ORCID Profile
0000-0001-6550-876X
Current Organisations
University of South Australia
,
University of Adelaide
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Publisher: Elsevier BV
Date: 06-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5SM00900F
Abstract: This review is an overview of the current developments in directed self-assembly of metal nanoparticles with tailored plasmonic properties.
Publisher: Elsevier BV
Date: 06-1997
Publisher: Wiley
Date: 20-06-2018
Abstract: Surface-inactive, highly hydrophilic particles are utilized to effectively and reversibly stabilize oil-in-water emulsions. This is a result of attractive van der Waals forces between particles and oil droplets in water, which are sufficient to trap the particles in close proximity to oil-water interfaces when repulsive forces between particles and oil droplets are suppressed. The emulsifying efficiency of the highly hydrophilic particles is determined by van der Waals attraction between particle monolayer shells and oil droplets enclosed therein and is inversely proportional to the particle size, while their stabilizing efficiency is determined by van der Waals attraction between single particles and oil droplets, which is proportional to the particle size. This differentiation in mechanism between emulsification and stabilization will significantly advance our knowledge of emulsions, thus enabling better control and design of emulsion-based technologies in practice.
Publisher: Elsevier BV
Date: 03-2019
DOI: 10.1016/J.CARBPOL.2018.11.053
Abstract: Thermoresponsive polymers have been used extensively for various applications including food additives, pharmaceutical formulations, therapeutic delivery, cosmetics and environmental remediation, to mention a few. Many thermoresponsive polymers have the ability to form physical hydrogel networks in response to temperature changes, which are particularly useful for emerging biomedical applications, including cell therapies, drug delivery systems, tissue engineering, wound healing and 3D bioprinting. In particular, the use of polysaccharides with thermoresponsive properties has been of interest due to their wide availability, versatile functionality, biodegradability, and in many cases, inherent biocompatibility. Naturally thermoresponsive polysaccharides include agarose, carrageenans and gellan gum, which exhibit upper critical solution temperatures, transitioning from a solution to a gel state upon cooling. Arguably, this limits their use in biomedical applications, particularly for cell encapsulation as they require raised temperatures to maintain a solution state that may be detrimental to living systems. Conversely, significant progress has been made over recent years to develop synthetically modified polysaccharides, which tend to exhibit lower critical solution temperatures, transitioning from a solution to a gel state upon warming. Of particular interest are thermoresponsive polysaccharides with a lower critical solution temperature in between room temperature and physiological temperature, as their solutions can conveniently be manipulated at room temperature before gelling upon warming to physiological temperature, which makes them ideal candidates for many biological applications. Therefore, this review provides an introduction to the different types of thermoresponsive polysaccharides that have been developed, their resulting hydrogels and properties, and the exciting applications that have emerged as a result of these properties.
Publisher: EDP Sciences
Date: 06-1999
Publisher: Elsevier BV
Date: 11-1999
Publisher: Springer International Publishing
Date: 2022
Publisher: MDPI AG
Date: 07-02-2020
Abstract: Injectable, thermoresponsive hydrogels are promising candidates for the delivery, maintenance and controlled release of adoptive cell therapies. Therefore, there is significant interest in the development of cytocompatible and biodegradable thermoresponsive hydrogels with appropriate gelling characteristics. Towards this end, a series of thermoresponsive copolymers consisting of poly(caprolactone) (PCL), poly(ethylene glycol) (PEG) and poly(propylene glycol) (PPG) segments, with various PEG:PPG ratios, were synthesised via ring-opening polymerisation (ROP) of ε-caprolactone and epoxy-functionalised PEG and PPG derivatives. The resultant PCL–PEG–PPG copolymers were characterised via proton nuclear magnetic resonance (1H NMR) spectroscopy, gel permeation chromatography (GPC) and differential scanning calorimetry (DSC). The thermoresponsive characteristics of the aqueous copolymer solutions at various concentrations was investigated using the inversion method. Whilst all of the copolymers displayed thermoresponsive properties, the copolymer with a ratio of 1:2 PEG:PPG exhibited an appropriate sol–gel transition (28 °C) at a relatively low concentration (10 wt%), and remained a gel at 37 °C. Furthermore, the copolymers were shown to be enzymatically degradable in the presence of lipases and could be used for the encapsulation of CD4+ T-cell lymphocytes. These results demonstrate that the thermoresponsive PCL–PEG–PPG hydrogels may be suitable for use as an adoptive cell therapy (ACT) delivery vehicle.
Publisher: Elsevier BV
Date: 02-2021
Publisher: Elsevier BV
Date: 2023
Publisher: Symbiosis Group
Date: 04-02-2017
Publisher: MDPI AG
Date: 26-04-2021
Abstract: Amino end-group functionalised polyglycols are important intermediates in the synthesis of sophisticated polymeric architectures and biomaterials. Herein, we report a facile strategy for the end-group conversion of hydroxyl-terminated polyglycols to amino-terminated polyglycols in high isolated yields and with excellent end-group fidelity. Following traditional conversion of polyglycol hydroxyl end-groups to azides via the corresponding mesylate, reduction with zinc in the presence of ammonium chloride afforded a range of amino end-group functionalised poly(ethylene glycol) and poly(propylene glycol) homopolymers and copolymers with isolated yields of 82–99% and end-group conversions of % as determined by NMR spectroscopy and MALDI ToF MS. Furthermore, this process is applicable to a sequential reagent addition approach without intermediate polymer isolation steps with only a slight reduction in yield and end-group conversion (95%). Importantly, a simple work-up procedure provides access to high purity polyglycols without contamination from other reagents.
