ORCID Profile
0000-0002-3243-5768
Current Organisations
University of South Australia
,
Charles Sturt University
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Research Topics
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Top 5 Research Topics
ANZSRC Field of Research (FoR)
Library and Information Studies | Human Information Behaviour | Computer Software | Computer System Security
ANZSRC Socio-Economic Objective (SEO)
Internet Hosting Services (incl. Application Hosting Services) | Expanding Knowledge in the Information and Computing Sciences | Information Processing Services (incl. Data Entry and Capture) |
Related Links
Publications
Directed Connectivity Analysis of Functional Brain Networks during Cognitive Activity Using Transfer Entropy
Publisher: Springer Science and Business Media LLC
Date: 27-02-2016
Contributing to social capital: An investigation of Asian immigrants' use of public library services
Publisher: Elsevier BV
Date: 2017
Hypophosphatemic osteomalacia after low-dose adefovir dipivoxil therapy for hepatitis B.
Publisher: The Endocrine Society
Date: 02-2010
DOI: 10.1210/JC.2009-2051
Examining the factors influencing college students’ continuance intention to use short-form video APP
Publisher: Emerald
Date: 09-09-2021
DOI: 10.1108/AJIM-03-2021-0080
Abstract: The purpose of this study is to explore the effects of recommendation algorithm, product reputation, new product novelty, privacy concern and privacy protection behavior on users’ satisfaction and continuance intention to use short-form video application (APP). Based on the existing theories, the research model of this study was developed and 445 valid data were collected through a questionnaire survey. The partial least squares structural equation modeling (PLS-SEM) was employed for data analysis to test the research model and hypotheses. The results reveal that the recommendation algorithm has a significant positive effect on user satisfaction, new product novelty and privacy concern. The influence of recommendation algorithm on privacy concern is negatively moderated by product reputation. Privacy concern has a significant and positive impact on privacy protection behavior, and privacy protection behavior has a significant and positive impact on user satisfaction. New product novelty also has significant impact on user satisfaction. This study is one of the earliest studies to incorporate recommendation algorithm as a construct into the college students’ continuance intention to use short-form video APP. The influence of reputation as a moderator variable on the relationship between algorithm and privacy concerns is also investigated.
Toward community-engaged information behavior research: a methodological framework
Publisher: Elsevier BV
Date: 10-2022
Understanding collaborative tourism information searching to support online travel planning
Publisher: Emerald
Date: 10-06-2019
Abstract: Collaborative information searching is common for people when planning their group trip. However, little research has explored how tourists collaborate during information search. Existing tourism Web portals or search engines rarely support tourists’ collaborative information search activities. Taking advantage of previous studies of collaborative tourism information search behavior, in the current paper the purpose of this paper is to propose the design of a collaborative search system collaborative tourism information search (ColTIS) to support online information search and travel planning. ColTIS was evaluated and compared with Google Talk-embedded Tripadvisor.com through a user study involving 18 pairs of participants. The data included pre- and post-search questionnaires, web search logs and chat history. For quantitative measurement, statistical analysis was performed using SPSS for log data and the qualitative feedback from participants, the content analysis was employed. Results suggest that collaborative query formulation, ision of search tasks, chatting and results sharing are important means to facilitate tourists’ collaborative search. ColTIS was found to outperform Tripadvisor significantly regarding the ease of use, collaborative support and system usefulness. The innovation of the study lies in the development of an integrated real-time collaborative tourism information search system with unique features. These features include collaborative query reformulation, travel planner and automatic result and query sharing that assist multiple people search for holiday information together. For system designers and tourism practitioners, implications are provided.
Understanding roles in collaborative information behaviour: a case of Chinese group travelling
Publisher: Elsevier BV
Date: 07-2021
The Establishment and Application of Evaluation Criteria Systems for Chinese E-Government Websites
Publisher: IEEE
Date: 09-2007
Integration of e-government services delivery in Australia: Implications for China
Publisher: IEEE
Date: 12-2010
Proceedings of the 26th Australasian Document Computing Symposium
Publisher: ACM
Date: 15-12-2022
DOI: 10.1145/3572960
Working with Indigenous communities: reflections on ethical information research with Ngarrindjeri people in South Australia
Publisher: Wiley
Date: 2018
Cultural use of ICT4D to promote Indigenous knowledge continuity of Ngarrindjeri stories and communal practices
Publisher: Wiley
Date: 24-03-2022
DOI: 10.1002/ASI.24710
Abstract: While there is a considerable amount of interest in information and communication technologies for development (ICT4D) in the Indigenous communities, it remains limited to those who can afford it and have the skills and knowledge to implement the technology and access appropriate digital tools. Hence, Indigenous communities are continually stigmatized as marginalized, leading to a cultural misrepresentation of histories that affects the continuing information disparity between Indigenous and Western knowledge systems, particularly the insufficient technology infrastructure designed for traditional users. In this article, ICT4D was conceptualized as a digital platform to support Senior Ngarrindjeri Elder Aunty Ellen Trevorrow in continuing her practice of weaving and storytelling throughout the pandemic. In this context, the community‐based participatory research (CBPR) principles within the structure of video ethnography were qualitatively designed to implement the ICT4D project culturally and ethically. Video recordings, image data, transcriptions, and the Ngarrindjeri ICT4D Pondi (Murray Cod) framework were embedded to justify the findings and the aim of illustrating Aunty Ellen's knowledge‐sharing process to online learners. Likewise, the results demonstrate the positive and negative impact of COVID‐19 on the continuity and orality of Aunty Ellen's cultural stories and practices. The future continuity of Aunty Ellen's knowledge ought to consider the inconsistency of technological infrastructure in regional areas, her waning health, and the interconnectedness of oral expertise, which often pose challenges. This study is a small step toward a better understanding of the value of oral knowledge emphasizing the creation of e‐learning weaving instructional videos is valuable for future digital management of Indigenous knowledge relevant to LIS.
Associations between drug burden index and physical function in older people in residential aged care facilities.
Publisher: Oxford University Press (OUP)
Date: 25-05-2010
Cohort Profile: The Concord Health and Ageing in Men Project (CHAMP)
Publisher: Oxford University Press (OUP)
Date: 14-05-2008
DOI: 10.1093/IJE/DYN071
Low-trauma fractures indicate increased risk of hip fracture in frail older people.
Publisher: Wiley
Date: 20-01-2011
DOI: 10.1002/JBMR.216
Abstract: This study aims to investigate the risk of subsequent fractures after low-trauma fracture in frail older people. A total of 1412 elderly residents (mean age 86.2 years, SD 7.0 years, female 77%) were recruited from aged care facilities in Australia. Residents were assessed and then followed for any fracture for 2 years and hip fractures for at least 5 years. Residents with and without a newly acquired fracture in the first 2 years were compared for risk of subsequent hip fracture. Residents with a nonhip fracture in the first 2 years had an increased risk of subsequent hip fracture for about 2.5 years, whereas those with a hip fracture had a similar risk over the whole period compared with those with no fracture. During these 2.5 years, 60, 28, and 6 subsequent hip fractures occurred in the nonfracture group (n = 953), the nonhip fracture group (n = 194), and the hip fracture group (n = 101), respectively, resulting in the probability of subsequent hip fracture of 8.0%, 19.9%, and 10.4%, respectively. Compared with the nonfracture group, the hazard ratio (HR) was 2.82 [95% confidence interval (CI) 1.73-4.59 p < .001] for the nonhip fracture group and 1.48 (95% CI 0.63-3.49, p = .37) for the hip fracture group after adjusting for age, sex, residence type, calcaneal broadband ultrasound attenuation, fracture history, weight, lower leg length, immobility, cognitive function, and medications. Frail institutionalized older people with newly acquired fractures are at increased risk of subsequent hip fracture for the next few years. Accordingly, despite their advanced age, they are a high-priority target group to investigate interventions that might reduce the risk of hip fracture.
Associations Between Drug Burden Index and Falls in Older People in Residential Aged Care
Publisher: Wiley
Date: 05-2011
DOI: 10.1111/J.1532-5415.2011.03386.X
Abstract: To evaluate the association between the Drug Burden Index (DBI), a measure of a person's total exposure to anticholinergic and sedative medications that includes principles of dose-response and maximal effect and is associated with impaired physical function in community-dwelling older people, and falls in residents of residential aged care facilities (RACFs). Data were drawn from participants in a randomized controlled trial that investigated falls and fractures. RACFs in Sydney, Australia. Study participants (N=602 70.9% female) were recruited from 51 RACFs. Mean age was 85.7 ± 6.4, and mean DBI was 0.60 ± 0.66. Medication history was obtained on each participant. Drugs were classified as anticholinergic or sedative and a DBI was calculated. Falls were measured over a 12-month period. Comorbidity, cognitive impairment (Mini-Mental State Examination) and depression (Geriatric Depression Scale) were determined. There were 998 falls in 330 in iduals during a follow-up period of 574.2 person-years, equating to an average rate of 1.74 falls per person-year. The univariate negative binomial regression model for falls showed incidence rate ratios of 1.69 (95% confidence interval (CI)=1.22-2.34) for low DBI (<1) and 2.11 (95% CI=1.47-3.04) for high DBI (≥1) when compared with those who had a DBI of 0. After adjusting for age, sex, history of falling, cognitive impairment, depression, use of a walking aid, comorbidities, polypharmacy, and incontinence, incident rate ratios of 1.61 (95% CI=1.17-2.23) for low DBI and 1.90 (95% CI=1.30-2.78) for high DBI were obtained. DBI is significantly and independently associated with falls in older people living in RACFs. Interventional studies designed for this population are needed to determine whether reducing DBI, through dose reduction or cessation of anticholinergic and sedative drugs, can prevent falls.
