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Flavour learning and food consumption in rats and humans: Implications for obesity. Between-meal snacks and sweet drinks are major contributors to human obesity. Consumption of a food is greatly influenced by its flavour and the properties of flavours are largely learned. This project examines how what is learned about a flavour influences both short-term and long-term food consumption by rats and humans. Short-term effects are studied by adding a flavour to a pre-meal (snack) and measuring how ....Flavour learning and food consumption in rats and humans: Implications for obesity. Between-meal snacks and sweet drinks are major contributors to human obesity. Consumption of a food is greatly influenced by its flavour and the properties of flavours are largely learned. This project examines how what is learned about a flavour influences both short-term and long-term food consumption by rats and humans. Short-term effects are studied by adding a flavour to a pre-meal (snack) and measuring how much is eaten in a subsequent meal. Long-term effects are studied when the value of sweetness is altered by exposure to non-nutritive sweeteners. The results will extend basic understanding of flavour learning in relation to obesity.Read moreRead less
Determining the role of disease avoidance in stigmatisation. The aim of this project is to test a disease avoidance model of stigmatisation. Stigmatisation is characterised by chronic avoidance of a person(s) by other people. Infectious disease may produce an apparently similar form of isolation—disease avoidance. This project proposes that many forms of stigmatisation reflect the activation of this disease avoidance system, which is predisposed to respond to signs of disease, irrespective of th ....Determining the role of disease avoidance in stigmatisation. The aim of this project is to test a disease avoidance model of stigmatisation. Stigmatisation is characterised by chronic avoidance of a person(s) by other people. Infectious disease may produce an apparently similar form of isolation—disease avoidance. This project proposes that many forms of stigmatisation reflect the activation of this disease avoidance system, which is predisposed to respond to signs of disease, irrespective of their accuracy. This will represent a significant shift in thinking about this issue and aims to provide the first empirically based model of stigmatisation as an evolved disposition that causes the exclusion of people who look like they may carry an infectious disease - even if they do not.Read moreRead less
Cannabis and the brain: the good, the bad and the unknown. Cannabis is the most widely used illicit drug but much remains unknown about how it affects the brain. This research will examine effects on brain cells through to whole brain function in humans to determine how cannabis use may lead to impaired thinking or psychological symptoms and why cannabis might affect individuals in different ways.
The development of the social brain in early childhood. This project aims to understand how the human brain develops social and emotional understanding. The brain has remarkable abilities for understanding our social environment, such as inferring other people’s thoughts and feelings. This project will use neuroscience techniques to investigate how brain networks combine to produce social understanding, how this changes throughout child development, and how it relates to complex social behaviour ....The development of the social brain in early childhood. This project aims to understand how the human brain develops social and emotional understanding. The brain has remarkable abilities for understanding our social environment, such as inferring other people’s thoughts and feelings. This project will use neuroscience techniques to investigate how brain networks combine to produce social understanding, how this changes throughout child development, and how it relates to complex social behaviours. This project’s findings could be used to develop educational programmes that enhance empathy and co-operation, strengthen family relationships, promote social inclusion and reduce maladaptive behaviours. It could also guide intervention in brain disorders that affect social understanding.Read moreRead less
Motor control of the upper airway muscle genioglossus. This project aims to evaluate a recent proposal about the motor control of the upper airway muscle Genioglossus. The upper airway muscles, the most complex in the human body, are critical for breathing and speaking, but are not well understood. Genioglossus draws the base of the tongue forward to maintain airway patency. This project will study genioglossus during wakefulness and sleep in normal healthy individuals. It is anticipated that th ....Motor control of the upper airway muscle genioglossus. This project aims to evaluate a recent proposal about the motor control of the upper airway muscle Genioglossus. The upper airway muscles, the most complex in the human body, are critical for breathing and speaking, but are not well understood. Genioglossus draws the base of the tongue forward to maintain airway patency. This project will study genioglossus during wakefulness and sleep in normal healthy individuals. It is anticipated that the project will suggest improved avenues for treatment of sleep related respiratory disorders.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100012
Funder
Australian Research Council
Funding Amount
$414,570.00
Summary
All-optical manipulation and recording of neural circuit activity. This project aims to establish all-optical approaches to image and manipulate neural function at single cell resolution in the awake, freely moving animal. The project will help build a 'cells to systems' understanding of neural circuit function and aid in understanding neural circuit dysregulation in brain disorders. This will enable new, fundamental knowledge creation about brain function, and lay a basic science platform for t ....All-optical manipulation and recording of neural circuit activity. This project aims to establish all-optical approaches to image and manipulate neural function at single cell resolution in the awake, freely moving animal. The project will help build a 'cells to systems' understanding of neural circuit function and aid in understanding neural circuit dysregulation in brain disorders. This will enable new, fundamental knowledge creation about brain function, and lay a basic science platform for the next generation of understanding of brain disorders, critical to reducing their economic burden.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120100235
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
A novel approach to modelling nicotine dependence in the rat. With repeated exposure, tobacco smoking can rapidly develop into a habit. How this happens is poorly understood. This project will model the changes to the brain and behaviour of rats during the development of nicotine-seeking habits with a view to better understanding how to reduce tobacco dependence.
