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Make up your mind! - Dissociating the roles of orbitofrontal cortex and striatum in human decision making. How we make everyday decisions is a crucial behaviour of humans but the underlying processes in the brain are still poorly understood. This project will investigate what the roles of specific brain regions are in human decision making, which enable us to gain a better understanding of how these brain structures contribute to our decisions.
Discovery Early Career Researcher Award - Grant ID: DE130100463
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Back to the future - dissociating mental simulation processes in the brain. Remembering the past and imagining the future are two linked processes that rely on a core brain network. The project will examine how damage to different parts of this brain network affects mental simulation of the past and future, providing fundamental information regarding the role of brain structures and systems for complex thought processes.
How satiation control reward value and cue-induced appetitive behaviours. This proposal aims to identify mechanisms that control environment-driven food-seeking behaviours. It seeks to do so by using modern virally-mediated and basic behavioural as well as histological techniques in a transgenic rat to characterise novel hindbrain circuits that control these feeding behaviours. This is significant as environment-driven overeating is problematic yet underlying mechanisms are unclear. This project ....How satiation control reward value and cue-induced appetitive behaviours. This proposal aims to identify mechanisms that control environment-driven food-seeking behaviours. It seeks to do so by using modern virally-mediated and basic behavioural as well as histological techniques in a transgenic rat to characterise novel hindbrain circuits that control these feeding behaviours. This is significant as environment-driven overeating is problematic yet underlying mechanisms are unclear. This project expects to provide new knowledge on when, where and how hindbrain neurons control environment-driven food-seeking behaviours. This should provide benefits to the advancement of knowledge on the neural mechanisms of food-seeking and provide a basic science platform for future research on the study of feeding behaviours.
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A comprehensive framework for modelling the human connectome. The human brain is an extraordinarily complex network of interconnected cells. This project aims to use mathematical modelling and brain imaging to uncover key principles of network wiring in the human brain. Using an interdisciplinary approach that combines elements of neuroscience, genetics, physics, and psychology, the project will result in a new, rigorous framework for testing competing theories of brain development, the identifi ....A comprehensive framework for modelling the human connectome. The human brain is an extraordinarily complex network of interconnected cells. This project aims to use mathematical modelling and brain imaging to uncover key principles of network wiring in the human brain. Using an interdisciplinary approach that combines elements of neuroscience, genetics, physics, and psychology, the project will result in a new, rigorous framework for testing competing theories of brain development, the identification of key wiring principles for developing brains, and an understanding of how these principles shape behaviour. This work will shed new light on the developmental processes that underlie human behaviour and disease.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882345
Funder
Australian Research Council
Funding Amount
$650,000.00
Summary
A 3.0 Tesla MRI system for human cognitive neuroscience research. For the first time scientists are beginning to reveal the complex relationship between human brain function and behaviour. These advances have stemmed almost exclusively from the development of sophisticated brain scanning techniques that provide high-resolution images of physiological changes associated with perceptual, cognitive and motor behaviours. This application seeks support for a state-of-the-art scanner to obtain high-re ....A 3.0 Tesla MRI system for human cognitive neuroscience research. For the first time scientists are beginning to reveal the complex relationship between human brain function and behaviour. These advances have stemmed almost exclusively from the development of sophisticated brain scanning techniques that provide high-resolution images of physiological changes associated with perceptual, cognitive and motor behaviours. This application seeks support for a state-of-the-art scanner to obtain high-resolution images of the brain as healthy adults perceive, think, learn, remember and decide. The facility will enable Australian scientists to understand the complex links between brain and behaviour in health and disease.Read moreRead less
Social psychological, personality, and neural processes underlying anger, aggression, and health. The Australian Institute of Criminology estimates the cost of assault, sexual assault, and homicide in Australia at over $2.5 billion per annum. Despite these enormous costs, very little is known about the cognitive and neural mechanisms guiding these phenomena. This research will also provide cues regarding risk for domestic violence. Understanding domestic violence is especially significant bec ....Social psychological, personality, and neural processes underlying anger, aggression, and health. The Australian Institute of Criminology estimates the cost of assault, sexual assault, and homicide in Australia at over $2.5 billion per annum. Despite these enormous costs, very little is known about the cognitive and neural mechanisms guiding these phenomena. This research will also provide cues regarding risk for domestic violence. Understanding domestic violence is especially significant because it is the leading cause of homicide among women in Australia. The insights gained from this research may lead to substantial social (e.g., stronger social fabric, reduced crime) and economic benefit (e.g., reduced spending on healthcare and crime).Read moreRead less