How Users' Gaze Behavior Is Related to Their Quality Evaluation of a Health Website Based on HONcode Principles?
Publisher: Elsevier BV
Date: 2021
How fast does the Grim Reaper walk? Receiver operating characteristics curve analysis in healthy men aged 70 and over
Publisher: BMJ
Date: 15-12-2011
DOI: 10.1136/BMJ.D7679
Biphasic Glucocorticoid-dependent regulation of Wnt expression and its inhibitors in mature osteoblastic cells
Publisher: Springer Science and Business Media LLC
Date: 30-10-2009
DOI: 10.1007/S00223-009-9303-1
Abstract: Glucocorticoids exert both anabolic and catabolic effects on bone. Previously, we reported that endogenous glucocorticoids control mesenchymal lineage commitment and osteoblastogenesis through regulation of Wnt signaling in osteoblasts. Here, we investigated the effects of glucocorticoids on Wnt expression in mature osteoblasts. Mature osteoblasts and their immature progenitors were separately isolated from Col2.3-GFP transgenic mice in which mature osteoblasts are identifiable through GFP expression. mRNA levels of Wnt2, Wnt2b, Wnt4, Wnt5a, Wnt10b, and Wnt11 were 4- to 12-fold higher in osteoblasts compared to their progenitors (P < 0.05). Expression of Wnt7b and Wnt10b in osteoblasts was modulated by corticosterone (CS), in a biphasic fashion with 3- to 3.5-fold upregulation at 10 nM CS (P < 0.01) and 50% downregulation at 100 nM CS (P < 0.05). CS 100 nM also increased expression of the Wnt inhibitors sFRP-1 and DKK-1 two- to threefold (P < 0.05). We conclude that the contrasting anabolic and catabolic effects of glucocorticoids on bone are, at least in part, mediated through the regulation of Wnt expression and its inhibitors in mature osteoblasts.
The role of fat and lean mass in bone loss in older men: Findings from the CHAMP study
Publisher: Elsevier BV
Date: 12-2011
DOI: 10.1016/J.BONE.2011.08.026
Abstract: Weight loss is associated with bone loss however, it is unclear whether loss of fat or loss of lean body mass plays the key role in this relationship. The aim of this longitudinal analysis was to clarify the relationship between hip BMD, hip BMC and whole body BMC with changes in fat and lean tissue mass in older men. The Concord Health and Aging in Men Project (CHAMP) is a population-based study in Sydney, Australia, involving 1705 men aged 70-97 years. Bone mineral density (BMD) of the total hip, and bone mineral content (BMC) of the hip and whole body (WB), lean mass and fat mass were measured with Dual X-ray Absorptiometry (DXA). Multivariate linear regression models were used to assess relationships. Over 2.2 years of follow-up, 368(33%) men lost at least 2% of their body weight, which included a mean loss of 0.8 kg/year of lean body mass and 0.9 kg/year of fat body mass. Fat loss was strongly associated with BMD loss in men who lost weight. As a group, weight losers lost 1.0% of hip BMD annually compared to 0.2% in men who gained weight, with each kilo of fat loss associated with 0.6%/year hip BMD loss (p<0.0001). Lean mass was not associated with hip BMD loss in weight losers, however, lean mass change was associated with BMD change in men who gained weight (0.3% hip BMD increase per kilo increase of lean mass p<0.01). Maintaining body weight is important for bone health in elderly men. Body fat plays an important role in this relationship, which may reflect the additional metabolic function of adipose tissue.
Modulatory Effect of Raloxifene and Estrogen on the Metabolic Action of Growth Hormone in Hypopituitary Women
Publisher: The Endocrine Society
Date: 05-2010
DOI: 10.1210/JC.2009-2743
Abstract: The metabolic action of GH is attenuated by estrogens administered via the oral route. Selective estrogen receptor modulators lower IGF-I to a lesser degree than 17beta-estradiol in GH-deficient women, and their effect on fat and protein metabolism is unknown. The aim of the study was to compare the modulatory effects of 17beta-estradiol and raloxifene, a selective estrogen receptor modulator, on the metabolic action of GH. We conducted an open-label, two-group, randomized, two-period crossover study. Ten hypopituitary women received GH therapy alone (0.5 mg/d) and GH plus 17beta-estradiol (E(2) 2 mg/d). Eleven hypopituitary women received GH therapy alone and GH plus raloxifene (R 60 mg/d). The treatment duration was 1 month, with a 4-wk washout period. IGF-I, IGFBP-3, resting energy expenditure, and fat oxidation were quantified by indirect calorimetry. We measured whole body leucine turnover from which leucine rate of appearance and leucine incorporation into protein were estimated. GH significantly stimulated all outcome measures. During GH treatment, addition of R significantly reduced mean IGF-I but not IGFBP-3, whereas E(2) reduced both IGF-I and IGFBP-3 levels. Cotreatment with R but not E(2) significantly attenuated the stimulatory effects of GH on fat oxidation. There was a strong trend (P = 0.08) toward a greater reduction in leucine incorporation into protein after R compared to E(2) cotreatment. The modulatory effects of E(2) and R at therapeutic doses on GH action are different. R during GH therapy exerts a greater inhibitory effect on lipid oxidation and protein anabolism compared to E(2).
Towards a model of collaborative information retrieval in tourism
Publisher: ACM
Date: 21-08-2012
Collaborative query reformulation in tourism information search
Publisher: Emerald
Date: 11-11-2019
Abstract: Collaborative information search (CIS) is a growing and significant research area. Query formulation and reformulation is an important search strategy in information search. However, limited research has investigated query behavior during CIS. The purpose of this paper is to characterize collaborative query reformulation (CQR) by exploring the sources of collaborative query (CQ) terms and the types and patterns of CQR in the context of tourism information search. An empirical study was designed to investigate search query reformulation as tourists performed CIS on a devised interface. A total of 36 participants (in 18 pairs) took part in the study data were documented in pre- and post-search questionnaires, search logs and chat logs. The findings show that participants intermixed in idual search and collaborative search during CIS. Participants constructed CQ terms mainly by selecting terms from in idual search queries and discussion chat logs. Eight types of CQR were identified, with specialization (82 percent) accounting for the most used search tactics. At most times, participants were found to add terms to the previous query. Findings demonstrated 27 specific CQR patterns in excess of two-third participants (69 percent) took only one move to reformulate CQ by adding terms, or replacing/using new words. The results of this research can be used to inform the design of search systems supporting collaborative querying in CIS. This study is highlighting an important research direction of CQ reformulation in collaborative search while previous studies of the topic are limited, comparing to the vast body of work on query reformulation in in idual information search using regular search systems.
Vitamin D deficiency promotes prostate cancer growth in bone
Publisher: Wiley
Date: 28-12-2011
DOI: 10.1002/PROS.21316
Abstract: Vitamin D is considered as an important determinant of bone turnover as well as cancer growth. Using a murine model of bone metastasis, we investigated the effect of vitamin D deficiency on prostate cancer cell growth in bone. Three-week-old male nude mice were fed either normal chow (control) or a diet deficient in vitamin D. The latter diet resulted in severe hypovitaminosis D within 6 weeks. At this point of time, 5 × 10(4) cells of the prostate cancer cell line, PC-3, were injected either into the bone marrow (tibia) or subcutaneously into soft tissues. Osteoprotegerin (OPG) was co-administered in subgroups of mice to suppress bone remodeling. Osteolytic lesions were monitored by serial X-ray, while soft tissue tumor growth was measured by caliper. All tissues were analyzed by micro-CT and histology at endpoint. Bone turnover was significantly accelerated in vitamin D deficient compared to vitamin D sufficient mice from week 6 onwards. Intra-tibially implanted PC-3 cells resulted in mixed osteolytic and osteosclerotic lesion. At endpoint, osteolytic and osteosclerotic lesion areas, total tumor area, and tumor mitotic activity were all significantly increased in vitamin D deficient mice compared to controls. Regardless of diet, OPG reduced bone turnover, total tumor, and osteosclerotic area as well as tumor mitotic activity, while promoting cell apoptosis. In contrast, vitamin D deficiency did not alter tumor growth in soft tissues. Vitamin D deficiency stimulates prostate cancer growth in bone through modulating the bone microenvironment.
The States of Uncertainty and Confidence of Asian Immigrants during Their Settlement in South Australia
Publisher: Informa UK Limited
Date: 02-04-2020
Toward a web search model: Integrating multitasking, cognitive coordination, and cognitive shifts
Publisher: Wiley
Date: 06-05-2011
DOI: 10.1002/ASI.21551
Exploring the dynamic contribution behavior of editors in wikis based on time series analysis
Publisher: Emerald
Date: 02-2016
DOI: 10.1108/PROG-06-2013-0034
Abstract: – Wiki is a new form of information production and organization, which has become one of the most important knowledge resources. In recent years, with the increase of users in wikis, “free rider problem” has been serious. In order to motivate editors to contribute more to a wiki system, it is important to fully understand their contribution behavior. The purpose of this paper is to explore the law of dynamic contribution behavior of editors in wikis. – After developing a dynamic model of contribution behavior, the authors employed both the metrological and clustering methods to process the time series data. The experimental data were collected from Baidu Baike, a renowned Chinese wiki system similar to Wikipedia. – There are four categories of editors: “testers,” “dropouts,” “delayers” and “stickers.” Testers, who contribute the least content and stop contributing rapidly after editing a few articles. After editing a large amount of content, dropouts stop contributing completely. Delayers are the editors who do not stop contributing during the observation time, but they may stop contributing in the near future. Stickers, who keep contributing and edit the most content, are the core editors. In addition, there are significant time-of-day and holiday effects on the number of editors’ contributions. – By using the method of time series analysis, some new characteristics of editors and editor types were found. Compared with the former studies, this research also had a larger s le. Therefore, the results are more scientific and representative and can help managers to better optimize the wiki systems and formulate incentive strategies for editors.