Publisher: American Vacuum Society
Date: 2019
DOI: 10.1116/1.5087737
Abstract: PolyJet three-dimensional (3D) printing allows for the rapid manufacturing of 3D moulds for the fabrication of cross-linked poly(dimethylsiloxane) microwell arrays (PMAs). As this 3D printing technique has a resolution on the micrometer scale, the moulds exhibit a distinct surface roughness. In this study, the authors demonstrate by optical profilometry that the topography of the 3D printed moulds can be transferred to the PMAs and that this roughness induced cell adhesive properties to the material. In particular, the topography facilitated immobilization of endothelial cells on the internal walls of the microwells. The authors also demonstrate that upon immobilization of endothelial cells to the microwells, a second population of cells, namely, pancreatic islets could be introduced, thus producing a 3D coculture platform.
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2TB00274D
Abstract: Highly efficient, selective and cytocompatible fulvene–maleimide cycloaddition chemistry was applied for the preparation of injectable, cell encapsulating/releasing hydrogels with tuneable gelation and degradation kinetics.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5SM00900F
Abstract: This review is an overview of the current developments in directed self-assembly of metal nanoparticles with tailored plasmonic properties.
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3PY00139C
Abstract: Investigating how different reaction conditions influence the reaction kinetics, monomer sequence and side reactions for the synthesis of a PLGA-PEG-PLGA triblock copolymer.
Publisher: MDPI AG
Date: 12-02-2018
Publisher: Elsevier BV
Date: 12-1995
DOI: 10.1016/0039-9140(95)01663-5
Abstract: Humic materials extracted from tree leaves of chestnut (Castanea sativa), eucalyptus (Eucalyptus globulus) and oak (Quercus robur) were analyzed by performing conductimetric titrations. Values between about 84 and 236 muS cm(-1) for the molar conductivity and between 0.42 and 0.74 for the charge distribution parameter were obtained when the concentrations of the extract are increased from 40 to 100 mg 1(-1). These variations were explained by using the counterion condensation theory, and the distance between the charged groups of the polyions, the volume of the counterion condensation and the Debye-Hückel potential were also calculated.
Publisher: Canadian Science Publishing
Date: 03-1996
DOI: 10.1139/V96-033
Abstract: The influence of pH (3.0–8.0), ionic strength (0.005–0.10 M), and concentration (ca. 50–300 mg L −1 ) on the viscosimetric behaviour of solutions of a soil fulvic acid has been determined. The results show a complex influence of the concentration on the specific viscosity with maxima at about 80–100 mg L −1 and a minimum at 140–160 mg L −1 . The viscosity is minimum at pH ca. 6 and decreases when the ionic strength increases. The results are interpreted by a rod-type model from which the dimensions of fulvic acid molecules are calculated. Key words: soil fulvic acids, viscosity, configurational changes.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8SC00678D
Abstract: Unconventionally, by placing hydrophilic particles in an oil phase before emulsification, the energy barrier is successfully eliminated and Pickering emulsions are easily formed.
Publisher: American Chemical Society (ACS)
Date: 23-06-2017
Abstract: Biofilms are aggregates of bacteria residing in a self-assembled matrix, which protects these sessile cells against external stress, including antibiotic therapies. In light of emerging multidrug-resistant bacteria, alternative strategies to antibiotics are emerging. The present study evaluated the activity of colloidal silver nanoparticles (AgNPs) of different shapes against biofilms formed by Staphylococcus aureus (SA), methicillin-resistant SA (MRSA), and Pseudomonas aeruginosa (PA). Colloidal quasi-spherical, cubic, and star-shaped AgNPs were synthesized, and their cytotoxicity on macrophages (THP-1) and bronchial epithelial cells (Nuli-1) was analyzed by the lactate dehydrogenase assay. The antibiofilm activity was assessed in vitro by the resazurin assay and in an in vivo infection model in Caenorhabditis elegans. Cubic and star-shaped AgNPs induced cytotoxicity, while quasi-spherical AgNPs were not toxic. Quasi-spherical AgNPs showed substantial antibiofilm activity in vitro with 96% (±2%), 97% (±1%), and 98% (±1%) biofilm killing of SA, MRSA, and PA, respectively, while significantly reducing mortality of infected nematodes. The in vivo antibiofilm activity was linked to the accumulation of AgNPs in the intestinal tract of C. elegans as observed by 3D X-ray tomography. Quasi-spherical AgNPs were physically stable in suspension for over 6 months with no observed loss in antibiofilm activity. While toxicity and stability limited the utilization of cubic and star-shaped AgNPs, quasi-spherical AgNPs could be rapidly synthesized, were stable and nontoxic, and showed substantial in vitro and in vivo activity against clinically relevant biofilms. Quasi-spherical AgNPs hold potential as pharmacotherapy, for ex le, as topical treatment for biofilm-related infections.
Location: Australia
No related grants have been discovered for Paula Facal Marina.