Discovery Projects - Grant ID: DP240103259

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP240103259

Funding Status
Active

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Funded Activity Summary

Defining how cells relay mechanical signals to changes in cell architecture. Mechanical signals play crucial roles in shaping organs and entire organisms during development, though how these signals are relayed to changes in cell architecture is a major unanswered question. Within vascular networks, mechanical signals including fluid flow, tension and stretch play key roles in vessel patterning, identity and maturation. This application aims to employ cutting-edge technologies to determine how the atypical cadherin FAT4 relays mechanical signals including flow and tension to the lymphatic endothelial cell skeleton, thereby enabling changes in cell shape important for building lymphatic vessels. This project will increase our understanding of how cells sense touch and may be applied for tissue engineering purposes.

Funded Activity Details

Start Date: 2024

End Date: 12-2026

Funding Scheme: Discovery Projects

Funding Amount: $947,849.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Developmental genetics (incl. sex determination) | Biochemistry and cell biology | Cell development proliferation and death | Signal transduction

ANZSRC Socio-Economic Objective (SEO)

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