-Insertion of a Protein Inside the Boron Nitride Nanotube
Publisher: American Chemical Society (ACS)
Date: 04-12-2020
Development and Validation of a Novel Tool for Assessing the Environmental Impact of 3D Printing Technologies: A Pharmaceutical Perspective
Publisher: MDPI AG
Date: 03-03-2022
DOI: 10.3390/PHARMACEUTICS14050933
Abstract: Technological advancements have created infinite opportunities and rendered our life easier at several fronts. Nonetheless, the environment has suffered the aftermaths of modernization. Ironically, the pharmaceutical industry was found to be a significant contributor to environmental deterioration. To tackle this issue, continuous eco-evaluation of newly introduced technologies is crucial. Three-dimensional printing (3DP) is rapidly establishing its routes in different industries. Interestingly, 3DP is revolutionising the production of pharmaceuticals and is regarded as a promising approach for the fabrication of patient-centric formulations. Despite the increasing applications in the pharmaceutical field, tools that evaluate the environmental impacts of 3DP are lacking. Energy and solvent consumption, waste generation, and disposal are the main associated factors that present major concerns. For the first time, we are proposing a quantitative tool, the index of Greenness Assessment of Printed Pharmaceuticals (iGAPP), that evaluates the greenness of the different 3DP technologies used in the pharmaceutical industry. The tool provides a colour-coded pictogram and a numerical score indicating the overall greenness of the employed printing method. Validation was performed by constructing the greenness profile of selected formulations produced using the different 3DP techniques. This tool is simple to use and indicates the greenness level of the procedures involved, thereby creating an opportunity to modify the processes for more sustainable practices.
Green chemistry and coronavirus
Publisher: Elsevier BV
Date: 06-2021
Accounting and passionate interests: The case of a Swedish football club
Publisher: Elsevier BV
Date: 04-2019
Greenness evaluation of different chromatographic approaches for the determination of dextromethorphan, phenylephrine & brompheniramine in their pharmaceutical formulation
Publisher: Elsevier BV
Date: 09-2020
All that glitters is not gold: Do movie quality and contents influence box-office revenues in China?
Publisher: Elsevier BV
Date: 03-2022
Green Liquid Chromatographic Methods with Ultraviolet and Tandem Mass Spectrometry Detection: An Application to Ternary Mixture of Paracetamol, Pseudoephedrine, and Cetirizine in Capsules
Publisher: Oxford University Press (OUP)
Date: 2020
Abstract: Background: Effective chromatographic methods were developed for the determination of a multicomponent capsule prescribed for treating the common cold. Greening approaches were adopted as opposed to conventional methods. Objectives: Two novel, green chromatographic methods were established to quantitatively analyze the combination. Methods: First, an HPLC/UV method utilizing green solvents (water and ethanol) and acetic acid to adjust pH at 5 was accomplished. The stationary phase was a ZorbaxSB-C18 column (150 × 4.6 mm, 5 μm), and peaks were detected at 215 nm. The second method is a highly sensitive ultra-performance LC (UPLC)-MS/MS method in which the greening approach was established through the reduction of the analysis time (2 min), decreased solvent consumption (flow rate 300 μL/min), and the utilization of a small volume of s les (injection volume 2 μL). The mixture was separated using a UPLC-BEH C18 column (50 × 2.1 mm, 1.7 μm) with an isocratic elution using methanol–0.1% formic acid aqueous solution (60+40, v/v) as mobile phase and utilizing diphenhydramine as an internal standard. Positive-ion electrospray ionization and multiple reaction monitoring were applied for detection. Results: Recovery percentages for paracetamol, pseudoephedrine, and cetirizine were 101.70 ± 0.969, 100.18 ± 1.563, and 99.67 ± 1.429 for the HPLC method and 99.18 ± 1.172, 100.03 ± 0.883, and 99.82 ± 0.912 for the UPLC-MS/MS method, respectively. Conclusions: The proposed methods efficiently analyzed paracetamol, pseudoephedrine, and cetirizine in Allercet Cold® capsules. Validation of the proposed methods was in accordance with the International Conference on Harmonization recommendations, and statistical comparison with the reported method displayed no significant difference regarding accuracy and precision. Highlights: Paracetamol, pseudoephedrine, and cetirizine were successfully quantified using two chromatographic methods. The HPLC method developed is considered green, using water and ethanol as a mobile phase. The UPLC-MS/MS method was rapid and determined the three drugs with accuracy at nanogram levels.
