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How satiation control reward value and cue-induced appetitive behaviours. This proposal aims to identify mechanisms that control environment-driven food-seeking behaviours. It seeks to do so by using modern virally-mediated and basic behavioural as well as histological techniques in a transgenic rat to characterise novel hindbrain circuits that control these feeding behaviours. This is significant as environment-driven overeating is problematic yet underlying mechanisms are unclear. This project ....How satiation control reward value and cue-induced appetitive behaviours. This proposal aims to identify mechanisms that control environment-driven food-seeking behaviours. It seeks to do so by using modern virally-mediated and basic behavioural as well as histological techniques in a transgenic rat to characterise novel hindbrain circuits that control these feeding behaviours. This is significant as environment-driven overeating is problematic yet underlying mechanisms are unclear. This project expects to provide new knowledge on when, where and how hindbrain neurons control environment-driven food-seeking behaviours. This should provide benefits to the advancement of knowledge on the neural mechanisms of food-seeking and provide a basic science platform for future research on the study of feeding behaviours.
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A comprehensive framework for modelling the human connectome. The human brain is an extraordinarily complex network of interconnected cells. This project aims to use mathematical modelling and brain imaging to uncover key principles of network wiring in the human brain. Using an interdisciplinary approach that combines elements of neuroscience, genetics, physics, and psychology, the project will result in a new, rigorous framework for testing competing theories of brain development, the identifi ....A comprehensive framework for modelling the human connectome. The human brain is an extraordinarily complex network of interconnected cells. This project aims to use mathematical modelling and brain imaging to uncover key principles of network wiring in the human brain. Using an interdisciplinary approach that combines elements of neuroscience, genetics, physics, and psychology, the project will result in a new, rigorous framework for testing competing theories of brain development, the identification of key wiring principles for developing brains, and an understanding of how these principles shape behaviour. This work will shed new light on the developmental processes that underlie human behaviour and disease.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220101087
Funder
Australian Research Council
Funding Amount
$453,580.00
Summary
Impact of shift work on emergency performance, decision making and stress. Sleep and circadian disruptions due to shift work are common for emergency personnel, but their impact on team performance and decision making is poorly understood. Using an ecologically relevant simulated work environment, this project aims to examine how shift work influences work performance and team decision making and identify potential stress-related mechanisms that may underpin impairments in these outcomes. By und ....Impact of shift work on emergency performance, decision making and stress. Sleep and circadian disruptions due to shift work are common for emergency personnel, but their impact on team performance and decision making is poorly understood. Using an ecologically relevant simulated work environment, this project aims to examine how shift work influences work performance and team decision making and identify potential stress-related mechanisms that may underpin impairments in these outcomes. By understanding the role poor sleep and circadian misalignment due to shift work play on work performance, this project will inform industry practices and training approaches designed to optimise workplace safety and emergency performance. This project will benefit emergency personnel and the people who depend on these services.Read moreRead less
How brain oscillations influence our behaviour. This project aims to reveal how sudden, intense stimuli impair or facilitate concurrent actions. Startling sounds can disrupt the execution of movements and distract attention from vital events in the environment, with potential disastrous consequences when handling complex equipment such as airplanes, cars and trucks, or surgical instruments. This project will combine classic experimental and novel neuro-modulatory techniques with the measurement ....How brain oscillations influence our behaviour. This project aims to reveal how sudden, intense stimuli impair or facilitate concurrent actions. Startling sounds can disrupt the execution of movements and distract attention from vital events in the environment, with potential disastrous consequences when handling complex equipment such as airplanes, cars and trucks, or surgical instruments. This project will combine classic experimental and novel neuro-modulatory techniques with the measurement of oscillatory brain activity. Expect outcomes will inform theories of cognitive function and the design of interventions to reduce the negative effects of sudden, distracting events.Read moreRead less
Evaluative learning: do all roads lead to Rome? This project aims to enhance understanding of how likes and dislikes are acquired and changed across a range of different settings. Evaluative learning, the acquisition and change of likes and dislikes, is ubiquitous and occurs in situations that range from trivial to traumatic. However, it is unknown whether evaluative learning in these different situations is mediated by a single or distinct learning mechanisms. Answering this question is critica ....Evaluative learning: do all roads lead to Rome? This project aims to enhance understanding of how likes and dislikes are acquired and changed across a range of different settings. Evaluative learning, the acquisition and change of likes and dislikes, is ubiquitous and occurs in situations that range from trivial to traumatic. However, it is unknown whether evaluative learning in these different situations is mediated by a single or distinct learning mechanisms. Answering this question is critically important for emotion science and the design of effective interventions for anxiety disorders and public health campaigns. The expected outcomes from this project will provide significant benefits, such as creating new knowledge to assist in applied areas ranging from the design of public health messages to the treatment for anxiety.Read moreRead less
