RCTs on Trial: How Placebo Effects Could Undermine Double-blind RCTs. Double-blind randomised placebo-controlled trials (RCTs) are considered the gold standard for establishing treatment efficacy. However, there are both theoretical and empirical reasons to believe that they do not adequately control for the placebo effect. Cost and ethical considerations prevent researchers conducting actual double-blind RCTs with patients from exploring these issues. To address this gap, this project uses nove ....RCTs on Trial: How Placebo Effects Could Undermine Double-blind RCTs. Double-blind randomised placebo-controlled trials (RCTs) are considered the gold standard for establishing treatment efficacy. However, there are both theoretical and empirical reasons to believe that they do not adequately control for the placebo effect. Cost and ethical considerations prevent researchers conducting actual double-blind RCTs with patients from exploring these issues. To address this gap, this project uses novel experimental models to systematically test key aspects of the double-blind RCT methodology that are intended to control for the placebo effect. The project aims to provide essential data on the validity of these trials, thereby improving Australia's health and ensuring that Government treatment subsidies are well spent.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100471
Funder
Australian Research Council
Funding Amount
$354,171.00
Summary
Expecting the worst: psychosocial contributors to the nocebo effect. This project aims to propose and test a new model of the nocebo effect, a powerful psychological phenomenon in which negative expectations are thought to cause unpleasant or harmful side effects following an inert treatment. Nocebo effects can lead to treatment non-adherence, unnecessary GP visits, reduced quality of life, and increased health costs. Understanding how nocebo effects are formed will assist in the development of ....Expecting the worst: psychosocial contributors to the nocebo effect. This project aims to propose and test a new model of the nocebo effect, a powerful psychological phenomenon in which negative expectations are thought to cause unpleasant or harmful side effects following an inert treatment. Nocebo effects can lead to treatment non-adherence, unnecessary GP visits, reduced quality of life, and increased health costs. Understanding how nocebo effects are formed will assist in the development of strategies to minimise their occurrence with will benefit both individuals and the health system.Read moreRead less
A social cure: how multiple social groups are key to health and wellbeing. Building on the increased recognition that social factors affect both mental and physical health, the research will examine how and when social identities and group membership determine wellbeing. The work is at the forefront of current societal concerns relating to coping with social disadvantage and life-transitions.
The nature and consequences of interruptions and multi-tasking. This project aims to generate new evidence of the nature and consequences of interruptions and multitasking in safety-critical clinical environments. Interruptions are ubiquitous in modern work environments. Multitasking, particularly with information technology, is now an attribute prized by many. However, there are increasing concerns that interruptions and multitasking contribute to errors and work inefficiency. Significant gaps ....The nature and consequences of interruptions and multi-tasking. This project aims to generate new evidence of the nature and consequences of interruptions and multitasking in safety-critical clinical environments. Interruptions are ubiquitous in modern work environments. Multitasking, particularly with information technology, is now an attribute prized by many. However, there are increasing concerns that interruptions and multitasking contribute to errors and work inefficiency. Significant gaps in our understanding of these relationships inhibit action to improve work productivity and safety. This project plans to measure the effects of these work practices, and to develop methods, statistical approaches and theory. It also plans to propose practical strategies to support safe and efficient work processes.Read moreRead less
The regulation of desire by bodily state. Many experiences, like food, wine and sex, are pleasurable. These experiences are also desired, but less so when sated. The aim of this proposal is to understand how satiation regulates desire. We propose two memory-based models, and test them using several new experimental approaches. This is significant, not only because poorly regulated desire is linked to many social and economic ills (e.g., over-eating), but also because it is a key part of huma ....The regulation of desire by bodily state. Many experiences, like food, wine and sex, are pleasurable. These experiences are also desired, but less so when sated. The aim of this proposal is to understand how satiation regulates desire. We propose two memory-based models, and test them using several new experimental approaches. This is significant, not only because poorly regulated desire is linked to many social and economic ills (e.g., over-eating), but also because it is a key part of human motivation that is poorly understood. The expected outcome is a new theoretical model of how memory processes interact with bodily signals to generate both sated states and desire. The benefits include a new understanding of how desire is regulated and how and why this might break down.Read moreRead less
