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Evaluation of peanuts as a source of bioactive nutrients for enhancement of endothelial function and cognitive performance. Functional foods represent one of the fastest growing food markets in the world, particularly foods which can offset adverse health conditions. The Partner Organisation, Peanut Company of Australia (PCA), is committed to developing peanut varieties, such as the high oleic peanut, that are nutritionally superior to the traditional varieties. By investing in research PCA aims ....Evaluation of peanuts as a source of bioactive nutrients for enhancement of endothelial function and cognitive performance. Functional foods represent one of the fastest growing food markets in the world, particularly foods which can offset adverse health conditions. The Partner Organisation, Peanut Company of Australia (PCA), is committed to developing peanut varieties, such as the high oleic peanut, that are nutritionally superior to the traditional varieties. By investing in research PCA aims to substantiate the nutritional benefits of these products and position itself in functional foods. Scientific evaluation of the health benefits that can be derived from consuming foods will enhance the national food industry through the growth of domestic and international licensing and export markets, and provide new employment opportunities in both rural and manufacturing sectors.Read moreRead less
The impact of motherhood on fear extinction in rats. This project aims to identify how motherhood, a time of significant hormonal flux, alters the mechanisms underlying fear regulation in female rats. Current theories of fear regulation are limited because they have been derived from studies that have focused on males but recent work suggests that sex hormones influence fear regulation. The expected outcomes of this project will help to develop a more ecologically valid model of fear regulation ....The impact of motherhood on fear extinction in rats. This project aims to identify how motherhood, a time of significant hormonal flux, alters the mechanisms underlying fear regulation in female rats. Current theories of fear regulation are limited because they have been derived from studies that have focused on males but recent work suggests that sex hormones influence fear regulation. The expected outcomes of this project will help to develop a more ecologically valid model of fear regulation that accounts for fluctuations in female sex hormones and reproductive experience. This should provide unique insights into fear reduction and protection against anxiety.Read moreRead less
Mapping the learning mechanisms linking adversity with maladjustment. Exposure to adversity, such as violence, neglect and natural disasters, is common and a powerful risk factor for emotional maladjustment. Yet knowledge of the underlying mechanisms linking adversity with emotional maladjustment is remarkably limited. By drawing from theories of adversity and learning and utilising novel experimental methodology, this project aims to map how adverse experiences have different negative effects o ....Mapping the learning mechanisms linking adversity with maladjustment. Exposure to adversity, such as violence, neglect and natural disasters, is common and a powerful risk factor for emotional maladjustment. Yet knowledge of the underlying mechanisms linking adversity with emotional maladjustment is remarkably limited. By drawing from theories of adversity and learning and utilising novel experimental methodology, this project aims to map how adverse experiences have different negative effects on daily emotional wellbeing by disrupting the mechanisms underlying how people learn to acquire and reduce reactivity to new threats. Expected benefits include new knowledge about the pathways linking adversity with psychopathology as well as the vital evidence-base for clear targets for behavioural interventions. Read moreRead less
Attentional asymmetries for navigation in healthy and clinical groups. This project plans to investigate how differences in attentional capacity between the left and right sides of the brain affect the ability to walk or manoeuvre vehicles between obstacles. To navigate our environment and avoid obstacles, we need to attend to stimuli that are important and ignore those that are not. Unfortunately, the brain’s attentional capacity is limited, which can result in errors and collisions. Using the ....Attentional asymmetries for navigation in healthy and clinical groups. This project plans to investigate how differences in attentional capacity between the left and right sides of the brain affect the ability to walk or manoeuvre vehicles between obstacles. To navigate our environment and avoid obstacles, we need to attend to stimuli that are important and ignore those that are not. Unfortunately, the brain’s attentional capacity is limited, which can result in errors and collisions. Using the techniques of cognitive neuroscience, the project aims to provide a better understanding of the cognitive and neural mechanisms that govern attention in an applied setting. It expects to identify the factors that exacerbate lapses in attention and collisions. The effect of everyday impediments such as mobile phones, alcohol and fatigue will be investigated together with means of minimising these attentional lapses and improving safety.Read moreRead less
Cannabis and the brain: the good, the bad and the unknown. Cannabis is the most widely used illicit drug but much remains unknown about how it affects the brain. This research will examine effects on brain cells through to whole brain function in humans to determine how cannabis use may lead to impaired thinking or psychological symptoms and why cannabis might affect individuals in different ways.
The causes of intrusive memories. Intrusive memories are pivotal to many psychological disorders. This project will extend current models of intrusive memories by integrating biological, cognitive, and neural measures to specify the causes of these memories.
Memory consolidation - Integrating cognitive science and neuroscience approaches to how we remember and how we forget. How can we forget what happened yesterday, but vividly remember our first kiss? Neuroscientists think the brain has a special mechanism to strengthen memories with time, but many psychologists disagree. The project aims to bring the brain and the mind closer together, using the cutting-edge combination of brain imaging and psychological modelling.
Testing theoretical models of age and disease related changes to inform prevention. Pathological brain changes associated with future cognitive decline become detectable in the 40s or earlier. Yet little is known about what constitutes normal brain ageing in mid-life. Using a number of neuroimaging and epidemiological techniques this project will scrutinise brain and cognitive ageing in middle-age and their significance.
Placing prediction into the fear circuit. How do we predict danger in our world? This project will identify the psychological mechanisms and brain pathways that allow us to learn to fear and to also overcome fear when it becomes pathological.
Discovery Early Career Researcher Award - Grant ID: DE140100588
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Gene-environment interactions in the regulation of neuroplasticity and cognitive function . This project will study the effects of different housing conditions on neuroplasticity-related cognitive function by combining an innovative operant conditioning behavioural test (computerised touch-screen technology) and new molecular approaches. Potential gene-environment interactions will be revealed using genetically targeted mice which have never been assessed in that context (mutants with altered gl ....Gene-environment interactions in the regulation of neuroplasticity and cognitive function . This project will study the effects of different housing conditions on neuroplasticity-related cognitive function by combining an innovative operant conditioning behavioural test (computerised touch-screen technology) and new molecular approaches. Potential gene-environment interactions will be revealed using genetically targeted mice which have never been assessed in that context (mutants with altered glucocorticoid and serotonin signalling). This project will study whether specific stages of the neuroplasticity process are differentially modulated through gene-environment interactions, ultimately resulting in changes to behaviour and cognitive functions. This will lead to a better understanding of the potential approaches that could be used to improve cognitive function.Read moreRead less