Analysis of paracetamol, pseudoephedrine and cetirizine in Allercet Cold® capsules using spectrophotometric techniques
Publisher: Springer Science and Business Media LLC
Date: 06-2018
Accounting for the cost of sports-related violence
Publisher: Emerald
Date: 15-11-2019
DOI: 10.1108/AAAJ-02-2018-3364
Abstract: The purpose of this paper is to extend the understanding of “the” accounting entity, demonstrating how it is a contestable socio-political construction informed by a nexus of market, state and community actors. A case study method is utilised to follow debate relating to Swedish football clubs’ responsibility for the payment/non-payment of policing costs between 1999 and 2014. The case study uses documentary and interview data, focusing on one of the high-risk Stockholm clubs. The paper makes four main contributions: first, demonstrating how the accounting entity is a changeable and contestable construction second, outlining how distinctions informing contests about the accounting arena are materialised through accounting calculations and other devices third, showing the importance of community in a coordinated sense in mediating accounting practices and fourth, contributing to the literature on accounting and sport, highlighting the importance of state actors in this arena. This research draws on original empirical data providing unique insights into debates regarding the responsibility for the payment of police costs in the context of sports-related violence. The authors show the importance of characterising accounting for sporting organisations as a shifting and contestable nexus of market, state and community actors.
Three-Dimensional Printing for Cancer Applications: Research Landscape and Technologies
Publisher: MDPI AG
Date: 10-08-2021
DOI: 10.3390/PH14080787
Abstract: As a variety of novel technologies, 3D printing has been considerably applied in the field of health care, including cancer treatment. With its fast prototyping nature, 3D printing could transform basic oncology discoveries to clinical use quickly, speed up and even revolutionise the whole drug discovery and development process. This literature review provides insight into the up-to-date applications of 3D printing on cancer research and treatment, from fundamental research and drug discovery to drug development and clinical applications. These include 3D printing of anticancer pharmaceutics, 3D-bioprinted cancer cell models and customised nonbiological medical devices. Finally, the challenges of 3D printing for cancer applications are elaborated, and the future of 3D-printed medical applications is envisioned.
3D Printing of Thermo-Sensitive Drugs
Publisher: MDPI AG
Date: 21-09-2021
DOI: 10.3390/PHARMACEUTICS13091524
Abstract: Three-dimensional (3D) printing is among the rapidly evolving technologies with applications in many sectors. The pharmaceutical industry is no exception, and the approval of the first 3D-printed tablet (Spiratam®) marked a revolution in the field. Several studies reported the fabrication of different dosage forms using a range of 3D printing techniques. Thermosensitive drugs compose a considerable segment of available medications in the market requiring strict temperature control during processing to ensure their efficacy and safety. Heating involved in some of the 3D printing technologies raises concerns regarding the feasibility of the techniques for printing thermolabile drugs. Studies reported that semi-solid extrusion (SSE) is the commonly used printing technique to fabricate thermosensitive drugs. Digital light processing (DLP), binder jetting (BJ), and stereolithography (SLA) can also be used for the fabrication of thermosensitive drugs as they do not involve heating elements. Nonetheless, degradation of some drugs by light source used in the techniques was reported. Interestingly, fused deposition modelling (FDM) coupled with filling techniques offered protection against thermal degradation. Concepts such as selection of low melting point polymers, adjustment of printing parameters, and coupling of more than one printing technique were exploited in printing thermosensitive drugs. This systematic review presents challenges, 3DP procedures, and future directions of 3D printing of thermo-sensitive formulations.
Analytical methods for the determination of paracetamol, pseudoephedrine and brompheniramine in Comtrex tablets
Publisher: Springer Science and Business Media LLC
Date: 02-07-2019
Effect of plasticizers on drug-in-adhesive patches containing 5-fluorouracil
Publisher: Elsevier BV
Date: 2022
DOI: 10.1016/J.IJPHARM.2021.121316
Abstract: Topical patches containing 5-fluorouracil (5-FU) are a feasible alternative to overcome the shortcomings of commercial cream for the treatment of non-melanoma skin cancer (NMSC). Plasticizers are a critical component of drug-in-adhesive (DIA) patches as they can significantly affect the mechanical, adhesive and drug release characteristics of the patches. Eudragit® E (EuE) is a methacrylate-based cationic copolymer capable of producing flexible and adhesive films for topical application. In this study, the effect of plasticizers on the mechanical, adhesive and 5-FU release characteristics of EuE-based patches was comprehensively evaluated. While the elongation at break (%) and adhesion of the films were significantly increased with increasing triacetin, dibutyl sebacate (DBS) and triethyl citrate (TEC) concentrations, the tensile strength showed an inverse relationship. EuE plasticized with 40% triacetin, 30% DBS or 40% w/w TEC produced elastic and adhesive films most suitable for topical application. In vitro release studies of the 5-FU-loaded patches demonstrated an initial burst release pattern during the first 10 min followed by a slow release over 120 min. In summary, this study provides important information on effect of plasticizers for preparation of EuE-based patches with desired mechanical, adhesive and release characteristics of 5-FU towards their potential application in the treatment of NMSC.
