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How does dopamine modulate adult new word learning? Stroke is a chronic disease of increasing prevalence with increasing age. There is a critical need to develop more effective treatments of communication disorders in this population. One way of achieving this is to combine certain drugs with language therapy. Through studying how these drugs influence language, this research will provide vital knowledge for developing effective forms of pharmacotherapy for adults with language disorders after b ....How does dopamine modulate adult new word learning? Stroke is a chronic disease of increasing prevalence with increasing age. There is a critical need to develop more effective treatments of communication disorders in this population. One way of achieving this is to combine certain drugs with language therapy. Through studying how these drugs influence language, this research will provide vital knowledge for developing effective forms of pharmacotherapy for adults with language disorders after brain injury. More effective language rehabilitation can have direct positive consequences on the ability to regain and maintain employment and social relationships after stroke or brain injury and will address the large and growing social and economic cost to the nation.Read moreRead less
A functional imaging study of semantic processing modulated by dopamine. The role of dopamine in language processing is largely unknown, despite emerging evidence that dopaminergic alterations can modulate language in schizophrenia, Parkinson's disease, and healthy individuals. The research aims to reveal the neural and behavioural correlates of dopaminergic modulation of semantic processing using neuroimaging in healthy individuals who have ingested levodopa. It is hypothesised that levodopa wi ....A functional imaging study of semantic processing modulated by dopamine. The role of dopamine in language processing is largely unknown, despite emerging evidence that dopaminergic alterations can modulate language in schizophrenia, Parkinson's disease, and healthy individuals. The research aims to reveal the neural and behavioural correlates of dopaminergic modulation of semantic processing using neuroimaging in healthy individuals who have ingested levodopa. It is hypothesised that levodopa will modulate brain activity under circumstances where there is heightened semantic competition, consistent with a contemporary theory of dopaminergic cognitive control. The expected outcome of the research is an increased understanding of the interactions between dopamine, the language faculty, and associated neural systems.Read moreRead less
The ingredients of conscious identification. Research from a variety of psychological domains indicates that a lot of mental processing goes on unconsciously, but that we are only generally aware of a small fraction of the information delivered by our senses. This research will provide new insights into the cognitive and neural mechanisms underlying our conscious and unconscious identification of visual stimuli and will lead to a better understanding of the limitations we are likely to experienc ....The ingredients of conscious identification. Research from a variety of psychological domains indicates that a lot of mental processing goes on unconsciously, but that we are only generally aware of a small fraction of the information delivered by our senses. This research will provide new insights into the cognitive and neural mechanisms underlying our conscious and unconscious identification of visual stimuli and will lead to a better understanding of the limitations we are likely to experience under conditions which make different demands on our perception, attention and the need to remember the relevant information. The results will also inform assessment and remediation of neurological conditions such as stroke and dementia.Read moreRead less
Phenotypic differences in behaviour, brain function and structure of genetically dissimilar forms of intellectual disability. How is the brain of someone with intellectual disability different from that of a normal person? Are behavioural phenotypes such as intellectual disability more related to similarities in brain structure and function than to the genotypic anomaly? This project will use neuroscience techniques of psychophysics, electrophysiology and fMRI to probe these questions. The ben ....Phenotypic differences in behaviour, brain function and structure of genetically dissimilar forms of intellectual disability. How is the brain of someone with intellectual disability different from that of a normal person? Are behavioural phenotypes such as intellectual disability more related to similarities in brain structure and function than to the genotypic anomaly? This project will use neuroscience techniques of psychophysics, electrophysiology and fMRI to probe these questions. The benefit of this project is that cortical flattening fMRI techniques together with new and efficient stimulus paradigms will result in a functional landmark mapping tool capable of application to many other brain genotype-phenotype questions. Also, the functional brain basis of intellectual disability will be further revealed.Read moreRead less
Processing of social communication calls in primate auditory cortex. This research will advance our understanding of the brain mechanisms involved in perception of sound. This will help to understand disorders of speech and hearing following brain damage and may assist in efforts to develop better hearing aids, as well as other speech recognition technologies. In addition, we will develop a primate for studying processing of sound in the brain that will be useful in future research to develop ....Processing of social communication calls in primate auditory cortex. This research will advance our understanding of the brain mechanisms involved in perception of sound. This will help to understand disorders of speech and hearing following brain damage and may assist in efforts to develop better hearing aids, as well as other speech recognition technologies. In addition, we will develop a primate for studying processing of sound in the brain that will be useful in future research to develop improved cochlear implants.Read moreRead less
Elucidating the neurobiological basis for developmental stuttering using modern brain imaging techniques. We plan to untilise brain imaging techniques to examine the neurological underpinnings of stuttering. We aim to develop new tools for functional magnetic resonance imaging (fMRI) to examine the patterns of brain activation in the motor, speech and language areas, specifically for use in children who stutter. We aim to answer the question of whether stuttering is a motor-speech or a language ....Elucidating the neurobiological basis for developmental stuttering using modern brain imaging techniques. We plan to untilise brain imaging techniques to examine the neurological underpinnings of stuttering. We aim to develop new tools for functional magnetic resonance imaging (fMRI) to examine the patterns of brain activation in the motor, speech and language areas, specifically for use in children who stutter. We aim to answer the question of whether stuttering is a motor-speech or a language disorder and to establish whether variations in the speech and language regions of the brain found in adult stuttering research are also present in children who stutter, and to explore the possibility that different variations in brain activation and/or morphology may predict persistence and recovery.