Personalised Web search and user satisfaction: a user-centred evaluation.
Publisher: University of Boras, Faculty of Librarianship, Information, Education and IT
Date: 2020
DOI: 10.47989/IRPAPER878
Abstract: Introduction. Most university students depend significantly, sometimes exclusively, on the Google search engine for their academic information needs. User satisfaction leads to users’ deeper engagement with an information system that is shown to improve learning in an educational setting. This paper evaluates students’ satisfaction with results from personalised Web search against non-personalised Web search. Method. During semi-structured study sessions, twenty-eight participants (university students) were required to complete a series of search tasks using both personalised and non-personalised Web search. Analysis. Evaluation was based on participants’ explicit feedback as well as their implicit behaviour including search time, number of queries and clicked result links per task, finding the answer and relevance of the search results. Results. There was no apparent significant increase in the participants’ overall level of satisfaction with personalised search results compared to non-personalised results. However, it was found that personalised search reduced the time spent to finish a task and reduced the number of clicks required to arrive at the selected outcome. Conclusions. Personalisation of search results does not increase students' satisfaction with their search results. However, it does reduce the time spent by students in locating information they judged to be satisfactory answers to their questions.
Balance impairment in chronic antiepileptic drug users: A twin and sibling study
Publisher: Wiley
Date: 29-01-2010
DOI: 10.1111/J.1528-1167.2009.02254.X
Abstract: Patients taking antiepileptic drugs (AEDs) have an increased incidence of fractures. This study investigated chronic AED use and physical contributors to falls risk using an AED-discordant, twin and sibling matched-pair approach, and assessed clinically relevant subgroups: AED polytherapy longer-duration AED and falls history. Twenty-nine same-sex (mean age 44.9 years, 59% female), ambulatory, community-dwelling twin and sibling pairs, discordant for AED exposure (and AED-indication), were recruited. Validated clinical and laboratory tests of strength, gait, and balance were performed. Relevant AED levels, and fasting serum s les for 25-hydroxyvitamin D (25OHD), 1,25-dihydroxyvitamin D [1,25(OH)(2)D], and immunoreactive parathyroid hormone (iPTH) levels were taken. There were significant mean within-pair differences in tests of static and dynamic balance, with the AED user having poorer balance function than the AED nonuser. No difference was seen in lower limb strength or gait measures. Increased duration of AED therapy and AED polytherapy were independent predictors of increased sway. No significant within-pair differences were seen in fasting serum levels of 1,25(OH)(2)D, 25OHD and iPTH after Bonferroni correction. Balance performance is impaired in AED users compared to their matched nonuser siblings. Pairs where the AED users took AED polytherapy, or had a longer duration of AED use, had more impaired balance performance. These balance deficits may contribute to the increased rate of fractures in this population.
Genetic and hormonal control of bone volume, architecture, and remodeling in XXY mice
Publisher: Wiley
Date: 07-04-2010
DOI: 10.1002/JBMR.104
Examining differences and similarities between graduate and undergraduate students' user satisfaction with digital libraries
Publisher: Elsevier BV
Date: 11-2019
Applying Photovoice to the Study of Asian Immigrants’ Information Needs
Publisher: Springer International Publishing
Date: 2019
Tourists' social interactions on social media during a group trip planning
Publisher: Wiley
Date: 2019
DOI: 10.1002/PRA2.120
Frailty and use of health and community services by community-dwelling older men: the Concord Health and Ageing in Men Project
Publisher: Oxford University Press (OUP)
Date: 14-01-2010
Abstract: frailty is a concept used to describe older people at high risk of adverse outcomes, including falls, functional decline, hospital or nursing home admission and death. The associations between frailty and use of specific health and community services have not been investigated. the cross-sectional relationship between frailty and use of several health and community services in the last 12 months was investigated in 1,674 community-dwelling men aged 70 or older in the Concord Health and Ageing in Men study, a population-based study conducted in Sydney, Australia. Frailty was assessed using a modified version of the Cardiovascular Health Study criteria. overall, 158 (9.4%) subjects were frail, 679 (40.6%) were intermediate (pre-frail) and 837 (50.0%) were robust. Frailty was associated with use of health and community services in the last 12 months, including consulting a doctor, visiting or being visited by a nurse or a physiotherapist, using help with meals or household duties and spending at least one night in a hospital or nursing home. Frail men without disability in activities of daily living were twice more likely to have seen a doctor in the previous 2 weeks than robust men (adjusted odds ratio 2.04, 95% confidence interval 1.21-3.44), independent of age, comorbidity and socio-economic status. frailty is strongly associated with use of health and community services in community-dwelling older men. The high level of use of medical services suggests that doctors and nurses could play a key role in implementation of preventive interventions.
Researchers' judgment criteria of high-quality answers on academic social Q&A platforms
Publisher: Emerald
Date: 14-02-2020
Abstract: Through a two-stage survey, this paper examines how researchers judge the quality of answers on ResearchGate Q& A, an academic social networking site. In the first-stage survey, 15 researchers from Library and Information Science (LIS) judged the quality of 157 answers to 15 questions and reported the criteria that they had used. The content of their reports was analyzed, and the results were merged with relevant criteria from the literature to form the second-stage survey questionnaire. This questionnaire was then completed by researchers recognized as accomplished at identifying high-quality LIS answers on ResearchGate Q& A. Most of the identified quality criteria for academic answers—such as relevance, completeness, and verifiability—have previously been found applicable to generic answers. The authors also found other criteria, such as comprehensiveness, the answerer's scholarship, and value-added. Providing opinions was found to be the most important criterion, followed by completeness and value-added. The findings here show the importance of studying the quality of answers on academic social Q& A platforms and reveal unique considerations for the design of such systems.
Loss of Muscle Strength, Mass (Sarcopenia), and Quality (Specific Force) and Its Relationship with Functional Limitation and Physical Disability: The Concord Health and Ageing in Men Project
Publisher: Wiley
Date: 11-2010
DOI: 10.1111/J.1532-5415.2010.03145.X
Abstract: To determine the association between loss of muscle strength, mass, and quality and functional limitation and physical disability in older men. Cross-sectional study of older men participating in the Concord Health and Ageing in Men Project (CHAMP). Elderly men living in a defined geographical region in Sydney, Australia. One thousand seven hundred five community-dwelling men aged 70 and older who participated in the baseline assessments of CHAMP. Upper and lower extremity strength were measured using dynamometers for grip and quadriceps strength. Appendicular skeletal lean mass was assessed using dual X-ray absorptiometry. Muscle quality was defined as the ratio of strength to mass in upper and lower extremities. For each parameter, subjects in the lowest 20% of the distribution were defined as below normal. Functional limitation was assessed according to self-report and objective lower extremity performance measures. Physical disability was measured according to self-report questionnaire. After adjusting for important confounders, the prevalence ratio (PR) for poor quadriceps strength and self-reported functional limitation was 1.91 (95% confidence interval (CI) = 1.10-2.40) for performance-based functional limitation the PR was 1.81 (95% CI = 1.45-2.24). The adjusted PR for poor grip strength and physical disability in instrumental activities of daily living (IADLs) was 1.37 (95% CI = 1.20-1.56). The adjusted PR for low skeletal lean mass (adjusted for fat mass) and physical disability in basic activities of daily living was 2.08 (95% CI = 1.37-3.15). For muscle quality, the PR for lower extremity specific force and functional limitation and physical disability was stronger than upper extremity specific force. Muscle strength is the single best measure of age-related muscle change and is associated with physical disability in IADLs and functional limitation.
Understanding link sharing tools continuance behavior in social media
Publisher: Emerald
Date: 13-02-2017
Abstract: The purpose of this paper is to investigate the continued use behavior (CU) of link sharing tools based on uses and gratifications theory, the theory of planned behavior and expectation confirmation theory. It then builds a conceptual model that is empirically tested. Data were collected from 343 students (undergraduates, masters, PhD students, and MBAs) from three Chinese universities via a two-phrase survey. The tools SPSS 18.0 and AMOS 18.0 were used to analyse the reliability, validity, model fits and SEM, respectively. The results indicate that an in idual’s CU of link sharing tools was determined by his or her continued use intention directly and subjective norm indirectly. Users’ satisfaction on link sharing tools was the main factor affecting the continuance intention. In iduals’ motivation needs such as cognitive needs, personal integrative needs, and social integrative needs were found to be the significant predictors of his or her satisfaction. Besides, people with high privacy concern tended to have less satisfaction with link sharing tools. This study explores users’ CU of link sharing tools in social media for the first time. The theoretical model developed shows the predictors behind people’s CU.