The interplay between ideological control and formal management control systems – A case study of a non-governmental organisation
Publisher: Elsevier BV
Date: 11-2017
Development of a novel chromatographic method for concurrent determination of 5-fluorouracil and cisplatin: validation, greenness evaluation, and application on drug-eluting film
Publisher: Elsevier BV
Date: 09-2021
Nonisothermal cure behavior and kinetics of cerium‐doped Fe3O4/epoxy nanocomposites
Publisher: Wiley
Date: 02-08-2022
DOI: 10.1002/AOC.6825
Abstract: How does the cerium (Ce) doping in ferrimagnetic magnetite (Fe 3 O 4 ) affect the crosslinking state and kinetics of epoxy crosslinking with amine curing agents? To answer this question, we electrochemically synthesized nanoparticles of Ce–Fe 3 O 4 and characterized them by FTIR, XRD, FE‐SEM, EDX, TEM, and XPS analyses. The presence of Ce atoms in Fe 3 O 4 crystalline lattice increased the surface area and active hydroxyl sites of the prepared magnetic nanoparticles (MNPs) associated with partial shrinkage of molecular lattice. The MNPs uniformly dispersed in epoxy resin and unconditionally tagged epoxy nanocomposites as Excellent cured systems. The effect of lanthanide doping on the cure kinetics of epoxy with amine was explored applying nonisothermal DSC and model‐free kinetic approaches, signifying that Ce–Fe 3 O 4 nanoparticles facilitated epoxy ring opening by intensification of etherification reaction whatever the heating rate. Even at very low loading of Ce–Fe 3 O 4 nanoparticles into the epoxy (0.1 wt.%), the average apparent activation energy significantly decreased by ≈10%. This outcome would highlight the role of crosslinking on the ultimate properties, such as anticorrosive and/or self‐healing characteristics contributed by Ce‐doped nanoparticles once added to epoxy coating formulation.
Inulin and Its Application in Drug Delivery
Publisher: MDPI AG
Date: 26-08-2021
DOI: 10.3390/PH14090855
Abstract: Inulin’s unique and flexible structure, stabilization rotective effects, and organ targeting ability make it an excellent drug delivery carrier compared to other biodegradable polysaccharides. The three hydroxyl groups attached to each fructose unit serve as an anchor for chemical modification. This, in turn, helps in increasing bioavailability, improving cellular uptake, and achieving targeted, sustained, and controlled release of drugs and biomolecules. This review focuses on the various types of inulin drug delivery systems such as hydrogel, conjugates, nanoparticles, microparticles, micelles, liposomes, complexes, prodrugs, and solid dispersion. The preparation and applications of the different inulin drug delivery systems are further discussed. This work highlights the fact that modification of inulin allows the use of this polymer as multifunctional scaffolds for different drug delivery systems.
The role of technocratic and socio-ideological controls in managing tensions when integrating international subsidiaries
Publisher: Emerald
Date: 13-06-2019
DOI: 10.1108/QRAM-05-2018-0032
Abstract: This paper aims to analyse how a multinational organisation uses technocratic and socio-ideological controls to manage tensions arising when integrating its international subsidiaries. Through interviews and company documentation, the authors analyse how a global German family business firm integrates its international subsidiaries into the corporate context. The findings suggest that technocratic and socio-ideological controls in combination help the firm manage three tensions – vertical vs lateral relations, standardisation vs differentiation of practices and centralisation vs decentralisation of decision-making – arising in the course of internationalisation. These results have important analytical implications for the understanding of how a high level of compliance to technocratic control initiatives is achieved. Prior work has, in the main, focussed on the resistance to technocratic controls without paying much attention to compliance. Specifically, the authors show how managers can use socio-ideological control to achieve a high level of compliance among employees when implementing technocratic controls. The results suggest that managers in multinational firms need to pay careful attention to the tensions that are created when they internationalise and to apply a combination of technocratic and socio-ideological controls to manage these tensions. There is limited knowledge of how managers use socio-ideological control to enact a particular form of experience for their employees and to create a highly valued sense of purpose. The findings suggest that these controls, in combination with technocratic ones, serve important roles when organisations expand internationally.
Quantum dots for photocatalysis: synthesis and environmental applications
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1GC00639H
Abstract: Synthetic methods of QDs from low cost and natural resources.
Related Organisations
Amirkabir University Of Technology Department Of Chemical Engineering
Location: Iran (Islamic Republic of)
Related Funding Activities
Percepção Ambiental Dos Consumidores De Pescado
Start Date: 2017
End Date: 2019
Funder: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
View Funded Activity