Centre-surround interactions in ageing human vision. Australia has a rapidly ageing population. This project will study how ageing affects the visual perception of objects presented on non-uniform backgrounds. Our ability to discriminate objects from their backgrounds is key to most natural visual tasks. The visual processes involved are known as centre-surround interactions, and are considered fundamental building blocks to human perception. This project will significantly advance our knowledge ....Centre-surround interactions in ageing human vision. Australia has a rapidly ageing population. This project will study how ageing affects the visual perception of objects presented on non-uniform backgrounds. Our ability to discriminate objects from their backgrounds is key to most natural visual tasks. The visual processes involved are known as centre-surround interactions, and are considered fundamental building blocks to human perception. This project will significantly advance our knowledge of which spatial visual mechanisms are altered due to age, supplying key information for understanding and improving visual environments for the elderly, as well as increasing knowledge of the brain mechanisms susceptible to the ageing process.Read moreRead less
Subcellular co-localisation of interacting proteins that control maturation in mammalian eggs. The final maturation of mammalian eggs (oocytes) before fertilisation involves a cascade of interactions between protein kinases and phosphatases, the shuttling of these proteins between cytoplasm and nucleus, and microtubule assembly and disassembly. In this project we have proposed that interacting proteins involved in oocyte maturation are co-localised at subcellular sites in oocytes, in a strict t ....Subcellular co-localisation of interacting proteins that control maturation in mammalian eggs. The final maturation of mammalian eggs (oocytes) before fertilisation involves a cascade of interactions between protein kinases and phosphatases, the shuttling of these proteins between cytoplasm and nucleus, and microtubule assembly and disassembly. In this project we have proposed that interacting proteins involved in oocyte maturation are co-localised at subcellular sites in oocytes, in a strict temporal and spatial manner. The co-localisation of proteins in oocytes is considered a fundamental mechanism that ensures coordination of time-bound cellular events and proper preparation of oocytes for fertilisation and early embryo development. There are important implications for IVF and cloning by nuclear transfer.Read moreRead less
A Multiscale Modelling Framework for Mechanical Properties of ECM. This project aims to develop a novel hierarchical multi-scale modelling framework to understand factors that influence the mechanical deformation behaviour of the extracellular matrix (ECM) such as cartilage, whose mechanical performance is critical to human wellbeing. Modelling ECM presents significant challenges due to the need to incorporate effects at scales from atomic interactions up to the fibre network in a continuum mode ....A Multiscale Modelling Framework for Mechanical Properties of ECM. This project aims to develop a novel hierarchical multi-scale modelling framework to understand factors that influence the mechanical deformation behaviour of the extracellular matrix (ECM) such as cartilage, whose mechanical performance is critical to human wellbeing. Modelling ECM presents significant challenges due to the need to incorporate effects at scales from atomic interactions up to the fibre network in a continuum model. The proposed framework follows ECM's natural hierarchical structure and integrates efficient models for each key structural scale based on rigorous experimental validations. It is expected to provide a powerful tool for designing successful artificial ECM materials and understanding the mechanisms of the ECM degradation.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668507
Funder
Australian Research Council
Funding Amount
$260,000.00
Summary
Real time PCR and nanoparticle diagnostic facilities for high-throughput quantitative analysis of genomic structure and gene expression. Modern molecular tools have lead to an explosion in genome projects and unification of all areas of biology. The most basic need for such research is access to improving technologies for detecting DNA fingerprints that distinguish genetically-diverse genes, and determining which genes are "switched on" or 'off' in various situations. Real time PCR technology, ....Real time PCR and nanoparticle diagnostic facilities for high-throughput quantitative analysis of genomic structure and gene expression. Modern molecular tools have lead to an explosion in genome projects and unification of all areas of biology. The most basic need for such research is access to improving technologies for detecting DNA fingerprints that distinguish genetically-diverse genes, and determining which genes are "switched on" or 'off' in various situations. Real time PCR technology, pioneered by The University of Queensland (UQ) and Southern Cross University (SCU) using ARC funding in 1996, is now the technology of choice for much of this research. This project will provide high-throughput equipment for real time PCR, and will develop complementary high-throughput "nanoparticle" DNA genotyping technologies, with applications to medicine and agriculture.
