Melissa Lim

Health related quality of life assessment in acute coronary syndrome patients: The effectiveness of early phase I cardiac rehabilitation

Publisher: Springer Science and Business Media LLC

Date: 2017

DOI: 10.1186/S12955-016-0583-7

A Novel 89Zr-labeled DDS Device Utilizing Human IgG Variant (scFv): “Lactosome” Nanoparticle-Based Theranostics for PET Imaging and Targeted Therapy

Publisher: MDPI AG

Date: 18-02-2021

DOI: 10.3390/LIFE11020158

Abstract: “Theranostics,” a new concept of medical advances featuring a fusion of therapeutic and diagnostic systems, provides promising prospects in personalized medicine, especially cancer. The theranostics system comprises a novel 89Zr-labeled drug delivery system (DDS), derived from the novel biodegradable polymeric micelle, “Lactosome” nanoparticles conjugated with specific shortened IgG variant, and aims to successfully deliver therapeutically effective molecules, such as the apoptosis-inducing small interfering RNA (siRNA) intracellularly while offering simultaneous tumor visualization via PET imaging. A 27 kDa-human single chain variable fragment (scFv) of IgG to establish clinically applicable PET imaging and theranostics in cancer medicine was fabricated to target mesothelin (MSLN), a 40 kDa-differentiation-related cell surface glycoprotein antigen, which is frequently and highly expressed by malignant tumors. This system coupled with the cell penetrating peptide (CPP)-modified and photosensitizer (e.g., 5, 10, 15, 20-tetrakis (4-aminophenyl) porphyrin (TPP))-loaded Lactosome particles for photochemical internalized (PCI) driven intracellular siRNA delivery and the combination of 5-aminolevulinic acid (ALA) photodynamic therapy (PDT) offers a promising nano-theranostic-based cancer therapy via its targeted apoptosis-inducing feature. This review focuses on the combined advances in nanotechnology and material sciences utilizing the “89Zr-labeled CPP and TPP-loaded Lactosome particles” and future directions based on important milestones and recent developments in this platform.

Lactosome-Conjugated siRNA Nanoparticles for Photo-Enhanced Gene Silencing in Cancer Cells

Publisher: Elsevier BV

Date: 04-2021

DOI: 10.1016/J.XPHS.2021.01.026

Ensuring Global Access to Cancer Medicines: A Generational Call to Action

Publisher: American Association for Cancer Research (AACR)

Date: 03-02-2023

DOI: 10.1158/2159-8290.CD-22-1372

Abstract: Essential cancer treatments are not accessible, affordable, or available to patients who need them in many parts of the world. A new Access to Oncology Medicines (ATOM) Coalition, using public–private partnerships, aims to bring essential cancer medicines and diagnostics to patients in low- and lower middle-income countries.

Swinburne University Of Technology Sarawak Campus

Location: Malaysia

View Organisation

Sarawak General Hospital

Location: Malaysia

View Organisation

Okayama University

Location: Japan

View Organisation

University Of South Australia

Location: Australia

View Organisation

University Malaysia Sarawak (UNIMAS)

Location: Malaysia

View Organisation