ORCID Profile
0000-0003-0796-6193
Current Organisations
Agricultural Sciences and Natural Resources University of Khuzestan
,
University of South Australia
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In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Architectural Science and Technology (incl. Acoustics, Lighting, Structure and Ecologically Sustainable Design) | Architecture | Demography | Multicultural, Intercultural and Cross-cultural Studies | Architectural Design | Urban Sociology and Community Studies | Migration |
Cultural Understanding not elsewhere classified | Ethnicity, Multiculturalism and Migrant Development and Welfare | Employment Patterns and Change | Expanding Knowledge in Built Environment and Design
Publisher: Baishideng Publishing Group Inc.
Date: 2012
Publisher: MDPI AG
Date: 25-06-2022
Abstract: Globally, there is an urgent need for solutions that can support our aging populations to live well and reduce the associated economic, social and health burdens. Implementing smart technologies within homes and communities may assist people to live well and ‘age in place’. To date, there has been little consultation with older Australians addressing either the perceived benefits, or the potential social and ethical challenges associated with smart technology use. To address this, we conducted five World Cafés in two Australian states, aiming to capture citizen knowledge about the possibilities and challenges of smart technologies. The participants (n = 84) were aged 55 years and over, English-speaking, and living independently. Grounding our analysis in values-based social science and biomedical ethical principles, we identified the themes reflecting the participants’ understanding, resistance, and acceptance of smart technologies, and the ethical principles, including beneficence, non-maleficence, autonomy, privacy, confidentiality, and justice. Similar to other studies, many of the participants demonstrated cautious and conditional acceptance of smart technologies, while identifying concerns about social isolation, breaches of privacy and confidentiality, surveillance, and stigmatization. Attention to understanding and incorporating the values of older citizens will be important for the acceptance and effectiveness of smart technologies for supporting independent and full lives for older citizens.
Publisher: Wiley
Date: 02-03-2020
DOI: 10.1111/AJAG.12788
Publisher: Wiley
Date: 14-10-2020
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 14-05-2011
DOI: 10.1002/HEP.24285
Abstract: Interleukin 32 (IL-32) is a recently described proinflammatory cytokine that activates p38 mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB), thereby inducing proinflammatory cytokines such as IL-1β and tumor necrosis factor alpha (TNF-α). We investigated the role of IL-32 in patients with chronic hepatitis C virus (HCV) infection. Steady-state hepatic messenger RNA (mRNA) levels of IL-32 were determined in a cohort of 90 subjects anti-IL-32 staining was used in a second cohort of 132 consecutive untreated chronic HCV patients. Correlations with histological features of steatosis, inflammation, and fibrosis were made. In vitro, endogenous IL-32 in monocytes and in the human hepatoma cell line Huh-7.5 were examined. The effects of IL-32-overexpression and IL-32-silencing on HCV replication were studied using HCV luciferase reporter viruses. There were highly significant positive associations between hepatic IL-32 mRNA expression and liver steatosis, inflammation, fibrosis, smooth muscle actin (SMA) area, and serum alanine aminotransferase (ALT) levels. IL-32 protein expression was positively associated with portal inflammation, SMA area, and ALT. In vitro, IL-1β and TNF-α significantly induced IL-32 expression in human Huh-7.5 cells. Alone, stimulation with interferon alpha (IFN-α) did not induce IL-32 expression in Huh-7.5. However, IFN-α exerted a significant additive effect on TNF-α-induced but not IL-1β-induced IL-32 expression, particularly in CD14+ monocytes. This effect was dependent both on NF-κB and Jak/STAT signaling. Viral infection of Huh-7.5 cells resulted in a significant (11-fold) induction of IL-32 mRNA expression. However, modulation of IL-32 in Huh-7.5 cells by overexpression or silencing did not influence HCV virus replication as determined by luciferase assays. IL-32 is a novel proinflammatory cytokine involved in HCV-associated liver inflammation/fibrosis. IL-32 is expressed by human hepatocytes and hepatoma cells and its expression is regulated by proinflammatory stimuli.
Publisher: The University of Adelaide
Date: 2018
Publisher: JMIR Publications Inc.
