Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP150101448
Funding Status
Closed
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Funded Activity Summary
Post-translational control of cell fate decision. Deciphering the multi-layered regulation of cell fate decisions is challenging. While progress has been made in understanding the role of transcriptional regulation, the influence of post-translational modification is poorly understood. Neural precursor cell expressed developmentally down-regulated protein 4 (NEDD4)-mediated ubiquitination is absolute necessary for sex determination, a unique model of cell fate decision where gonadal cell precursors differentiate either along the male or the female pathway. Thus, this project aims to analyse in detail at which stage NEDD4 action is required and what are the crucial target proteins. This project could provide a deeper understanding of how post-translational modifications influence cell fate decisions during embryogenesis.Funded Activity Details
Start Date: 2015
End Date: 12-2017
Funding Scheme: Discovery Projects
Funding Amount: $515,300.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Developmental Genetics (incl. Sex Determination) | Enzymes | Genetics