Understanding the physiological changes accompanying arousal from sleep. This project aims to investigate neural memory in upper airway dilator muscles. Following brief awakening from sleep (arousal), upper airway dilator muscle activity is elevated for 20–30 seconds despite inhibitory stimuli being present. The cause for the elevated activity is unknown. This project aims to investigate whether a form of neural memory contributes to the elevated activity. It expects to demonstrate that arousal ....Understanding the physiological changes accompanying arousal from sleep. This project aims to investigate neural memory in upper airway dilator muscles. Following brief awakening from sleep (arousal), upper airway dilator muscle activity is elevated for 20–30 seconds despite inhibitory stimuli being present. The cause for the elevated activity is unknown. This project aims to investigate whether a form of neural memory contributes to the elevated activity. It expects to demonstrate that arousal can induce a neural memory that is not inhibited by usual stimuli. The findings are expected to increase our understanding of normal human functioning but may also have implications for conditions where upper airway muscles are important such as dysphagia, sleep apnea and numerous other sleep disorders.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101097
Funder
Australian Research Council
Funding Amount
$395,127.00
Summary
Treatment-induced compulsive behaviours: Ethical and policy implications. Compulsive behaviours represent one of the largest preventable burdens in society. Some medications, such as those used to treat Parkinson's disease, can produce severe compulsions in certain individuals, which are akin to addiction. This project will explore: neurocognitive changes caused by these medications; the impact that drug-induced compulsive behaviours have on affected individuals, their sense of agency, identity ....Treatment-induced compulsive behaviours: Ethical and policy implications. Compulsive behaviours represent one of the largest preventable burdens in society. Some medications, such as those used to treat Parkinson's disease, can produce severe compulsions in certain individuals, which are akin to addiction. This project will explore: neurocognitive changes caused by these medications; the impact that drug-induced compulsive behaviours have on affected individuals, their sense of agency, identity and moral responsibility; and the ethical, legal and policy consequences of drug-induced behaviour. This project will help us to understand the neuropsychology of compulsive behaviour and reduce its occurrence. It will also enable society to meet the ethical and policy challenges raised by neuroscience research on compulsive behaviour.Read moreRead less
Withdrawal and relapse to sugar drinks. This project aims to understand whether damage caused by excessive consumption of sugar can be recovered. This project will study whether removal is enough to reverse the damage induced by excess sugar consumption. This project will conduct experiments to measure the behavioural and metabolic outcomes that accompany withdrawal from and relapse to sugar-sweetened beverages. The results will increase understanding of the extent to which damage caused by exce ....Withdrawal and relapse to sugar drinks. This project aims to understand whether damage caused by excessive consumption of sugar can be recovered. This project will study whether removal is enough to reverse the damage induced by excess sugar consumption. This project will conduct experiments to measure the behavioural and metabolic outcomes that accompany withdrawal from and relapse to sugar-sweetened beverages. The results will increase understanding of the extent to which damage caused by excessive consumption of sugar can be reversed.Read moreRead less