ORCID Profile
0000-0002-9074-2125
Current Organisation
University of South Australia
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Composite and Hybrid Materials | Organic Chemical Synthesis | Manufacturing Processes and Technologies (excl. Textiles) | Materials Engineering
Rehabilitation of Degraded Fresh, Ground and Surface Water Environments | Environmentally Sustainable Manufacturing not elsewhere classified | Environmental Health |
Publisher: Public Library of Science (PLoS)
Date: 14-07-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C2RA20232H
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4TB00231H
Abstract: An optical biosensor based on the switching of poly(4-vinylphenylboronic acid) (PVPBA) grafted to the pores of porous silicon (pSi) films in response to pH and glucose.
Publisher: Royal Society of Chemistry (RSC)
Date: 22-07-2014
DOI: 10.1039/C4CC04470C
Abstract: In the quest for solutions to meeting future energy demands, solar fuels play an important role. A particularly promising ex le is photocatalysis since even incremental improvements in performance in this process are bound to translate into significant cost benefits. Here, we report that semiconducting and high surface area 3D silicon replicas prepared from abundantly available diatom fossils sustain photocurrents and enable solar energy conversion.
Publisher: Elsevier BV
Date: 2016
DOI: 10.1016/J.BIOMATERIALS.2015.09.045
Abstract: Advanced biosensors in future medicine hinge on the evolvement of biomaterials. Porous silicon (pSi), a generally biodegradable and biocompatible material that can be fabricated to include environment-responsive optical characteristics, is an excellent candidate for in vivo biosensors. However, the feasibility of using this material as a subcutaneously implanted optical biosensor has never been demonstrated. Here, we investigated the stability and biocompatibility of a thermally-hydrocarbonised (THC) pSi optical rugate filter, and demonstrated its optical functionality in vitro and in vivo. We first compared pSi films with different surface chemistries and observed that the material was cytotoxic despite the outstanding stability of the THC pSi films. We then showed that the cytotoxicity correlates with reactive oxygen species levels, which could be mitigated by pre-incubation of THC pSi (PITHC pSi). PITHC pSi facilitates normal cellular phenotypes and is biocompatible in vivo. Importantly, the material also possesses optical properties capable of responding to microenvironmental changes that are readable non-invasively in cell culture and subcutaneous settings. Collectively, we demonstrate, for the first time, that PITHC pSi rugate filters are both biocompatible and optically functional for lab-on-a-chip and subcutaneous biosensing scenarios. We believe that this study will deepen our understanding of cell-pSi interactions and foster the development of implantable biosensors.
Publisher: SPIE
Date: 21-12-2008
DOI: 10.1117/12.759211
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5CC02689J
Abstract: Here, we report a novel surface modification for porous silicon (pSi).
Publisher: IWA Publishing
Date: 19-06-2018
DOI: 10.2166/WS.2017.123
Abstract: The performance of activated carbon water filters, with respect to the breakthrough of dissolved organic matter (DOM) and dangerous trihalomethanes (THMs) from supplied water, has been analysed by fluorescence spectroscopy. Fluorescence spectroscopy has been demonstrated as a viable technique to monitor carbon filter performance, using the fluorescently active DOM species as an indicator. Due to the relationship between DOM and THMs, where DOM is the precursor for THM formation during the chlorine treatment of water, fluorescence spectroscopy can be used to predict the breakthrough of both species from activated carbon filters. In order to establish a versatile measurement technique, the most appropriate fluorescence excitation and emission wavelengths for detecting the DOM in water were firstly determined. These fluorescence measurement parameters were then applied to effluent water s les from carbon filters, over a total filtrate volume of 4,200 L. The total THM concentration in filtered water s les was determined by headspace gas chromatography (HSGC), with the fluorescence and HSGC results showing a high degree of correlation for the amount of DOM and THM respectively. Importantly, this correlation is observed for both of the determined fluorescence measurement parameters, highlighting the validity and versatility of this technique.
Publisher: MDPI AG
Date: 23-12-2021
Abstract: Fluorescence microscopy has become a critical tool for researchers to understand biological processes at the cellular level. Micrographs from fixed and live-cell imaging procedures feature in a plethora of scientific articles for the field of cell biology, but the complexities of fluorescence microscopy as an imaging tool can sometimes be overlooked or misunderstood. This review seeks to cover the three fundamental considerations when designing fluorescence microscopy experiments: (1) hardware availability (2) amenability of biological models to fluorescence microscopy and (3) suitability of imaging agents for intended applications. This review will help equip the reader to make judicious decisions when designing fluorescence microscopy experiments that deliver high-resolution and informative images for cell biology.