Date: 31-07-2019
DOI: 10.2196/12632
Abstract: Young people with refugee experiences are widely acknowledged as encountering multiple disadvantages that affect their school completion and retention, university entry, and subsequent employment. This paper discusses the rationale for and protocol of a mixed methods investigation focusing on improving education and employment outcomes among refugee background youth aged 15 to 24 years from three focus regions: the Middle East (Afghanistan, Iran, Iraq, Syria), South Asia (Nepal, Bhutan, Myanmar/Burma, Pakistan) and Africa (Sudan, South Sudan, Liberia, Ethiopia, Somalia, DR Congo). The rationale of the project is to identify the facilitators and barriers to successful transition from school to further education and employment investigate participant awareness of support systems available when faced with education and employment difficulties redress the disadvantages encountered by refugee background youth and bridge the gap between research, policy, and practice in relation to social inclusion and participation. The study involves collecting survey data from 600 youth followed by in idual interviews with a subset of 60 youth, their parents rimary caregivers, and their teachers. A cross-sectional survey will assess facilitators and barriers to successful transition from school to further education and employment. In idual interviews will provide context-rich data on key issues relevant to education and employment outcomes. The study began in 2016 and is due for completion by the end of 2019. The quantitative survey has been conducted with 635 participants and was closed in March 2019. The qualitative interview stage is ongoing, and the current total in April 2019 is 93 participants including educators, youth, and family members of the youth. Analysis and presentation of results will be available in 2020. Some preliminary findings will be available during the late half of 2019. This project will contribute new and unique insights to knowledge in relation to key factors influencing education and employment outcomes among refugee youth. This research will enable effective planning for the needs of some of Australia’s most disadvantaged and marginalized young people, leading to a sustainable improvement in the education and employability of young refugees. DERR1-10.2196/12632
Publisher: Australian Housing and Urban Research Institute (AHURI)
Date: 08-2023
Publisher: SAGE Publications
Date: 05-05-2020
Abstract: Neighborhood physical characteristics have been consistently associated with the health of older adults. This article investigates links between frailty and perceptions of the neighborhood environment. Using a cross-sectional analysis of 370 community-dwelling older adults from Nagoya, Japan, neighborhood perceptions were assessed using the Neighborhood Environmental Walkability Scale (NEWS) in addition to frailty, using a frailty index. Frailty was associated with the NEWS composite index, land use mix ersity, land use mix access, street connectivity, walking infrastructure, aesthetics, and crime safety, after adjustment for covariates. Older adults with increasing frailty have poorer perceptions of their neighborhoods, which could lead to further constriction of the life-space, less social and physical engagement, and worsening of frailty status.
Publisher: Elsevier BV
Date: 05-2014
Publisher: Springer Science and Business Media LLC
Date: 2011
DOI: 10.1186/GM273
Publisher: Australian Housing and Urban Research Institute (AHURI)
Date: 05-2022
Publisher: MDPI AG
Date: 11-2019
DOI: 10.3390/HEALTHCARE7040126
Abstract: Outdoor and indoor environments impact older people’s mobility, independence, quality of life, and ability to “age in place”. Considerable evidence suggests that not only the amount, but also the quality, of public green spaces in the living environment is important. The quality of public green spaces is mostly measured through expert assessments by planners, designers and developers. A disadvantage of this expert-determined approach is that it often does not consider the appraisals or perceptions of residents. Daily experience, often over long periods of time, means older residents have acquired insider knowledge of their neighbourhood, and thus, may be more qualified to assess these spaces, including measuring what makes a valued or quality public green space. The aim of this Australian pilot study on public green spaces for ageing well was to test an innovative citizen science approach to data collection using smart phones. “Senior” citizen scientists trialed the smart phone audit tool over a three-month period, recording and auditing public green spaces in their neighbourhoods. Data collected included geocoded location data, photographs, and qualitative comments along with survey data. While citizen science research is already well established in the natural sciences, it remains underutilised in the social sciences. This paper focuses on the use of citizen science with older participants highlighting the potential for this methodology in the fields of environmental gerontology, urban planning and landscape architecture.
Publisher: Ubiquity Press, Ltd.