Cognitive coordinating behaviors in multitasking web search
Publisher: ACM
Date: 24-07-2011
Charting the Australian COVID-19 Information Flow
Publisher: Wiley
Date: 10-2023
DOI: 10.1002/PRA2.763
Understanding the information landscape of Indigenous Elders knowledge and cultural practices
Publisher: Wiley
Date: 2019
DOI: 10.1002/PRA2.125
Hypophosphataemic osteomalacia in patients on adefovir dipivoxil.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 05-2011
Information use and information sharing in marketing: A diary study
Publisher: Wiley
Date: 2012
The information journey of marketing professionals: Incorporating work task‐driven information seeking, information judgments, information use, and information sharing
Publisher: Wiley
Date: 18-03-2014
DOI: 10.1002/ASI.23085
Investigating mobile social media users' behaviors in tourism collaborative information seeking
Publisher: ACM
Date: 07-03-2017
Antiracism in the LIS Profession: Not Just Lip Service
Publisher: Wiley
Date: 10-2021
DOI: 10.1002/PRA2.519
Abstract: With rising cases of brutality, gun violence, and racial injustice towards particularly the Black and AAPI (Asians, Asian Americans, Pacific Islanders) communities, racism is being recognized and declared as an emergency and public health threat. Diversity, equity, and antiracism are core to the Library and Information Science (LIS) profession as we strive to uphold the principle of “libraries serve humanities” and the motto of “free to all.” During this extended period of “racial‐injustice as a public crisis”, what are the roles of LIS professionals in battling racism, violence, and other systems of oppression? This panel session features experienced LIS professionals and educators who specialize in DEI, reporting their activities, stories, and thoughts on antiracism. A breakout room activity is envisioned following panelists' presentations, with participants discussing and sharing their antiracism initiatives. Participants will also brainstorm the next course of action in the LIS profession's journey in battling racism.
Characteristics of the health information seeking behavior of LGBTQ+ individuals: a systematic review on information types, information sources and influencing factors
Publisher: Emerald
Date: 23-07-2022
Abstract: Lesbian, gay, bisexual, transgender and queer/questioning (LGBTQ+) in iduals' health information seeking is an important topic across multiple disciplines and areas. The aim of this systematic review is to create a holistic view of sexual and gender minority in iduals' health information seeking reported in multidisciplinary studies, with regard to the types of health information LGBTQ+ in iduals sought and information sources they used, as well as the factors influencing their health information seeking behavior. The review is based on the literature search in 10 major academic databases. A set of inclusion and exclusion criteria was applied to identify studies that provide evidence on LGBTQ+ in iduals' health information seeking behavior. The studies were first screened by title and abstract to determine whether they met the inclusion criteria. The full texts of each relevant study were obtained to confirm whether the exclusion criteria were met. The reference lists of the included studies were manually scanned. The relevant information was then extracted from selected articles and analyzed using thematic content analysis. A seed set of 3,122 articles published between 1997 and 2020 was evaluated, and 46 total articles were considered for further analysis. The review results show that two major categories of health information sought by LGBTQ+ in iduals were sexual and nonsexual, which were further classified into 17 specific types. In terms of health information sources, researchers have reported that online resources, interpersonal sources and traditional media were frequently used. Moreover, 25 factors affecting LGBTQ+ in iduals' health information seeking were identified from the literature. Through evidence-based understanding, this review preliminarily bridged the knowledge gap in understanding the status quo of studies on LGBTQ+ in iduals' health information seeking and proposed the potential research directions that information science researchers could contribute to this important area.
Transgenic disruption of glucocorticoid signaling in mature osteoblasts and osteocytes attenuates K/BxN mouse serum-induced arthritis in vivo
Publisher: Wiley
Date: 29-06-2009
DOI: 10.1002/ART.24619
Abstract: Endogenous glucocorticoids (GCs) modulate numerous biologic systems involved in the initiation and maintenance of arthritis. Bone cells play a critical role in the progression of arthritis, and some of the effects of GCs on inflammation may be mediated via these cells. The aim of this study was to investigate the impact of osteoblast-targeted disruption of GC signaling on joint inflammation, cartilage damage, and bone metabolism in the K/BxN mouse serum transfer model of autoimmune arthritis. Intracellular GC signaling was disrupted in osteoblasts through transgenic overexpression of 11beta-hydroxysteroid dehydrogenase type 2 under the control of a type I collagen promoter. Arthritis was induced in 5-week-old male transgenic mice and their wild-type (WT) littermates, and paw swelling was assessed daily until the mice were killed. The mice were examined by histology, histomorphometry, and microfocal computed tomography, and serum was analyzed for cytokines, adrenocorticotropic hormone, and corticosterone. Acute arthritis developed in both transgenic and WT mice treated with K/BxN mouse serum. However, the arthritis and local inflammatory activity were significantly attenuated in transgenic mice, as judged by clinical and histologic indices of inflammation and cartilage damage. Bone turnover and bone volume remained unchanged in arthritic transgenic mice, while WT mice exhibited stimulated bone resorption, suppressed osteoblast activity, and significantly reduced bone volume, compatible with the known effects of active inflammation on bone. Circulating levels of proinflammatory cytokines tended to be lower in arthritic transgenic mice than in control transgenic mice. Disruption of GC signaling in osteoblasts significantly attenuates K/BxN mouse serum-induced autoimmune arthritis in mice. These data suggest that osteoblasts modulate the immune-mediated inflammatory response via a GC-dependent pathway.
Endogenous glucocorticoid signalling in osteoblasts is necessary to maintain normal bone structure in mice
Publisher: Elsevier BV
Date: 07-2009
DOI: 10.1016/J.BONE.2009.03.673
Abstract: The role of endogenous glucocorticosteroids (GC) in bone development is ill-defined. Using the Col2.3-11betaHSD2 transgenic (tg) mouse model, we examined the effect of osteoblast-targeted disruption of intracellular GC signalling on bone growth and strength, and its modulation by factors such as age, gender and skeletal site. Tibiae and L3 vertebrae of 3 and 7-week-old, male and female wild type (WT) mice and their tg, age and sex matched littermates were analysed by micro-CT and mechanical testing. Data were analysed separately for 3 and 7-week-old mice by 2-way ANOVA using genotype (WT, tg), gender and their interactions as factors. Transgenic mice were characterised by lower bone volume, lower trabecular number and higher trabecular separation in tibial trabecular bone, as well as lower tibial cortical bone area and periosteal and endosteal perimeters. These changes resulted in a marked decrease in mechanical bone strength and stiffness in sexually mature, 7-week-old mice. In the tibia, the observed transgene effect was present in 3 and 7-week-old animals, indicating that the biological effect of disrupted GC signalling was independent of sexual maturity. This was not the case for the vertebral bones, where significant differences between tg and WT mice were seen in 7 but not in 3-week-old animals, suggesting that the effects of the transgene at this site may be modulated by age and/or changes in circulating sex hormone levels. Taken together, our results demonstrate that endogenous glucocorticoids may be required for normal bone growth but that their effect on bone structure and strength varies according to the skeletal site and sexual maturity of the animals.
Research on the drivers of undergraduates' intention to use university digital libraries: affinity theory as an additional construct of information system success model
Publisher: Emerald
Date: 19-07-2022
Abstract: This study aims to examine the factors influencing undergraduates' intention to use university digital libraries by integrating the information system success model and affinity theory. Based on the 265 valid responses gathered through a survey, the structural equation modelling (SEM) technique was employed to test the research model and hypotheses. The results indicated that system quality and digital libraries (DLs)' affinity significantly affect undergraduates' user satisfaction. However, information quality and service quality does not. User satisfaction has significant impact on undergraduates' intention to use university digital libraries. Librarians and service providers should focus on enhancing the system quality of digital library and DLs' affinity, to improve the undergraduates' user satisfaction, further motivating undergraduates to use university digital libraries. The information system success model is enriched by affinity as an additional construct.
JASIST special issue on ICT4D and intersections with the information field
Publisher: Wiley
Date: 20-10-2023
DOI: 10.1002/ASI.24838
Overview of Theory and Practice in Library and Information Science Research in Asia-Oceania
Publisher: IGI Global
Date: 2014
DOI: 10.4018/978-1-4666-5158-6.CH001
Abstract: This chapter provides a concise overview dealing with the theory and practice in Library and Information Science (LIS) research development in Asia-Oceania. It also provides the reader with an introduction to the sections and the in idual chapters of the book. The field of LIS has experienced significant growth, both in the number of LIS schools and research outputs, in recent years in the region. As a professional field, both theory and practice are viewed as equally important for the development of the LIS discipline. In this book, both theoretical as well as practical work in LIS research in Asia-Oceania region is presented.
A selection strategy was developed for fracture reduction programs in frail older people.
Publisher: Elsevier BV
Date: 06-2010
DOI: 10.1016/J.JCLINEPI.2009.08.018
Abstract: The aims of this study were to develop and evaluate a simple index for assessing the risk of fractures after a fall and to propose a selection strategy for identifying elderly in iduals at high risk of both falls and fall-related fractures. Two thousand five institutionalized older men and women were assessed for clinical risk factors and then followed up for falls and fall-related fractures for up to 2 years. Our fracture risk index is derived from seven previously identified significant independent risk factors: weight, lower leg length, balance, cognitive function, type of institution, fracture history, and falls in the past year. The fracture rate was 6.5 times greater in the one-sixth of the falls with the highest index (9.7/100 falls) than in the lowest sixth (1.5/100 falls). Our proposed approach (based on balance, risk of falls, and the fracture risk index) selected a group of older people with high risk of both falls and fall-related fracture. The fracture incidence rate was 144% higher, and the falls incidence rate was 31% higher in the selected residents than in the remainder. The index could help rationalize fracture prevention programs for frail older people.
