ORCID Profile
0000-0002-5053-4591
Current Organisations
University of South Australia
,
Shiraz University of Medical Sciences
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Publisher: Bentham Science Publishers Ltd.
Date: 09-2022
DOI: 10.2174/1570163819666220428123059
Abstract: Genus Dracocephalum belongs to the Lamiaceae family, representing 11 species in Iran, containing D. ghahremanii Jamzad, D. lindbergii Rech. F, D. oligadenium Bornm. & Gauba, D. kotschyi Boiss., D.multicaule, D.Aucheri, D.Subcapitatum, D.Thymifolium, D.Moldavica, D. polychaetum Borm, and D. surmandinum Rech.f. The current study aimed to investigate the morphological and phytochemical properties of Dracocephalum species in Iran and their pharmacological effects. The search was restricted to scientific articles from PubMed, Google Scholar, Science Direct, SpringerLink, and Scopus. The search was limited to scientific journals, books, and book chapters focusing on the medicinal properties of Dracocephalum in Iran for the era from 1993 to 2020. Findings show that Dracocephalum species were utilized to treat various disorders in traditional medicine. Phytochemical studies show that the main constituents isolated from the plant consist of lignans, phytosterol, flavonoids, phenols, alkaloids, Sesquiterpenes, and oxygenated and hydro carbonated monoterpenes. These main components are responsible for antihyperlipidemic, antimicrobial, anticancer, antispasmodic, antioxidant, and cardiovascular effects of the plant. This plant has a good potential for drug discovery and curing different diseases. Therefore, more research will be done on the Iranian species of Dracocephalum based on clinical and animal studies to develop an effective drug formulation.
Publisher: Hindawi Limited
Date: 03-08-2020
DOI: 10.1155/2020/6942707
Abstract: Background . The dental pulp is a heterogeneous soft tissue that supplies nutrients and acts as a biosensor to identify pathogenic stimuli. Regeneration of the dental pulp is one of the desirable topics for researchers. Graphene oxide nanosheets (nGOs) help overexpression of the genes related to odontogenic differentiation of stem cells from dental pulps and increases attachment and proliferation of dental pulp stem cells. Despite its benefits, nGO may be considered as a threat to the environment and human health. Therefore, the purpose of this study was to evaluate the biocompatibility potential of graphene oxide (nGO), chitosan functionalized graphene oxide (nGO-CS), and carboxylated graphene (nGO-COOH) when exposed to human dental pulp stem cells (hDPSCs). Material and Methods . Some different aspects of biocompatibility of nGO, nGO-CS, and nGO-COOH were synthesized, and several intracellular effects induced by different concentrations of graphene-based nanosheets, including cell viability, intracellular oxidative damages, and various factors such as LDH, GSH, SOD, MDA, and MMP, were studied on hDPSCs. Results . According to results, IC 50 was determined as 232.01, 467.81, and ≥1000 μ g/mL for nGO, nGO-CS, and nGO-COOH, respectively. These results demonstrated the lower toxicity and higher cytocompatibility of nGO-CS and nGO-COOH compared to nGO. nGO-COOH not only has any adverse effect on the cell membrane and mitochondrial activity but also shows slight antioxidant activity at some concentrations. Conclusion . The findings help design safe and cytocompatible nGO derivatives for biomedical applications in dental fields.
Publisher: Elsevier BV
Date: 06-2020
Publisher: Bentham Science Publishers Ltd.
Date: 21-09-2020
DOI: 10.2174/1389201021666200318131422
Abstract: Graphene Derivatives (GDs) have captured the interest and imagination of pharmaceutical scientists. This review exclusively provides pharmacokinetics and pharmacodynamics information with a particular focus on biopharmaceuticals. GDs can be used as multipurpose pharmaceutical delivery systems due to their ultra-high surface area, flexibility, and fast mobility of charge carriers. Improved effects, targeted delivery to tissues, controlled release profiles, visualization of biodistribution and clearance, and overcoming drug resistance are ex les of the benefits of GDs. This review focuses on the application of GDs for the delivery of biopharmaceuticals. Also, the pharmacokinetic properties and the advantage of using GDs in pharmaceutics will be reviewed to achieve a comprehensive understanding about the GDs in pharmaceutical sciences.
Publisher: Springer Science and Business Media LLC
Date: 22-04-2020
Publisher: Elsevier BV
Date: 08-2021
Publisher: Springer Science and Business Media LLC
Date: 10-02-2017
DOI: 10.1038/SREP42258
Abstract: Proteins have short half-life because of enzymatic cleavage. Here, a new protein nanocarrier made of graphene oxide (GO) + Chitosan (CS) is proposed to successfully prevent proteolysis in protein and simultaneously retain its activity. Bovine serum albumin (BSA) and collagenase were loaded on GO and GO-CS to explore the stability and activity of proteins. SEM, AFM, TEM, DSC, UV-Vis, FT-IR, RBS, Raman, SDS-PAGE and zymography were utilized as characterization techniques. The protecting role of GO and GO-CS against enzymatic cleavage was probed by protease digestion analysis on BSA, where the protease solution was introduced to GO-BSA and GO-CS-BSA at 37 °C for 0.5-1-3-6 hours. Characterizations showed the successful synthesis of few layers of GO and the coverage by CS. According to gelatin zymographic analysis, the loaded collagenase on GO and GO-CS lysed the gelatin and created non-staining bands which confirmed the activity of loaded collagenase. SDS-PAGE analysis revealed no significant change in the intact protein in the GO-BSA and GO-CS-BSA solution after 30-minute and 1-hour exposure to protease however, free BSA was completely digested after 1 hour. After 6 hours, intact proteins were detected in GO-BSA and GO-CS-BSA solutions, while no intact protein was detected in the free BSA solution.
Publisher: Elsevier BV
Date: 12-0040
Location: Iran (Islamic Republic of)
No related grants have been discovered for Fatemeh Emadi.