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Biomarkers and objective assessment of cognitive and brain effects of fish oil dietary supplementation. There are potential widespread community benefits from knowing whether consuming fish oils will improve cognitive function. This is mainfest in children and even more so in those suffering attention deficits at a time when inattention and hyperacitvity is likely to permanently lower their overall career prospects.
The Ins and Outs of the Central Bottleneck. Humans display severe capacity limitations at multiple levels of information processing. When considering, with modern technological advances, the amount of multitasking one is called upon to do in every day life (e.g., talking on a hands-free mobile phone device and driving) it is vital to understand what stages of information processing interfere with one another. The present work will extend our knowledge regarding which cognitive operations can be ....The Ins and Outs of the Central Bottleneck. Humans display severe capacity limitations at multiple levels of information processing. When considering, with modern technological advances, the amount of multitasking one is called upon to do in every day life (e.g., talking on a hands-free mobile phone device and driving) it is vital to understand what stages of information processing interfere with one another. The present work will extend our knowledge regarding which cognitive operations can be performed concurrently without impairment. In addition, it will help us better understand processing limitations that have been linked to a variety of clinical groups such as those suffering from schizophrenia and mood disorders.Read moreRead less
How the brain produces speech. Speech production is a fundamental ability that enables human interaction through language. Brain injuries impair this ability, with profound negative consequences for the individual and their immediate family and friends. This project will increase our understanding of the brain mechanisms involved in producing speech by using state-of-the-art brain imaging techniques. The findings will inform future clinical research and improve the advice given to clinicians, pa ....How the brain produces speech. Speech production is a fundamental ability that enables human interaction through language. Brain injuries impair this ability, with profound negative consequences for the individual and their immediate family and friends. This project will increase our understanding of the brain mechanisms involved in producing speech by using state-of-the-art brain imaging techniques. The findings will inform future clinical research and improve the advice given to clinicians, patients and the broader community about the nature of language production and its impairments and ultimately the treatment of speech disorders.Read moreRead less
Seeing the forest and the trees: Cognitive and neural mechanisms underlying recognition of individual objects and sets. When confronted with a set of similar objects, such as a crowd of faces or a flow of oncoming cars, human observers can rapidly and seemingly automatically extract summary statistics of these sets of objects (e.g., mean expression or location). This research will provide insights into how the human visual system executes this massive feat of computation. This represents a vital ....Seeing the forest and the trees: Cognitive and neural mechanisms underlying recognition of individual objects and sets. When confronted with a set of similar objects, such as a crowd of faces or a flow of oncoming cars, human observers can rapidly and seemingly automatically extract summary statistics of these sets of objects (e.g., mean expression or location). This research will provide insights into how the human visual system executes this massive feat of computation. This represents a vital step in understanding vision in general and in eventually applying our knowledge to the development of artificial vision systems and to rehabilitation of visual disorders. The research will also investigate the effects of attentional load on perception of summary statistics of the environment, which is critical for tasks such as driving in busy traffic.Read moreRead less