“Active followers”: An emerging role of information behaviour among group holiday makers
Publisher: Wiley
Date: 2019
DOI: 10.1002/PRA2.194
Characteristics of collaborative information seeking activities during group trip planning: A preliminary study
Publisher: Wiley
Date: 2019
DOI: 10.1002/PRA2.119
Differentially Private Demand Side Management for Incentivized Dynamic Pricing in Smart Grid
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 06-2022
Sunlight and health: attitudes of older people living in intermediate care facilities in southern Australia.
Publisher: Elsevier BV
Date: 11-2010
DOI: 10.1016/J.ARCHGER.2010.01.008
Abstract: Older people have a high prevalence of falls and fractures, partly due to vitamin D deficiency. Sunlight is a major source of vitamin D, but many older people living in intermediate care facilities have inadequate sunlight exposure. The aim of this study was to determine the sun exposure practices and attitudes to sunlight in this population. Fifty-seven older residents of intermediate care facilities in Sydney, Australia were interviewed to determine their sun exposure practices, their views on sunlight and health and whether these have changed over their lives, factors affecting sunlight exposure and their knowledge of vitamin D. Sixty percent of the participants preferred to be outdoors, despite more than 92% believing that sunlight was healthy. In their youth however, almost 90% had preferred to be outdoors. Poor health, physical constraints and a sense of lack of ownership of outdoor spaces were barriers to sunlight exposure. Improved physical access, more outdoor leisure activities and promotion of greater autonomy may improve safe and appropriate sunlight exposure in this population.
Follicle-stimulating hormone increases bone mass in female mice
Publisher: Proceedings of the National Academy of Sciences
Date: 13-12-2010
Abstract: Elevated follicle-stimulating hormone (FSH) activity is proposed to directly cause bone loss independent of estradiol deficiency in aging women. Using transgenic female mice expressing human FSH (TgFSH), we now reveal that TgFSH dose-dependently increased bone mass, markedly elevating tibial and vertebral trabecular bone volume. Furthermore, TgFSH stimulated a striking accrual of bone mass in hypogonadal mice lacking endogenous FSH and luteinizing hormone (LH) function, showing that FSH-induced bone mass occurred independently of background LH or estradiol levels. Higher TgFSH levels increased osteoblast surfaces in trabecular bone and stimulated de novo bone formation, filling marrow spaces with woven rather than lamellar bone, reflective of a strong anabolic stimulus. Trabecular bone volume correlated positively with ovarian-derived serum inhibin A or testosterone levels in TgFSH mice, and ovariectomy abolished TgFSH-induced bone formation, proving that FSH effects on bone require an ovary-dependent pathway. No detectable FSH receptor mRNA in mouse bone or cultured osteoblasts or osteoclasts indicated that FSH did not directly stimulate bone. Therefore, contrary to proposed FSH-induced bone loss, our findings demonstrate that FSH has dose-dependent anabolic effects on bone via an ovary-dependent mechanism, which is independent of LH activity, and does not involve direct FSH actions on bone cells.
Fracture risk assessment in frail older people using clinical risk factors.
Publisher: Oxford University Press (OUP)
Date: 16-05-2008
Abstract: this study aims to develop and evaluate a simple fracture risk index for use in frail older people. clinical risk factors were assessed at baseline for 2,005 older people (473 males, 1,532 females mean age 85.7 years, SD 7.1 years) living in aged-care facilities. Fractures were ascertained for 2 years from baseline. Cox regression model was used to identify significant risk factors for fracture. Hazard ratios (HRs) from the model were assigned as weights. The risk index was calculated by multiplying the weights of all risk factors. during a mean follow-up of 1.64 years, 401 fractures occurred in 338 participants. Significant independent clinical risk factors for fracture were institution type, balance, history of previous fracture, cognitive function, number of medications, weight and lower leg length (n = 1,813). The index was capable of identifying higher-risk in iduals, with almost an 8-fold increase in the risk of fracture for residents from the lowest 15% to the highest 18% of the score. Among 1-year survivors, a high score (>or=15) indicated approximately a one-in-six chance of fracture, while a low score (<8) indicated only a one-in-forty chance of fracture within a year. The area under the receiver operating characteristic (ROC) curve was 0.69 (95% CI: 0.65-0.72) and 0.68 (95% CI: 0.65-0.71) for identifying someone who would have a fracture in 1 and 2 years respectively. this risk index could identify in iduals at higher fracture risk among institutionalised older people, and thus, could help to rationalise the provision of fracture prevention programs in this population.
Modeling Web search: Preliminary results
Publisher: Wiley
Date: 2009
Marginalized communities, emerging technologies, and social innovation in the digital age: Introduction to the special issue
Publisher: Elsevier BV
Date: 05-2020
Osteoblast-targeted disruption of glucocorticoid signalling does not delay intramembranous bone healing
Publisher: Elsevier BV
Date: 03-2010
DOI: 10.1016/J.STEROIDS.2010.01.005
Abstract: Glucocorticoids at pharmacological doses have been shown to interfere with fracture repair. The role of endogenous glucocorticoids in fracture healing is not well understood. We examined whether endogenous glucocorticoids affect bone healing in an in vivo model of cortical defect repair. Experiments were performed using a well characterised mouse model in which intracellular glucocorticoid signalling was disrupted in osteoblasts through transgenic overexpression of 11beta-hydroxysteroid-dehydrogenase type 2 (11beta-HSD2) under the control of a collagen type I promoter (Col2.3-11beta-HSD2). Unicortical bone defects (ø 0.8mm) were created in the tibiae of 7-week-old male transgenic mice and their wild-type littermates. Repair was assessed via histomorphometry, immunohistochemistry and microcomputed tomography (micro-CT) analysis at 1-3 weeks after defect creation. At week 1, micro-CT images of the defect demonstrated formation of mineralized intramembranous bone which increased in volume and density by week 2. At week 3, healing of the defect was nearly complete in all animals. Analysis by histomorphometry and micro-CT revealed that repair of the bony defect was similar in Col2.3-11beta-HSD2 transgenic animals and their wild-type littermates at all time-points. Disrupting endogenous glucocorticoid signalling in mature osteoblasts did not affect intramembranous fracture healing in a tibia defect repair model. It remains to be shown whether glucocorticoid signalling has a role in endochondral fracture healing.
Video ethnographic documentation of stories and cultural practices with Indigenous Elders
Publisher: Wiley
Date: 2018
Cognitive Activity during Web Search
Publisher: ACM
Date: 09-08-2015
Does hierarchical badges system affect users' efforts and opinions? A preliminary study
Publisher: Wiley
Date: 10-2020
DOI: 10.1002/PRA2.345
Abstract: Hierarchical badges system is often used to encourage user contribution in many user‐generated content (UGC) platforms. But little is known whether this mechanism is effective in inducing users to provide more substantial and useful contents. In this research, we aim to study how the badge levels impact users’ contribution behavior such as their efforts and opinions, using data from a large online review platform. Our preliminary results show that users increase their efforts such as review frequency and review length as their badge levels upgrade. In terms of opinions they express, users with higher badges are less likely to post extreme ratings. Our finding has important implications for business modes that rely on UGC, such as social question‐and‐answering, social media, and crowdsourcing.
The Association of Alanine Transaminase With Aging, Frailty, and Mortality
Publisher: Oxford University Press (OUP)
Date: 24-05-2010
Project Governance, Project Performance, and the Mediating Role of Project Quality and Project Management Risk: An Agency Theory Perspective
Publisher: Informa UK Limited
Date: 02-10-2018
Transfer Entropy and Information Flow Patterns in Functional Brain Networks during Cognitive Activity
Publisher: Springer International Publishing
Date: 2014
Factors influencing users’ satisfaction and loyalty to digital libraries in Chinese universities
Publisher: Elsevier BV
Date: 06-2018
Vitamin D deficiency promotes growth of MCF-7 human breast cancer in a rodent model of osteosclerotic bone metastasis
Publisher: Elsevier BV
Date: 10-2010
DOI: 10.1016/J.BONE.2010.07.012
Abstract: Breast cancer metastases to bone are common in advanced stage disease. We have recently demonstrated that vitamin D deficiency enhances breast cancer growth in an osteolytic mouse model of breast cancer metastasis. In this study, we examined the effects of vitamin D deficiency on tumor growth in an osteosclerotic model of intra-skeletal breast cancer in mice. The effects of 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] on proliferation and apoptosis of MCF-7 breast cancer cells, and changes in the expression of genes within the vitamin D metabolic pathway (VDR, 1α- and 24-hydroxylase) were examined in vitro. MCF-7 breast cancer cells were injected intra-tibially into vitamin D deficient and vitamin D sufficient mice co-treated with and without osteoprotegerin (OPG). The development of tumor-related lesions was monitored via serial X-ray analysis. Tumor burden and indices of proliferation and apoptosis were determined by histology along with markers of bone turnover and serum intact PTH levels. In vitro, MCF-7 cells expressed critical genes for vitamin D signalling and metabolism. Treatment with 1,25(OH)(2)D(3) inhibited cell growth and proliferation, and increased apoptosis. In vivo, osteosclerotic lesions developed faster and were larger at endpoint in the tibiae of vitamin D deficient mice compared to vitamin D sufficient mice (1.49±0.08 mm(2) versus 1.68±0.15 mm(2), P<0.05). Tumor area was increased by 55.8% in vitamin D deficient mice (0.81±0.13 mm(2) versus 0.52±0.11 mm(2) in vitamin D sufficient mice). OPG treatment inhibited bone turnover and caused an increase in PTH levels, while tumor burden was reduced by 90.4% in vitamin D sufficient mice and by 92.6% in vitamin D deficient mice. Tumor mitotic activity was increased in the tibiae of vitamin D deficient mice and apoptosis was decreased, consistent with faster growth. Vitamin D deficiency enhances both the growth of tumors and the tumor-induced osteosclerotic changes in the tibiae of mice following intratibial implantation of MCF-7 cells. Enhancement of tumor growth appears dependent on increased bone resorption rather than increased bone formation induced by these tumors.