Smells that 'taste': Flavour perception and its consequences. The experience of flavour during eating and drinking has surprising social and economic ramifications. Our preference for sweet and fatty food has contributed to progressive increases in body mass over the last twenty years. Many experts now consider this to be a major public health crisis in the making. Economically, Australia is heavily dependent upon food exports, both in terms of primary production and value added processed food ....Smells that 'taste': Flavour perception and its consequences. The experience of flavour during eating and drinking has surprising social and economic ramifications. Our preference for sweet and fatty food has contributed to progressive increases in body mass over the last twenty years. Many experts now consider this to be a major public health crisis in the making. Economically, Australia is heavily dependent upon food exports, both in terms of primary production and value added processed food. Understanding the psychology of flavour, which is central to this project, should assist the development of non-fattening additives that appreciably alter fat and sweetness perception, creating new food products that are healthy, preferred and potential export earners. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100055
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
State-of-the-art upgrade to multi-transmit multi-receive technology for research dedicated 3 Tesla magnetic resonance imaging (MRI) scanner. Projects requiring the proposed infrastructure are aligned with two National Research Priorities. The research will lead to new methods for imaging and detecting soft tissue changes, identifying developmental, cognitive and degenerative disorders, and pharmacological research. The understanding of the basis of physiological, cognitive and biochemical proces ....State-of-the-art upgrade to multi-transmit multi-receive technology for research dedicated 3 Tesla magnetic resonance imaging (MRI) scanner. Projects requiring the proposed infrastructure are aligned with two National Research Priorities. The research will lead to new methods for imaging and detecting soft tissue changes, identifying developmental, cognitive and degenerative disorders, and pharmacological research. The understanding of the basis of physiological, cognitive and biochemical processes which will be facilitated by the new equipment will contribute to the priority area Promoting and Maintaining Good Health and will underpin an array of subsequent medical research. The new equipment will extend capabilities and training in signal analysis, biomedical engineering and biomedicine, contributing to the priority area Frontier technologies for Building and Transforming Australian Industries.Read moreRead less
Flavour learning and food consumption in rats and humans: Implications for obesity. Between-meal snacks and sweet drinks are major contributors to human obesity. Consumption of a food is greatly influenced by its flavour and the properties of flavours are largely learned. This project examines how what is learned about a flavour influences both short-term and long-term food consumption by rats and humans. Short-term effects are studied by adding a flavour to a pre-meal (snack) and measuring how ....Flavour learning and food consumption in rats and humans: Implications for obesity. Between-meal snacks and sweet drinks are major contributors to human obesity. Consumption of a food is greatly influenced by its flavour and the properties of flavours are largely learned. This project examines how what is learned about a flavour influences both short-term and long-term food consumption by rats and humans. Short-term effects are studied by adding a flavour to a pre-meal (snack) and measuring how much is eaten in a subsequent meal. Long-term effects are studied when the value of sweetness is altered by exposure to non-nutritive sweeteners. The results will extend basic understanding of flavour learning in relation to obesity.Read moreRead less
Overcoming distraction by reward-related stimuli. This project aims to establish the cognitive processes underlying distraction by reward associated stimuli, and whether 'attentional control' processes can reduce distraction. Even when people try to concentrate on a certain task, they can be distracted and they are more likely to be distracted by events associated with reward (such as money, food, sex, etc.). The expected outcomes of this project should show how to minimise distraction when it i ....Overcoming distraction by reward-related stimuli. This project aims to establish the cognitive processes underlying distraction by reward associated stimuli, and whether 'attentional control' processes can reduce distraction. Even when people try to concentrate on a certain task, they can be distracted and they are more likely to be distracted by events associated with reward (such as money, food, sex, etc.). The expected outcomes of this project should show how to minimise distraction when it is most detrimental: when safety depends on staying focussed (such as when driving), or for recovering addicts trying to ignore drug-related stimuli.Read moreRead less