Creating new methods to study structure vision. The majority of the structure within natural images is due to third to fifth order correlations between image points. Research has shown that sensitivity to this higher order structure, provides so called Structure Vision. Research has also shown that as few as three to four brain mechanisms are involved, and these may be related to the Minkowski functionals, which in turn are related to the structural and surface properties of real materials. This ....Creating new methods to study structure vision. The majority of the structure within natural images is due to third to fifth order correlations between image points. Research has shown that sensitivity to this higher order structure, provides so called Structure Vision. Research has also shown that as few as three to four brain mechanisms are involved, and these may be related to the Minkowski functionals, which in turn are related to the structural and surface properties of real materials. This project aims to build on recent discoveries of new stimuli to implement objective tests with which to study structure vision with the Partner Organisation. The project aims to also expand on realistic models of how Structure Vision may be computed by just a few coupled cortical pyramidal cells.Read moreRead less
To focus on pain or not to focus: WHEN is the question. The experience of pain is a ubiquitous experience, and persistent pain is common and causes enormous personal and
societal burden. Anyone who has been in severe pain will understand that pain captures attention, but the role that attention plays in
increasing pain perception is poorly understood. This project will test a new conceptual model that calls for a change in the paradigm underlying research into attention and pain. We will use nov ....To focus on pain or not to focus: WHEN is the question. The experience of pain is a ubiquitous experience, and persistent pain is common and causes enormous personal and
societal burden. Anyone who has been in severe pain will understand that pain captures attention, but the role that attention plays in
increasing pain perception is poorly understood. This project will test a new conceptual model that calls for a change in the paradigm underlying research into attention and pain. We will use novel experimental tasks in virtual reality environments to address
these important gaps in our knowledge. The project will significantly advance our fundamental understanding of
the role of attention in pain perception and pave the way for translational research to reduce the substantial burden pain causes.Read moreRead less
Transformations in Human Visual Cortex - from Neural Input to Recognition. Human behaviour is dominated by the visual system. This project proposes to trace the M, P, K neural systems isolated through Red/Green, Blue/Yellow and luminance stimuli to investigate processing for percepts of and attention to colour, motion and form in neurotypical humans. Nonlinear magnetoencephalography (MEG) is intended to provide the temporal structure of the different neural streams that feed these percepts. MEG ....Transformations in Human Visual Cortex - from Neural Input to Recognition. Human behaviour is dominated by the visual system. This project proposes to trace the M, P, K neural systems isolated through Red/Green, Blue/Yellow and luminance stimuli to investigate processing for percepts of and attention to colour, motion and form in neurotypical humans. Nonlinear magnetoencephalography (MEG) is intended to provide the temporal structure of the different neural streams that feed these percepts. MEG based population receptive field analysis from virtual electrodes, will provide information about cortical feedback. A new theory of perception is expected to emerge, incorporating connections with contextual and top-down cognitive processes, furthering basic understanding.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100864
Funder
Australian Research Council
Funding Amount
$382,536.00
Summary
Something from nothing: how placebo effects are formed and maintained. This project seeks to develop and experimentally test a new model of placebo effects that will unpack how expectancy, control, and conditioning combine to produce placebo effects. The placebo effect is a fascinating and important psychological phenomenon whereby improvement occurs following a sham treatment. Despite considerable evidence for placebo effects across various health, sporting, and educational outcomes, exactly ho ....Something from nothing: how placebo effects are formed and maintained. This project seeks to develop and experimentally test a new model of placebo effects that will unpack how expectancy, control, and conditioning combine to produce placebo effects. The placebo effect is a fascinating and important psychological phenomenon whereby improvement occurs following a sham treatment. Despite considerable evidence for placebo effects across various health, sporting, and educational outcomes, exactly how these effects are formed and maintained remains unclear. Greater understanding of the placebo effect would enable us to accurately evaluate health, educational, and sporting interventions and would facilitate the development of interventions that harness the placebo effect to improve outcomes.Read moreRead less
Creating new methods to study structure vision. The majority of the structure within natural images is due to third to fifth order correlations between image points. Research has shown that sensitivity to this higher order structure, provides so called Structure Vision. Research has also shown that as few as three to four brain mechanisms are involved, and these may be related to the Minkowski functionals, which in turn are related to the structural and surface properties of real materials. This ....Creating new methods to study structure vision. The majority of the structure within natural images is due to third to fifth order correlations between image points. Research has shown that sensitivity to this higher order structure, provides so called Structure Vision. Research has also shown that as few as three to four brain mechanisms are involved, and these may be related to the Minkowski functionals, which in turn are related to the structural and surface properties of real materials. This project aims to build on recent discoveries of new stimuli to implement objective tests with which to study structure vision with the Partner Organisation. The project aims to also expand on realistic models of how Structure Vision may be computed by just a few coupled cortical pyramidal cells.Read moreRead less