Examining collaborative query reformulation
Publisher: ACM
Date: 03-07-2014
Making a Difference: Translating Information Research into Practice, Policy, and Action
Publisher: Wiley
Date: 10-2023
DOI: 10.1002/PRA2.850
Academic Users' Information Searching on Research Topics: Characteristics of Research Tasks and Search Strategies
Publisher: Elsevier BV
Date: 07-2011
Relationship between indices of adiposity obtained by peripheral quantitative computed tomography and dual-energy X-ray absorptiometry in pre-pubertal children
Publisher: Informa UK Limited
Date: 18-11-2009
DOI: 10.3109/03014460903055139
Abstract: The study investigated the relationship between indices of adiposity measured by peripheral quantitative computed tomography (pQCT) and dual-energy X-ray absorptiometry (DXA) in pre-pubertal children. DXA-derived per cent body fat (%BF) was measured in 284 boys and 288 girls, aged 7-10 years. Cross-sections of the forearm (n=427) and lower leg (n=560) were obtained by pQCT to measure total cross-sectional area of the limb (Total CSA), Muscle CSA, Fat CSA, %Fat CSA (Fat CSA/Total CSAx100) and muscle density. Peripheral QCT-derived %Fat CSA in the forearm and lower leg correlated strongly with DXA-derived %BF (r=0.83-0.89, p<0.01) in both boys and girls. However, forearm and lower leg %Fat CSA were higher than whole body %BF by 5% and 10%, respectively. A better prediction of whole-body %BF was achieved by including %Fat CSA, muscle density and height into a hierarchical regression model. Using sex-specific regression equations, 87.7% of the boys and 83.7% of the girls had a predicted %BF within 3% units of the %BF obtained by DXA. In pre-pubertal children, pQCT measures of adiposity are strongly associated with whole-body per cent body fat. This reproducible method could be an alternative technique to estimate body composition in this population.
Ethnicity and falls in older men: low rate of falls in Italian-born men in Australia
Publisher: Oxford University Press (OUP)
Date: 02-07-2011
Abstract: past research suggests that fall rates in older persons may differ by ethnicity. The aim of this study was to compare the incidence of falls between older male Italian-born immigrants and their Australian-born counterparts. this study analysed data from 335 Italian-born and 848 Australian-born men aged 70 years and over participating in the Concord Health and Ageing in Men Project (CHAMP). Prospective falls data were collected by 4 monthly phone calls (mean follow-up time: 26.7 months). Negative binomial regression compared falls incidence rate ratios (IRR) between the two groups of men. there were 37 (11%) Italian-born men and 185 (22%) Australian-born men who had two or more falls during follow-up (P < 0.001). Negative binomial analysis demonstrated that Italian-born men had half the incidence rate of falls compared with Australian-born men (IRR = 0.51, 95% CI = 0.38-0.67). After adjustment for falls risk factors, Italian-born men remained significantly less likely to fall with a 43% lower fall rate (IRR = 0.57, 95% CI = 0.39-0.85). older male Italian-born immigrants are less likely to fall than their Australian-born counterparts. Differences in fall rates between the two groups are not explained by established falls risk factors.
Intrusive pain and worry about health in older men: The CHAMP study
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 02-2011
DOI: 10.1016/J.PAIN.2010.11.022
Abstract: The role of anxiety in pain is less well understood than the role of depression. Based on recent conceptual thinking about worry and pain, we explored the relationship between pain status and worry about health and anxiety in 1217 community-dwelling men aged 70 years or older who participated in the baseline phase of the Concord Health and Ageing in Men Project study, a large population-based epidemiological study of healthy ageing based in Sydney, Australia. We hypothesised that worry about health would be associated with having persistent pain, and that the association would be stronger in the presence of co-existing pain-related interference with activities (intrusive pain). Of men in the study, 12.5% had persistent and intrusive pain, 22.4% were worried about their health, and 6.3% had anxiety. We found a strong association between worry about health and pain that was both persistent and intrusive, and that remained after accounting for age, number of comorbidities, depression, self-rated health status, arthritis, and gait speed (adjusted odds ratio 2.9 95% confidence interval 1.8-4.7), P<0.0001). The corresponding adjusted odds ratio for the association between anxiety and pain was 2.3 (95% confidence interval 1.0-4.8 P=0.0363). These findings suggest that at a population level, subthreshold anxiety and pain are strongly related, and worry about health occurs much more commonly than anxiety itself. To our knowledge, this is the first study to explore, specifically, the relationship between pain status and worry about health in older men. In older community-dwelling men, pain was robustly associated with worry about health, highlighting the potential importance of subthreshold anxiety-related psychological factors.
Glucocorticoid-dependent Wnt signaling by mature osteoblasts is a key regulator of cranial skeletal development in mice
Publisher: The Company of Biologists
Date: 02-2009
DOI: 10.1242/DEV.027706
Abstract: Glucocorticoids are important regulators of bone cell differentiation and mesenchymal lineage commitment. Using a cell-specific approach of osteoblast-targeted transgenic disruption of intracellular glucocorticoid signaling, we discovered a novel molecular pathway by which glucocorticoids,mainly through the mature osteoblast, regulate the cellular mechanisms that govern cranial skeleton development. Embryonic and neonatal transgenic mice revealed a distinct phenotype characterized by hypoplasia and osteopenia of the cranial skeleton disorganized frontal, parietal and interparietal bones increased suture patency ectopic differentiation of cartilage in the sagittal suture and disturbed postnatal removal of parietal cartilage. Concurrently,expression of Mmp14, an enzyme essential for calvarial cartilage removal, was markedly reduced in parietal bone and cartilage of transgenic animals. Expression of Wnt9a and Wnt10b was significantly reduced in osteoblasts with disrupted glucocorticoid signaling, and accumulation of β-catenin, the upstream regulator of Mmp14 expression, was decreased in osteoblasts,chondrocytes and mesenchymal progenitors of transgenic mice. Supracalvarial injection of Wnt3a protein rescued the transgenic cranial phenotype. These results define novel roles for glucocorticoids in skeletal development and delineate how osteoblasts - under steroid hormone control - orchestrate the intricate process of intramembranous bone formation by directing mesenchymal cell commitment towards osteoblastic differentiation while simultaneously initiating and controlling cartilage dissolution in the postnatal mouse.
Group trip planning and information seeking behaviours by mobile social media users: A study of tourists in Australia, Bangladesh and China
Publisher: SAGE Publications
Date: 10-12-2021
Abstract: Social media plays an increasingly important role in travel information seeking and decision-making. However, there is limited understanding of how a group of tourists use social media to plan trips collaboratively and the different practices between countries. In this study, we investigated the collaborative information seeking (CIS) and sharing behaviours of mobile social media users from Australia, Bangladesh and China. Specifically, we surveyed a total of 219 participants to explore the differences in CIS behaviours when people were planning a group trip. The findings suggest significant differences among three countries in terms of the motivations of using social media, CIS activities and social interactions outside the group. Key findings include Bangladeshi and Chinese travellers preferred known contacts on social media, while Australian tourists intended to use both known contacts and user-generated contents for seeking information. The findings also show that social interactions employed by in iduals are considered as an important complement of and are interwoven with in-group CIS both contribute to tourism information seeking. Finally, we propose a framework for CIS research in the tourism domain.
Conceptualizing co-mapping knowledges to promote social justice outcomes with Aboriginal communities through design pedagogy
Publisher: Routledge
Date: 15-11-2022
Risk factors for hip fracture among institutionalised older people.
Publisher: Oxford University Press (OUP)
Date: 30-04-2009
Abstract: risk factors for hip fracture in community-dwelling in iduals have been extensively studied, but there have been fewer studies of institutionalised older people. a total of 1,894 older people (1,433 females, 461 males mean age 86 years, SD 7.1 years) were recruited from 52 nursing homes and 30 intermediate-care nursing care facilities in Australia during March 1999 and February 2003. We assessed clinical risk factors for hip fracture and skeletal fragility by calcaneus broadband ultrasound attenuation (BUA) at baseline and then followed up for fracture for 4 years. Hip fractures were validated by x-ray reports. Survival analysis with age as a time-dependent covariate was used to analyse the data. during a mean follow-up period of 2.65 years (SD 1.38), 201 hip fractures in 191 residents were recorded, giving an overall hip fracture incidence rate of 4.0% per person year (males 3.6% and females 4.1%). Residents living in intermediate-care hostels had a higher crude hip fracture rate (4.6% vs. 3.0%) than those living in high-care nursing homes. In multivariate analysis, an increased risk of hip fracture was significantly associated with older age, cognitive impairment, a history of fracture since age 50, lower body weight, longer lower leg length and poorer balance in intermediate-care hostel residents, but not with lower BUA. institutionalised older people, who are at a higher risk of hip fracture than community-dwelling in iduals, have differences in some risk factors for hip fracture that should be considered in targeting intervention programs.