Date: 2023
DOI: 10.5334/BC.339
Publisher: Elsevier BV
Date: 08-2019
DOI: 10.1016/J.EXGER.2019.05.010
Abstract: Detailed information about the current and future geographic distribution of Australia's frail population provides critical evidence to inform policy, resource allocation and planning initiatives that aim to treat and reverse frailty. Frailty is associated with poor health outcomes, including disability and death. It is also characterised by increased health care usage and costs. Understanding the distribution and growth of frailty is important for planning and budgeting service provision and health interventions aimed to support the needs of Australia's growing ageing population. The objective of this research is to provide baseline mapping and area level population estimates of Australia's current and future frail and pre-frail populations. Geospatial modelling was applied to national frailty prevalence rates to provide estimates of the size, distribution and potential growth of Australia's frail and pre-frail population. It is estimated that in 2016 approximately 415,769 people living in Australia aged 65 years or more are frail and almost 1.7 million people are pre-frail. In future years, as the population ages, these figures will increase rapidly, reaching 609,306 frail and 2,248,977 pre-frail by 2027, if prevalence continues at current levels. The geographic distribution of this projected growth is not uniform and while the largest frail populations will continue to be located in the major cities, the fastest growth will be in the outer metropolitan, regional and remote areas. The projected growth of frail populations in outer metropolitan, regional and remote areas may be reduced by targeting health interventions in these areas and improving access to support services. Frailty is a dynamic condition that is amenable to intervention. Reducing frailty will lead to benefits in wellbeing for older Australians in addition to reductions in health care costs.
Publisher: Informa UK Limited
Date: 25-08-2018
Publisher: SERDI
Date: 2018
DOI: 10.14283/JFA.2018.23
Abstract: It is essential to evaluate frail older adults understanding and execution of survey tools to improve data quality and accurate representation in research. The study tested the feasibility and acceptability of a survey that assesses various measures of functional status in frail older people. The study evaluated: 1) recruitment rate 2) time to complete questionnaires and difficulties encountered and 3) acceptability by participants. Validated tools including: FRAIL Scale, EuroQoL 5D-5L, Charlson’s Comorbidities Index, Baecke’s Physical Activity Questionnaire, Life-Space Assessment, Katz and Lawton ADL and NEWS Walkability Scale were assessed. Twenty-five older patients (63% recruitment rate) of a post-acute restorative program (residential Transition Care Program) in Adelaide, South Australia were interviewed. Although not statistically different, time to complete the overall questionnaire differed between robust, pre-frail and frail participants. Overall, the survey was considered acceptable and feasible, with consideration with NEWS and Life-Space assessment regarding length, phrasing and layout.
Publisher: Ubiquity Press, Ltd.
Date: 24-07-2023
DOI: 10.5334/BC.336
Abstract: High-rise urban development has been controversial for its inability to foster cohesive and flourishing neighbourhoods. A social value perspective can help to better understand and evaluate how new developments in dense urban settings affect places and communities. While the link between wellbeing and social value is well-established in the literature, the question of how design can affect wellbeing and thus contribute to the social value of a development still requires further research and clarification. A better understanding of this relationship can assist architects, developers or consultants during the design process. A review is presented of relevant quantifiable aspects of building design that affect wellbeing in relation to the indoor environment and to social value specifically. A framework for fostering wellbeing is developed to test these aspects and evaluate the indoor environment performance. A case study building is used to analyse the relationship between building design and wellbeing. These lessons can be used to inform and evaluate building design during the design phases to complement the assessment of qualitative factors within a social value framework. Practice relevance This study identifies quantifiable aspects of the indoor environment affecting wellbeing in a high-rise development that can form part of a social value framework. This list of identified aspects provides a useful starting point for architects or consultants to assess designs. The indicators relate to quantifiable indoor environment aspects that can be directly controlled by building design and complement the broader concepts of wellbeing within a social value framework. The paper demonstrates how these aspects can be quantified in a case study mixed-use urban development as part of a post-occupancy evaluation. These quantifiable aspects could be integrated within digital tools to evaluate the building at the design stage to ensure that wellbeing is at the forefront of the project considerations.