How the brain produces speech: Neuronal oscillations to neuromodulation. Speech is crucial for facilitating human communication through language, yet there is a lack of clarity about where, when and what type of activity occurs in the brain during key stages of production. This project will use intracranial recordings to characterise neuronal oscillations in combination with direct electrical stimulation, functional neuroimaging and non-invasive brain stimulation to establish critical areas and ....How the brain produces speech: Neuronal oscillations to neuromodulation. Speech is crucial for facilitating human communication through language, yet there is a lack of clarity about where, when and what type of activity occurs in the brain during key stages of production. This project will use intracranial recordings to characterise neuronal oscillations in combination with direct electrical stimulation, functional neuroimaging and non-invasive brain stimulation to establish critical areas and their timecourses with millisecond resolution. The outcome will be a better theoretical account of the brain mechanisms involved in spoken production. The benefit of this new theoretical account will be a better basis for prevention of post-surgical language impairment and neuromodulatory treatments after brain injury.Read moreRead less
The emotional face: What determines preferential expression processing. The processing of facial expressions of emotion is essential for successful social functioning. However, we still lack a good understanding of key factors that facilitate or impede the processing of these important social signals. The current project aims to address this knowledge gap by providing a) a more rigorous test of the currently dominant account of expression processing, the evaluative congruence account, and deline ....The emotional face: What determines preferential expression processing. The processing of facial expressions of emotion is essential for successful social functioning. However, we still lack a good understanding of key factors that facilitate or impede the processing of these important social signals. The current project aims to address this knowledge gap by providing a) a more rigorous test of the currently dominant account of expression processing, the evaluative congruence account, and delineating how b) contextual factors and c) person knowledge affect expression processing. The research aims to advance our understanding of facial expression processing, to build international collaborations, and to train the next generation of emotion scientists.Read moreRead less
A more sound approach to the neurobiology of language. How does the brain attain spoken language? Current neurobiological models assume either implicitly or explicitly that there is no relationship between a word's sound and its meaning. Yet considerable evidence shows this strong assumption about the arbitrariness of language is invalid. This project will use a combination of behavioural, neuroimaging and computational studies to characterise how the brain processes statistical regularities in ....A more sound approach to the neurobiology of language. How does the brain attain spoken language? Current neurobiological models assume either implicitly or explicitly that there is no relationship between a word's sound and its meaning. Yet considerable evidence shows this strong assumption about the arbitrariness of language is invalid. This project will use a combination of behavioural, neuroimaging and computational studies to characterise how the brain processes statistical regularities in sound-to-meaning correspondences as probabilistic cues to attain spoken language. The outcome will be a better neural account of language comprehension and production. The benefit of this new account will be a stronger basis for assessment and treatment of developmental and acquired language impairments.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190101244
Funder
Australian Research Council
Funding Amount
$342,411.00
Summary
Unravelling the relationship between food and the brain. This project aims to investigate how highly palatable foods that are high in fat and sugar, interact with the brain to cause their overconsumption. Highly palatable foods cause plasticity in brain reward circuitry in a manner similar to drugs of abuse. Identifying how these "junk" foods interact with reward areas of the brain will explore the neural mechanisms underlying the hedonic nature of appetite. This project will not only inform our ....Unravelling the relationship between food and the brain. This project aims to investigate how highly palatable foods that are high in fat and sugar, interact with the brain to cause their overconsumption. Highly palatable foods cause plasticity in brain reward circuitry in a manner similar to drugs of abuse. Identifying how these "junk" foods interact with reward areas of the brain will explore the neural mechanisms underlying the hedonic nature of appetite. This project will not only inform our understanding of how exposure to these foods can contribute to overeating and obesity, a huge and growing problem in Australia, but will also provide evidence to inform policy options relevant to advertising and marketing of these foods.Read moreRead less
Investigating memory reliability in intoxicated witnesses of crime. Eyewitness testimony is a crucial piece of evidence for solving a crime. Inaccurate testimony leads to miscarriages of justice such as failed prosecutions or false convictions. Many witnesses and victims are affected by alcohol or other drugs during the crime. This project brings together a multidisciplinary team aiming to improve understanding of how intoxication with different substances affects the reliability of victim and w ....Investigating memory reliability in intoxicated witnesses of crime. Eyewitness testimony is a crucial piece of evidence for solving a crime. Inaccurate testimony leads to miscarriages of justice such as failed prosecutions or false convictions. Many witnesses and victims are affected by alcohol or other drugs during the crime. This project brings together a multidisciplinary team aiming to improve understanding of how intoxication with different substances affects the reliability of victim and witness memory accuracy. Crucially, crimes are frequently distressing; therefore the interaction between intoxication and stress urgently requires exploration. This project will significantly advance our understanding of key mechanisms behind drug effects on memory, and support fairer judicial outcomes for all. Read moreRead less