Understanding tourists' collaborative information retrieval behavior to inform design
Publisher: Wiley
Date: 27-03-2015
DOI: 10.1002/ASI.23319
Information for a Better World: Normality, Virtuality, Physicality, Inclusivity
Publisher: Springer Nature Switzerland
Date: 2023
Inspiring information communities to advance the UN sustainable development goals: information action briefs for social transformation
Publisher: Routledge
Date: 15-11-2022
Immigrating after 60: Information experiences of older Chinese migrants to Australia and Canada
Publisher: Elsevier BV
Date: 05-2020
Engaging voluntary contributions in online review platforms: The effects of a hierarchical badges system
Publisher: Elsevier BV
Date: 02-2022
Geo-Ellipse-Indistinguishability: Community-Aware Location Privacy Protection for Directional Distribution
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2022
Urinary incontinence and quality of life among older community-dwelling Australian men: the CHAMP study
Publisher: Oxford University Press (OUP)
Date: 19-03-2010
Abstract: to describe the prevalence and impact on quality of life of urinary incontinence in a population-based cohort of older community-dwelling Australian men. the population comprised 1,705 men aged >or=70 years participating in the Concord Health and Ageing in Men Project, a population-based study of urban older Australian men. data were collected between January 2005 and June 2007, and the participation rate was 47%. Data on demographics, medical history and from the 12-item Short Form Health Survey (SF-12) and International Consultation on Incontinence Questionnaire were collected. Urinary incontinence was defined as urinary leakage at least two times a week over the past 4 weeks. the prevalence of urinary incontinence was 14.8%, increasing from 12.0% for men aged 70-74 years old to 16.3% for those aged >or=90 years, with urgency incontinence being the most frequent type of urinary incontinence. Daily urine leakage was reported by 3% of men. Men with incontinence had lower overall SF-12 scores with greater impact on the physical (PCS) than the mental (MCS) components of that scale. After adjusting for age, number of co-morbidities, enlarged prostate and prostate cancer, men with incontinence had worse PCS (43.6 vs 45.9) and MCS scores (52.2 vs 54.6) compared with continent men. urinary incontinence is common among older community-dwelling men and is associated with worse quality of life with greater impact on physical than mental factors. As the population ages, urinary incontinence prevalence will increase and increased resources will be needed to address this growing problem.
Estimation of lean body weight in older community‐dwelling men
Publisher: Wiley
Date: 21-01-2010
Vitamin D deficiency promotes human breast cancer growth in a murine model of bone metastasis
Publisher: American Association for Cancer Research (AACR)
Date: 28-02-2010
DOI: 10.1158/0008-5472.CAN-09-3194
Abstract: Vitamin D exerts antiproliferative, prodifferentiation, and proapoptotic effects on nonclassic target tissues such as breast. Blood levels of 25-hydroxyvitamin D [25(OH)D], the most sensitive indicator of vitamin D status, are inversely correlated with breast cancer risk however, a causal relationship between vitamin D deficiency and breast cancer growth in bone has not been assessed. We examined the effect of vitamin D deficiency on the intraskeletal growth of the human breast cancer cell line MDA-MB-231-TxSA in a murine model of malignant bone lesions. Subsets of mice were treated concurrently with osteoprotegerin (OPG) to abrogate bone resorption. Outcomes were assessed by repeated radiographic and end-point micro–computed tomography and histologic analyses. Mice weaned onto a vitamin D–free diet developed vitamin D deficiency within 4 weeks [mean ± SE serum 25(OH)D: 11.5 ± 0.5 nmol/L], which was sustained throughout the study and was associated with secondary hyperparathyroidism and accelerated bone turnover. Osteolytic lesions appeared earlier and were significantly larger in vitamin D–deficient than in vitamin D–sufficient mice after 2 weeks (radiographic osteolysis: +121.5% histologic tumor area: +314% P & 0.05). Although OPG treatment reduced the size of radiographic osteolyses and tumor area in both groups, tumors remained larger in OPG-treated vitamin D–deficient compared with OPG-treated vitamin D–sufficient mice (0.53 ± 0.05 mm2 versus 0.19 ± 0.05 mm2 P & 0.05). We conclude that vitamin D deficiency promotes the growth of human breast cancer cells in the bones of nude mice. These effects are partly mediated through secondary changes in the bone microenvironment, along with direct effects of vitamin D on tumor growth. Cancer Res 70(5) 1835–44
Application of Data Mining in MOOCs for Developing Vocational Education: A Review and Future Research Directions
Publisher: EJournal Publishing
Date: 2018
Socioeconomic status and bone health in community-dwelling older men: the CHAMP Study
Publisher: Springer Science and Business Media LLC
Date: 23-06-2010
DOI: 10.1007/S00198-010-1332-0
Abstract: The association between socioeconomic status (SES) and bone health, specifically in men, is unclear. Based upon data from the large prospective Concord Health in Ageing Men Project (CHAMP) Study of community-dwelling men aged 70 years or over, we found that specific sub-characteristics of SES, namely, marital status, living circumstances, and acculturation, reflected bone health in older Australian men. Previous studies reported conflicting results regarding the relationship between SES and bone health, specifically in men. The main objective of this study was to investigate associations of SES with bone health in community-dwelling men aged 70 years or over who participated in the baseline phase of the CHAMP Study in Sydney, Australia. The Australian Socioeconomic Index 2006 (AUSEI06) based on the Australian and New Zealand Standard Classification of Occupations was used to determine SES in 1,705 men. Bone mineral density and bone mineral content (BMC) were determined by dual-energy X-ray absorptiometry. Bone-related biochemical and hormonal parameters, including markers of bone turnover, parathyroid hormone, and vitamin D, were measured in all men. General linear models adjusted for age, weight, height, and bone area revealed no significant differences across crude AUSEI06 score quintiles for BMC at any skeletal site or for any of the bone-related biochemical measures. However, multivariate regression models revealed that in Australian-born men, marital status was a predictor of higher lumbar BMC (β = 0.07, p = 0.002), higher total body BMC (β = 0.05, p = 0.03), and lower urinary NTX-I levels (β=-0.08, p = 0.03), while living alone was associated with lower BMC at the lumbar spine (β=-0.05, p = 0.04) and higher urinary NTX-I levels (β=0.07, p = 0.04). Marital status was also a predictor of higher total body BMC (β = 0.14, p = 0.003) in immigrants from Eastern and South Eastern Europe. However, in immigrants from Southern Europe, living alone and acculturation were predictors of higher femoral neck BMC (β = 0.11, p = 0.03) and lumbar spine BMC (β = 0.10, p = 0.008), respectively. Although crude occupation-based SES scores were not significantly associated with bone health in older Australian men, specific sub-characteristics of SES, namely, marital status, living circumstances, and acculturation, were predictors of bone health in both Australia-born men and European immigrants.
Examining Personalization in Academic Web Search
Publisher: ACM Press
Date: 2015
Studying health anxiety related attentional bias during online health information seeking: Impacts of stages and task types
Publisher: Elsevier BV
Date: 09-2023
Understanding the information journeys of late-life migrants to inform support design: Information seeking driven by a major life transition
Publisher: Elsevier BV
Date: 03-2023
Gender inclusivity and equity in academic libraries: Insights from around the globe
Publisher: American Library Association
Date: 06-09-2019
Abstract: In order to draw attention to and learn about gender inclusivity and equity in the academic library workplace in a fluid non-binary gendered society, academic librarians and researchers from major world regions were invited to respond to the question: What are the three most significant issues that are impeding and the three most significant issues that are enhancing gender inclusivity/equity in your region? The regions included are Africa, Asia and Oceania, Europe, Latin American and the Caribbean, the Middle East, and North America.We chose to focus on gender as the understanding of the concept is evolving and gender has classified people in such a way to limit or deny opportunities and equal treatment. Gender has been used to reference three dimensions that include the physical (characteristics of the human body), identity (the internal sense of self, which has traditionally been categorized as binary [e.g., feminine, masculine] and now as nonbinary or ungendered), and sociocultural (how one presents oneself socially or culturally, conformity to gendered roles and expectations).
Personalised Information Retrieval and Access: Concepts, Methods and Practices
Publisher: Emerald
Date: 20-02-2009
Using a Delphi method and the analytic hierarchy process to evaluate Chinese search engines
Publisher: Emerald
Date: 29-11-2011
DOI: 10.1108/14684521111193210
Abstract: The purpose of this study is to develop an evaluation criteria system for search engines using the Delphi method and the analytic hierarchy process, and to conduct an empirical study on Chinese search engines to verify it. This is because the evaluation criteria in current research rarely considers expert opinions and experience, and seldom calculates the weight of each criterion by quantitative methods. Expert investigation of the web‐based Delphi method was employed to develop the evaluation criteria, and the analytic hierarchy process based on an exponential scale was adopted to calculate the weight of each criterion. An empirical study was designed to test the evaluation criteria system. A total of 12 study participants were invited to evaluate six popular Chinese search engines by means of e‐mail questionnaires. All the calculation processes were executed automatically by Java programming. The indexing structure and search method were the core criteria for evaluating the search engines. Google (using simplified Chinese characters) achieved the best performance among the six typical Chinese search engines. The criteria for search engine evaluation were determined and weighted by the web‐based Delphi method and the analytic hierarchy process based on an exponential scale.