Publisher: MDPI AG
Date: 04-01-2021
DOI: 10.3390/MOLECULES26010219
Abstract: Conventional chemotherapies used for breast cancer (BC) treatment are non-selective, attacking both healthy and cancerous cells. Therefore, new technologies that enhance drug efficacy and ameliorate the off-target toxic effects exhibited by currently used anticancer drugs are urgently needed. Here we report the design and synthesis of novel mesoporous silica nanoparticles (MSNs) equipped with the hormonal drug tamoxifen (TAM) to facilitate guidance towards estrogen receptors (ERs) which are upregulated in breast tumours. TAM is linked to the MSNs using a poly-ʟ-histidine (PLH) polymer as a pH-sensitive gatekeeper, to ensure efficient delivery of encapsulated materials within the pores. XRD, HR-TEM, DLS, SEM, FT-IR and BET techniques were used to confirm the successful fabrication of MSNs. The MSNs have a high surface area ( m2/g) and a mean particle size of 150 nm, which is an appropriate size to allow the penetration of premature blood vessels surrounding breast tumours. Successful surface functionalization was supported by FT-IR, XPS and TGA techniques, with a grafting ratio of approximately 29%. The outcomes of this preliminary work could be used as practical building blocks towards future formulations.
Publisher: Wiley
Date: 30-08-2019
Publisher: Elsevier BV
Date: 05-2017
DOI: 10.1016/J.BIOS.2017.01.004
Abstract: A label-free porous silicon (pSi) based, optical biosensor, using both an antibody and aptamer bioreceptor motif has been developed for the detection of insulin. Two parallel biosensors were designed and optimised independently, based on each bioreceptor. Both bioreceptors were covalently attached to a thermally hydrosilylated pSi surface though amide coupling, with unreacted surface area rendered stable and low fouling by incorporation of PEG moieties. The insulin detection ability of each biosensor was determined using interferometric reflectance spectroscopy, using a range of different media both with and without serum. Sensing performance was compared in terms of response value, response time and limit of detection (LOD) for each platform. In order to demonstrate the capability of the best performing biosensor to detect insulin from real s les, an in vitro investigation with the aptamer-modified surface was performed. This biosensor was exposed to buffer conditioned by glucose-stimulated human islets, with the result showing a positive response and a high degree of selectivity towards insulin capture. The obtained results correlated well with the ELISA used in the clinic for assaying glucose-stimulated insulin release from donor islets. We anticipate that this type of sensor can be applied as a rapid point-of-use biosensor to assess the quality of donor islets in terms of their insulin production efficiency, prior to transplantation.
Publisher: American Chemical Society (ACS)
Date: 07-2011
DOI: 10.1021/LA201760W
Publisher: American Chemical Society (ACS)
Date: 23-06-2011
DOI: 10.1021/AM2003526
Publisher: Elsevier BV
Date: 11-2018
Publisher: Wiley
Date: 19-01-2012
Publisher: American Chemical Society (ACS)
Date: 03-06-2019
Publisher: Wiley
Date: 07-02-2019
Publisher: MDPI AG
Date: 02-06-2017
DOI: 10.3390/C3020018
Publisher: Elsevier BV
Date: 12-2011
Publisher: Elsevier BV
Date: 11-2018
Publisher: Wiley
Date: 26-01-2016
Abstract: Porous silicon microparticles (pSi MPs) functionalized with fluorescent dyes (lissamine and carboxy-5-fluorescein) and intrinsically luminescent pSi MPs were explored as novel fingerprint dusting powders. The versatility of luminescent pSi MPs is demonstrated through time-gated imaging of their long-lived (lifetime>28 μs) near-IR emission, and mass spectrometry analysis of fingerprints dusted with luminescent pSi MPs to provide further information on exogenous small molecules present in latent fingerprints.
Publisher: MDPI AG
Date: 30-06-2021
DOI: 10.3390/APP11136121
Abstract: Functionalized nanoparticles have played a major role in the field of targeted therapy, owing to their ability to control the release and for the selective delivery of entrapped materials to tumours. In this work, we described the loading capacity and in vitro release kinetics of mesoporous silica nanoparticles (MSNs), functionalized with Poly-L-Histidine and Tamoxifen. The model drug Doxorubicin (DOX) was successfully encapsulated into MSN-based systems, using the technique of solvent immersion. A post-surface grafting loading method was investigated on functionalized systems, with DOX loading content determined using HPLC. Dialysis bag diffusion was employed to investigate the release kinetics of DOX-loaded-systems at pH 7.4 and 5. The amount of DOX released from native MSNs systems over a 72 h period at pH 5 was approximately 40% and at pH 7.4 ≈ 30%. A moderate pH dependent release behaviour was observed with both our functionalized systems: DOX@MSN-PLH and DOX@MSN-PLH-TAM with approximately 5% of DOX released from DOX@MSN-PLH-TAM at pH 7.4 and about 9% released at pH 7.4 over 72 h. The maximal cumulated release of DOX molecules from DOX@MSN-PLH after 72 h was ≈18% at pH 7.4 and ≈23% at pH 5, respectively. The outcome of this work offers a promising contribution towards building future stimuli-responsive nano-drug delivery systems.
Start Date: 04-2020
End Date: 04-2020
Amount: $497,638.00
Funder: Australian Research Council
View Funded Activity