Publisher: University of South Australia
Date: 2019
Publisher: Elsevier BV
Date: 11-2020
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 07-2008
DOI: 10.1002/HEP.22311
Abstract: Obesity and fatty liver are commonly observed among patients with chronic hepatitis C virus (HCV) and are risk factors for increased hepatic fibrosis. Obesity is accompanied by a low-grade, chronic inflammatory response that may contribute to pathogenesis of obesity-related comorbidities. To assess whether obesity and steatosis potentiate expression of inflammatory markers in chronic HCV, serum protein and hepatic messenger RNA (mRNA) levels of c-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) were measured in 171 patients with chronic HCV. The relationships of body mass index, steatosis, histological features of inflammation and fibrosis with serum and hepatic levels of these factors were determined. In comparison with lean patients, overweight and obese subjects had increased circulating (P < 0.001) and hepatic (P = 0.003) CRP, and there was a significant correlation between serum protein and hepatic CRP mRNA levels (r(s)= 0.51, P < 0.001). Obesity (P = 0.001) and steatosis (P < 0.001) were associated with increased circulating but not hepatic IL-6, and a weak correlation was seen between serum protein and hepatic IL-6 mRNA levels (r(s)= 0.29, P = 0.003). An independent relationship was seen between hepatic TNF-alpha mRNA levels and higher total inflammatory score (P < 0.001) and stage of fibrosis (P = 0.037). Subjects with HCV genotype 3 had lower hepatic TNF-alpha mRNA levels compared with subjects with genotype 1 (P = 0.017), but there was no relationship between serum TNF-alpha protein and hepatic TNF-alpha mRNA levels. In patients with chronic HCV, obesity and steatosis are associated with increased expression of selected inflammatory markers however, circulating levels of IL-6 and TNF-alpha do not reflect hepatic expression. Hepatic TNF-alpha was associated with both increased inflammatory activity and hepatic fibrosis, providing support for the key role of this pro-inflammatory cytokine in liver injury in chronic HCV.
Publisher: Elsevier BV
Date: 10-2023
Publisher: Wiley
Date: 24-09-2022
DOI: 10.1002/HPJA.541
Abstract: Aboriginal and Torres Strait Islander peoples face challenges in accessing aged care and are less likely to use some services than their non‐Indigenous counterparts. Culturally safe care is increasingly recognised as an enabler to improve access and quality of care. This study explored older Aboriginal peoples’ perceptions and experience of culturally safe aged care. We conducted semi‐structured interviews with sixty‐three older Aboriginal people, purposively s led from three rural and remote geographic locations in South Australia, between April and October 2018, with participants who were both receiving and not receiving aged care services. We asked participants how organisations do or could meet their aged care needs. We analysed interview data inductively into themes. These themes were incorporated into six principles of culturally safe aged care which were subsequently endorsed by participants and study stakeholders. Participants described culturally safe aged care services as those which facilitated or maintained connection to participants’ culture, traditional lands and community. Five themes were identified: maintaining cultural identity, culturally informed service delivery, culturally competent workforce, culturally supportive environments and partnerships and collaboration within the aged care service system. Addressing cultural safety in aged care will require organisations to adapt their policies, service delivery, environments and work practices to meet the needs of older Aboriginal peoples. SO WHAT? Identifying culturally safe aged care from the perspectives of older Aboriginal and Torres Strait Islander peoples provides timely insight to how services may be better designed and implemented to promote quality of life.
Publisher: Elsevier BV
Date: 2021
Publisher: Elsevier BV
Date: 12-2008
DOI: 10.1016/J.JHEP.2008.06.022
Abstract: Increased expression of sterol regulatory element binding protein (SREBP)-1c, a transcription factor regulating lipogenesis, has been reported in HCV core protein-transfected hepatocytes. Our aim was to investigate the role of SREBP-1c in the pathogenesis of HCV-related steatosis. One hundred and twenty-four patients with HCV and 13 subjects with histologically normal liver (NDL) were studied. The mRNA expression of SREBP-1c, fatty acid synthase (FAS), glycerol-3-phosphate acyltransferase (GPAT) and microsomal triglyceride transfer protein (MTP) was measured by qPCR, and SREBP-1 protein quantitated by immunohistochemistry. There was no significant difference in the hepatic expression of SREBP-1c mRNA between subjects with HCV and NDL. In patients with HCV, a significant negative relationship was seen between hepatic SREBP-1c mRNA expression and grade of steatosis (r(s)=-0.28, p=0.002), stage of fibrosis (r(s)=-0.375, p<0.001) and severity of inflammation (r(s)=-0.313, p 2 had significantly higher expression of FAS mRNA than HCV-infected subjects with HOMA2 (p=0.006) and NDL (p=0.016). SREBP-1c may not play a prominent role in the pathogenesis of HCV-related steatosis.