Collaborative information retrieval in tourism
Publisher: ACM
Date: 21-08-2012
Cognitive Load Driven Directed Information Flow in Functional Brain Networks
Publisher: Springer International Publishing
Date: 2015
A belief–desire–intention model for blog users’ negative emotional norm compliance
Publisher: Emerald
Date: 07-08-2017
Abstract: The purpose of this paper is to understand blog users’ negative emotional norm compliance decision-making in crises (blog users’-NNDC). A belief–desire–intention (BDI) model to evaluate the blog users’-NNDC (the BDI-NNDC model) was developed. This model was based on three social characteristics: self-interests, expectations and emotions. An experimental study was conducted to evaluate the efficiency of the BDI-NNDC model by using data retrieved from a popular Chinese social network called “Sina Weibo” about three major crises. The BDI-NNDC model strongly predicted the Blog users’-NNDC. The predictions were as follows: a self-interested blog user posted content that was targeting his own interests a blogger with high expectations wrote and commented emotionally negative blogs on the condition that the numbers of negative posts increased, while he ignored the norm when there was relatively less negative emotional news and an emotional blog user obeyed the norm based on the emotional intentions of the blogosphere in most of the cases. The BDI-NNDC model can explain the diffusion of negative emotions by blog users during crises, and this paper shows a way to bridge the social norm modelling and the research of blog users’ activity and behaviour characteristics in the context of “real life” crises. However, the criterion for differentiating blog users according to social characteristics needs to be further revised, as the generalizability of the results is limited by the number of cases selected in this study. The current method could be applied to predict emotional trends of blog users who have different social characteristics and it could support government agencies to build strategic responses to crises. This paper supports the creation of normative models and engineering methods to predict blog users’-NNDC and mitigate their effect in real-world crises.
Corticosterone selectively targets endo-cortical surfaces by an osteoblast-dependent mechanism
Publisher: Elsevier BV
Date: 10-2011
DOI: 10.1016/J.BONE.2011.06.013
Abstract: The pathogenesis of glucocorticoid-induced osteoporosis remains ill defined. In this study, we examined the role of the osteoblast in mediating the effects of exogenous glucocorticoids on cortical and trabecular bone, employing the Col2.3-11βHSD2 transgenic mouse model of osteoblast-targeted disruption of glucocorticoid signalling. Eight week-old male transgenic (tg) and wild-type (WT) mice (n=20-23/group) were treated with either 1.5 mg corticosterone (CS) or placebo for 4 weeks. Serum tartrate-resistant acid phosphatase 5b (TRAP5b) and osteocalcin (OCN) were measured throughout the study. Tibiae and lumbar vertebrae were analysed by micro-CT and histomorphometry at endpoint. CS suppressed serum OCN levels in WT and tg mice, although they remained higher in tg animals at all time points (p<0.05). Serum TRAP5b levels increased in WT mice only. The effect of CS on cortical bone differed by site: At the endosteal surface, exposure to CS significantly increased bone resorption and reduced bone formation, resulting in a larger bone marrow cavity cross-sectional area (p<0.01). In contrast, at the pericortical surface bone resorption was significantly decreased accompanied with a significant increase in pericortical cross-sectional area (p<0.05) while bone formation remained unaffected. Vertebral cortical thickness and area were reduced in CS treatment mice. Tg mice were partially protected from the effects of exogenous CS, both on a cellular and structural level. At the CS doses used in this study, trabecular bone remained largely unaffected. Endocortical osteoblasts appear to be particularly sensitive to the detrimental actions of exogenous glucocorticoids. The increase in tibial pericortical cross-sectional area and the according changes in pericortical circumference suggest an anabolic bone response to GC treatment at this site. The protection of tg mice from these effects indicates that both catabolic and anabolic action of glucocorticoids are, at least in part, mediated by osteoblasts.
Needs for Relatedness: LGBTQ+ Individuals' Information Seeking and Sharing in an Online Community
Publisher: ACM
Date: 14-03-2021
Adequacy of vitamin D replacement in severe deficiency is dependent on body mass index.
Publisher: Elsevier BV
Date: 11-2009
DOI: 10.1016/J.AMJMED.2009.06.008
Abstract: Obesity is associated with hypovitaminosis D. Whether body mass index (BMI) determines the replacement dose of vitamin D to achieve sufficiency is unclear. To determine the relationship between BMI and serum 25-OH vitamin D concentrations and whether the increase in serum 25-OH vitamin D concentrations with vitamin D replacement is dependent on BMI. Retrospective review of anthropometric data and serum 25-OH vitamin D concentrations in 95 patients attending an outpatient clinic in a tertiary hospital. In a second component of the study, 17 hospital inpatients with severe vitamin D deficiency (serum 25-OH D concentrations<6 ng/mL [15 nmol/L]) were supplemented with 10,000 units vitamin D(3)/day orally for 1 week. Biochemistry and anthropometric measurements were compared before and after vitamin D replacement. Serum 25-OH vitamin D concentrations correlated negatively with BMI in the 95 outpatients (r(2) = 0.11, P <.01). In the longitudinal study, BMI correlated positively with serum intact parathyroid hormone (r(2) = 0.84, P <.01) and negatively with 1.25-(OH)(2) vitamin D (r(2) = 0.19, P=.06) at baseline. Serum 25-OH D concentrations achieved following 1 week of vitamin D(3) replacement correlated negatively with BMI (r(2) = 0.63, P <.01). Efficacy of vitamin D supplementation is dependent on BMI. Overweight and obese patients with hypovitaminosis D might require higher doses of vitamin D to achieve vitamin D repletion compared with in iduals with normal body weight.
University-industry collaboration as a driver of digital transformation: Types, benefits and enablers
Publisher: Elsevier BV
Date: 10-2023
Information sharing in community associations: Asian immigrants' experiences
Publisher: Wiley
Date: 2015
How Many Features Do We Need to Identify Bots on Twitter?
Publisher: Springer Nature Switzerland
Date: 2023
Study of multitasking, cognitive coordination and cognitive shifts in Web search: Preliminary findings
Publisher: Wiley
Date: 2011
How online ratings and trust influence health consumers’ physician selection intentions: An experimental study
Publisher: Elsevier BV
Date: 09-2021
Serum uric acid is associated with bone health in older men: A cross‐sectional population‐based study
Publisher: Wiley
Date: 05-2011
DOI: 10.1002/JBMR.286
Abstract: Serum uric acid (UA) is a strong endogenous antioxidant. Since oxidative stress has been linked to osteoporosis, we examined the association between serum UA levels and bone mineral density (BMD), prevalent vertebral and nonvertebral fractures, and laboratory measures such as calcitropic hormones and bone turnover marker levels. This cross-sectional analysis consisted of 1705 community-dwelling men aged 70 years or over who participated in the baseline part of the Concord Health and Ageing in Men Project (CHAMP), a population-based study of older men in Sydney, Australia. BMD at all sites was significantly higher among men with serum UA levels above the group median than among men with UA levels below the median. In multiple regression analyses adjusted for potential confounders, serum UA remained associated with BMD at all sites (β = 0.12 to 0.14, p < .001), serum calcium (β = 0.11, p = .001), parathyroid hormone (β = 0.09, p = .002), 25-hydroxyvitamin D (β = 0.09, p = .005), and was negatively associated with urinary excretion amino-terminal cross-linked telopeptide of type 1 collagen (β = -0.09, p = .006). Overall, serum UA accounted for 1.0% to 1.44% of the variances in BMD (R(2) = 0.10 to 0.22). In multiple logistic regression analyses, above-median serum UA levels were associated with a lower prevalence of osteoporosis at the femoral neck [odds ratio (OR) = 0.42, 95% confidence interval (CI) 0.22-0.81, p = .010) and lumbar spine (OR = 0.44, 95% CI 0.23-0.86, p = .016) and a lower prevalence of vertebral (OR = 0.62, 95% CI 0.43-0.91, p = .015) and nonvertebral (OR = 0.51, 95% CI 0.29-0.89, p = .018) fractures. In conclusion, higher serum UA levels are associated with higher BMD at all skeletal sites and with a lower prevalence of vertebral and nonvertebral fractures in older men.
Trends and Research of Wikis' Quality and Governance Based on Bibliometric and Content Analysis
Publisher: IGI Global
Date: 2014
DOI: 10.4018/978-1-4666-4892-0.CH008
Abstract: Wiki is a typical representative of the User-Generated Content. Its appearance greatly promotes the creation, organization, management, and sharing of knowledge on the Internet. As articles grow rapidly in Wikis, the quality of the articles has aroused many people’s concerns. The topics on how to assess and control the quality of articles have attracted many researchers. However, few studies have been conducted to investigate the status of this research topic. This chapter explores the current research status and trends of wikis' quality and governance. The authors selected papers from the databases of ISI, EI, IEEE, and other widely used databases. They reported the trends and research of wikis’ quality and governance using bibliometric analysis and content analysis of a total of 99 relevant papers. The results show that although the research topics in the field have experienced a very rapid development, they are still at an early age that lacks theories to support them. The discipline of Library and Information Science was found to play a very active role in this new area. Future research agenda and directions are also discussed.
Factors enabling the use of mobile Internet services by information disadvantaged people
Publisher: IEEE
Date: 10-2016
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