Discovery Projects - Grant ID: DP0210493

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0210493

Funding Status
Closed

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Funded Activity Summary

Gating and permeation in ClC channels. Chloride ion channels are essential proteins in all living cells but, compared to other channels, little is known of their structure or how this defines and controls chloride transport. We will produce both normal and structurally modified (mutant and known to cause disease) chloride channels in cultured cells by genetic engineering so that we can analyse channel function using a combination of electrophysiological and chemical methods. We expect to learn which channel parts are fundamental and how subtle changes in structure can alter the opening and closing of these channels and the way that chloride passes through them.

Funded Activity Details

Start Date: 2002

End Date: 12-2004

Funding Scheme: Discovery Projects

Funding Amount: $141,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Genetic Technologies: Transformation, Site-Directed Mutagenesis, Etc. | Biochemistry and Cell Biology | Membrane Biology | Animal Physiology—Cell

ANZSRC Socio-Economic Objective (SEO)

Biological sciences |

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