Publisher: Wiley
Date: 25-01-2011
DOI: 10.1111/J.1440-1746.2010.06368.X
Abstract: Hepatitis C virus (HCV) proteins activate the unfolded protein response (UPR) in experimental models. The role of the UPR in the pathogenesis of HCV-induced liver injury has not been determined. Our aim was to investigate the role of the UPR in the pathogenesis of chronic HCV. Liver biopsy s les from 124 patients with chronic HCV and 24 HCV/HBV-negative subjects with histologically normal liver (NDL) were assessed. The hepatic mRNA expression of components of the UPR was measured by semi-quantitative real-time polymerase chain reaction. Glucose regulated protein (GRP) 78 protein expression was assessed by immunohistochemistry. The expression of GRP78 mRNA and growth arrest and damage inducible protein 34 (GADD34) mRNA was significantly lower in subjects with HCV than NDL (P = 0.007 and P < 0.001, respectively). There was no significant difference in the expression of GRP94 mRNA, spliced X box binding protein 1 (sXBP1) mRNA, C/EBP homologous protein mRNA (CHOP) and ER degradation enhancing α-mannosidase-like protein (EDEM) mRNA and GRP78 protein between patients with HCV and NDL. There were no relationships between elements of the UPR and inflammation or fibrosis in patients with HCV. Downstream components of UPR were not activated in patients with chronic HCV. Therefore, the UPR may not play a prominent role in liver injury in patients with chronic HCV infection.
Publisher: Australian Housing and Urban Research Institute (AHURI)
Date: 11-2022
Publisher: Australian Housing and Urban Research Institute (AHURI)
Date: 11-11-2021
Abstract: This research examines the policy and practice issues raised by increasing demand for public housing among older Australians, and how public housing authorities can support older tenants to age well. People aged 55 years and over now comprise 35 per cent of public housing tenants nationally, in the coming years it is expected the demand on the public housing system from lower income older households will increase significantly.
Publisher: SAGE Publications
Date: 26-05-2021
Abstract: The public areas of the hospital built environment have hardly been investigated for their age-friendliness. This exploratory, multidisciplinary pilot study investigates the relationship between the physical environment and design of hospital spaces and older people’s outpatient experience. Sixteen participants were recruited from a geriatric Outpatient Clinic at a metropolitan public hospital in Australia. Participants were engaged in a concurrent mixed-method approach, comprising a comprehensive geriatric survey, walking observation, semi-structured interview and an independent architectural audit. Several elements arising from the hospital environment were identified as facilitators and barriers for its utilization and intrinsically related to participants’ physical capacity. Age-friendly hospital design needs to consider strategies to remove barriers for older adults of different capacities, thus promoting healthy aging.
Publisher: Elsevier BV
Date: 09-2019
DOI: 10.1016/J.ARCHGER.2019.103908
Abstract: Frailty prevalence defined by the deficit accumulation model (Frailty Index) has limited exploration in a Japanese population. The objective of this paper is to investigate the prevalence of frailty by Frailty Index among a cohort of healthy Japanese older adults, define risk factors associated with pre-frailty and frailty status and evaluate Frailty Index's agreement with Frailty Phenotype and Kihon checklist. Data from 673 participants of the 2014 wave of the Nagoya Longitudinal Study - Healthy Elderly were used. Annual assessments include investigation of mood, memory, health status, nutrition, physical performance and oral health. The Frailty Index was compared to Frailty Phenotype and Kihon Checklist, and factors associated to Frailty Index were investigated through univariate and multivariate logistic regression. Frailty prevalence was 13.5% (n = 91) by Frailty Index, 1.5% (n = 10) by Frailty Phenotype and 4% (n = 27) by Kihon Checklist. Although the correlations between the three scales were moderate to high, the agreement between the scales was poor. In terms of risk factors, age, polypharmacy and physical activity level were associated with being pre-frail and frail. Having a higher waist circumference was associated with being pre-frail, and lower handgrip strength and lower walking speed were associated with being frail. The Frailty Index showed similar metrics and agreement comparable to findings of previous studies, and was able to identify a higher number of in iduals who were pre-frail and frail. Age, polypharmacy, physical activity, waking speed and waist circumference were associated with pre-frailty and frailty by frailty index.
Publisher: Informa UK Limited
Date: 24-07-2019
Publisher: MDPI AG
Date: 03-11-2019
DOI: 10.3390/HEALTHCARE7040130
Abstract: Taking an international perspective of healthy ageing, people are living longer and are generally in better health than previous generations [...]
Location: Iran (Islamic Republic of)
Start Date: 2015
End Date: 2016
Funder: Department of State Development
View Funded ActivityStart Date: 2015
End Date: 2018
Funder: Australian Research Council
View Funded ActivityStart Date: 06-2015
End Date: 12-2019
Amount: $279,461.00
Funder: Australian Research Council
View Funded ActivityStart Date: 2022
End Date: 12-2024
Amount: $287,994.00
Funder: Australian Research Council
View Funded Activity