Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0449485
Funding Status
Closed
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Funded Activity Summary
Regenerating lizard tails: A model for understanding the process of lymphangiogenesis. In humans, impaired lymphatic drainage in limbs causes the debilitating swelling termed lymphoedema. Lymphoedema affects 500,000,000 people worldwide. In the developed world lymphoedema predominantly results from surgery for cancer, and occurs in approximately 25% of breast cancer patients. We will examine lymph vessel regeneration (lymphangiogenesis) in a naturally regenerating, complex structure (the lizard tail), to describe the regrowth process and determine the abundance, location, functional properties and molecular control of the new lymphatics. Furthermore, if reptilian lymphatic growth factors can promote lymphangiogenesis in mammals, we can design novel therapeutic approaches using reptilian ligands to promote lymphangiogenesis in lymphoedematous human tissues.Funded Activity Details
Start Date: 2004
End Date: 12-2008
Funding Scheme: Discovery Projects
Funding Amount: $240,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Animal Physiology—Systems | Systems Physiology | Physiology | Cardiology (Incl. Cardiovascular Diseases)
ANZSRC Socio-Economic Objective (SEO)
Cardiovascular system and diseases | Treatments (e.g. chemicals, antibiotics) | Biological sciences |
