Discovery Projects - Grant ID: DP240101588

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP240101588

Funding Status
Active

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Funded Activity Summary

Hippo signalling control of transcription in lymphatic vascular development. Lymphatic vasculature forms complex, branched networks present in almost all vertebrate tissues and organs. Signalling in lymphatic endothelial cells determines the fate, structure and function of these complex and essential networks. This project follows our recent discovery of a major role for the Hippo signalling pathway in lymphatic vascular development. It aims to investigate how Hippo signalling regulates essential target genes that drive lymphatic development. The project expects to generate fundamental knowledge in vascular signalling, transcription and the control of vascular network growth and expansion. Outcomes may provide significant benefits in new approaches in stem cell biology, tissue engineering and regenerative biology.

Funded Activity Details

Start Date: 2024

End Date: 12-2026

Funding Scheme: Discovery Projects

Funding Amount: $1,042,311.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Developmental genetics (incl. sex determination) | Genetics |

ANZSRC Socio-Economic Objective (SEO)

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