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Ultra-faint signatures of galaxy growth seen through the cosmic haze. This project aims to uncover the cosmic cannibalism of galaxy mergers, by using innovative new instrumentation to detect some of the faintest structures ever seen by astronomers. The project will provide a comprehensive measurement of the mass growth experienced by large galaxies consuming their smaller siblings, which will provide a critical test of our understanding of dark matter. The project will also conduct ultra-high-se ....Ultra-faint signatures of galaxy growth seen through the cosmic haze. This project aims to uncover the cosmic cannibalism of galaxy mergers, by using innovative new instrumentation to detect some of the faintest structures ever seen by astronomers. The project will provide a comprehensive measurement of the mass growth experienced by large galaxies consuming their smaller siblings, which will provide a critical test of our understanding of dark matter. The project will also conduct ultra-high-sensitivity measurements of the foreground haze from nearby interstellar clouds, a crucial step towards mitigating its impact on billion-dollar projects such as the Euclid space telescope. The statistics of spatial structures in these clouds will help us to understand how new stars are born in our own Milky Way.Read moreRead less
Temporary Overseas Migration to Australia. A recent development in immigration policy is the shift to temporary entry arrangements for business and skill migration. Together with an increase in other types of temporary visitors, this has resulted in a significant rise in temporary migration and the number of temporary residents in Australia. The project will examine the key features of temporary overseas migration to Australia and the socioeconomic circumstances of temporary migrants. It will im ....Temporary Overseas Migration to Australia. A recent development in immigration policy is the shift to temporary entry arrangements for business and skill migration. Together with an increase in other types of temporary visitors, this has resulted in a significant rise in temporary migration and the number of temporary residents in Australia. The project will examine the key features of temporary overseas migration to Australia and the socioeconomic circumstances of temporary migrants. It will improve understanding of the factors motivating temporary migration, the labour market experiences and residential intentions of temporary migrants and assist the industry partner in assessing the demographic implications of Australia's immigration policies.Read moreRead less
Multi-Agent Solutions for the Development of Self-Organised and Self-Adapted Distributed Energy Generation Systems. The project aims to develop a self-organised multi-agent framework for modelling Marco-Smart Grid (SMG), dynamic coordination mechanisms between SMGs in distributed energy systems, and self-adaptation approaches for SMGs and restoration strategies to detect and recover an SMG network from faults and outages. The significance of this project lies in its promise to solve the challeng ....Multi-Agent Solutions for the Development of Self-Organised and Self-Adapted Distributed Energy Generation Systems. The project aims to develop a self-organised multi-agent framework for modelling Marco-Smart Grid (SMG), dynamic coordination mechanisms between SMGs in distributed energy systems, and self-adaptation approaches for SMGs and restoration strategies to detect and recover an SMG network from faults and outages. The significance of this project lies in its promise to solve the challenging issues of Smart Grid (SG) in multi-agent research and provide practical solutions to the development of effective and higher-quality distributed energy-generation systems with renewable energy resources. The expected outcomes are a framework, models, mechanisms and approaches in SG research and their practical applications.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101313
Funder
Australian Research Council
Funding Amount
$383,536.00
Summary
New chromatography-electrophysiology methods for semiochemical discovery. The aim of this research is to develop new tools for discovering natural products that mediate insect-insect and plant-insect communication. Knowledge of such semiochemicals is critical for many applications in conservation biology, agriculture, and horticulture. Many of these compounds are difficult to identify with current chemical and electrophysiological methods. The goal is to develop new technology combining state-of ....New chromatography-electrophysiology methods for semiochemical discovery. The aim of this research is to develop new tools for discovering natural products that mediate insect-insect and plant-insect communication. Knowledge of such semiochemicals is critical for many applications in conservation biology, agriculture, and horticulture. Many of these compounds are difficult to identify with current chemical and electrophysiological methods. The goal is to develop new technology combining state-of-the-art chemical separation techniques and electroantennography to enable detection and identification of a broad range of chemicals of biological importance. The intended outcome is to apply this technology to pollination systems of plants of conservation and evolutionary significance, and of commercial importance in terms of insect control and pollination.Read moreRead less
New directions in health inequalities research: understanding the intersection between housing, employment and health in Australia. People employed on a casual basis in Australia are nearly three times more likely to live in a household that is in housing affordability stress than their permanently employed counterparts. Employment and housing are both determinants of health. While social inclusion, employment and housing affordability are critical components of the government's current social p ....New directions in health inequalities research: understanding the intersection between housing, employment and health in Australia. People employed on a casual basis in Australia are nearly three times more likely to live in a household that is in housing affordability stress than their permanently employed counterparts. Employment and housing are both determinants of health. While social inclusion, employment and housing affordability are critical components of the government's current social policy agenda, articulation between these policy domains is limited and little researched. This important study will provide robust evidence on the ways that housing and employment interact to both cause and prevent health inequities. This will directly benefit agencies delivering services to vulnerable people and contribute to an evidence base of benefit to policy makers.Read moreRead less
Glucocorticoid receptor-αD1 modulates stress and inflammation . Environmental stressors in mammalian pregnancy often cause inflammation in the mother which has an adverse effect on the fetus and its survival. The current grant aims to examine the mechanism by which stress and inflammation coexist in pregnancy because stress hormones normally exert anti-inflammatory actions. Contrary to convention, a new glucocorticoid receptor (GR), GRalpha D1, is linked to increasing inflammation. Using innova ....Glucocorticoid receptor-αD1 modulates stress and inflammation . Environmental stressors in mammalian pregnancy often cause inflammation in the mother which has an adverse effect on the fetus and its survival. The current grant aims to examine the mechanism by which stress and inflammation coexist in pregnancy because stress hormones normally exert anti-inflammatory actions. Contrary to convention, a new glucocorticoid receptor (GR), GRalpha D1, is linked to increasing inflammation. Using innovative molecular biology approaches, GRalphaD1's function will be examined to provide a deeper understanding of how stress regulates inflammation in animal reproduction. The project aims to enhance interdisciplinary collaborations with expected benefits including a paradigm shift in our knowledge in this field.Read moreRead less